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269 results on '"Nohria, A."'

8. Comparison of comorbidities and adverse events in dermatology and rheumatology patients prescribed tofacitinib: A retrospective analysis

Author

Needle, Carli D., primary, Klein, Elizabeth J., additional, Gjonaj, Jessica, additional, Nohria, Ambika, additional, Karim, Maria, additional, Liu, Lynn, additional, Shah, Jinal, additional, Betensky, Rebecca A., additional, Garshick, Michael, additional, Lo Sicco, Kristen, additional, and Karagounis, Theodora K., additional

Published
2024
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11. Statins for Attenuating Cardiotoxicity in Patients Receiving Anthracyclines: A Systematic Review and Meta-Analysis

Author

Titus, Anoop, primary, Cheema, Huzaifa Ahmad, additional, Shafiee, Arman, additional, Seighali, Niloofar, additional, Shahid, Abia, additional, Bhanushali, Karan B., additional, Kumar, Ashish, additional, Khan, Safi U., additional, Khadke, Sumanth, additional, Thavendiranathan, Paaladinesh, additional, Hundley, W. Gregory, additional, Scherrer-Crosbie, Marielle, additional, Nohria, Anju, additional, Neilan, Tomas G., additional, Dani, Sourbha S., additional, Nasir, Khurram, additional, and Ganatra, Sarju, additional

Published
2023
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12. Impact of SGLT2 Inhibitors on AF Recurrence After Catheter Ablation in Patients With Type 2 Diabetes

Author

Abu-Qaoud, Moh’d Rasheed, primary, Kumar, Ashish, additional, Tarun, Tushar, additional, Abraham, Sonu, additional, Ahmad, Javaria, additional, Khadke, Sumanth, additional, Husami, Raya, additional, Kulbak, Guy, additional, Sahoo, Sibasis, additional, Januzzi, James L., additional, Neilan, Tomas G., additional, Baron, Suzanne J., additional, Martin, David, additional, Nohria, Anju, additional, Reynolds, Matthew R., additional, Kosiborod, Mikhail, additional, Dani, Sourbha S., additional, and Ganatra, Sarju, additional

Published
2023
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14. A Picture Is Worth 2,000 Words

Author

Osnat Itzhaki Ben Zadok, Robert Padera, and Anju Nohria

Subjects
Oncology, Cardiology and Cardiovascular Medicine
Published
2023

16. COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease

Author

Moey, Melissa Y.Y., primary, Hennessy, Cassandra, additional, French, Benjamin, additional, Warner, Jeremy L., additional, Tucker, Matthew D., additional, Hausrath, Daniel J., additional, Shah, Dimpy P., additional, DeCara, Jeanne M., additional, Bakouny, Ziad, additional, Labaki, Chris, additional, Choueiri, Toni K., additional, Dent, Susan, additional, Akhter, Nausheen, additional, Ismail-Khan, Roohi, additional, Tachiki, Lisa, additional, Slosky, David, additional, Polonsky, Tamar S., additional, Awosika, Joy A., additional, Crago, Audrey, additional, Wise-Draper, Trisha, additional, Balanchivadze, Nino, additional, Hwang, Clara, additional, Fecher, Leslie A., additional, Gomez, Cyndi Gonzalez, additional, Hayes-Lattin, Brandon, additional, Glover, Michael J., additional, Shah, Sumit A., additional, Gopalakrishnan, Dharmesh, additional, Griffiths, Elizabeth A., additional, Kwon, Daniel H., additional, Koshkin, Vadim S., additional, Mahmood, Sana, additional, Bashir, Babar, additional, Nonato, Taylor, additional, Razavi, Pedram, additional, McKay, Rana R., additional, Nagaraj, Gayathri, additional, Oligino, Eric, additional, Puc, Matthew, additional, Tregubenko, Polina, additional, Wulff-Burchfield, Elizabeth M., additional, Xie, Zhuoer, additional, Halfdanarson, Thorvardur R., additional, Farmakiotis, Dimitrios, additional, Klein, Elizabeth J., additional, Robilotti, Elizabeth V., additional, Riely, Gregory J., additional, Durand, Jean-Bernard, additional, Hayek, Salim S., additional, Kondapalli, Lavanya, additional, Berg, Stephanie, additional, O'Connor, Timothy E., additional, Bilen, Mehmet A., additional, Castellano, Cecilia, additional, Accordino, Melissa K., additional, Sibel, Blau, additional, Weissmann, Lisa B., additional, Jani, Chinmay, additional, Flora, Daniel B., additional, Rudski, Lawrence, additional, Dutra, Miriam Santos, additional, Nathaniel, Bouganim, additional, Ruíz-García, Erika, additional, Vilar-Compte, Diana, additional, Gupta, Shilpa, additional, Morgans, Alicia, additional, and Nohria, Anju, additional

