37 results on '"Northcott, Paul A"'
Search Results
2. Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility
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Liu, Anthony Pak-Yin, primary, Northcott, Paul A., additional, Robinson, Giles W., additional, and Gajjar, Amar, additional
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- 2022
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3. Serial assessment of measurable residual disease in medulloblastoma liquid biopsies
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Liu, Anthony P.Y., primary, Smith, Kyle S., additional, Kumar, Rahul, additional, Paul, Leena, additional, Bihannic, Laure, additional, Lin, Tong, additional, Maass, Kendra K., additional, Pajtler, Kristian W., additional, Chintagumpala, Murali, additional, Su, Jack M., additional, Bouffet, Eric, additional, Fisher, Michael J., additional, Gururangan, Sridharan, additional, Cohn, Richard, additional, Hassall, Tim, additional, Hansford, Jordan R., additional, Klimo, Paul, additional, Boop, Frederick A., additional, Stewart, Clinton F., additional, Harreld, Julie H., additional, Merchant, Thomas E., additional, Tatevossian, Ruth G., additional, Neale, Geoffrey, additional, Lear, Matthew, additional, Klco, Jeffery M., additional, Orr, Brent A., additional, Ellison, David W., additional, Gilbertson, Richard J., additional, Onar-Thomas, Arzu, additional, Gajjar, Amar, additional, Robinson, Giles W., additional, and Northcott, Paul A., additional
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- 2021
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4. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination
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Martirosian, Vahan, primary, Deshpande, Krutika, additional, Zhou, Hao, additional, Shen, Keyue, additional, Smith, Kyle, additional, Northcott, Paul, additional, Lin, Michelle, additional, Stepanosyan, Vazgen, additional, Das, Diganta, additional, Remsik, Jan, additional, Isakov, Danielle, additional, Boire, Adrienne, additional, De Feyter, Henk, additional, Hurth, Kyle, additional, Li, Shaobo, additional, Wiemels, Joseph, additional, Nakamura, Brooke, additional, Shao, Ling, additional, Danilov, Camelia, additional, Chen, Thomas, additional, and Neman, Josh, additional
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- 2021
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5. Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond
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Garcia-Lopez, Jesus, primary, Kumar, Rahul, additional, Smith, Kyle S., additional, and Northcott, Paul A., additional
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- 2021
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6. DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma
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Patmore, Deanna M., primary, Jassim, Amir, additional, Nathan, Erica, additional, Gilbertson, Reuben J., additional, Tahan, Daniel, additional, Hoffmann, Nadin, additional, Tong, Yiai, additional, Smith, Kyle S., additional, Kanneganti, Thirumala-Devi, additional, Suzuki, Hiromichi, additional, Taylor, Michael D., additional, Northcott, Paul, additional, and Gilbertson, Richard J., additional
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- 2020
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7. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
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Nobre, Liana, primary, Zapotocky, Michal, additional, Khan, Sara, additional, Fukuoka, Kohei, additional, Fonseca, Adriana, additional, McKeown, Tara, additional, Sumerauer, David, additional, Vicha, Ales, additional, Grajkowska, Wieslawa A., additional, Trubicka, Joanna, additional, Li, Kay Ka Wai, additional, Ng, Ho-Keung, additional, Massimi, Luca, additional, Lee, Ji Yeoun, additional, Kim, Seung-Ki, additional, Zelcer, Shayna, additional, Vasiljevic, Alexandre, additional, Faure-Conter, Cécile, additional, Hauser, Peter, additional, Lach, Boleslaw, additional, van Veelen-Vincent, Marie-Lise, additional, French, Pim J., additional, Van Meir, Erwin G., additional, Weiss, William A., additional, Gupta, Nalin, additional, Pollack, Ian F., additional, Hamilton, Ronald L., additional, Nageswara Rao, Amulya A., additional, Giannini, Caterina, additional, Rubin, Joshua B., additional, Moore, Andrew S., additional, Chambless, Lola B., additional, Vibhakar, Rajeev, additional, Ra, Young Shin, additional, Massimino, Maura, additional, McLendon, Roger E., additional, Wheeler, Helen, additional, Zollo, Massimo, additional, Ferruci, Veronica, additional, Kumabe, Toshihiro, additional, Faria, Claudia C., additional, Sterba, Jaroslav, additional, Jung, Shin, additional, López-Aguilar, Enrique, additional, Mora, Jaume, additional, Carlotti, Carlos G., additional, Olson, James M., additional, Leary, Sarah, additional, Cain, Jason, additional, Krskova, Lenka, additional, Zamecnik, Josef, additional, Hawkins, Cynthia E., additional, Tabori, Uri, additional, Huang, Annie, additional, Bartels, Ute, additional, Northcott, Paul A., additional, Taylor, Michael D., additional, Yip, Stephen, additional, Hansford, Jordan R., additional, Bouffet, Eric, additional, and Ramaswamy, Vijay, additional
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- 2020
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8. Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma
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García-López, Jesus, primary, Wallace, Kirby, additional, Otero, Joel H., additional, Olsen, Rachelle, additional, Wang, Yong-dong, additional, Finkelstein, David, additional, Gudenas, Brian L., additional, Rehg, Jerold E., additional, Northcott, Paul, additional, Davidoff, Andrew M., additional, and Freeman, Kevin W., additional
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- 2020
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9. Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation
