53 results on '"Miguel Angel Diaz"'
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2. Expanded HCT-CI Definitions Capture Comorbidity Better for Younger Patients of Allogeneic HCT for Nonmalignant Diseases
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Broglie, Larisa, primary, Friend, Brian D., additional, Chhabra, Saurabh, additional, Logan, Brent R., additional, Bupp, Caitrin, additional, Schiller, Gary, additional, Savani, Bipin N., additional, Stadtmauer, Edward, additional, Abraham, Allistair A., additional, Aljurf, Mahmoud, additional, Badawy, Sherif M., additional, Perez, Miguel Angel Diaz, additional, Guinan, Eva C., additional, Hashem, Hasan, additional, Krem, Maxwell M., additional, Lazarus, Hillard M., additional, Rotz, Seth J., additional, Wirk, Baldeep, additional, Yared, Jean A., additional, Pasquini, Marcelo, additional, Thakar, Monica S., additional, and Sorror, Mohamed L., additional
- Published
- 2022
- Full Text
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3. Collection of Peripheral Blood Progenitor Cells in 1 Day Is Associated with Decreased Donor Toxicity Compared to 2 Days in Unrelated Donors
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Miguel Angel Diaz, Jane L. Liesveld, Ibrahim Ahmed, Jack W. Hsu, Raquel M. Schears, Hillard M. Lazarus, Sachiko Seo, Michael A. Pulsipher, Hemant S. Murthy, Richard F. Olsson, Gregory A. Hale, Soyoung Kim, Siddhartha Ganguly, John R. Wingard, Peiman Hematti, Dennis L. Confer, Galen E. Switzer, Thomas R. Spitzer, Amir Steinberg, Phyllis I. Warkentin, Kimberly A. Kasow, Nirali N. Shah, Jennifer A. Sees, Rammurti T. Kamble, Brent R. Logan, Bronwen E. Shaw, Michele W. Sugrue, Bipin N. Savani, Melhern Solh, Paulo N. Anderlini, Saurabh Chhabra, Christopher E. Dandoy, Nosha Farhadfar, Muneer H. Abidi, Christopher Bredeson, and Usama Gergis
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Transplantation ,medicine.medical_specialty ,Hematology ,business.industry ,Physiology ,Bone Marrow Stem Cell ,Filgrastim ,Apheresis ,Unrelated Donor ,Internal medicine ,Toxicity ,Medicine ,Progenitor cell ,business ,medicine.drug - Abstract
Peripheral blood stem cells (PBSCs) have been increasingly used for allogeneic hematopoietic cell transplantation instead of bone marrow stem cells. Current National Marrow Donor Program policy recommends 5 days of daily filgrastim, followed by either 1 or 2 days of apheresis for unrelated donors, depending on collection center choice. To date, there are no published studies comparing the differences in donor experience between 1 day and 2 days of apheresis. We examined 22,348 adult unrelated donor collections in 184 centers between 2006 and 2016. Of these 22,348 donors, 20,004 (89.5%) had collection on 1 day, and the other 2344 (9.5%) had collection over 2 days. Information on why donors underwent apheresis in 1 day or 2 days was not available. Donors who underwent apheresis in 1 day were more likely to be male (67% versus 46%; P 30, 30% versus 22%; P
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- 2020
4. Expanded HCT-CI Definitions Capture Comorbidity Better for Younger Patients of Allogeneic HCT for Nonmalignant Diseases
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Larisa Broglie, Brian D. Friend, Saurabh Chhabra, Brent R. Logan, Caitrin Bupp, Gary Schiller, Bipin N. Savani, Edward Stadtmauer, Allistair A. Abraham, Mahmoud Aljurf, Sherif M. Badawy, Miguel Angel Diaz Perez, Eva C. Guinan, Hasan Hashem, Maxwell M. Krem, Hillard M. Lazarus, Seth J. Rotz, Baldeep Wirk, Jean A. Yared, Marcelo Pasquini, Monica S. Thakar, and Mohamed L. Sorror
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Transplantation ,Molecular Medicine ,Immunology and Allergy ,Cell Biology ,Hematology - Abstract