Published
2023
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18. External validation of Cardiac disease, Hypertension, and Logarithmic Left anterior descending coronary artery radiation dose (CHyLL) for predicting major adverse cardiac events after lung cancer radiotherapy

Author

Tjong, M.C., primary, Zhang, S., additional, Gasho, J., additional, Silos, K., additional, Gay, C., additional, McKenzie, E., additional, Steers, J., additional, Bitterman, D.S., additional, Nikolova, A., additional, Nohria, A., additional, Hoffmann, U., additional, Brantley, K.D., additional, Mak, R.H., additional, and Atkins, K.M., additional

Published
2023
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19. Real-World Efficacy of Tafamidis in Patients With Transthyretin Amyloidosis and Heart Failure

Author

Ghoneem, Ahmed, primary, Bhatti, Ammar W., additional, Khadke, Sumanth, additional, Mitchell, Joshua, additional, Liu, Jennifer, additional, Zhang, Kathleen, additional, Trachtenberg, Barry, additional, Wechalekar, Ashutosh, additional, Cheng, Richard K., additional, Baron, Suzanne J., additional, Nohria, Anju, additional, Lenihan, Daniel, additional, Ganatra, Sarju, additional, and Dani, Sourbha S., additional

Published
2023
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21. AB-452666-4 ATRIAL FIBRILLATION CATHETER ABLATION IN PATIENTS WITH SOLID TUMORS VERSUS HEMATOLOGIC MALIGNANCIES

Author

Chang, David, primary, Tedrow, Usha B., additional, Tadros, Thomas M., additional, Kapur, Sunil, additional, Steiger, Nathaniel, additional, Romero, Jorge, additional, Martin, David T., additional, Koplan, Bruce A., additional, Peng, Gary, additional, Ajufo, Ezim, additional, Hoyos-Ochoa, Carolina, additional, Rivera, Estefania, additional, Patino, Carlos, additional, Matos, Carlos, additional, Zei, Paul C., additional, Nohria, Anju, additional, and Sauer, William H., additional

Published
2023
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23. Systematic review and updated recommendations for cardiomyopathy surveillance for survivors of childhood, adolescent, and young adult cancer from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Ehrhardt, Matthew J, primary, Leerink, Jan M, additional, Mulder, Renée L, additional, Mavinkurve-Groothuis, Annelies, additional, Kok, Wouter, additional, Nohria, Anju, additional, Nathan, Paul C, additional, Merkx, Remy, additional, de Baat, Esmée, additional, Asogwa, Ogechukwu A, additional, Skinner, Roderick, additional, Wallace, Hamish, additional, Lieke Feijen, E A M, additional, de Ville de Goyet, Maëlle, additional, Prasad, Maya, additional, Bárdi, Edit, additional, Pavasovic, Vesna, additional, van der Pal, Helena, additional, Fresneau, Brice, additional, Demoor-Goldschmidt, Charlotte, additional, Hennewig, Ulrike, additional, Steinberger, Julia, additional, Plummer, Chris, additional, Chen, Ming Hui, additional, Teske, Arco J, additional, Haddy, Nadia, additional, van Dalen, Elvira C, additional, Constine, Louis S, additional, Chow, Eric J, additional, Levitt, Gill, additional, Hudson, Melissa M, additional, Kremer, Leontien C M, additional, and Armenian, Saro H, additional

Published
2023
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24. IMPACT OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON RECURRENCE OF ATRIAL FIBRILLATION AFTER CATHETER ABLATION

