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Your search keyword '"Norris, R"' showing total 40 results
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40 results on '"Norris, R"'

1. 575 Molecular characterization of trametinib-induced cardiotoxicity

Author

Beck, T.C., primary, Morningstar, J., additional, Arhontoulis, D., additional, Guo, L., additional, Cortney, G., additional, Biggs, R., additional, Moore, K., additional, Koren, N., additional, Petrucci, T., additional, Mukherjee, R., additional, Helke, K., additional, Vaena, S., additional, Romeo, M., additional, and Norris, R., additional

Published
2022
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6. Quantitative determination of the enantiomers of methadone in human plasma and saliva by chiral column chromatography coupled with mass spectrometric detection

Author

George, R, Lobb, M, Haywood, A, Khan, S, Hardy, J, Good, P, Hennig, S, and Norris, R

Subjects
Adult, Plasma, Tandem Mass Spectrometry, Humans, Adsorption, Saliva, Chromatography, High Pressure Liquid, Methadone, 0301 Analytical Chemistry, 0399 Other Chemical Sciences, Analytical Chemistry
Abstract

Methadone is a potent lipophilic synthetic opioid that is effective in the treatment of cancer pain and perceived benefit in difficult pain control scenarios (especially in cases of neuropathic pain). The use of methadone in clinical practice is challenging however, due to the narrow therapeutic window and large inter- and intra-individual variability in therapeutic response. Quantitation of the enantiomers d- and l-methadone (d- and l-MTD) in plasma and saliva provides a basis for studying its pharmacokinetics in patients with cancer and for monitoring efficacy, toxicity and side-effects. This assay involves quantitation of the enantiomers of methadone using their respective deuterated internal standards, in plasma and saliva matrices with no impact of ion suppression in either matrix. The analytical recoveries of d- and l-MTD from the saliva collection devices (Salivette®) are optimised in this novel method with an accurate and simple extraction method employing dichloromethane. Optimal enantioselective separations were achieved using an α1-acid glycoprotein chiral stationary phase and triple quadrupole tandem mass spectrometer. Linearity was demonstrated over 0.05-1000µg/L for both enantiomers in plasma and in saliva with correlation coefficients greater than 0.998. The lower limit of quantitation (LLOQ) was determined to be 0.1µg/L in plasma and saliva for d- and l-MTD. Accuracy of the method ranges from 100% to 106% even at the LLOQ and total precision, expressed as the coefficient of variation, was between 0.2% and 4.4% for both analytes in both matrices. A simple one step extraction procedure resulted in recoveries greater than 95% for both analytes, at concentrations as low as 0.5µg/L, from the Salivette®. The validated method was applied successfully in 14 paired plasma and saliva samples obtained from adult patients with cancer pain receiving methadone.

Published
2015

7. A zebrafish model for Winchester syndrome

Author

Julian L. Goggi, Thomas J. Carney, Ivo J. H. M. de Vos, John Soon Yew Lim, Barry J. Coull, Norris R. Dunn, Maurice A. M. van Steensel, Sheena Li Ming Ong, and Chee Bing Ong

Subjects
Embryology, biology, medicine, Winchester syndrome, biology.organism_classification, medicine.disease, Neuroscience, Zebrafish, Developmental Biology
Published
2017

8. THE IMPACT OF EXIT INSTRUCTIONS AND NUMBER OF EXITS IN FIRE EMERGENCIES: A COMPUTER SIMULATION INVESTIGATION

Author

Norris R. Johnson and William E. Feinberg

Subjects
Social Psychology, Injury control, Operations research, Computer science, Accident prevention, media_common.quotation_subject, Poison control, Ambiguity, Crowding, ALARM, Identification (information), Emergency evacuation, Applied Psychology, media_common
Abstract

Research on emergency evacuation in situations threatened by fire suggests that an authoritative announcement of the need to evacuate and clear identification of available exits affect survival rates. Clear instructions remove much of the ambiguity that often leads actors to delay exiting, thereby reducing crowding at the exits with which those involved are most familiar. Additional exits should also speed evacuation of all those seeking to leave. Using a computer simulation model of social behavior in response to a fire alarm (fire bell), we conducted an exercise in which we varied ambiguity (presence or absence of exit instructions) and number of available exits from a simulated room in which a fire alarm had sounded. The Monte Carlo model emphasizes how the changing responses of those surrounding an individual or bonded pair influence probabilistically changes in the behavior of that individual or pair. Both absence of ambiguity (evacuation instructions) and number of exits available have a positive effect on how many exit safely as time passes.

Published
1997

21. Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration

Author

Yusuf, S, primary, Zucker, D, additional, Passamani, E, additional, Peduzzi, P, additional, Takaro, T, additional, Fisher, L.D, additional, Kennedy, J.W, additional, Davis, K, additional, Killip, T, additional, Norris, R, additional, Morris, C, additional, Mathur, V, additional, Varnauskas, E, additional, and Chalmers, T.C, additional

Published
1994
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