Allogeneic hematopoietic cell transplantation (HCT) can cure many nonmalignant conditions, but concern for morbidity and mortality remains. To help physicians estimate patient-specific transplant mortality risk, the HCT comorbidity index (HCT-CI) is used. However, pediatric physicians use the HCT-CI less frequently than adult counterparts. We used the Center for International Blood and Marrow Transplant Research database to expand the HCT-CI comorbidity definitions to be more inclusive of children and adolescent and young adult (AYA) patients, adding history of mechanical ventilation, history of invasive fungal infection, assessment of chronic kidney disease (CKD) by estimated glomerular filtration rate, expanding the definition of obesity, and adding an underweight category. A total of 2815 children and AYAs (40 years old) who received first allogeneic HCT for nonmalignant diseases from 2008 to 2017 were included to create an expanded youth nonmalignant HCT-CI (expanded ynHCT-CI) and a simplified non-malignant (simplified ynHCT-CI) HCT-CI. The expanded comorbidities occurred frequently-history of mechanical ventilation (9.6%), history of invasive fungal infection (5.9%), mild CKD (12.2%), moderate/severe CKD (2.1%), obesity (10.9%), and underweight (14.5%). Thirty-nine percent of patients had an increase in their comorbidity score using the expanded ynHCT-CI, leading to a redistribution of scores: ynHCT-CI score 0 (35%), 1-2 (36.4%), and ≥3 (28.6%). Patients with an increase in their comorbidity score had an increased hazard of mortality compared to those whose score remained the same (hazard ratio = 1.41; 95% confidence interval, 1.01-1.98). Modifications to the HCT-CI can benefit children and AYA patients with nonmalignant diseases, creating a risk assessment tool that is clinically relevant and better captures comorbidity in this younger population.
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- 2023
5. Comparison of High Doses of Total Body Irradiation in Myeloablative Conditioning before Hematopoietic Cell Transplantation
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Leona Holmberg, Lori Muffly, Alison W. Loren, Miguel-Angel Perales, Usama Gergis, Tao Wang, Christopher A. Barker, Betty K. Hamilton, Allistair Abraham, Peiman Hematti, Miguel Angel Diaz, Eva C. Guinan, Edward A. Stadtmauer, Sanghee Hong, Jeffery J. Auletta, Gerhard C. Hildebrandt, Marcelo C. Pasquini, Christopher Bredeson, Siddhartha Ganguly, Shin Mineishi, Shahrukh K. Hashmi, Caitrin Fretham, Robert Peter Gale, Hillard M. Lazarus, Jean-Yves Cahn, Kehinde Adekola, Jean A. Yared, Natasha Kekre, Cesar O. Freytes, Saurabh Chhabra, Taiga Nishihori, Rodrigo Martino, Amer Beitinjaneh, and Mitchell Sabloff
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Adult ,Male ,medicine.medical_specialty ,Transplantation Conditioning ,Adolescent ,Cyclophosphamide ,medicine.medical_treatment ,Malignancy ,Gastroenterology ,Disease-Free Survival ,Article ,03 medical and health sciences ,0302 clinical medicine ,Myeloablative conditioning ,Total body irradiation ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,Transplantation ,business.industry ,Hazard ratio ,Hematopoietic Stem Cell Transplantation ,Hematology ,Allogeneic hematopoietic cell transplantation ,Middle Aged ,Allografts ,medicine.disease ,Confidence interval ,Survival Rate ,Radiation therapy ,Hematologic Neoplasms ,030220 oncology & carcinogenesis ,Hematologic malignancies ,Female ,business ,Whole-Body Irradiation ,030215 immunology ,medicine.drug - Abstract
Malignancy relapse is the most common cause of treatment failure among recipients of hematopoietic cell transplantation (HCT). Conditioning dose intensity can reduce disease relapse but is offset by toxicities. Improvements in radiotherapy techniques and supportive care may translate to better outcomes with higher irradiation doses in the modern era. This study compares outcomes of recipients of increasing doses of high-dose total body irradiation (TBI) divided into intermediate high dose (IH; 13-13.75 Gy) and high dose (HD; 14 Gy) with standard dose (SD; 12 Gy) with cyclophosphamide. A total of 2721 patients ages 18 to 60 years with hematologic malignancies receiving HCT from 2001 to 2013 were included. Cumulative incidences of nonrelapse