Author

Abu-Qaoud, Moh'D Rasheed, primary, Kumar, Ashish, additional, Tarun, Tushar, additional, Ahmad, Javaria, additional, Kulbak, Guy, additional, Januzzi, James L., additional, Neilan, Tomas G., additional, Baron, Suzanne, additional, Martin, David T., additional, Nohria, Anju, additional, Reynolds, Matthew R., additional, Kosiborod, Mikhail, additional, Dani, Sourbha S., additional, and Ganatra, Sarju, additional

Published
2023
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25. ASSOCIATION OF USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS WITH ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

Author

Gong, Jingyi, primary, Drobni, Zsofia, additional, Silva, Thiago Quinaglia, additional, Zafar, Amna, additional, Reynolds, Kerry, additional, Gilman, Hannah, additional, Sullivan, Ryan, additional, Ho, Jor Sam, additional, Nohria, Anju, additional, Ricciotti, Emanuela, additional, Fitzgerald, Garret, additional, Zlotoff, Daniel A., additional, and Neilan, Tomas G., additional

Published
2023
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26. REPLY

Author

Aziz-Bose, Rahela, primary, Armenian, Saro H., additional, Nohria, Anju, additional, and Kenney, Lisa B., additional

Published
2023
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27. Safety and efficacy of transcatheter edge-to-edge repair (TEER) in patients with history of cancer

Author

Khan, Sahoor, primary, Dani, Sourbha S., additional, Hermann, Joerg, additional, Neilan, Tomas.G., additional, Lenihan, Daniel J., additional, Fradley, Michael, additional, Parikh, Rohan, additional, Khan, Saafi, additional, Deswal, Anita, additional, Liu, Jennifer, additional, Barac, Ana, additional, Labib, Sherif, additional, Majithia, Arjun, additional, Nohria, Anju, additional, Baron, Suzanne J., additional, and Ganatra, Sarju, additional

Published
2023
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29. Reflection on the development of a patient case in twine

Author

Rahul Nohria, Josephine Marie Belen, and Joseph Kang

Subjects
Medical education, Reflection (computer programming), business.industry, Interpretation (philosophy), Preceptor, Student engagement, Problem-Based Learning, Pharmacy, Faculty, Faculty, Pharmacy, Pharmacy curriculum, Education, Pharmacy, Active learning, Health care, ComputingMilieux_COMPUTERSANDEDUCATION, Humans, Curriculum, General Pharmacology, Toxicology and Pharmaceutics, Psychology, business
Abstract

Purpose With technology becoming an essential component in classrooms, it is becoming more crucial for pharmacy faculty to explore innovative active learning strategies that engage students inside and outside the classroom. This manuscript discusses how two fourth-year students and their preceptor developed interactive patient cases using an open-source software application called Twine ( www.twinery.org ). Description Two different cases were developed in Twine. The first patient case story was created by the fourth-year students and will be implemented in the future. The second patient case, consisting of two Twine stories, was created by the faculty preceptor and was implemented during new student orientation. Analysis/interpretation Resources for development as well as advantages and disadvantages of developing and implementing Twine stories into the curriculum are discussed. Implementation of the faculty's Twine stories into the pharmacy curriculum is also discussed. Conclusions Twine is a user-friendly application and has the potential to be utilized in healthcare programs as an effective and engaging teaching strategy that both professor and students enjoy. Implications While development of a Twine story could be time-consuming, the benefit of increasing student engagement outweighs the cost. Active learning is an essential component in the classroom, and finding new and innovative ways to enhance student learning is imperative.

