1. Protective effects of tetrahydroneopterin against free radical-induced injury
- Author
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Takeshi Icho, Naomi Shinohara, Katsuaki Kitabatake, Yoshio Kajiwara, Kazuhiko Kubota, and Shuji Kojima
- Subjects
Lipopolysaccharides ,Male ,Free Radicals ,Lipopolysaccharide ,Ratón ,Tetrahydroneopterin ,Myocardial Ischemia ,Ischemia ,Mice, Inbred Strains ,Pharmacology ,Biochemistry ,Foot Diseases ,Mice ,chemistry.chemical_compound ,Superoxides ,Forelimb ,medicine ,Animals ,Edema ,Potency ,Carbon Tetrachloride ,Mice, Inbred ICR ,Cardiotoxicity ,Foot ,Chemistry ,Liver Diseases ,Free Radical Scavengers ,medicine.disease ,Biopterin ,Hindlimb ,Doxorubicin ,Toxicity ,Carbon tetrachloride ,Chemical and Drug Induced Liver Injury - Abstract
The therapeutic potency of 5,6,7,8-tetrahydroneopterin (NPH4) was investigated in ischemic paw edema, Adriamycin® (ADR)-induced cardiotoxicity, and endotoxin [lipopolysaccharide (LPS)]- and carbon tetrachloride (CCl 4 )-induced hepatotoxicity in mice. Ischemic paw edema was completely suppressed by pre-administration of NPH4. ADR-induced cardiotoxicity and LPS-induced hepatotoxicity were significantly decreased by post-administration of NPH4. Furthermore, NPH4 ameliorated ccl 4 -induced hepatotoxicity. These results suggest that NPH4 may be useful for the treatment of free radical, especially Superoxide radical, -related tissue injury.
- Published
- 1993
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