mortality (NRM) at 5 years were 28% (95% confidence interval [CI], 25% to 30%), 32% (95% CI, 29% to 36%), and 34% (95% CI, 28% to 39%) for SD, IH, and HD, respectively (P = .02). Patients receiving IH-TBI had a 25% higher risk of NRM compared with those receiving SD-TBI (12 Gy) (P = .007). Corresponding cumulative incidences of relapse were 36% (95% CI, 34% to 38%), 32% (95% CI, 29% to 36%), and 26% (95% Cl, 21% to 31%; P = .001). Hazard ratios for mortality compared with SD were 1.06 (95% CI,.94 to 1.19; P = .36) for IH and .89 (95% CI,.76 to 1.05; P = .17) for HD. The study demonstrates that despite improvements in supportive care, myeloablative conditioning using higher doses of TBI (with cyclophosphamide) leads to worse NRM and offers no survival benefit over SD, despite reducing disease relapse. (C) 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
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- 2019
6. First Late Effect in Pediatric Survivors with Chronic Graft-Versus-Host Disease Following Hematopoietic Cell Transplantation for Hematologic Malignancy
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Peiman Hematti, Daniel R. Couriel, Sagar S. Patel, Minoo Battiwalla, Lazaros J. Lekakis, Sanghee Hong, Catherine J. Lee, Jeffery J. Auletta, Scott R. Solomon, Leo F. Verdonck, Mukta Arora, Joseph Pidala, Margaret L. MacMillan, Shahinaz M. Gadalla, Shahrukh K. Hashmi, Hasan Hashem, Karen Chen, Stephen R. Spellman, Yoshihiro Inamoto, Sherif M. Badawy, Zachariah DeFilipp, Vijaya Raj Bhatt, Nasheed Hossain, Anita J. Kumar, Rammurti T. Kamble, Tao Wang, Miguel Angel Diaz, Carrie L. Kitko, Robert Peter Gale, Nosha Farhadfar, David Buchbinder, Bipin N. Savani, Dipenkumar Modi, Akshay Sharma, and Jean-Yves Cahn
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Oncology ,Transplantation ,medicine.medical_specialty ,Hematopoietic cell ,business.industry ,Late effect ,Cell Biology ,Hematology ,medicine.disease ,Graft-versus-host disease ,Internal medicine ,Hematologic malignancy ,medicine ,Molecular Medicine ,Immunology and Allergy ,medicine.symptom ,business - Published
- 2021
7. WITHDRAWN: Malformación venosa verrugosa y sobrecrecimiento: a propósito de 2 casos
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M Velayos, K Estefanía-Fernández, Juan Carlos López-Gutiérrez, Miguel Angel Diaz, P Triana, MC Sarmiento-Caldas, L Moratilla-Lapeña, V Martínez González, and L Rodriguez Laguna
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General Medicine - Abstract
The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.36959/472/363. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
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- 2021
8. Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults
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Metheny, Leland, primary, Callander, Natalie S., additional, Hall, Aric C., additional, Zhang, Mei-Jei, additional, Bo-Subait, Khalid, additional, Wang, Hai-Lin, additional, Agrawal, Vaibhav, additional, Al-Homsi, A. Samer, additional, Assal, Amer, additional, Bacher, Ulrike, additional, Beitinjaneh, Amer, additional, Bejanyan, Nelli, additional, Bhatt, Vijaya Raj, additional, Bredeson, Chris, additional, Byrne, Michael, additional, Cairo, Mitchell, additional, Cerny, Jan, additional, DeFilipp, Zachariah, additional, Perez, Miguel Angel Diaz, additional, Freytes, César O., additional, Ganguly, Siddhartha, additional, Grunwald, Michael R., additional, Hashmi, Shahrukh, additional, Hildebrandt, Gerhard C., additional, Inamoto, Yoshihiro, additional, Kanakry, Christopher G., additional, Kharfan-Dabaja, Mohamed A., additional, Lazarus, Hillard M., additional, Lee, Jong Wook, additional, Nathan, Sunita, additional, Nishihori, Taiga, additional, Olsson, Richard F., additional, Ringdén, Olov, additional, Rizzieri, David, additional, Savani, Bipin N., additional, Savoie, Mary Lynn, additional, Seo, Sachiko, additional, van der Poel, Marjolein, additional, Verdonck, Leo F., additional, Wagner, John L., additional, Yared, Jean A., additional, Hourigan, Christopher S., additional, Kebriaei, Partow, additional, Litzow, Mark, additional, Sandmaier, Brenda M., additional, Saber, Wael, additional, Weisdorf, Daniel, additional, and de Lima, Marcos, additional
