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Start Over Author "Milos Mraz" Publisher elsevier bv
7 results on '"Milos Mraz"'

3. Serum concentrations and tissue expression of components of insulin-like growth factor-axis in females with type 2 diabetes mellitus and obesity: The influence of very-low-calorie diet

Author

Martin Haluzik, J. Drapalova, P Kaválková, V. Touskova, Milos Mraz, P Trachta, Z Lacinová, Denisa Haluzikova, and Josef Marek

Subjects
medicine.medical_specialty, food.diet, medicine.medical_treatment, Subcutaneous Fat, Adipose tissue, Type 2 diabetes, Biochemistry, Monocytes, Insulin-like growth factor-binding protein, Insulin-like growth factor, Endocrinology, food, Internal medicine, Diabetes mellitus, medicine, Humans, Obesity, RNA, Messenger, Insulin-Like Growth Factor I, Molecular Biology, Caloric Restriction, biology, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Hormones, Very low calorie diet, Diabetes Mellitus, Type 2, Gene Expression Regulation, biology.protein, Female, Signal Transduction
Abstract

We explored serum concentrations and mRNA expression of insulin-like-growth factor-1 (IGF-1) axis components in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) of 18 healthy females, 11 obese non-diabetic females (OB) and 13 obese women with type 2 diabetes (T2DM) examined at baseline and after very-low-calorie diet (VLCD). T2DM women had decreased expression of IGF-1, IGF-1 receptor (IGF-1R), IGFBP-2 (IGF binding protein-2) and IGFBP-3 in SCAT and increased expression of IGF-1R in PM compared to control group. IGF-1R and IGFBP-3 mRNA expression in SCAT of OB was comparable to control group. In T2DM women VLCD increased serum levels and SCAT expression of IGFBP-2 and PM expression of IGFBP-3. We conclude that decreased IGF-1, IGF-1R and IGFBP-3 expression in SCAT and increased IGF-1R expression in PM of T2DM subjects might contribute to changes of fat differentiation capacity and to regulation of subclinical inflammation by PM, respectively. Increased SCAT and circulating IGFBP-2 and IGFBP-3 in PM might participate in metabolic improvements after VLCD.

Published
2012
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4. P009 CONTINUOUS GLUCOSE SENSOR COMBINED WITH COMPUTER ALGORITHM FOR TIGHT GLUCOSE CONTROL IN CARDIAC SURGERY PATIENTS

Author

J Kremen, Petr Kopecky, Jan Bláha, Kotrlíková E, Martin Haluzik, Štěpán Svačina, R. Hovorka, and Milos Mraz

Subjects
medicine.medical_specialty, Nutrition and Dietetics, business.industry, Internal medicine, medicine, Cardiology, Medicine (miscellaneous), Tight glucose control, Critical Care and Intensive Care Medicine, business, Computer algorithm, Cardiac surgery
Published
2009
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5. SERUM CONCENTRATIONS AND ADIPOSE TISSUE EXPRESSION OF PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) IN OBESE PATIENTS WITH TYPE 2 DIABETES MELLITUS: THE INFLUENCE OF VERY-LOW-CALORIE DIET

Author

Štěpán Svačina, Zuzana Stránská, Zdeňka Lacinová, Martin Haluzik, Martin Matoulek, Milos Mraz, Denisa Haluzikova, Věra Toušková, and P Trachta

Subjects
medicine.medical_specialty, business.industry, food.diet, Type 2 Diabetes Mellitus, Adipose tissue, White adipose tissue, Serum concentration, Very low calorie diet, Endocrinology, food, PEDF, Internal medicine, Internal Medicine, medicine, PIGMENT EPITHELIUM-DERIVED FACTOR, business
Published
2011
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