Published
2021

31. Statin Use, Heart Radiation Dose, and Survival in Locally Advanced Lung Cancer

Author

Tafadzwa L. Chaunzwa, Udo Hoffmann, Anju Nohria, Raymond H. Mak, Elizabeth H. Baldini, Hugo J.W.L. Aerts, Balaji Tamarappoo, Christopher L. Williams, Danielle S. Bitterman, Katelyn M. Atkins, David Kozono, and Rifaquat Rahman

Subjects
medicine.medical_specialty, Lung Neoplasms, Statin, medicine.drug_class, medicine.medical_treatment, Radiation Dosage, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Lung cancer, Retrospective Studies, Framingham Risk Score, business.industry, Proportional hazards model, Hazard ratio, medicine.disease, Confidence interval, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Cohort, Cardiology, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business
Abstract

Patients with locally advanced non-small cell lung cancer (LA-NSCLC) have a high prevalence of pre-existing coronary heart disease and face excess cardiac risk after thoracic radiation therapy. We sought to assess whether statin therapy is a predictor of overall survival (OS) after thoracic radiation therapy.We performed a retrospective analysis of 748 patients with LA-NSCLC treated with thoracic radiation therapy, using Kaplan-Meier OS estimates and Cox regression.Statin use among high cardiac risk patients (Framingham risk ≥20% or pre-existing coronary heart disease; n = 496) was 51.2%. After adjustment for baseline cardiac risk and other prognostic factors, statin therapy was associated with a significantly increased risk of all-cause mortality (adjusted hazard ratio, 1.39; 95% confidence interval [CI], 1.00-1.91; P = .048) but not major adverse cardiac events (adjusted hazard ratio, 1.18; 95% CI, 0.52-2.68; P = .69). Among statin-naïve patients, mean heart dose ≥10 Gy versus10 Gy was associated with a significantly increased risk of all-cause mortality (hazard ratio, 1.32; 95% CI, 1.04-1.68; P = .022), with 2-year OS estimates of 46.9% versus 60.0%, respectively. However, OS did not differ by heart dose among patients on statin therapy (hazard ratio, 1.00; 95% CI, 0.76-1.32; P = 1.00; P-interaction = .031), with 2-year OS estimates of 46.9% versus 50.3%, respectively.Among patients with LA-NSCLC, only half of statin-eligible high cardiac risk patients were on statin therapy, reflecting the highest cardiac risk level of our cohort. Statin use was an independent predictor of all-cause mortality but not major adverse cardiac events. Elevated mean heart dose (≥10 Gy) was associated with increased risk of all-cause mortality in statin-naïve patients but not among those on statin therapy, identifying a group of patients in which early intervention with statins may mitigate the deleterious effects of high heart radiation therapy dose. This warrants evaluation in prospective trials.

Published
2021

32. Strategies to balance stroke and bleeding risk in patients with atrial fibrillation and cancer

Author

Shiv Bagga, Sarju Ganatra, Sourbha S. Dani, Bruce G. Hook, and Anju Nohria

Subjects
Cardiac Catheterization, medicine.medical_specialty, Septal Occluder Device, Risk Factors, Neoplasms, Physiology (medical), Internal medicine, Atrial Fibrillation, medicine, Humans, Atrial Appendage, In patient, Cardiac Surgical Procedures, Stroke, Aged, Balance (ability), business.industry, Cancer, Atrial fibrillation, medicine.disease, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Intracranial Hemorrhages
Published
2021

35. Global Circumferential and Radial Strain Among Patients With Immune Checkpoint Inhibitor Myocarditis

Author

Quinaglia, Thiago, primary, Gongora, Carlos, additional, Awadalla, Magid, additional, Hassan, Malek Z.O., additional, Zafar, Amna, additional, Drobni, Zsofia D., additional, Mahmood, Syed S., additional, Zhang, Lili, additional, Coelho-Filho, Otavio R., additional, Suero-Abreu, Giselle A., additional, Rizvi, Muhammad A., additional, Sahni, Gagan, additional, Mandawat, Anant, additional, Zatarain-Nicolás, Eduardo, additional, Mahmoudi, Michael, additional, Sullivan, Ryan, additional, Ganatra, Sarju, additional, Heinzerling, Lucie M., additional, Thuny, Franck, additional, Ederhy, Stephane, additional, Gilman, Hannah K., additional, Sama, Supraja, additional, Nikolaidou, Sofia, additional, Mansilla, Ana González, additional, Calles, Antonio, additional, Cabral, Marcella, additional, Fernández-Avilés, Francisco, additional, Gavira, Juan José, additional, González, Nahikari Salterain, additional, García de Yébenes Castro, Manuel, additional, Barac, Ana, additional, Afilalo, Jonathan, additional, Zlotoff, Daniel A., additional, Zubiri, Leyre, additional, Reynolds, Kerry L., additional, Devereux, Richard, additional, Hung, Judy, additional, Picard, Michael H., additional, Yang, Eric H., additional, Gupta, Dipti, additional, Michel, Caroline, additional, Lyon, Alexander R., additional, Chen, Carol L., additional, Nohria, Anju, additional, Fradley, Michael G., additional, Thavendiranathan, Paaladinesh, additional, and Neilan, Tomas G., additional