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- 2021
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9. Revised International Staging System Is Predictive and Prognostic for Early Relapse (<24 months) after Autologous Transplantation for Newly Diagnosed Multiple Myeloma
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Ayman Saad, Tamila L. Kindwall-Keller, Raphael Fraser, Sathish Kumar Gopalakrishnan, Rammurti T. Kamble, Anita D'Souza, Cesar O. Freytes, Melhem Solh, Robert A. Kyle, Hillard M. Lazarus, Jesus G. Berdeja, Siddhartha Ganguly, Robert Peter Gale, Taiga Nishihori, Parameswaran Hari, Kenneth R. Meehan, Tomer M Mark, Saad Z. Usmani, Cindy Lee, Miguel Angel Diaz, Usama Gergis, Binod Dhakal, Abraham S. Kanate, Shaji Kumar, Amer Assal, Omar Davila, Emma C. Scott, Frederick L. Locke, Yago Nieto, Cristina Gasparetto, Gerhard C. Hildebrandt, Bipin N. Savani, Nina Shah, and Sachiko Seo
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Transplantation Conditioning ,health care facilities, manpower, and services ,Early Relapse ,Newly diagnosed ,Transplant ,Transplantation, Autologous ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Recurrence ,health services administration ,Internal medicine ,Lactate dehydrogenase ,medicine ,Humans ,Autologous transplantation ,Staging system ,Multiple myeloma ,Aged ,Neoplasm Staging ,Transplantation ,business.industry ,Myeloma stage ,Hematopoietic Stem Cell Transplantation ,food and beverages ,Hematology ,Middle Aged ,Prognosis ,medicine.disease ,Postrelapse survival ,chemistry ,030220 oncology & carcinogenesis ,Female ,Multiple Myeloma ,business ,human activities ,030215 immunology - Abstract
The revised International Staging System (R-ISS) combines ISS with genetic markers and lactate dehydrogenase and can prognosticate newly diagnosed multiple myeloma (MM). Early relapse (
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- 2019
10. Second Hematopoietic Stem Cell Transplantation for Post-Transplantation Relapsed Acute Leukemia in Children: A Retrospective EBMT-PDWP Study
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Petr Sedlacek, Stefania Varotto, Miguel Angel Diaz, Arnaud Dalissier, Isaac Yaniv, Christina Peters, Boris V. Afanasyev, Peter Bader, Eric Beohou, Selim Corbacioglu, Krzysztof Kałwak, Aviva Krauss, Massimo Berger, and Marco Zecca
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Male ,Reoperation ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Graft vs Host Disease ,Disease ,Hematopoietic stem cell transplantation ,03 medical and health sciences ,Myelogenous ,0302 clinical medicine ,Recurrence ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Nonrelapse mortality ,Child ,Retrospective Studies ,Transplantation ,Acute leukemia ,Marrow transplantation ,business.industry ,Hematopoietic Stem Cell Transplantation ,Hematology ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Prognosis ,medicine.disease ,Survival Analysis ,Post transplant ,Leukemia, Myeloid, Acute ,Leukemia ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,business ,030215 immunology - Abstract
Outcome data were collected from the European Society for Blood and Marrow Transplantation registry on 373 children from 120 centers with relapsed leukemia (214 with acute lymphoblastic leukemia [ALL] and 159 with acute myelogenous leukemia [AML]) who underwent second allogeneic hematopoietic stem cell transplantation (HSCT) between 2004 and 2013. Overall survival (OS) was 38% at 2 years and 29% at 5 years, and leukemia-free survival (LFS) was 30% at 2 years and 25% at 5 years. Median follow-up after second HSCT was 36.4 months in the ALL group and 50.2 months in the AML group. In the ALL group, OS was 43% at 2 years and 33% at 5 years, and LFS was 34% at 2 years and 31% at 5 years. In