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Erkek, Serap, primary, Johann, Pascal D., additional, Finetti, Martina A., additional, Drosos, Yiannis, additional, Chou, Hsien-Chao, additional, Zapatka, Marc, additional, Sturm, Dominik, additional, Jones, David T.W., additional, Korshunov, Andrey, additional, Rhyzova, Marina, additional, Wolf, Stephan, additional, Mallm, Jan-Philipp, additional, Beck, Katja, additional, Witt, Olaf, additional, Kulozik, Andreas E., additional, Frühwald, Michael C., additional, Northcott, Paul A., additional, Korbel, Jan O., additional, Lichter, Peter, additional, Eils, Roland, additional, Gajjar, Amar, additional, Roberts, Charles W.M., additional, Williamson, Daniel, additional, Hasselblatt, Martin, additional, Chavez, Lukas, additional, Pfister, Stefan M., additional, and Kool, Marcel, additional
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- 2019
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10. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
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Nobre, Liana, primary, Zapotocky, Michal, additional, Khan, Sara, additional, Fukuoka, Kohei, additional, Fonseca, Adriana, additional, Sumerauer, David, additional, Vicha, Ales, additional, Grajkowska, Wieslawa, additional, Trubicka, Joanna, additional, Li, Kay Ka Wai, additional, Ng, Ho-Keung, additional, Massimi, Luca, additional, Lee, Ji Yeoun, additional, Kim, Seung-Ki, additional, Zelcer, Shayna, additional, VASILJEVIC, Alexandre, additional, Faure-Contre, Cecile, additional, Hauser, Peter, additional, Lach, Boleslaw, additional, van vincent veelen, Marie-Lise, additional, French, Pim J., additional, Van Meir, Erwin G., additional, Weiss, William A., additional, Gupta, Nalin, additional, Pollack, Ian F., additional, Hamilton, Ronald L., additional, Nageswara Rao, Amulya, additional, Giannini, Caterina, additional, Rubin, Joshua B., additional, Moore, Andrew S., additional, Chambless, Lola B., additional, Vibhakar, Rajeev, additional, Ra, Young Shin, additional, Massimino, Maura, additional, MacLendon, Roger E., additional, Wheeler, Helen, additional, Zollo, Massimo, additional, Ferruci, Veronica, additional, Kumabe, Toshihiro, additional, Faria, Claudia C., additional, Sterba, Jaroslav, additional, Jung, Shin, additional, López-Aguilar, Enrique, additional, Mora, Jaume, additional, Carlotti, Carlos, additional, Olson, James M., additional, Leary, Sarah, additional, Cain, Jason, additional, Krskova, Lenka, additional, Zamecnik, Josef, additional, Hawkins, Cynthia E., additional, Tabori, Uri, additional, Huang, Annie, additional, Bartels, Ute, additional, Northcott, Paul, additional, Taylor, Michael D., additional, Hansford, Jordan, additional, Bouffet, Eric, additional, and ramaswamy, vijay, additional
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- 2019
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11. A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum
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Carter, Robert A., primary, Bihannic, Laure, additional, Rosencrance, Celeste, additional, Hadley, Jennifer L., additional, Tong, Yiai, additional, Phoenix, Timothy N., additional, Natarajan, Sivaraman, additional, Easton, John, additional, Northcott, Paul A., additional, and Gawad, Charles, additional
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- 2018
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12. Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
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Archer, Tenley C., primary, Ehrenberger, Tobias, additional, Mundt, Filip, additional, Gold, Maxwell P., additional, Krug, Karsten, additional, Mah, Clarence K., additional, Mahoney, Elizabeth L., additional, Daniel, Colin J., additional, LeNail, Alexander, additional, Ramamoorthy, Divya, additional, Mertins, Philipp, additional, Mani, D.R., additional, Zhang, Hailei, additional, Gillette, Michael A., additional, Clauser, Karl, additional, Noble, Michael, additional, Tang, Lauren C., additional, Pierre-François, Jessica, additional, Silterra, Jacob, additional, Jensen, James, additional, Tamayo, Pablo, additional, Korshunov, Andrey, additional, Pfister, Stefan M., additional, Kool, Marcel, additional, Northcott, Paul A., additional, Sears, Rosalie C., additional, Lipton, Jonathan O., additional, Carr, Steven A., additional, Mesirov, Jill P., additional, Pomeroy, Scott L., additional, and Fraenkel, Ernest, additional
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- 2018
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13. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
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Dhar, Shilpa S., primary, Zhao, Dongyu, additional, Lin, Tao, additional, Gu, Bingnan, additional, Pal, Khusboo, additional, Wu, Sarah J., additional, Alam, Hunain, additional, Lv, Jie, additional, Yun, Kyuson, additional, Gopalakrishnan, Vidya, additional, Flores, Elsa R., additional, Northcott, Paul A., additional, Rajaram, Veena, additional, Li, Wei, additional, Shilatifard, Ali, additional, Sillitoe, Roy V., additional, Chen, Kaifu, additional, and Lee, Min Gyu, additional
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- 2018
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14. Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial
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Robinson, Giles W, primary, Rudneva, Vasilisa A, additional, Buchhalter, Ivo, additional, Billups, Catherine A, additional, Waszak, Sebastian M, additional, Smith, Kyle S, additional, Bowers, Daniel C, additional, Bendel, Anne, additional, Fisher, Paul G, additional, Partap, Sonia, additional, Crawford, John R, additional, Hassall, Tim, additional, Indelicato, Daniel J, additional, Boop, Frederick, additional, Klimo, Paul, additional, Sabin, Noah D, additional, Patay, Zoltan, additional, Merchant, Thomas E, additional, Stewart, Clinton F, additional, Orr, Brent A, additional, Korbel, Jan O, additional, Jones, David T W, additional, Sharma, Tanvi, additional, Lichter, Peter, additional, Kool, Marcel, additional, Korshunov, Andrey, additional, Pfister, Stefan M, additional, Gilbertson, Richard J, additional, Sanders, Robert P, additional, Onar-Thomas, Arzu, additional, Ellison, David W, additional, Gajjar, Amar, additional, and Northcott, Paul A, additional
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- 2018
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15. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