Published
2022
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36. Cardiovascular Drug Interactions With Nirmatrelvir/Ritonavir in Patients With COVID-19

Author

Abraham, Sonu, primary, Nohria, Anju, additional, Neilan, Tomas G., additional, Asnani, Aarti, additional, Saji, Anu Mariam, additional, Shah, Jui, additional, Lech, Tara, additional, Grossman, Jason, additional, Abraham, George M., additional, McQuillen, Daniel P., additional, Martin, David T., additional, Sax, Paul E., additional, Dani, Sourbha S., additional, and Ganatra, Sarju, additional

Published
2022
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38. Impact of Social Vulnerability on Comorbid Cancer and Cardiovascular Disease Mortality in the United States

Author

Ganatra, Sarju, primary, Dani, Sourbha S., additional, Kumar, Ashish, additional, Khan, Safi U., additional, Wadhera, Rishi, additional, Neilan, Tomas G., additional, Thavendiranathan, Paaladinesh, additional, Barac, Ana, additional, Hermann, Joerg, additional, Leja, Monika, additional, Deswal, Anita, additional, Fradley, Michael, additional, Liu, Jennifer E., additional, Sadler, Diego, additional, Asnani, Aarti, additional, Baldassarre, Lauren A., additional, Gupta, Dipti, additional, Yang, Eric, additional, Guha, Avirup, additional, Brown, Sherry-Ann, additional, Stevens, Jennifer, additional, Hayek, Salim S., additional, Porter, Charles, additional, Kalra, Ankur, additional, Baron, Suzanne J., additional, Ky, Bonnie, additional, Virani, Salim S., additional, Kazi, Dhruv, additional, Nasir, Khurram, additional, and Nohria, Anju, additional

Published
2022
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39. Delphi Panel Consensus Recommendations for Screening and Managing Childhood Cancer Survivors at Risk for Cardiomyopathy

Author

Aziz-Bose, Rahela, primary, Margossian, Renee, additional, Ames, Bethany L., additional, Moss, Kerry, additional, Ehrhardt, Matthew J., additional, Armenian, Saro H., additional, Yock, Torunn I., additional, Nekhlyudov, Larissa, additional, Williams, David, additional, Hudson, Melissa, additional, Nohria, Anju, additional, and Kenney, Lisa B., additional

Published
2022
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41. Mean Heart Dose Is an Inadequate Surrogate for Left Anterior Descending Coronary Artery Dose and the Risk of Major Adverse Cardiac Events in Lung Cancer Radiation Therapy

Author

Danielle S. Bitterman, Udo Hoffmann, Elizabeth H. Baldini, Anju Nohria, Raymond H. Mak, Katelyn M. Atkins, Hugo J.W.L. Aerts, Tafadzwa L. Chaunzwa, David Kozono, and Balaji Tamarappoo

Subjects
Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Heart Diseases, medicine.medical_treatment, Myocardial Infarction, Locally advanced, Anterior Descending Coronary Artery, Radiation Dosage, Angina Pectoris, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, Myocardial Revascularization, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Lung cancer, Aged, Retrospective Studies, Heart Failure, Radiation, business.industry, Incidence, Heart, Middle Aged, medicine.disease, Coronary Vessels, Cardiotoxicity, Death, Radiation therapy, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, cardiovascular system, Cardiology, Female, Non small cell, business, Mace, Artery
Abstract

