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1. Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms (VINTAGE)

Author

Halaby, Rim N., primary, Bruce, Christopher G., additional, Kolandaivelu, Aravindan, additional, Bhatia, Neal K., additional, Rogers, Toby, additional, Khan, Jaffar M., additional, Yildirim, D. Korel, additional, Jaimes, Andi E., additional, O’Brien, Kendall, additional, Babaliaros, Vasilis C., additional, Greenbaum, Adam B., additional, and Lederman, Robert J., additional

Published
2024
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2. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Gasperetti, Alessio, primary, Carrick, Richard, additional, Protonotarios, Alexandros, additional, Laredo, Mikael, additional, van der Schaaf, Iris, additional, Syrris, Petros, additional, Murray, Brittney, additional, Tichnell, Crystal, additional, Cappelletto, Chiara, additional, Gigli, Marta, additional, Medo, Kristen, additional, Crabtree, Peter, additional, Saguner, Ardan M., additional, Duru, Firat, additional, Hylind, Robyn, additional, Abrams, Dominic, additional, Lakdawala, Neal K., additional, Massie, Charles, additional, Cadrin-Tourigny, Julia, additional, Targetti, Mattia, additional, Olivotto, Iacopo, additional, Graziosi, Maddalena, additional, Cox, Moniek, additional, Biagini, Elena, additional, Charron, Philippe, additional, Casella, Michela, additional, Tondo, Claudio, additional, Yazdani, Momina, additional, Ware, James S., additional, Prasad, Sanjay, additional, Calò, Leonardo, additional, Smith, Eric, additional, Helms, Adam, additional, Hespe, Sophie, additional, Ingles, Jodie, additional, Tandri, Harikrishna, additional, Ader, Flavie, additional, Mestroni, Luisa, additional, Wilde, Arthur, additional, Merlo, Marco, additional, Gandjbakhch, Estelle, additional, Calkins, Hugh, additional, te Riele, Anneline S.J.M., additional, Peter van Tintelen, J., additional, Elliot, Perry, additional, and James, Cynthia A., additional

Published
2024
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3. Gender differences with leadless pacemakers: Peri-procedural complications, long-term device function, and clinical outcomes

Author

Huang, Jingwen, primary, Bhatia, Neal K., additional, Lloyd, Michael S., additional, Westerman, Stacy, additional, Shah, Anand, additional, Leal, Miguel, additional, Delurgio, David, additional, Patel, Anshul M., additional, Tompkins, Christine, additional, Leon, Angel R, additional, El-Chami, Mikhael F., additional, and Merchant, Faisal M., additional

Published
2023
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7. Hypertrophic Cardiomyopathy as an Unexpected Mimic of Inducible Laryngeal Obstruction: The Case for Cardiopulmonary Exercise Testing in Otolaryngology

Author

Neal K. Lakdawala, Bradley M. Wertheim, Thomas L. Carroll, and Sunil Kapur

Subjects
medicine.medical_specialty, Exercise limitation, business.industry, Hypertrophic cardiomyopathy, Cardiopulmonary exercise testing, LPN and LVN, medicine.disease, Article, Laryngeal Obstruction, 030507 speech-language pathology & audiology, 03 medical and health sciences, Speech and Hearing, Laryngopharyngeal reflux, 0302 clinical medicine, Otorhinolaryngology, Internal medicine, medicine, Cardiology, Expiration, 030223 otorhinolaryngology, 0305 other medical science, business, Atrial flutter
Abstract

Summary Introduction Inducible laryngeal obstruction is a common and challenging cause of exertional dyspnea. We report a case of an unanticipated cardiac condition that presented with symptoms suggestive of inducible laryngeal obstruction. Discussion A 55-year-old man was evaluated for progressive exertional dyspnea and throat tightness, unexplained after multiple medical evaluations. Resting laryngeal examination was suspicious for laryngopharyngeal reflux and mild vocal fold adduction during quiet expiration. Given progressive and refractory symptoms, maximal cardiopulmonary exercise testing with intermittent laryngeal examination was performed. This study excluded laryngeal causes of exercise limitation and led to an unexpected diagnosis of persistent atrial flutter and hypertrophic cardiomyopathy. Conclusion Cardiopulmonary exercise testing with laryngeal examination can identify unexpected and life-threatening mimics of inducible laryngeal obstruction that may be missed by unmonitored exercise challenges. Suspicion for inducible laryngeal obstruction at rest may not predict the true nature of exercise limitation on cardiopulmonary exercise testing.