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Waszak, Sebastian M, primary, Northcott, Paul A, additional, Buchhalter, Ivo, additional, Robinson, Giles W, additional, Sutter, Christian, additional, Groebner, Susanne, additional, Grund, Kerstin B, additional, Brugières, Laurence, additional, Jones, David T W, additional, Pajtler, Kristian W, additional, Morrissy, A Sorana, additional, Kool, Marcel, additional, Sturm, Dominik, additional, Chavez, Lukas, additional, Ernst, Aurelie, additional, Brabetz, Sebastian, additional, Hain, Michael, additional, Zichner, Thomas, additional, Segura-Wang, Maia, additional, Weischenfeldt, Joachim, additional, Rausch, Tobias, additional, Mardin, Balca R, additional, Zhou, Xin, additional, Baciu, Cristina, additional, Lawerenz, Christian, additional, Chan, Jennifer A, additional, Varlet, Pascale, additional, Guerrini-Rousseau, Lea, additional, Fults, Daniel W, additional, Grajkowska, Wiesława, additional, Hauser, Peter, additional, Jabado, Nada, additional, Ra, Young-Shin, additional, Zitterbart, Karel, additional, Shringarpure, Suyash S, additional, De La Vega, Francisco M, additional, Bustamante, Carlos D, additional, Ng, Ho-Keung, additional, Perry, Arie, additional, MacDonald, Tobey J, additional, Hernáiz Driever, Pablo, additional, Bendel, Anne E, additional, Bowers, Daniel C, additional, McCowage, Geoffrey, additional, Chintagumpala, Murali M, additional, Cohn, Richard, additional, Hassall, Timothy, additional, Fleischhack, Gudrun, additional, Eggen, Tone, additional, Wesenberg, Finn, additional, Feychting, Maria, additional, Lannering, Birgitta, additional, Schüz, Joachim, additional, Johansen, Christoffer, additional, Andersen, Tina V, additional, Röösli, Martin, additional, Kuehni, Claudia E, additional, Grotzer, Michael, additional, Kjaerheim, Kristina, additional, Monoranu, Camelia M, additional, Archer, Tenley C, additional, Duke, Elizabeth, additional, Pomeroy, Scott L, additional, Shelagh, Redmond, additional, Frank, Stephan, additional, Sumerauer, David, additional, Scheurlen, Wolfram, additional, Ryzhova, Marina V, additional, Milde, Till, additional, Kratz, Christian P, additional, Samuel, David, additional, Zhang, Jinghui, additional, Solomon, David A, additional, Marra, Marco, additional, Eils, Roland, additional, Bartram, Claus R, additional, von Hoff, Katja, additional, Rutkowski, Stefan, additional, Ramaswamy, Vijay, additional, Gilbertson, Richard J, additional, Korshunov, Andrey, additional, Taylor, Michael D, additional, Lichter, Peter, additional, Malkin, David, additional, Gajjar, Amar, additional, Korbel, Jan O, additional, and Pfister, Stefan M, additional
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- 2018
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16. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma
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Garancher, Alexandra, primary, Lin, Charles Y., additional, Morabito, Morgane, additional, Richer, Wilfrid, additional, Rocques, Nathalie, additional, Larcher, Magalie, additional, Bihannic, Laure, additional, Smith, Kyle, additional, Miquel, Catherine, additional, Leboucher, Sophie, additional, Herath, Nirmitha I., additional, Dupuy, Fanny, additional, Varlet, Pascale, additional, Haberler, Christine, additional, Walczak, Christine, additional, El Tayara, Nadine, additional, Volk, Andreas, additional, Puget, Stéphanie, additional, Doz, François, additional, Delattre, Olivier, additional, Druillennec, Sabine, additional, Ayrault, Olivier, additional, Wechsler-Reya, Robert J., additional, Eychène, Alain, additional, Bourdeaut, Franck, additional, Northcott, Paul A., additional, and Pouponnot, Celio, additional
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- 2018
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17. Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma
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Vo, BaoHan T., primary, Li, Chunliang, additional, Morgan, Marc A., additional, Theurillat, Ilan, additional, Finkelstein, David, additional, Wright, Shaela, additional, Hyle, Judith, additional, Smith, Stephanie M.C., additional, Fan, Yiping, additional, Wang, Yong-Dong, additional, Wu, Gang, additional, Orr, Brent A., additional, Northcott, Paul A., additional, Shilatifard, Ali, additional, Sherr, Charles J., additional, and Roussel, Martine F., additional
- Published
- 2017
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18. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
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Thompson, Eric M, primary, Hielscher, Thomas, additional, Bouffet, Eric, additional, Remke, Marc, additional, Luu, Betty, additional, Gururangan, Sridharan, additional, McLendon, Roger E, additional, Bigner, Darell D, additional, Lipp, Eric S, additional, Perreault, Sebastien, additional, Cho, Yoon-Jae, additional, Grant, Gerald, additional, Kim, Seung-Ki, additional, Lee, Ji Yeoun, additional, Rao, Amulya A Nageswara, additional, Giannini, Caterina, additional, Li, Kay Ka Wai, additional, Ng, Ho-Keung, additional, Yao, Yu, additional, Kumabe, Toshihiro, additional, Tominaga, Teiji, additional, Grajkowska, Wieslawa A, additional, Perek-Polnik, Marta, additional, Low, David C Y, additional, Seow, Wan Tew, additional, Chang, Kenneth T E, additional, Mora, Jaume, additional, Pollack, Ian F, additional, Hamilton, Ronald L, additional, Leary, Sarah, additional, Moore, Andrew S, additional, Ingram, Wendy J, additional, Hallahan, Andrew R, additional, Jouvet, Anne, additional, Fèvre-Montange, Michelle, additional, Vasiljevic, Alexandre, additional, Faure-Conter, Cecile, additional, Shofuda, Tomoko, additional, Kagawa, Naoki, additional, Hashimoto, Naoya, additional, Jabado, Nada, additional, Weil, Alexander G, additional, Gayden, Tenzin, additional, Wataya, Takafumi, additional, Shalaby, Tarek, additional, Grotzer, Michael, additional, Zitterbart, Karel, additional, Sterba, Jaroslav, additional, Kren, Leos, additional, Hortobágyi, Tibor, additional, Klekner, Almos, additional, László, Bognár, additional, Pócza, Tímea, additional, Hauser, Peter, additional, Schüller, Ulrich, additional, Jung, Shin, additional, Jang, Woo-Youl, additional, French, Pim J, additional, Kros, Johan M, additional, van Veelen, Marie-Lise C, additional, Massimi, Luca, additional, Leonard, Jeffrey R, additional, Rubin, Joshua