Mean heart dose (MHD) over 10 Gy and left anterior descending (LAD) coronary artery volume (V) receiving 15 Gy (V15Gy) greater than 10% can significantly increase the risk of major adverse cardiac events (MACE) in patients with non-small cell lung cancer (NSCLC). We sought to characterize the discordance between MHD and LAD dose and the association of this classification on the risk of MACE after radiation therapy.The coefficient of determination for MHD and LAD V15Gy was calculated in this retrospective analysis of 701 patients with locally advanced NSCLC treated with radiation therapy. Four groups were defined on the basis of high or low MHD (≥10 Gy vs10 Gy) and LAD V15Gy (≥10% vs10%). MACE (unstable angina, heart failure, myocardial infarction, coronary revascularization, and cardiac death) cumulative incidence was estimated, and Fine and Gray regressions were performed.The proportion of variance in LAD V15Gy predictable from MHD was only 54.5% (RMHD is insufficient to predict LAD V15Gy with confidence. When MHD and LAD V15Gy dose exposure is discordant, isolated low LAD V15Gy significantly reduces the risk of MACE in patients with locally advanced NSCLC after radiation therapy, suggesting that the validity of whole heart metrics for optimally predicting cardiac events should be reassessed.

Published
2021

42. Management of Patients With Giant Cell Myocarditis

Author

Monika Leja, Leslie T. Cooper, Anju Nohria, Rushin Patel, Paaladinesh Thavendiranathan, Daniel J. Lenihan, Ana Barac, Frederic S. Resnic, Ajay K. Sharma, Sarju Ganatra, David M. Venesy, Thomas C. Piemonte, Richard D. Patten, Salim S. Hayek, Sourbha S. Dani, Rohan Parikh, Sachin P. Shah, Mark R. Vesely, Ghulam M. Chaudhry, Vigyan Bang, and Tomas G. Neilan

Subjects
medicine.medical_specialty, business.industry, Heart block, Cardiogenic shock, medicine.medical_treatment, Immunosuppression, Inflammation, Disease, 030204 cardiovascular system & hematology, medicine.disease, Giant cell myocarditis, Transplantation, 03 medical and health sciences, 0302 clinical medicine, Heart failure, Internal medicine, medicine, Cardiology, 030212 general & internal medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Giant cell myocarditis is a rare, often rapidly progressive and potentially fatal, disease due to T-cell lymphocyte-mediated inflammation of the myocardium that typically affects young and middle-aged adults. Frequently, the disease course is marked by acute heart failure, cardiogenic shock, intractable ventricular arrhythmias, and/or heart block. Diagnosis is often difficult due to its varied clinical presentation and overlap with other cardiovascular conditions. Although cardiac biomarkers and multimodality imaging are often used as initial diagnostic tests, endomyocardial biopsy is required for definitive diagnosis. Combination immunosuppressive therapy, along with guideline-directed medical therapy, has led to a paradigm shift in the management of giant cell myocarditis resulting in an improvement in overall and transplant-free survival. Early diagnosis and prompt management can decrease the risk of transplantation or death, which remain common in patients who present with cardiogenic shock.

Published
2021

43. Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes Among Patients Treated With Anthracyclines

Author

Gongora, Carlos A., primary, Drobni, Zsofia D., additional, Quinaglia Araujo Costa Silva, Thiago, additional, Zafar, Amna, additional, Gong, Jingyi, additional, Zlotoff, Daniel A., additional, Gilman, Hannah K., additional, Hartmann, Sarah E., additional, Sama, Supraja, additional, Nikolaidou, Sofia, additional, Suero-Abreu, Giselle Alexandra, additional, Jacobsen, Eric, additional, Abramson, Jeremy S., additional, Hochberg, Ephraim, additional, Barnes, Jeffrey, additional, Armand, Philippe, additional, Thavendiranathan, Paaladinesh, additional, Nohria, Anju, additional, and Neilan, Tomas G., additional

Published
2022
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50. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation

