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Your search keyword '"Nick J. Wareham"' showing total 3 results
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3 results on '"Nick J. Wareham"'

1. Type 1 and Type 2 Diabetes and COVID-19 Related Mortality in England: A Cohort Study in People with Diabetes

Author

Naomi Holman, Peter Knighton, Partha Kar, Jackie O’Keefe, Matt Curley, Andy Weaver, Emma Barron, Chirag Bakhai, Kamlesh Khunti, Nick J. Wareham, Naveed Sattar, Bob Young, and Jonathan Valabhji

Subjects
endocrine system, Type 1 diabetes, 2019-20 coronavirus outbreak, endocrine system diseases, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), digestive, oral, and skin physiology, nutritional and metabolic diseases, Type 2 diabetes, medicine.disease, Sars virus, Environmental health, Diabetes mellitus, Medicine, business, Cohort study
Abstract

Background: Although diabetes has been associated with COVID-19 mortality, its scale and relationships with modifiable risk factors including hyperglycaemia and

Published
2020
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2. Type 1 and Type 2 Diabetes and COVID-19 Related Mortality in England: A Whole Population Study

Author

Emma Barron, Chirag Bakhai, Partha Kar, Andy Weaver, Dominique Bradley, Hassan Ismail, Peter Knighton, Naomi Holman, Kamlesh Khunti, Naveed Sattar, Nick J. Wareham, Bob Young, and Jonathan Valabhji

Subjects
Type 1 diabetes, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Relative risk, Diabetes mellitus, medicine, Population study, Type 2 diabetes, medicine.disease, business, Demography, Cohort study
Abstract

Background: Although diabetes has been associated with COVID-19 mortality, the absolute and relative risks for Type 1 and Type 2 diabetes are unknown brbrMe

Published
2020
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3. KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

Author

Laura R, Pearce, Neli, Atanassova, Matthew C, Banton, Bill, Bottomley, Agatha A, van der Klaauw, Jean-Pierre, Revelli, Audrey, Hendricks, Julia M, Keogh, Elana, Henning, Deon, Doree, Sabrina, Jeter-Jones, Sumedha, Garg, Elena G, Bochukova, Rebecca, Bounds, Sofie, Ashford, Emma, Gayton, Peter C, Hindmarsh, Julian P H, Shield, Elizabeth, Crowne, David, Barford, Nick J, Wareham, Stephen, O'Rahilly, Michael P, Murphy, David R, Powell, Ines, Barroso, and I Sadaf, Farooqi

Subjects
Male, Models, Molecular, Proto-Oncogene Proteins B-raf, MAP Kinase Signaling System, Biochemistry, Genetics and Molecular Biology(all), Fatty Acids, Molecular Sequence Data, Age Factors, Hyperphagia, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Mice, Glucose, Animals, Humans, Female, Amino Acid Sequence, Obesity, Age of Onset, Insulin Resistance, Child, Energy Metabolism, Oxidation-Reduction, Sequence Alignment
Abstract

SummaryKinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways. Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and 1,536 controls. We identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEK-ERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells; effects that can be ameliorated by the commonly prescribed antidiabetic drug, metformin. Mutation carriers exhibit hyperphagia in childhood, low heart rate, reduced basal metabolic rate and severe insulin resistance. These data establish KSR2 as an important regulator of energy intake, energy expenditure, and substrate utilization in humans. Modulation of KSR2-mediated effects may represent a novel therapeutic strategy for obesity and type 2 diabetes.PaperFlick

Published
2013
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