the AML group, OS was 32% at 2 years and 24% at 5 years, and LFS was 24% at 2 years and 17% at 5 years. The 2-year nonrelapse mortality (NRM) rate was 22% in the ALL group and 18% in the AML group. Favorable prognostic factors (P .05) for OS and LFS included12 months between transplantations and chronic graft-versus-host disease after the first HSCT (in both groups), complete response before the second HSCT (ALL group only), and age12 years (AML group only). Findings were more consistent over time in the ALL group, with no significant differences between 2-year and 5-year rates of relapse, NRM, and LFS. Children with relapsed acute leukemias have a substantial likelihood of long-term survival following second HSCT. Given the many novel targeted and immunomodulation therapies currently under development, it is important to identify specific patient subpopulations that may benefit from a second HSCT compared with those better suited to new approaches.
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- 2018
11. Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo Español de Trasplante Hematopoyetico (GETH)
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Isabel Badell, Blanca Molina, David P. Serrano, Jaime Sanz, Miguel A. Sanz, Laura Fox, José María Fernández, Miguel Angel Diaz, A. Benito, Joan Cid, Javier de la Serna, José Luis Fuster, José Miguel Couselo, Marta González-Vicent, Antonia Pascual, Daniel Morillo, and Cristina Díaz de Heredia
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Biochemistry (medical) ,Clinical Biochemistry ,Hematology ,Hematopoietic stem cell transplantation ,medicine.disease ,HLA Mismatch ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Cord blood ,Internal medicine ,ABO blood group system ,medicine ,Rituximab ,Cumulative incidence ,Autoimmune hemolytic anemia ,Complication ,business ,030215 immunology ,medicine.drug - Abstract
Autoimmune hemolytic anemia (AIHA) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT) associated with poor outcome. However, an optimal therapeutic approach is lacking. Between 2000 and 2015, 4099 allogeneic HSCT were performed in eight pediatric centers of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and six adult centers of the Grupo Español de Trasplante Hematopoyetico (GETH). Sixty cases of AIHA were registered with a cumulative incidence of 1.5% occurring at a median of 6 months after HSCT. Patients aged less than 15 years (P=.005), and patients using cord blood (P=.005) or an HLA mismatch donor (P=.005) were more likely to develop AIHA. Most patients were lymphopenic at the time of diagnosis of AIHA, including a low number of regulatory T lymphocytes (median 3/μL). Median lines of treatment received for AIHA was 3 (range, 1-7). Almost all patients received corticosteroids (88%) and more than half received immunoglobulins or rituximab (63% and 67%, respectively). Complete resolution of AIHA was achieved in 33 of 60 cases (55%). Cumulative incidence of AIHA-related mortality was 17±6%. We found a correlation of AIHA outcome with age (better outcome in younger than 15 years, RR=1.87, P=.01) and rituximab response (higher rate of complete remission in patients responding to rituximab, RR=1.72, P=.025). We analyzed the factors involved in the response to rituximab and found a better response when there was ABO donor/receptor disparity (P=.014) and in those patients with B lymphocytes count above the median (38/μL) (P=.05).Thirty-six of 60 patients survived yielding a disease free survival of 52±8% at 40 months. In Cox analysis, age (children vs adults, HR: 8.19, CI 95%: 2.39-28.12, P=.001) and AIHA outcome (complete remission vs partial remission/non-response, HR: 4.18, CI 95%: 1.55-11.22, P=.005) were associated with a better survival. Our data suggest that patients who developed AIHA after HSCT are severely lymphopenic and have a high risk of mortality. Outcome is better in children and in patients treated with rituximab. We also propose an algorithm for treatment of AIHA after HSCT.
