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4. Effect of Rehabilitation Treatments on Disability in Persons With Disorders of Consciousness: A Propensity Score Study

Author

Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., Semerjian M., Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, and Semerjian, M

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Propensity score, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Disorders of consciousness, Severity of Illness Index, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Severity of illness, medicine, Humans, Longitudinal Studies, Aged, Vegetative state, Rehabilitation, business.industry, Minimally conscious state, Recovery of Function, Disability Rating Scale, Middle Aged, medicine.disease, Treatment Outcome, Italy, Propensity score matching, Physical therapy, Consciousness Disorders, Female, Observational study, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract

To evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and Disability Rating Scale (DRS) scores, adjusted for a number of potential confounders measured at baseline, in a large cohort of patients with disorders of consciousness across time.An observational, longitudinal (2 evaluations), multicenter project was made in 90 Italian centers.Patients (N=364) with a diagnosis of disorders of consciousness.Primary outcome was the severity of diagnosis, expressed on an ordinal scale (OtherMCSVSdeath). In the Other group were included patients who emerged from an MCS and recovered consciousness. The secondary outcome was the DRS score (range of 0-30 with 30 being the worst value). The DRS is a tool used to define the level of residual disability, commonly used to classify the level of functional impairment in patients with acquired brain injury. Both outcomes were measured for each wave.A total of 364 subjects having a complete set of demographic, clinical, and pharmacologic data were included in the propensity score (PS) analysis. Results showed that the rehabilitation treatments (physical and cognitive) reduced the clinical worsening over time in both severity diagnosis and DRS (around 6.5 points) in patients with disorders of consciousness across different propensity score strategies (ie, PS matching, PS adjustment, and PS-weighted procedures). In addition, cognitive protocols seem to be limited to patients with a median value of DRS=23.Our propensity score analysis suggests that rehabilitation treatment protocols seem effective and should be applied to a broader spectrum of patients with disorders of consciousness.

Published
2020

14. Pulse oxymetry evaluation of oxygen saturation in the upper extremity with an arteriovenous fistula before and during hemodialysis

Author

Ariel Halevy, M. Cohn, Zvi Halpern, Jan Averbukh, Negri M, Guy Lin, Joshua Weissgarten, David Chayen, and Hassan Kais

Subjects
medicine.medical_specialty, Fistula, medicine.medical_treatment, Ischemia, Pain, Arteriovenous fistula, Arteriovenous Shunt, Surgical, Renal Dialysis, medicine, Humans, Oximetry, Prospective Studies, Prospective cohort study, Dialysis, Oxygen saturation (medicine), business.industry, musculoskeletal, neural, and ocular physiology, respiratory system, medicine.disease, respiratory tract diseases, Surgery, Oxygen, Nephrology, Arm, Pulse oxymetry, Hemodialysis, business, psychological phenomena and processes, circulatory and respiratory physiology
Abstract

We noticed that some patients with arteriovenous (AV) fistula on chronic hemodialysis experience pain in the limb with the fistula a short time after being connected to the dialysis machine. We postulated that the pain is caused by relative ischemia and therefore performed this study to determine whether oxygen saturation (SaO2) of the extremities with AV fistula decreases during hemodialysis. Seventy-two patients with a side-to-side primary AV fistula were evaluated by pulse oxymetry. SaO2 was measured before hemodialysis and 20 minutes after initiation of dialysis. The contralateral arm served as a control. In 48 patients, SaO2 difference between the arms of each patient before hemodialysis was less than 4%. SaO2 values of this group of patients did not change significantly 20 minutes after initiation of dialysis. In 24 patients, SaO2 differences between the hands of each patient before hemodialysis were 4% or more. In this group of patients, SaO2 values of the hands with the AV fistula decreased significantly 20 minutes after hemodialysis from a mean of 90.85 +/- 2.84% to 81.60 +/- 3.94 (P < 0.001). SaO2 remained unchanged in the contralateral arm. Nine patients in this group complained of pain and change in sensation in the arm with the fistula during hemodialysis. One patient complained of severe pain in the arm with the fistula before hemodialysis, and SaO2 was unmeasurable. We conclude that, in some patients, SaO2 of the arm with the AV fistula decreases only during hemodialysis. This phenomenon may be symptomatic. A predialysis SaO2 difference of 4% or more between the arms predicts decreased SaO2 of the arm with the AV fistula during hemodialysis.