Published
2023

8. Risk of Arrhythmic Death in Patients With Nonischemic Cardiomyopathy

Author

Chrispin, Jonathan, primary, Merchant, Faisal M., additional, Lakdawala, Neal K., additional, Wu, Katherine C., additional, Tomaselli, Gordon F., additional, Navara, Rachita, additional, Torbey, Estelle, additional, Ambardekar, Amrut V., additional, Kabra, Rajesh, additional, Arbustini, Eloisa, additional, Narula, Jagat, additional, Guglin, Maya, additional, Albert, Christine M., additional, Chugh, Sumeet S., additional, Trayanova, Natalia, additional, and Cheung, Jim W., additional

Published
2023
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9. The Feasibility and Safety of Flecainide Use Among Patients With Varying Degrees of Coronary Disease

Author

Kiani, Soroosh, primary, Sayegh, Michael N., additional, Ibrahim, Rand, additional, Bhatia, Neal K., additional, Merchant, Faisal M., additional, Shah, Anand D., additional, Westerman, Stacy B., additional, De Lurgio, David B., additional, Patel, Anshul M., additional, Thompkins, Christine M., additional, Leon, Angel R., additional, Lloyd, Michael S., additional, and El-Chami, Mikhael F., additional

Published
2023
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12. PO-03-058 S-ICD GENERATOR EXCHANGE AND PERFORMANCE: A SINGLE TERTIARY CARE EXPERIENCE

Author

Ibrahim, Rand, primary, Al-Gibbawi, Mounir, additional, Bhatia, Neal K., additional, Westerman, Stacy B., additional, Patel, Anshul M., additional, Tompkins, Christine, additional, Shah, Anand D., additional, De Lurgio, David B., additional, Lloyd, Michael S., additional, Leon, Angel R., additional, Merchant, Faisal M., additional, and El-Chami, Mikhael F., additional

Published
2023
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13. PO-04-196 MULTIVARIATE PREDICTORS OF MORTALITY IN PATIENTS WITH VENTRICULAR TACHYARRHYTHMIA: INSIGHTS FROM A COMMUNITY COHORT OF 24000 INDIVIDUALS

Author

Deb, Brototo, primary, Goyal, Jatin, additional, Tjong, Fleur V., additional, Somani, Sulaiman, additional, Rogers, Albert J., additional, Desai, Yaanik, additional, Azizi, Zahra, additional, John, Roy M., additional, Perez, Marco, additional, Perino, Alexander, additional, Wang, Paul J., additional, Viswanathan, Mohan N., additional, Badhwar, Nitish, additional, Bhatia, Neal K., additional, and Narayan, Sanjiv M., additional

Published
2023
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16. MP-453091-11 INCIDENCE, REASONS FOR, AND PREDICTORS OF DISCONTINUATION OF DOFETILIDE THERAPY

Author

Koch, Rachel, primary, Bhatia, Neal K., additional, Lloyd, Michael S., additional, Westerman, Stacy B., additional, Shah, Anand D., additional, De Lurgio, David B., additional, Patel, Anshul M., additional, Tompkins, Christine, additional, Leon, Angel R., additional, El-Chami, Mikhael F., additional, Merchant, Faisal M., additional, and Kiani, Soroosh, additional

Published
2023
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19. COMPARISON OF COST BETWEEN PERCUTANEOUS VASCULAR CLOSURE COMPARED TO MANUAL COMPRESSION IN ATRIAL FIBRILLATION ABLATION: SECONDARY ANALYSIS OF A RANDOMIZED CLINICAL TRIAL.