Author

Philippe B. Bertrand, Jessica R. Overbey, Xin Zeng, Robert A. Levine, Gorav Ailawadi, Michael A. Acker, Peter K. Smith, Vinod H. Thourani, Emilia Bagiella, Marissa A. Miller, Lopa Gupta, Michael J. Mack, A. Marc Gillinov, Gennaro Giustino, Alan J. Moskowitz, Annetine C. Gelijns, Michael E. Bowdish, Patrick T. O’Gara, James S. Gammie, Judy Hung, Wendy C. Taddei-Peters, Dennis Buxton, Ron Caulder, Nancy L. Geller, David Gordon, Neal O. Jeffries, Albert Lee, Claudia S. Moy, Ilana Kogan Gombos, Jennifer Ralph, Richard D. Weisel, Timothy J. Gardner, Eric A. Rose, Michael K. Parides, Deborah D. Ascheim, Ellen Moquete, Helena Chang, Melissa Chase, James Foo, Yingchun Chen, Seth Goldfarb, Katherine Kirkwood, Edlira Dobrev, Ron Levitan, Karen O’Sullivan, Jessica Overbey, Milerva Santos, Deborah Williams, Michael Weglinski, Paula Williams, Carrie Wood, Xia Ye, Sten Lyager Nielsen, Henrik Wiggers, Henning Malgaard, Michael Mack, Tracine Adame, Natalie Settele, Jenny Adams, William Ryan, Robert L. Smith, Paul Grayburn, Frederick Y. Chen, Anju Nohria, Lawrence Cohn, Prem Shekar, Sary Aranki, Gregory Couper, Michael Davidson, R. Morton Bolman, Anne Burgess, Debra Conboy, Rita Lawrence, Nicolas Noiseux, Louis-Mathieu Stevens, Ignacio Prieto, Fadi Basile, Joannie Dionne, Julie Fecteau, Eugene H. Blackstone, Pamela Lackner, Leoma Berroteran, Diana Dolney, Suzanne Fleming, Roberta Palumbo, Christine Whitman, Kathy Sankovic, Denise Kosty Sweeney, Carrie Geither, Kristen Doud, Gregory Pattakos, Pamela A. Clarke, Michael Argenziano, Mathew Williams, Lyn Goldsmith, Craig R. Smith, Yoshifumi Naka, Allan Stewart, Allan Schwartz, Daniel Bell, Danielle Van Patten, Sowmya Sreekanth, John H. Alexander, Carmelo A. Milano, Donald D. Glower, Joseph P. Mathew, J. Kevin Harrison, Stacey Welsh, Mark F. Berry, Cyrus J. Parsa, Betty C. Tong, Judson B. Williams, T. Bruce Ferguson, Alan P. Kypson, Evelio Rodriguez, Malissa Harris, Brenda Akers, Allison O'Neal, John D. Puskas, Robert Guyton, Jefferson Baer, Kim Baio, Alexis A. Neill, Pierre Voisine, Mario Senechal, François Dagenais, Kim O’Connor, Gladys Dussault, Tatiana Ballivian, Suzanne Keilani, Alan M. Speir, Patrick Magee, Niv Ad, Sally Keyte, Minh Dang, Mark Slaughter, Marsha Headlee, Heather Moody, Naresh Solankhi, Emma Birks, Mark A. Groh, Leslie E. Shell, Stephanie A. Shepard, Benjamin H. Trichon, Tracy Nanney, Lynne C. Hampton, Ralph Mangusan, Robert E. Michler, David A. D'Alessandro, Joseph J. DeRose, Daniel J. Goldstein, Ricardo Bello, William Jakobleff, Mario Garcia, Cynthia Taub, Daniel Spevak, Roger Swayze, Nadia Sookraj, Louis P. Perrault, Arsène-Joseph Basmadjian, Denis Bouchard, Michel Carrier, Raymond Cartier, Michel Pellerin, Jean François Tanguay, Ismail El-Hamamsy, André Denault, Philippe Demers, Sophie Robichaud Jonathan Lacharité, Keith A. Horvath, Philip C. Corcoran, Michael P. Siegenthaler, Mandy Murphy, Margaret Iraola, Ann Greenberg, Chittoor Sai-Sudhakar, Ayseha Hasan, Asia McDavid, Bradley Kinn, Pierre Pagé, Carole Sirois, David Latter, Howard Leong-Poi, Daniel Bonneau, Lee Errett, Mark D. Peterson, Subodh Verma, Randi Feder-Elituv, Gideon Cohen, Campbell Joyner, Stephen E. Fremes, Fuad Moussa, George Christakis, Reena Karkhanis, Terry Yau, Michael Farkouh, Anna Woo, Robert James Cusimano, Tirone David, Christopher Feindel, Lisa Garrard, Suzanne Fredericks, Amelia Mociornita, John C. Mullen, Jonathan Choy, Steven Meyer, Emily Kuurstra, Cindi A. Young, Dana Beach, Robert Villanueva, Pavan Atluri, Y. Joseph Woo, Mary Lou Mayer, Michael Bowdish, Vaughn A. Starnes, David Shavalle, Ray Matthews, Shadi Javadifar, Linda Romar, Irving L. Kron, Karen Johnston, John M. Dent, John Kern, Jessica Keim, Sandra Burks, Kim Gahring, David A. Bull, Patrice Desvigne-Nickens, Dennis O. Dixon, Mark Haigney, Richard Holubkov, Alice Jacobs, Frank Miller, John M. Murkin, John Spertus, Andrew S. Wechsler, Frank Sellke, Cheryl L. McDonald, Robert Byington, Neal Dickert, John S. Ikonomidis, David O. Williams, Clyde W. Yancy, James C. Fang, Nadia Giannetti, Wayne Richenbacher, Vivek Rao, Karen L. Furie, Rachel Miller, Sean Pinney, William C. Roberts, Mary N. Walsh, Niamh Kilcullen, David Hung, Stephen J. Keteyian, Clinton A. Brawner, Heather Aldred, Jeffrey Browndyke, and Yanne Toulgoat-Dubois