Published
1997

15. How does infected bile affect the postoperative course of patients undergoing laparoscopic cholecystectomy?

Author

Ruth Gold-Deutch, Zvi Halperin, Negri M, Roi Mashiach, Mariana Ferszt, Ariel Halevy, Guy Lin, Jonathan Sackier, and Ida Boldur

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.drug_class, medicine.medical_treatment, Antibiotics, Postoperative Complications, Risk Factors, Bile, Humans, Medicine, In patient, Laparoscopy, Laparoscopic cholecystectomy, Aged, Bacteria, medicine.diagnostic_test, business.industry, Bacterial Infections, General Medicine, Middle Aged, Surgery, Cholecystectomy, Laparoscopic, Female, Cholecystectomy, Anaerobic bacteria, Complication, business, Biliary tract disease
Abstract

Objectives To assess the rate of infected bile in patients undergoing laparoscopic cholecystectomy (LC) and to study the influence on the postoperative infective complications in this group of patients. Methods Bile samples of 247 patients undergoing LC were collected and cultured for aerobic and anaerobic bacteria. All patients were given prophylactic antibiotics. Results The overall rate of infected bile was 12.8% (56 positive cultures); of these, 54 were aerobic and 2 anaerobic bacteria. Only 2 patients developed infection at the umbilical site, and in both, the bile was sterile. None of the patients with positive bile cultures developed any signs of infection during a mean follow-up period of 26 months. Conclusion The overall rate of septic complications following LC is extremely low, and at least in our study no correlation was found between infected bile and septic complications.

Published
1996

22. 9213 Induction and prolonged exposure to Rituximab in combination with Chlorambucil in untreated follicular lymphoma patients: a treatment with sustained response rate and a low toxicity profile

Author

Bassi, S., primary, Sammassimo, S., additional, Gigli, F., additional, Cocorocchio, E., additional, Bertazzoni, P., additional, Nassi, L., additional, Laszlo, D., additional, Lionetti, M.T., additional, Negri, M., additional, and Martinelli, G., additional

Published
2009
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24. Final size planar edgeless silicon detectors for the TOTEM experiment

Author

Noschis, E., primary, Alagoz, E., additional, Anelli, G., additional, Avati, V., additional, Berardi, V., additional, Boccone, V., additional, Bozzo, M., additional, Brucken, E., additional, Buzzo, A., additional, Catanesi, M.G., additional, Cereseto, R., additional, Cuneo, S., additional, Da Viá, C., additional, Deile, M., additional, Dinapoli, R., additional, Eggert, K., additional, Egorov, N., additional, Eremin, I., additional, Ferro, F., additional, Hasi, J., additional, Haug, F., additional, Heino, J., additional, Jarron, P., additional, Kalliopuska, J., additional, Kašpar, J., additional, Kok, A., additional, Kozlov, Y., additional, Kundrát, W., additional, Kurvinen, K., additional, Lauhakangas, R., additional, Lokajíček, M., additional, Luntama, T., additional, Macina, D., additional, Macrí, M., additional, Minutoli, S., additional, Mirabito, L., additional, Morelli, A., additional, Musico, P., additional, Negri, M., additional, Niewiadomski, H., additional, Oljemark, F., additional, Orava, R., additional, Oriunno, M., additional, Österberg, K., additional, Perrot, A.-L., additional, Puppo, R., additional, Radermacher, E., additional, Radicioni, E., additional, Saarikko, H., additional, Santroni, A., additional, Sette, G., additional, Sidorov, A., additional, Siegrist, P., additional, Smotlacha, J., additional, Snoeys, W., additional, Taylor, C., additional, Watts, S., additional, and Whitmore, J., additional

Published
2006
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26. Met-enkephalin levels during PTCA-induced myocardial ischemia

Author

Parlapiano, C., primary, Borgia, M.C., additional, Tonnarini, G., additional, Giancaspro, G., additional, Pizzuto, F., additional, Campana, E., additional, Giovanniello, T., additional, Pantone, P., additional, Vincentelli, G.M., additional, Alegiani, F., additional, and Negri, M., additional

Published
2001
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