Author

Ibrahim, Rand, primary, Blank, Evan, additional, Bhatia, Neal K., additional, Shah, Anand D., additional, Westerman, Stacy, additional, De Lurgio, David B., additional, Tompkins, Christine, additional, Patel, Anshul M., additional, Leon, Angel R., additional, Merchant, Faisal M., additional, El Chami, Mikhael Faris, additional, Lloyd, Michael Shane, additional, and Kiani, Soroosh, additional

Published
2023
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20. IMPROVEMENT IN MULTI-DOMAIN PATIENT-REPORTED OUTCOME SCORES WITH MAVACAMTEN TREATMENT IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: INSIGHTS FROM THE VALOR-HCM STUDY

Author

Desai, Milind Y., primary, Spertus, John A., additional, Owens, Anjali Tiku, additional, Geske, Jeffrey Benjamin, additional, Wolski, Kathy, additional, Saberi, Sara, additional, Wang, Andrew, additional, Sherrid, Mark V., additional, Cremer, Paul, additional, Lakdawala, Neal K., additional, Fifer, Michael A., additional, Fermin, David R., additional, Naidu, Srihari S., additional, Smedira, Nicholas G., additional, Schaff, Hartzell V., additional, Lam, Jenny, additional, Lampl, Kathy, additional, Nissen, Steven E., additional, Balasubramanyam, Aarthi, additional, Wyrwich, Kathleen, additional, and Zhong, Yue, additional

Published
2023
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21. THE EFFECT OF MAVACAMTEN TREATMENT FOR SYMPTOMATIC, OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN PATIENTS OF OLDER AGE AND LONGER DURATION OF DIAGNOSIS: ANALYSIS OF THE EXPLORER-HCM TRIAL

Author

Wang, Andrew, primary, Lakdawala, Neal K., additional, Abraham, Theodore P., additional, Nilles, Ester Kim, additional, Wojdyla, Daniel M., additional, Owens, Anjali Tiku, additional, Bach, Richard G., additional, Saberi, Sara, additional, Sehnert, Amy, additional, and Cresci, Sharon, additional

Published
2023
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22. THE EFFECT OF MAVACAMTEN TREATMENT FOR SYMPTOMATIC, OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY IN PATIENTS WITH OR WITHOUT HYPERTENSION: ANALYSIS OF THE EXPLORER-HCM TRIAL

Author

Wang, Andrew, primary, Spertus, John A., additional, Wojdyla, Daniel M., additional, Abraham, Theodore P., additional, Nilles, Ester Kim, additional, Owens, Anjali Tiku, additional, Saberi, Sara, additional, Cresci, Sharon, additional, Sehnert, Amy, additional, and Lakdawala, Neal K., additional

Published
2023
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25. 96-WEEK CARDIAC MAGNETIC RESONANCE (CMR) RESULTS OF TREATMENT WITH MAVACAMTEN FROM THE EXPLORER COHORT OF THE MAVA-LONG-TERM EXTENSION (LTE) STUDY IN PATIENTS (PTS) WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (HCM)

Author

Saberi, Sara, primary, Kramer, Christopher M., additional, Oreziak, Artur, additional, Masri, Ahmad, additional, Villa, Roberto Barriales, additional, Abraham, Theodore P., additional, Lakdawala, Neal K., additional, Wang, Andrew, additional, Choudhury, Lubna, additional, Rader, Florian, additional, Hegde, Sheila M., additional, Kwong, Raymond Y., additional, Balaratnam, Ganesh, additional, Kurio, Greg, additional, Fox, Shawna, additional, Olivotto, Iacopo, additional, and Owens, Anjali Tiku, additional

Published
2023
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29. Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy

Author

Maron, Martin S., primary, Masri, Ahmad, additional, Choudhury, Lubna, additional, Olivotto, Iacopo, additional, Saberi, Sara, additional, Wang, Andrew, additional, Garcia-Pavia, Pablo, additional, Lakdawala, Neal K., additional, Nagueh, Sherif F., additional, Rader, Florian, additional, Tower-Rader, Albree, additional, Turer, Aslan T., additional, Coats, Caroline, additional, Fifer, Michael A., additional, Owens, Anjali, additional, Solomon, Scott D., additional, Watkins, Hugh, additional, Barriales-Villa, Roberto, additional, Kramer, Christopher M., additional, Wong, Timothy C., additional, Paige, Sharon L., additional, Heitner, Stephen B., additional, Kupfer, Stuart, additional, Malik, Fady I., additional, Meng, Lisa, additional, Wohltman, Amy, additional, and Abraham, Theodore, additional

