1. Evaluation of the Uncertainty of Passive Cavitation Measurements for Blood–Brain Barrier Disruption Monitoring
- Author
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Cyril Lafon, Nicolas Asquier, Jean-Yves Chapelon, Application des ultrasons à la thérapie (LabTAU), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier
- Subjects
Materials science ,Acoustics and Ultrasonics ,Swine ,Ultrasonography, Doppler, Transcranial ,[SDV]Life Sciences [q-bio] ,Biophysics ,In Vitro Techniques ,01 natural sciences ,Signal ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,0103 physical sciences ,Animals ,Radiology, Nuclear Medicine and imaging ,010301 acoustics ,Radiological and Ultrasound Technology ,business.industry ,Attenuation ,Detector ,Ultrasound ,Uncertainty ,[SDV] Life Sciences [q-bio] ,Amplitude ,Blood-Brain Barrier ,Cavitation ,Microbubbles ,Blood-brain barrier disruption ,business ,Biomedical engineering - Abstract
Exposure to ultrasound combined with intravenous injection of microbubbles is a technique that can be used to temporarily disrupt the blood-brain barrier. Transcranial monitoring of cavitation can be done with one or more passive cavitation detectors (PCDs). However, the positioning of the PCDs relative to the cavitation site and the attenuation of these signals by the skull are two sources of error in the quantification of cavitation activity. The aim of this study was to evaluate in vitro the amplitude variation of cavitation signals that can be expected for an excised porcine skull model. The variation caused by the relative positioning of the PCD with respect to the cavitation site was quantified. A position-based correction of the signal amplitude was evaluated. Pig skull samples were used to assess variation in signal amplitude caused by bone. The overall coefficient of variation of the signals owing to these measurement biases was estimated at 30.8%.
- Published
- 2020
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