B, additional, Vibhakar, Rajeev, additional, Chambless, Lola B, additional, Cooper, Michael K, additional, Thompson, Reid C, additional, Faria, Claudia C, additional, Carvalho, Alice, additional, Nunes, Sofia, additional, Pimentel, José, additional, Fan, Xing, additional, Muraszko, Karin M, additional, López-Aguilar, Enrique, additional, Lyden, David, additional, Garzia, Livia, additional, Shih, David J H, additional, Kijima, Noriyuki, additional, Schneider, Christian, additional, Adamski, Jennifer, additional, Northcott, Paul A, additional, Kool, Marcel, additional, Jones, David T W, additional, Chan, Jennifer A, additional, Nikolic, Ana, additional, Garre, Maria Luisa, additional, Van Meir, Erwin G, additional, Osuka, Satoru, additional, Olson, Jeffrey J, additional, Jahangiri, Arman, additional, Castro, Brandyn A, additional, Gupta, Nalin, additional, Weiss, William A, additional, Moxon-Emre, Iska, additional, Mabbott, Donald J, additional, Lassaletta, Alvaro, additional, Hawkins, Cynthia E, additional, Tabori, Uri, additional, Drake, James, additional, Kulkarni, Abhaya, additional, Dirks, Peter, additional, Rutka, James T, additional, Korshunov, Andrey, additional, Pfister, Stefan M, additional, Packer, Roger J, additional, Ramaswamy, Vijay, additional, and Taylor, Michael D, additional
- Published
- 2016
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19. Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes
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Johann, Pascal D., primary, Erkek, Serap, additional, Zapatka, Marc, additional, Kerl, Kornelius, additional, Buchhalter, Ivo, additional, Hovestadt, Volker, additional, Jones, David T.W., additional, Sturm, Dominik, additional, Hermann, Carl, additional, Segura Wang, Maia, additional, Korshunov, Andrey, additional, Rhyzova, Marina, additional, Gröbner, Susanne, additional, Brabetz, Sebastian, additional, Chavez, Lukas, additional, Bens, Susanne, additional, Gröschel, Stefan, additional, Kratochwil, Fabian, additional, Wittmann, Andrea, additional, Sieber, Laura, additional, Geörg, Christina, additional, Wolf, Stefan, additional, Beck, Katja, additional, Oyen, Florian, additional, Capper, David, additional, van Sluis, Peter, additional, Volckmann, Richard, additional, Koster, Jan, additional, Versteeg, Rogier, additional, von Deimling, Andreas, additional, Milde, Till, additional, Witt, Olaf, additional, Kulozik, Andreas E., additional, Ebinger, Martin, additional, Shalaby, Tarek, additional, Grotzer, Michael, additional, Sumerauer, David, additional, Zamecnik, Josef, additional, Mora, Jaume, additional, Jabado, Nada, additional, Taylor, Michael D., additional, Huang, Annie, additional, Aronica, Eleonora, additional, Bertoni, Anna, additional, Radlwimmer, Bernhard, additional, Pietsch, Torsten, additional, Schüller, Ulrich, additional, Schneppenheim, Reinhard, additional, Northcott, Paul A., additional, Korbel, Jan O., additional, Siebert, Reiner, additional, Frühwald, Michael C., additional, Lichter, Peter, additional, Eils, Roland, additional, Gajjar, Amar, additional, Hasselblatt, Martin, additional, Pfister, Stefan M., additional, and Kool, Marcel, additional
- Published
- 2016
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20. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
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Sturm, Dominik, primary, Orr, Brent A., additional, Toprak, Umut H., additional, Hovestadt, Volker, additional, Jones, David T.W., additional, Capper, David, additional, Sill, Martin, additional, Buchhalter, Ivo, additional, Northcott, Paul A., additional, Leis, Irina, additional, Ryzhova, Marina, additional, Koelsche, Christian, additional, Pfaff, Elke, additional, Allen, Sariah J., additional, Balasubramanian, Gnanaprakash, additional, Worst, Barbara C., additional, Pajtler, Kristian W., additional, Brabetz, Sebastian, additional, Johann, Pascal D., additional, Sahm, Felix, additional, Reimand, Jüri, additional, Mackay, Alan, additional, Carvalho, Diana M., additional, Remke, Marc, additional, Phillips, Joanna J., additional, Perry, Arie, additional, Cowdrey, Cynthia, additional, Drissi, Rachid, additional, Fouladi, Maryam, additional, Giangaspero, Felice, additional, Łastowska, Maria, additional, Grajkowska, Wiesława, additional, Scheurlen, Wolfram, additional, Pietsch, Torsten, additional, Hagel, Christian, additional, Gojo, Johannes, additional, Lötsch, Daniela, additional, Berger, Walter, additional, Slavc, Irene, additional, Haberler, Christine, additional, Jouvet, Anne, additional, Holm, Stefan, additional, Hofer, Silvia, additional, Prinz, Marco, additional, Keohane, Catherine, additional, Fried, Iris, additional, Mawrin, Christian, additional, Scheie, David, additional, Mobley, Bret C., additional, Schniederjan, Matthew J., additional, Santi, Mariarita, additional, Buccoliero, Anna M., additional, Dahiya, Sonika, additional, Kramm, Christof M., additional, von Bueren, André O., additional, von Hoff, Katja, additional, Rutkowski, Stefan, additional, Herold-Mende, Christel, additional, Frühwald, Michael C., additional, Milde, Till, additional, Hasselblatt, Martin, additional, Wesseling, Pieter, additional, Rößler, Jochen, additional, Schüller, Ulrich, additional, Ebinger, Martin, additional, Schittenhelm, Jens, additional, Frank, Stephan, additional, Grobholz, Rainer, additional, Vajtai, Istvan, additional, Hans, Volkmar, additional, Schneppenheim, Reinhard, additional, Zitterbart, Karel, additional, Collins, V. Peter, additional, Aronica, Eleonora, additional, Varlet, Pascale, additional, Puget, Stephanie, additional, Dufour, Christelle, additional, Grill, Jacques, additional, Figarella-Branger, Dominique, additional, Wolter, Marietta, additional, Schuhmann, Martin U., additional, Shalaby, Tarek, additional, Grotzer, Michael, additional, van Meter, Timothy, additional, Monoranu, Camelia-Maria, additional, Felsberg, Jörg, additional, Reifenberger, Guido, additional, Snuderl, Matija, additional, Forrester, Lynn Ann, additional, Koster, Jan, additional, Versteeg, Rogier, additional, Volckmann, Richard, additional, van Sluis, Peter, additional, Wolf, Stephan, additional, Mikkelsen, Tom, additional, Gajjar, Amar, additional, Aldape, Kenneth, additional, Moore, Andrew S., additional, Taylor, Michael D., additional, Jones, Chris, additional, Jabado, Nada, additional, Karajannis, Matthias A., additional, Eils, Roland, additional, Schlesner, Matthias, additional, Lichter, Peter, additional, von Deimling, Andreas, additional, Pfister, Stefan M., additional, Ellison, David W., additional, Korshunov, Andrey, additional, and Kool, Marcel, additional