Published
2023
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30. The Road Not Yet Traveled: Distinction in Critical Care Cardiology through the Advanced Heart Failure and Transplant Cardiology Training Pathway

Author

Ann Gage, Erin A. Bohula, Anthony P. Carnicelli, Vanessa Blumer, Neal K. Lakdawala, Leonard Genovese, Richa Agarwal, and Jason N. Katz

Subjects
Heart Failure, medicine.medical_specialty, Highly skilled, Critical Care, business.industry, education, Cardiology, Disease, Certification, medicine.disease, Viewpoints, Subspecialty, Training (civil), Article, Cardiologists, Education, Medical, Graduate, Intensive care, Heart failure, Internal medicine, Humans, Medicine, Cardiology and Cardiovascular Medicine, business
Abstract

As the acuity, complexity, and illness severity of patients admitted to cardiac intensive care units have increased, the need to recognize critical care cardiology (CCC) as a dedicated subspecialty in cardiovascular disease has received increasing support. Differing viewpoints exist regarding the optimal pathway for CCC training. Currently, all proposed CCC training pathways involve permutations of individual training years culminating in subspecialty certification across multiple disciplines; however, there are significant disadvantages to these training paradigms. We propose an innovative, pragmatic approach to CCC training through tailored subspecialty training in advanced heart failure and transplant cardiology (AHFTC), using elective time to enrich AHFTC training with skills and experiences necessary to become a highly skilled critical care cardiologist. The completion of this pathway would lead to completion of AHFTC training with a novel designation: distinction in critical care cardiology.

Published
2022

31. Synthetic probes and chemical tools in sphingolipid research

Author

Neal K. Devaraj and Jiyue Chen

Subjects
Sphingolipids, Cell signaling, integumentary system, Neurodegenerative Diseases, Computational biology, Biology, Lipid Metabolism, Biochemistry, Sphingolipid, Analytical Chemistry, Metabolic Diseases, Sphingolipid metabolism, Humans, Signal Transduction
Abstract

Sphingolipids (SLs) are a unique class of nitrogen-linked lipids that are involved in membrane structure, cell signaling, and other important cellular processes. Abnormal sphingolipid metabolism is observed in several diseases including cancer, diabetes, metabolic disorders, and neurodegenerative diseases, such as Alzheimer's. However, the direct study of SLs has been hampered by their ubiquitous presence in cells and their complex metabolism. In the past few decades, efforts have been focused on creating synthetic probes and chemical tools to study SLs and decipher their roles in cellular biology. In this brief perspective, we seek to provide a concise snapshot of recently developed state-of-the-art chemical tools in SL research and the challenges that can be addressed through further development of SL probes.

Published
2021

37. 2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in neuromuscular disorders

Author

Groh, William J., primary, Bhakta, Deepak, additional, Tomaselli, Gordon F., additional, Aleong, Ryan G., additional, Teixeira, Ricardo Alkmim, additional, Amato, Anthony, additional, Asirvatham, Samuel J., additional, Cha, Yong-Mei, additional, Corrado, Domenico, additional, Duboc, Denis, additional, Goldberger, Zachary D., additional, Horie, Minoru, additional, Hornyak, Joseph E., additional, Jefferies, John Lynn, additional, Kääb, Stefan, additional, Kalman, Jonathan M., additional, Kertesz, Naomi J., additional, Lakdawala, Neal K., additional, Lambiase, Pier D., additional, Lubitz, Steven A., additional, McMillan, Hugh J., additional, McNally, Elizabeth M., additional, Milone, Margherita, additional, Namboodiri, Narayanan, additional, Nazarian, Saman, additional, Patton, Kristen K., additional, Russo, Vincenzo, additional, Sacher, Frederic, additional, Santangeli, Pasquale, additional, Shen, Win-Kuang, additional, Sobral Filho, Dario C., additional, Stambler, Bruce S., additional, Stöllberger, Claudia, additional, Wahbi, Karim, additional, Wehrens, Xander H.T., additional, Weiner, Menachem Mendel, additional, Wheeler, Matthew T., additional, and Zeppenfeld, Katja, additional