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- 2018
12. A case-control study of Drug-Induced Sleep Endoscopy (DISE) in pediatric population: A proposal for indications
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Maria Antonietta Collu, Raúl Haspert, Raghav C. Dwivedi, Miguel Angel Diaz, Fiorella Lipari, Demetrio Mulas, and Eduard Esteller
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Male ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Decision Making ,Physical examination ,Polysomnography ,Adenoidectomy ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,medicine ,Humans ,Child ,030223 otorhinolaryngology ,Tonsillectomy ,Sleep Apnea, Obstructive ,medicine.diagnostic_test ,business.industry ,Case-control study ,Infant ,Endoscopy ,General Medicine ,nervous system diseases ,respiratory tract diseases ,Otorhinolaryngology ,Sleep endoscopy ,Case-Control Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Deep Sedation ,Airway ,business ,030217 neurology & neurosurgery ,Pediatric population - Abstract
To evaluate whether and when Drug-Induced Sleep Endoscopy (DISE) changes diagnosis and treatment plan in pediatric Obstructive Sleep Apnoea Syndrome (OSAS) with the aim to identify specific subgroups of patients for whom DISE should be especially considered.A case-control study of DISE in 150 children with OSAS. Pre-operative OSA were assessed through detailed history, Chervin questionnaire, physical examination and overnight polysomnography. The group of study was divided into three subgroups according to clinical and polysomnographyc criteria: conventional OSAS, disproportional OSAS and persistent OSAS. Endoscopic evaluation of the upper airway during DISE was scored using Chan classification. Surgical treatment was tailored individually upon the basis of sleep endoscopy findings: performance of any surgery other than tonsillectomy and adenoidectomy (TA) was considered as a change of the treatment plan. Cases and controls were compared considering presence and absence of DISE-directed extra surgery, respectively.150 patients with mean age (SD) 56.09 (23.94) months and mean apnoea-hypopnea index (AHI) of 5.79 (6.52) underwent DISE. The conventional subgroup represented the 58.67% of the sample (n = 88), while the disproportional one counted for the 26.67% (n = 40), and the persistent one for 14.66% (n = 22) of the population. Sleep endoscopy changed the surgical plan in 4.5% of conventional OSAS, 17.5% of disproportional OSAS and 72.7% of persistent OSAS (p 0.005). Overall, a change of the treatment plan operated by DISE was associated with a non-conventional OSAS status (OR = 6; 95% CI = 1.6-26.4).DISE is a safe procedure in children suffering from OSAS, and, despite being unnecessary in conventional cases of OSA, DISE should be considered not only in syndromic children, as previously demonstrated, but also in the general non-syndromic pediatric population, in the case of non-conventional OSA patients, and in children with persistent OSAS.