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- 2016
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21. Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies
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Northcott, Paul A, primary, Pfister, Stefan M, additional, and Jones, David T W, additional
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- 2015
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22. The Shh Receptor Boc Promotes Progression of Early Medulloblastoma to Advanced Tumors
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Mille, Frédéric, primary, Tamayo-Orrego, Lukas, additional, Lévesque, Martin, additional, Remke, Marc, additional, Korshunov, Andrey, additional, Cardin, Julie, additional, Bouchard, Nicolas, additional, Izzi, Luisa, additional, Kool, Marcel, additional, Northcott, Paul A., additional, Taylor, Michael D., additional, Pfister, Stefan M., additional, and Charron, Frédéric, additional
- Published
- 2014
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23. Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma
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Vanner, Robert J., primary, Remke, Marc, additional, Gallo, Marco, additional, Selvadurai, Hayden J., additional, Coutinho, Fiona, additional, Lee, Lilian, additional, Kushida, Michelle, additional, Head, Renee, additional, Morrissy, Sorana, additional, Zhu, Xueming, additional, Aviv, Tzvi, additional, Voisin, Veronique, additional, Clarke, Ian D., additional, Li, Yisu, additional, Mungall, Andrew J., additional, Moore, Richard A., additional, Ma, Yussanne, additional, Jones, Steven J.M., additional, Marra, Marco A., additional, Malkin, David, additional, Northcott, Paul A., additional, Kool, Marcel, additional, Pfister, Stefan M., additional, Bader, Gary, additional, Hochedlinger, Konrad, additional, Korshunov, Andrey, additional, Taylor, Michael D., additional, and Dirks, Peter B., additional
- Published
- 2014
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24. Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
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Kool, Marcel, primary, Jones, David T.W., additional, Jäger, Natalie, additional, Northcott, Paul A., additional, Pugh, Trevor J., additional, Hovestadt, Volker, additional, Piro, Rosario M., additional, Esparza, L. Adriana, additional, Markant, Shirley L., additional, Remke, Marc, additional, Milde, Till, additional, Bourdeaut, Franck, additional, Ryzhova, Marina, additional, Sturm, Dominik, additional, Pfaff, Elke, additional, Stark, Sebastian, additional, Hutter, Sonja, additional, Şeker-Cin, Huriye, additional, Johann, Pascal, additional, Bender, Sebastian, additional, Schmidt, Christin, additional, Rausch, Tobias, additional, Shih, David, additional, Reimand, Jüri, additional, Sieber, Laura, additional, Wittmann, Andrea, additional, Linke, Linda, additional, Witt, Hendrik, additional, Weber, Ursula D., additional, Zapatka, Marc, additional, König, Rainer, additional, Beroukhim, Rameen, additional, Bergthold, Guillaume, additional, van Sluis, Peter, additional, Volckmann, Richard, additional, Koster, Jan, additional, Versteeg, Rogier, additional, Schmidt, Sabine, additional, Wolf, Stephan, additional, Lawerenz, Chris, additional, Bartholomae, Cynthia C., additional, von Kalle, Christof, additional, Unterberg, Andreas, additional, Herold-Mende, Christel, additional, Hofer, Silvia, additional, Kulozik, Andreas E., additional, von Deimling, Andreas, additional, Scheurlen, Wolfram, additional, Felsberg, Jörg, additional, Reifenberger, Guido, additional, Hasselblatt, Martin, additional, Crawford, John R., additional, Grant, Gerald A., additional, Jabado, Nada, additional, Perry, Arie, additional, Cowdrey, Cynthia, additional, Croul, Sydney, additional, Zadeh, Gelareh, additional, Korbel, Jan O., additional, Doz, Francois, additional, Delattre, Olivier, additional, Bader, Gary D., additional, McCabe, Martin G., additional, Collins, V. Peter, additional, Kieran, Mark W., additional, Cho, Yoon-Jae, additional, Pomeroy, Scott L., additional, Witt, Olaf, additional, Brors, Benedikt, additional, Taylor, Michael D., additional, Schüller, Ulrich, additional, Korshunov, Andrey, additional, Eils, Roland, additional, Wechsler-Reya, Robert J., additional, Lichter, Peter, additional, and Pfister, Stefan M., additional
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- 2014
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25. Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
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Ramaswamy, Vijay, primary, Remke, Marc, additional, Bouffet, Eric, additional, Faria, Claudia C, additional, Perreault, Sebastien, additional, Cho, Yoon-Jae, additional, Shih, David J, additional, Luu, Betty, additional, Dubuc, Adrian M, additional, Northcott, Paul A, additional, Schüller, Ulrich, additional, Gururangan, Sridharan, additional, McLendon, Roger, additional, Bigner, Darell, additional, Fouladi, Maryam, additional, Ligon, Keith L, additional, Pomeroy, Scott L, additional, Dunn, Sandra, additional, Triscott, Joanna, additional, Jabado, Nada, additional, Fontebasso, Adam, additional, Jones, David T W, additional, Kool, Marcel, additional, Karajannis, Matthias A, additional, Gardner, Sharon L, additional, Zagzag, David, additional, Nunes, Sofia, additional, Pimentel, José, additional, Mora, Jaume, additional, Lipp, Eric, additional, Walter, Andrew W, additional, Ryzhova, Marina, additional, Zheludkova, Olga, additional, Kumirova, Ella, additional, Alshami, Jad, additional, Croul, Sidney E, additional, Rutka, James T, additional, Hawkins, Cynthia, additional, Tabori, Uri, additional, Codispoti, Kari-Elise T, additional, Packer, Roger J, additional, Pfister, Stefan M, additional, Korshunov, Andrey, additional, and Taylor, Michael D, additional
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- 2013