Published
2022
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39. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain

Author

Crouch, Elizabeth E., primary, Bhaduri, Aparna, additional, Andrews, Madeline G., additional, Cebrian-Silla, Arantxa, additional, Diafos, Loukas N., additional, Birrueta, Janeth Ochoa, additional, Wedderburn-Pugh, Kaylee, additional, Valenzuela, Edward J., additional, Bennett, Neal K., additional, Eze, Ugomma C., additional, Sandoval-Espinosa, Carmen, additional, Chen, Jiapei, additional, Mora, Cristina, additional, Ross, Jayden M., additional, Howard, Clare E., additional, Gonzalez-Granero, Susana, additional, Lozano, Jaime Ferrer, additional, Vento, Maximo, additional, Haeussler, Maximilian, additional, Paredes, Mercedes F., additional, Nakamura, Ken, additional, Garcia-Verdugo, Jose Manuel, additional, Alvarez-Buylla, Arturo, additional, Kriegstein, Arnold R., additional, and Huang, Eric J., additional

Published
2022
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42. Quantifying arrhythmic long QT effects of hydroxychloroquine and azithromycin with whole-heart optical mapping and simulations

Author

James C. Gumbart, Abouzar Kaboudian, Flavio H. Fenton, Shahriar Iravanian, Ilija Uzelac, Jimena G. Siles-Paredes, Elizabeth M. Cherry, Robert F. Gilmour, Hiroshi Ashikaga, and Neal K. Bhatia

Subjects
Drug, medicine.medical_specialty, Optical mapping, media_common.quotation_subject, Arrhythmias, Azithromycin, 030204 cardiovascular system & hematology, Experimental, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diseases of the circulatory (Cardiovascular) system, Repolarization, Medicine, Adverse effect, 030304 developmental biology, media_common, 0303 health sciences, Cardiotoxic drugs, business.industry, COVID-19, Cardiac arrhythmia, Action potential, Hydroxychloroquine, 3. Good health, Clinical trial, CiPA, RC666-701, Cardiology, business, Alternans, medicine.drug
Abstract

Background In March 2020, hydroxychloroquine (HCQ) alone or combined with azithromycin (AZM) was authorized as a treatment for COVID-19 in many countries. The therapy proved ineffective with long QT and deadly cardiac arrhythmia risks, illustrating challenges to determine the new safety profile of repurposed drugs. Objective To investigate proarrhythmic effects and mechanism of HCQ and AZM (combined and alone) with high doses of HCQ as in the COVID-19 clinical trials. Methods Proarrhythmic effects of HCQ and AZM are quantified using optical mapping with voltage-sensitive dyes in ex vivo Langendorff-perfused guinea pig (GP) hearts and with numerical simulations of a GP Luo-Rudy and a human O'Hara-Virag-Varro-Rudy models, for Epi, Endo, and M cells, in cell and tissue, incorporating the drug's effect on cell membrane ionic currents. Results Experimentally, HCQ alone and combined with AZM leads to long QT intervals by prolonging the action potential duration and increased spatial dispersion of action potential (AP) repolarization across the heart, leading to proarrhythmic discordant alternans. AZM alone had a lesser arrhythmic effect with less triangulation of the AP shape. Mathematical cardiac models fail to reproduce most of the arrhythmic effects observed experimentally. Conclusions During public health crises, the risks and benefits of new and repurposed drugs could be better assessed with alternative experimental and computational approaches to identify proarrhythmic mechanisms. Optical mapping is an effective framework suitable to investigate the drug's adverse effects on cardiac cell membrane ionic channels at the cellular level and arrhythmia mechanisms at the tissue and whole-organ level.

Published
2021

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