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- 2018
13. Impact of Chronic Graft-Versus-Host Disease on First Late Effect Among Adult Survivors of Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research (CIBMTR) Analysis
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Lazaros J. Lekakis, Nosha Farhadfar, Sanghee Hong, Stephen R. Spellman, Dipenkumar Modi, Carrie L. Kitko, Joseph Pidala, Vijaya Raj Bhatt, Miguel Angel Diaz, Shahrukh K. Hashmi, Akshay Sharma, Tao Wang, Robert Peter Gale, Minoo Battiwalla, Nasheed Hossain, Shahinaz M. Gadalla, Anita J. Kumar, Catherine J. Lee, Mukta Arora, Sherif M. Badawy, Zachariah DeFilipp, Rammurti T. Kamble, Margaret L. MacMillan, Karen Chen, Yoshihiro Inamoto, Jeffery J. Auletta, Peiman Hematti, David Buchbinder, Hasan Hashem, Leo F. Verdonck, Jean-Yves Cahn, Daniel R. Couriel, Sagar S. Patel, Bipin B. Savani, and Scott R. Solomon
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Oncology ,Transplantation ,medicine.medical_specialty ,Hematopoietic cell ,business.industry ,Late effect ,Cell Biology ,Hematology ,medicine.disease ,Graft-versus-host disease ,Bone transplantation ,Internal medicine ,Molecular Medicine ,Immunology and Allergy ,Medicine ,medicine.symptom ,business - Published
- 2021
14. Optimal Donor for African Americans with Hematologic Malignancy: HLA-Haploidentical Relative or Umbilical Cord Blood Transplant
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Solomon, Scott R., primary, Martin, Andrew St, additional, Zhang, Mei-Jie, additional, Ballen, Karen, additional, Bashey, Asad, additional, Battiwalla, Minoo, additional, Baxter-Lowe, Lee Ann, additional, Brunstein, Claudio, additional, Chhabra, Saurabh, additional, Perez, Miguel Angel Diaz, additional, Fuchs, Ephraim J., additional, Ganguly, Siddhartha, additional, Hardy, Nancy, additional, Hematti, Peiman, additional, McGuirk, Joseph, additional, Peres, Edward, additional, Ringden, Olle, additional, Rizzieri, David, additional, Romee, Rizwan, additional, Solh, Melhem, additional, Szwajcer, David, additional, van der Poel, Marjolein, additional, Waller, Edmund, additional, William, Basem M., additional, and Eapen, Mary, additional
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- 2020
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15. Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide
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Im, Annie, primary, Rashidi, Armin, additional, Wang, Tao, additional, Hemmer, Michael, additional, MacMillan, Margaret L., additional, Pidala, Joseph, additional, Jagasia, Madan, additional, Pavletic, Steven, additional, Majhail, Navneet S., additional, Weisdorf, Daniel, additional, Abdel-Azim, Hisham, additional, Agrawal, Vaibhav, additional, Al-Homsi, A. Samer, additional, Aljurf, Mahmoud, additional, Askar, Medhat, additional, Auletta, Jeffery J., additional, Bashey, Asad, additional, Beitinjaneh, Amer, additional, Bhatt, Vijaya Raj, additional, Byrne, Michael, additional, Cahn, Jean-Yves, additional, Cairo, Mitchell, additional, Castillo, Paul, additional, Cerny, Jan, additional, Chhabra, Saurabh, additional, Choe, Hannah, additional, Ciurea, Stefan, additional, Daly, Andrew, additional, Perez, Miguel Angel Diaz, additional, Farhadfar, Nosha, additional, Gadalla, Shahinaz M., additional, Gale, Robert, additional, Ganguly, Siddhartha, additional, Gergis, Usama, additional, Hanna, Rabi, additional, Hematti, Peiman, additional, Herzig, Roger, additional, Hildebrandt, Gerhard C., additional, Lad, Deepesh P., additional, Lee, Catherine, additional, Lehmann, Leslie, additional, Lekakis, Lazaros, additional, Kamble, Rammurti T., additional, Kharfan-Dabaja, Mohamed A., additional, Khandelwal, Pooja, additional, Martino, Rodrigo, additional, Murthy, Hemant S., additional, Nishihori, Taiga, additional, O'Brien, Tracey A., additional, Olsson, Richard F., additional, Patel, Sagar S., additional, Perales, Miguel-Angel, additional, Prestidge, Tim, additional, Qayed, Muna, additional, Romee, Rizwan, additional, Schoemans, Hélène, additional, Seo, Sachiko, additional, Sharma, Akshay, additional, Solh, Melhem, additional, Strair, Roger, additional, Teshima, Takanori, additional, Urbano-Ispizua, Alvaro, additional, Van der Poel, Marjolein, additional, Vij, Ravi, additional, Wagner, John L., additional, William, Basem, additional, Wirk, Baldeep, additional, Yared, Jean A., additional, Spellman, Steve R., additional, Arora, Mukta, additional, and Hamilton, Betty K., additional