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26. Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
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Bender, Sebastian, primary, Tang, Yujie, additional, Lindroth, Anders M., additional, Hovestadt, Volker, additional, Jones, David T.W., additional, Kool, Marcel, additional, Zapatka, Marc, additional, Northcott, Paul A., additional, Sturm, Dominik, additional, Wang, Wei, additional, Radlwimmer, Bernhard, additional, Højfeldt, Jonas W., additional, Truffaux, Nathalène, additional, Castel, David, additional, Schubert, Simone, additional, Ryzhova, Marina, additional, Şeker-Cin, Huriye, additional, Gronych, Jan, additional, Johann, Pascal David, additional, Stark, Sebastian, additional, Meyer, Jochen, additional, Milde, Till, additional, Schuhmann, Martin, additional, Ebinger, Martin, additional, Monoranu, Camelia-Maria, additional, Ponnuswami, Anitha, additional, Chen, Spenser, additional, Jones, Chris, additional, Witt, Olaf, additional, Collins, V. Peter, additional, von Deimling, Andreas, additional, Jabado, Nada, additional, Puget, Stephanie, additional, Grill, Jacques, additional, Helin, Kristian, additional, Korshunov, Andrey, additional, Lichter, Peter, additional, Monje, Michelle, additional, Plass, Christoph, additional, Cho, Yoon-Jae, additional, and Pfister, Stefan M., additional
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- 2013
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27. Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer
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Jäger, Natalie, primary, Schlesner, Matthias, additional, Jones, David T.W., additional, Raffel, Simon, additional, Mallm, Jan-Philipp, additional, Junge, Kristin M., additional, Weichenhan, Dieter, additional, Bauer, Tobias, additional, Ishaque, Naveed, additional, Kool, Marcel, additional, Northcott, Paul A., additional, Korshunov, Andrey, additional, Drews, Ruben M., additional, Koster, Jan, additional, Versteeg, Rogier, additional, Richter, Julia, additional, Hummel, Michael, additional, Mack, Stephen C., additional, Taylor, Michael D., additional, Witt, Hendrik, additional, Swartman, Benedict, additional, Schulte-Bockholt, Dietrich, additional, Sultan, Marc, additional, Yaspo, Marie-Laure, additional, Lehrach, Hans, additional, Hutter, Barbara, additional, Brors, Benedikt, additional, Wolf, Stephan, additional, Plass, Christoph, additional, Siebert, Reiner, additional, Trumpp, Andreas, additional, Rippe, Karsten, additional, Lehmann, Irina, additional, Lichter, Peter, additional, Pfister, Stefan M., additional, and Eils, Roland, additional
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- 2013
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28. The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
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Leprivier, Gabriel, primary, Remke, Marc, additional, Rotblat, Barak, additional, Dubuc, Adrian, additional, Mateo, Abigail-Rachele F., additional, Kool, Marcel, additional, Agnihotri, Sameer, additional, El-Naggar, Amal, additional, Yu, Bin, additional, Prakash Somasekharan, Syam, additional, Faubert, Brandon, additional, Bridon, Gaëlle, additional, Tognon, Cristina E., additional, Mathers, Joan, additional, Thomas, Ryan, additional, Li, Amy, additional, Barokas, Adi, additional, Kwok, Brian, additional, Bowden, Mary, additional, Smith, Stephanie, additional, Wu, Xiaochong, additional, Korshunov, Andrey, additional, Hielscher, Thomas, additional, Northcott, Paul A., additional, Galpin, Jason D., additional, Ahern, Christopher A., additional, Wang, Ye, additional, McCabe, Martin G., additional, Collins, V. Peter, additional, Jones, Russell G., additional, Pollak, Michael, additional, Delattre, Olivier, additional, Gleave, Martin E., additional, Jan, Eric, additional, Pfister, Stefan M., additional, Proud, Christopher G., additional, Derry, W. Brent, additional, Taylor, Michael D., additional, and Sorensen, Poul H., additional
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- 2013
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29. The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis
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Vo, Dat T., primary, Subramaniam, Dharmalingam, additional, Remke, Marc, additional, Burton, Tarea L., additional, Uren, Philip J., additional, Gelfond, Jonathan A., additional, de Sousa Abreu, Raquel, additional, Burns, Suzanne C., additional, Qiao, Mei, additional, Suresh, Uthra, additional, Korshunov, Andrey, additional, Dubuc, Adrian M., additional, Northcott, Paul A., additional, Smith, Andrew D., additional, Pfister, Stefan M., additional, Taylor, Michael D., additional, Janga, Sarath C., additional, Anant, Shrikant, additional, Vogel, Christine, additional, and Penalva, Luiz O.F., additional
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- 2012
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30. High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in Chordoma Pathogenesis
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Diaz, Roberto Jose, primary, Guduk, Mustafa, additional, Romagnuolo, Rocco, additional, Smith, Christian A., additional, Northcott, Paul, additional, Shih, David, additional, Berisha, Fitim, additional, Flanagan, Adrienne, additional, Munoz, David G., additional, Cusimano, Michael D., additional, Pamir, M. Necmettin, additional, and Rutka, James T., additional
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- 2012
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31. Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor
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Li, Meihua, primary, Lockwood, Will, additional, Zielenska, Maria, additional, Northcott, Paul, additional, Ra, Young Shing, additional, Bouffet, Eric, additional, Yoshimoto, Maisa, additional, Rutka, James T., additional, Yan, Hai, additional, Taylor, Michael D., additional, Eberhart, Charles, additional, Hawkins, Cynthia E., additional, Lam, Wan, additional, Squire, Jeremy A., additional, and Huang, Annie, additional
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- 2012
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32. Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC
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Swartling, Fredrik J., primary, Savov, Vasil, additional, Persson, Anders I., additional, Chen, Justin, additional, Hackett, Christopher S., additional, Northcott, Paul A., additional, Grimmer, Matthew R., additional, Lau, Jasmine, additional, Chesler, Louis, additional, Perry, Arie, additional, Phillips, Joanna J., additional, Taylor, Michael D., additional, and Weiss, William A., additional
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- 2012
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33. An Animal Model of MYC-Driven Medulloblastoma
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Pei, Yanxin, primary, Moore, Colin E., additional, Wang, Jun, additional, Tewari, Alok K., additional, Eroshkin, Alexey, additional, Cho, Yoon-Jae, additional, Witt, Hendrik, additional, Korshunov, Andrey, additional, Read, Tracy-Ann, additional, Sun, Julia L., additional, Schmitt, Earlene M., additional, Miller, C. Ryan, additional, Buckley, Anne F., additional, McLendon, Roger E., additional, Westbrook, Thomas F., additional, Northcott, Paul A., additional, Taylor, Michael D., additional, Pfister, Stefan M., additional, Febbo, Phillip G., additional, and Wechsler-Reya, Robert J., additional
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- 2012
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34. Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations
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Rausch, Tobias, primary, Jones, David T.W., additional, Zapatka, Marc, additional, Stütz, Adrian M., additional, Zichner, Thomas, additional, Weischenfeldt, Joachim, additional, Jäger, Natalie, additional, Remke, Marc, additional, Shih, David, additional, Northcott, Paul A., additional, Pfaff, Elke, additional, Tica, Jelena, additional, Wang, Qi, additional, Massimi, Luca, additional, Witt, Hendrik, additional, Bender, Sebastian, additional, Pleier, Sabrina, additional, Cin, Huriye, additional, Hawkins, Cynthia, additional, Beck, Christian, additional, von Deimling, Andreas, additional, Hans, Volkmar, additional, Brors, Benedikt, additional, Eils, Roland, additional, Scheurlen, Wolfram, additional, Blake, Jonathon, additional, Benes, Vladimir, additional, Kulozik, Andreas E., additional, Witt, Olaf, additional, Martin, Dianna, additional, Zhang, Cindy, additional, Porat, Rinnat, additional, Merino, Diana M., additional, Wasserman, Jonathan, additional, Jabado, Nada, additional, Fontebasso, Adam, additional, Bullinger, Lars, additional, Rücker, Frank G., additional, Döhner, Konstanze, additional, Döhner, Hartmut, additional, Koster, Jan, additional, Molenaar, Jan J., additional, Versteeg, Rogier, additional, Kool, Marcel, additional, Tabori, Uri, additional, Malkin, David, additional, Korshunov, Andrey, additional, Taylor, Michael D., additional, Lichter, Peter, additional, Pfister, Stefan M., additional, and Korbel, Jan O., additional
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- 2012
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35. Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma
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Witt, Hendrik, primary, Mack, Stephen C., additional, Ryzhova, Marina, additional, Bender, Sebastian, additional, Sill, Martin, additional, Isserlin, Ruth, additional, Benner, Axel, additional, Hielscher, Thomas, additional, Milde, Till, additional, Remke, Marc, additional, Jones, David T.W., additional, Northcott, Paul A., additional, Garzia, Livia, additional, Bertrand, Kelsey C., additional, Wittmann, Andrea, additional, Yao, Yuan, additional, Roberts, Stephen S., additional, Massimi, Luca, additional, Van Meter, Tim, additional, Weiss, William A., additional, Gupta, Nalin, additional, Grajkowska, Wiesia, additional, Lach, Boleslaw, additional, Cho, Yoon-Jae, additional, von Deimling, Andreas, additional, Kulozik, Andreas E., additional, Witt, Olaf, additional, Bader, Gary D., additional, Hawkins, Cynthia E., additional, Tabori, Uri, additional, Guha, Abhijit, additional, Rutka, James T., additional, Lichter, Peter, additional, Korshunov, Andrey, additional, Taylor, Michael D., additional, and Pfister, Stefan M., additional
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- 2011
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36. Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma
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Nakahara, Yukiko, primary, Northcott, Paul A., additional, Li, Meihua, additional, Kongkham, Paul N., additional, Smith, Christian, additional, Yan, Hai, additional, Croul, Sidney, additional, Ra, Young-Shin, additional, Eberhart, Charles, additional, Huang, Annie, additional, Bigner, Darell, additional, Grajkowska, Wesia, additional, Van Meter, Timothy, additional, Rutka, James T., additional, and Taylor, Michael D., additional
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- 2010
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37. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
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Waszak, Sebastian M, Northcott, Paul A, Buchhalter, Ivo, Robinson, Giles W, Sutter, Christian, Groebner, Susanne, Grund, Kerstin B, Brugières, Laurence, Jones, David TW, Pajtler, Kristian W, Morrissy, A Sorana, Kool, Marcel, Sturm, Dominik, Chavez, Lukas, Ernst, Aurelie, Brabetz, Sebastian, Hain, Michael, Zichner, Thomas, Segura-Wang, Maia, Weischenfeldt, Joachim, Rausch, Tobias, Mardin, Balca R, Zhou, Xin, Baciu, Cristina, Lawerenz, Christian, Chan, Jennifer A, Varlet, Pascale, Guerrini-Rousseau, Lea, Fults, Daniel W, Grajkowska, Wiesława, Hauser, Peter, Jabado, Nada, Ra, Young-Shin, Zitterbart, Karel, Shringarpure, Suyash S, De La Vega, Francisco M, Bustamante, Carlos D, Ng, Ho-Keung, Perry, Arie, MacDonald, Tobey J, Hernáiz Driever, Pablo, Bendel, Anne E, Bowers, Daniel C, McCowage, Geoffrey, Chintagumpala, Murali M, Cohn, Richard, Hassall, Timothy, Fleischhack, Gudrun, Eggen, Tone, Wesenberg, Finn, Feychting, Maria, Lannering, Birgitta, Schüz, Joachim, Johansen, Christoffer, Andersen, Tina V, Röösli, Martin, Kuehni, Claudia E, Grotzer, Michael, Kjaerheim, Kristina, Monoranu, Camelia M, Archer, Tenley C, Duke, Elizabeth, Pomeroy, Scott L, Shelagh, Redmond, Frank, Stephan, Sumerauer, David, Scheurlen, Wolfram, Ryzhova, Marina V, Milde, Till, Kratz, Christian P, Samuel, David, Zhang, Jinghui, Solomon, David A, Marra, Marco, Eils, Roland, Bartram, Claus R, Von Hoff, Katja, Rutkowski, Stefan, Ramaswamy, Vijay, Gilbertson, Richard J, Korshunov, Andrey, Taylor, Michael D, Lichter, Peter, Malkin, David, Gajjar, Amar, Korbel, Jan O, and Pfister, Stefan M