Subjects
Male, Pacemaker, Artificial, medicine.medical_specialty, medicine.medical_treatment, Myocardial Ischemia, 030204 cardiovascular system & hematology, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Recurrence, medicine, Humans, Clinical significance, Prospective Studies, 030212 general & internal medicine, Stroke, Aged, Heart Failure, Mitral valve repair, business.industry, Area under the curve, Mitral Valve Insufficiency, Atrial fibrillation, medicine.disease, Tricuspid Valve Insufficiency, Defibrillators, Implantable, Surgery, Hospitalization, Echocardiography, Heart failure, Disease Progression, Female, Tricuspid Valve, Tricuspid Valve Regurgitation, Cardiology and Cardiovascular Medicine, Mitral valve regurgitation, business, Follow-Up Studies
Abstract

Whether to repair nonsevere tricuspid regurgitation (TR) during surgery for ischemic mitral valve regurgitation (IMR) remains uncertain.The goal of this study was to investigate the incidence, predictors, and clinical significance of TR progression and presence of ≥moderate TR after IMR surgery.Patients (n = 492) with untreated nonsevere TR within 2 prospectively randomized IMR trials were included. Key outcomes were TR progression (either progression by ≥2 grades, surgery for TR, or severe TR at 2 years) and presence of ≥moderate TR at 2 years.Patients' mean age was 66 ± 10 years (67% male), and TR distribution was 60% ≤trace, 31% mild, and 9% moderate. Among 2-year survivors, TR progression occurred in 20 (6%) of 325 patients. Baseline tricuspid annular diameter (TAD) was not predictive of TR progression. At 2 years, 37 (11%) of 323 patients had ≥moderate TR. Baseline TR grade, indexed TAD, and surgical ablation for atrial fibrillation were independent predictors of ≥moderate TR. However, TAD alone had poor discrimination (area under the curve, ≤0.65). Presence of ≥moderate TR at 2 years was higher in patients with MR recurrence (20% vs. 9%; p = 0.02) and a permanent pacemaker/defibrillator (19% vs. 9%; p = 0.01). Clinical event rates (composite of ≥1 New York Heart Association functional class increase, heart failure hospitalization, mitral valve surgery, and stroke) were higher in patients with TR progression (55% vs. 23%; p = 0.003) and ≥moderate TR at 2 years (38% vs. 22%; p = 0.04).After IMR surgery, progression of unrepaired nonsevere TR is uncommon. Baseline TAD is not predictive of TR progression and is poorly discriminative of ≥moderate TR at 2 years. TR progression and presence of ≥moderate TR are associated with clinical events. (Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting [CABG] Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation, NCT00806988; Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation, NCT00807040).

Published
2021

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