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4 results on '"Niall Lennon"'

1. The All of Us Research Program: Data quality, utility, and diversity

Author

Andrea H. Ramirez, Lina Sulieman, David J. Schlueter, Alese Halvorson, Jun Qian, Francis Ratsimbazafy, Roxana Loperena, Kelsey Mayo, Melissa Basford, Nicole Deflaux, Karthik N. Muthuraman, Karthik Natarajan, Abel Kho, Hua Xu, Consuelo Wilkins, Hoda Anton-Culver, Eric Boerwinkle, Mine Cicek, Cheryl R. Clark, Elizabeth Cohn, Lucila Ohno-Machado, Sheri D. Schully, Brian K. Ahmedani, Maria Argos, Robert M. Cronin, Christopher O’Donnell, Mona Fouad, David B. Goldstein, Philip Greenland, Scott J. Hebbring, Elizabeth W. Karlson, Parinda Khatri, Bruce Korf, Jordan W. Smoller, Stephen Sodeke, John Wilbanks, Justin Hentges, Stephen Mockrin, Christopher Lunt, Stephanie A. Devaney, Kelly Gebo, Joshua C. Denny, Robert J. Carroll, David Glazer, Paul A. Harris, George Hripcsak, Anthony Philippakis, Dan M. Roden, Brian Ahmedani, Christine D. Cole Johnson, Habib Ahsan, Donna Antoine-LaVigne, Glendora Singleton, Eric Topol, Katie Baca-Motes, Steven Steinhubl, James Wade, Mark Begale, Praduman Jain, Scott Sutherland, Beth Lewis, Melissa Behringer, Ali G. Gharavi, Louise Bier, Murray H. Brilliant, Narayana Murali, Scott Joseph Hebbring, Dorothy Farrar-Edwards, Elizabeth Burnside, Marc K. Drezner, Amy Taylor, Veena Channamsetty, Wanda Montalvo, Yashoda Sharma, Carmen Chinea, Nancy Jenks, Steve Thibodeau, Beverly Wilson Holmes, Eric Schlueter, Ever Collier, Joyce Winkler, John Corcoran, Nick D’Addezio, Martha Daviglus, Robert Winn, Dan Roden, Joshua Denny, Kim Doheny, Debbie Nickerson, Evan Eichler, Gail Jarvik, Gretchen Funk, Heidi Rehm, Niall Lennon, Sekar Kathiresan, Stacey Gabriel, Richard Gibbs, Edgar M. Gil Rico, Joannie Grand, Paul Harris, Elizabeth Shenkman, William R. Hogan, Priscilla Igho-Pemu, Cliff Pollan, Milena Jorge, Sally Okun, Jordan Smoller, Shawn N. Murphy, Margaret Elizabeth Ross, Rainu Kaushal, Eboni Winford, Febe Wallace, Vik Kheterpal, Akinlolu Ojo, Francisco A. Moreno, Irving Kron, Rachele Peterson, Usha Menon, Patricia Watkins Lattimore, Noga Leviner, Juno Obedin-Maliver, Mitchell Lunn, Lynda Malik-Gagnon, Lara Mangravite, Adria Marallo, Oscar Marroquin, Shyam Visweswaran, Steven Reis, Gailen Marshall, Patrick McGovern, Deb Mignucci, John Moore, Fatima Munoz, Gregory Talavera, George T. O'Connor, Christopher O'Donnell, Greg Orr, Fornessa Randal, Andreas A. Theodorou, Eric Reiman, Mercedita Roxas-Murray, Louisa Stark, Ronnie Tepp, Alicia Zhou, Scott Topper, Rhonda Trousdale, Phil Tsao, Lisa Weidman, Scott T. Weiss, David Wellis, Jeffrey Whittle, Amanda Wilson, Stephan Zuchner, and Michael E. Zwick

Subjects
General Decision Sciences
Published
2022

2. Durvalumab, Tremelimumab Alone or in Combination With Low-Dose or Hypofractionated Targeted Radiotherapy in Metastatic Non-Small Cell Lung Cancer Refractory to Prior PD-1 Therapy: A Multicentre, Open-Label, Randomized, Phase 2 Trial

