Search

Your search keyword '"Nima Sayyadi"' showing total 2 results
Start Over Author "Nima Sayyadi" Publisher elsevier bv
2 results on '"Nima Sayyadi"'

1. Investigating the scope of pseudoproline assisted peptide cyclization

Author

Nima Sayyadi, Katrina A. Jolliffe, Samira Leesch, and Deni Taleski

Subjects
chemistry.chemical_classification, Pseudoproline, Chemistry, Organic Chemistry, Peptide, Biochemistry, Combinatorial chemistry, Cyclic peptide, Amino acid, Serine, Turn (biochemistry), chemistry.chemical_compound, Yield (chemistry), Drug Discovery, Threonine
Abstract

The cyclization of linear peptides from six to nine amino acids in length and containing between two and four pseudoproline turn inducers derived from serine or threonine was investigated to determine the effect of peptide length, amino acid composition and spacing between the pseudoproline residues on macrocyclization yield.

Published
2014
Full Text
View/download PDF

2. Synthesis of the cyclic heptapeptide axinellin A

Author

Kelly A. Fairweather, Katrina A. Jolliffe, Nima Sayyadi, and Christos Roussakis

Subjects
chemistry.chemical_classification, Natural product, Pseudoproline, Stereochemistry, Natural compound, Organic Chemistry, Peptide, Biochemistry, Chemical synthesis, Combinatorial chemistry, Cyclic peptide, chemistry.chemical_compound, Residue (chemistry), chemistry, Drug Discovery, Cytotoxicity
Abstract

The first synthesis of the naturally occurring cyclic peptide axinellin A has been achieved. Cyclization and subsequent deprotection of linear precursors containing either a t-butyl protected Thr residue or a Thr(ΨMe,Mepro) derivative gave a cyclic peptide, identical in all respects to the naturally occurring material, with the exception that the synthetic peptide does not exhibit the cytotoxic activity reported for the natural product.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results