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Adult ,Male ,Heredity ,Adolescent ,DNA Mutational Analysis ,Young Adult ,Predictive Value of Tests ,Risk Factors ,Exome Sequencing ,Biomarkers, Tumor ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Prospective Studies ,Cerebellar Neoplasms ,Child ,Germ-Line Mutation ,Retrospective Studies ,Models, Genetic ,Gene Expression Profiling ,Infant ,Reproducibility of Results ,DNA Methylation ,Progression-Free Survival ,3. Good health ,Pedigree ,Phenotype ,Child, Preschool ,Female ,Transcriptome ,Medulloblastoma - Abstract
BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and testing for paediatric patients are not available. We aimed to assess and define these genes to provide evidence for future screening guidelines. METHODS: In this international, multicentre study, we analysed patients with medulloblastoma from retrospective cohorts (International Cancer Genome Consortium [ICGC] PedBrain, Medulloblastoma Advanced Genomics International Consortium [MAGIC], and the CEFALO series) and from prospective cohorts from four clinical studies (SJMB03, SJMB12, SJYC07, and I-HIT-MED). Whole-genome sequences and exome sequences from blood and tumour samples were analysed for rare damaging germline mutations in cancer predisposition genes. DNA methylation profiling was done to determine consensus molecular subgroups: WNT (MBWNT), SHH (MBSHH), group 3 (MBGroup3), and group 4 (MBGroup4). Medulloblastoma predisposition genes were predicted on the basis of rare variant burden tests against controls without a cancer diagnosis from the Exome Aggregation Consortium (ExAC). Previously defined somatic mutational signatures were used to further classify medulloblastoma genomes into two groups, a clock-like group (signatures 1 and 5) and a homologous recombination repair deficiency-like group (signatures 3 and 8), and chromothripsis was investigated using previously established criteria. Progression-free survival and overall survival were modelled for patients with a genetic predisposition to medulloblastoma. FINDINGS: We included a total of 1022 patients with medulloblastoma from the retrospective cohorts (n=673) and the four prospective studies (n=349), from whom blood samples (n=1022) and tumour samples (n=800) were analysed for germline mutations in 110 cancer predisposition genes. In our rare variant burden analysis, we compared these against 53 105 sequenced controls from ExAC and identified APC, BRCA2, PALB2, PTCH1, SUFU, and TP53 as consensus medulloblastoma predisposition genes according to our rare variant burden analysis and estimated that germline mutations accounted for 6% of medulloblastoma diagnoses in the retrospective cohort. The prevalence of genetic predispositions differed between molecular subgroups in the retrospective cohort and was highest for patients in the MBSHH subgroup (20% in the retrospective cohort). These estimates were replicated in the prospective clinical cohort (germline mutations accounted for 5% of medulloblastoma diagnoses, with the highest prevalence [14%] in the MBSHH subgroup). Patients with germline APC mutations developed MBWNT and accounted for most (five [71%] of seven) cases of MBWNT that had no somatic CTNNB1 exon 3 mutations. Patients with germline mutations in SUFU and PTCH1 mostly developed infant MBSHH. Germline TP53 mutations presented only in childhood patients in the MBSHH subgroup and explained more than half (eight [57%] of 14) of all chromothripsis events in this subgroup. Germline mutations in PALB2 and BRCA2 were observed across the MBSHH, MBGroup3, and MBGroup4 molecular subgroups and were associated with mutational signatures typical of homologous recombination repair deficiency. In patients with a genetic predisposition to medulloblastoma, 5-year progression-free survival was 52% (95% CI 40-69) and 5-year overall survival was 65% (95% CI 52-81); these survival estimates differed significantly across patients with germline mutations in different medulloblastoma predisposition genes. INTERPRETATION: Genetic counselling and testing should be used as a standard-of-care procedure in patients with MBWNT and MBSHH because these patients have the highest prevalence of damaging germline mutations in known cancer predisposition genes. We propose criteria for routine genetic screening for patients with medulloblastoma based on clinical and molecular tumour characteristics. FUNDING: German Cancer Aid; German Federal Ministry of Education and Research; German Childhood Cancer Foundation (Deutsche Kinderkrebsstiftung); European Research Council; National Institutes of Health; Canadian Institutes for Health Research; German Cancer Research Center; St Jude Comprehensive Cancer Center; American Lebanese Syrian Associated Charities; Swiss National Science Foundation; European Molecular Biology Organization; Cancer Research UK; Hertie Foundation; Alexander and Margaret Stewart Trust; V Foundation for Cancer Research; Sontag Foundation; Musicians Against Childhood Cancer; BC Cancer Foundation; Swedish Council for Health, Working Life and Welfare; Swedish Research Council; Swedish Cancer Society; the Swedish Radiation Protection Authority; Danish Strategic Research Council; Swiss Federal Office of Public Health; Swiss Research Foundation on Mobile Communication; Masaryk University; Ministry of Health of the Czech Republic; Research Council of Norway; Genome Canada; Genome BC; Terry Fox Research Institute; Ontario Institute for Cancer Research; Pediatric Oncology Group of Ontario; The Family of Kathleen Lorette and the Clark H Smith Brain Tumour Centre; Montreal Children's Hospital Foundation; The Hospital for Sick Children: Sonia and Arthur Labatt Brain Tumour Research Centre, Chief of Research Fund, Cancer Genetics Program, Garron Family Cancer Centre, MDT's Garron Family Endowment; BC Childhood Cancer Parents Association; Cure Search Foundation; Pediatric Brain Tumor Foundation; Brainchild; and the Government of Ontario.
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