Author

Jonathan D. Schoenfeld, Anita Giobbie-Hurder, Srinika Ranasinghe, Katrina Z. Kao, Ana Lako, Junko Tsuji, Yang Liu, Ryan C. Brennick, Ryan Gentzler, Carrie Lee, Joleen Hubbard, James L. Abbruzzese, Salma K. Jabbour, Nataliya Uboha, Kevin Stephans, Jennifer M. Johnson, Haesong Park, Lisa C. Villaruz, Elad Sharon, Howard Streicher, Mansoor Ahmed, Hayley Lyon, Carrie Cibuskis, Niall Lennon, Aashna Jhaveri, Lin Yang, Jennifer Altreuter, Lauren Gunasti, Jason L. Weirather, Raymond H. Mak, Mark M. Awad, Scott J. Rodig, Helen X. Chen, Catherine J. Wu, Arta M. Monjazeb, and F. Stephen Hodi

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2021

3. Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999–2008

Author

John F. Anderson, Niall Lennon, Philip M. Armstrong, Gregory D. Ebel, Charles R. Vossbrinck, Bruce W. Birren, Mathew R. Henn, Kendra N. Pesko, Theodore G. Andreadis, and Ruchi M. Newman

Subjects
Time Factors, Climate, viruses, 030231 tropical medicine, Population, Zoology, Article, Virus, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, Molecular evolution, Phylogenetics, Virology, Humans, Viral evolution, education, Phylogeny, 030304 developmental biology, 0303 health sciences, education.field_of_study, Molecular epidemiology, biology, Phylogenetic tree, Flavivirus, Flaviviridae, biology.organism_classification, Adaptation, Physiological, Connecticut, West Nile virus, West Nile Fever
Abstract

West Nile virus (WNV) has become firmly established in northeastern US, reemerging every summer since its introduction into North America in 1999. To determine whether WNV overwinters locally or is reseeded annually, we examined the patterns of viral lineage persistence and replacement in Connecticut over 10 consecutive transmission seasons by phylogenetic analysis. In addition, we compared the full protein coding sequence among WNV isolates to search for evidence of convergent and adaptive evolution. Viruses sampled from Connecticut segregated into a number of well-supported subclades by year of isolation with few clades persisting ≥ 2 years. Similar viral strains were dispersed in different locations across the state and divergent strains appeared within a single location during a single transmission season, implying widespread movement and rapid colonization of virus. Numerous amino acid substitutions arose in the population but only one change, V → A at position 159 of the envelope protein, became permanently fixed. Several instances of parallel evolution were identified in independent lineages, including one amino acid change in the NS4A protein that appears to be positively selected. Our results suggest that annual reemergence of WNV is driven by both reintroduction and local-overwintering of virus. Despite ongoing evolution of WNV, most amino acid variants occurred at low frequencies and were transient in the virus population.

Published
2011

4. 3 POPULATIONAL ANALYSIS REVEALS A LINK BETWEEN COMPLEX VIRAL ESCAPE FROM CD8+ T-CELL RESPONSES AND PROTECTION IN HCV INFECTION

Author

J Schulze zur Wiesch, Brian R. Edlin, Matthew R. Henn, Raymond T. Chung, Eric S. Daar, Laura L. Reyor, K. Wunsch, Ira M. Jacobson, Bruce W. Birren, Bruce D. Walker, S. Adams, Robert Thimme, Edward D. Gomperts, Hugo R. Rosen, David E. Heckerman, F. Marincola, Andrew H. Talal, Jörg Timm, Chad Nusbaum, Mary Carrington, Christopher E. Birch, Arne Schneidewind, Georg M. Lauer, Ulrich Spengler, Christoph Neumann-Haefelin, Jonathan M. Carlson, Todd M. Allen, Chanson J. Brumme, James E. Galagan, Arthur Y. Kim, Christian Brander, Thomas Kuntzen, Andreas Cerny, Gerond Lake-Bakaar, Marianna Kleyman, Niall Lennon, T. Ledlie, K. Michael, Andrew Roberts, Sharyne M. Donfield, Chinnappa D. Kodira, Aaron M. Berlin, A. Berical, Florian Bihl, Tony N. Marion, Sarah Young, Cory M. McMahon, and Julia Schmidt

Subjects
Hepatology, Immunology, Cytotoxic T cell, Link (geometry), Biology, Virology
Published
2011

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