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- 2020
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16. Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report
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Sonali Chaudhury, Ka Wah Chan, Kristin Page, Morton J. Cowan, Gregory A. Hale, Kimberly A. Kasow, Allistair Abraham, Elizabeth Thiel, Anne B. Warwick, Valerie I. Brown, Jeffery J. Auletta, Miguel Angel-Diaz, Amy K. Keating, Hisham Abdel-Azim, Baldeep Wirk, Farid Boulad, Carrie L. Kitko, Richard F. Olsson, Shahinaz M. Gadalla, Bruce M. Camitta, Heather R. Millard, Robert Peter Gale, Pooja Khandelwal, Margaret L. MacMillan, Adriana Seber, Angela R. Smith, and Parinda A. Mehta
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Male ,Oncology ,Transplantation Conditioning ,medicine.medical_treatment ,Pediatric cancers ,Hematopoietic stem cell transplantation ,Regenerative Medicine ,Neuroblastoma ,0302 clinical medicine ,Stem Cell Research - Nonembryonic - Human ,Child ,Autografts ,Cancer ,Pediatric ,Hematology ,Brain Neoplasms ,Hematopoietic Stem Cell Transplantation ,Allografts ,surgical procedures, operative ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,Pediatric Research Initiative ,medicine.medical_specialty ,Adolescent ,Childhood Leukemia ,Pediatric Cancer ,Calcineurin Inhibitors ,Clinical Sciences ,Immunology ,Article ,03 medical and health sciences ,Rare Diseases ,Clinical Research ,Internal medicine ,medicine ,Humans ,Preschool ,Intensive care medicine ,Retrospective Studies ,Transplantation ,business.industry ,Infant ,Stem Cell Research ,medicine.disease ,Pediatric cancer ,Methotrexate ,Orphan Drug ,Bone transplantation ,business ,030215 immunology - Abstract
This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 undergoing autologous (auto) HSCT in the United States between 2008 and 2014. In both settings, there was a greater proportion of boys (n = 4327; 57%), children < 10 years of age (n = 4412; 59%), whites (n = 5787; 77%), and children with a performance score ≥ 90% at HSCT (n = 6187; 83%). Leukemia was the most common indication for an allo-transplant (n = 4170; 94%), and among these, acute lymphoblastic leukemia in second complete remission (n = 829; 20%) and acute myeloid leukemia in first complete remission (n = 800; 19%) werethe most common. The most frequently used donor relation, stem cell sources, and HLA match were unrelated donor (n = 2933; 67%), bone marrow (n = 2378; 54%), and matched at 8/8 HLA antigens (n = 1098; 37%) respectively. Most allo-transplants used myeloablative conditioning (n = 4070; 92%) and calcineurin inhibitors and methotrexate (n = 2245; 51%) for acute graft-versus-host disease prophylaxis. Neuroblastoma was the most common primary neoplasm for an auto-transplant (n = 1338; 44%). Tandem auto-transplants for neuroblastoma declined after 2012 (40% in 2011, 25% in 2012, and 8% in 2014), whereas tandem auto-transplants increased for brain tumors (57% in 2008 and 77% in 2014). Allo-transplants from relatives other than HLA-identical siblings doubled between 2008 and 2014 (3% in 2008 and 6% in 2014). These trends will be monitored in future reports of transplant practices in the United States.
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- 2017
17. J/ψ suppression at forward rapidity in Pb–Pb collisions at sNN=5.02 TeV
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Alessandra Lattuca, Jochen Klein, Silvia Arcelli, Dariusz Czeslaw Miskowiec, Trine Spedstad Tveter, Ivan Kisel, Jinsook Kim, Nora De Marco, Gabriele Gaetano Fronze, Ionel Stan, Levente Molnar, Paolo Camerini, Sergey Voloshin, Meike Charlotte Danisch, Pasquale Di Nezza, Christophe Furget, Jean Willy Andre Cleymans, Volker Lindenstruth, Francesca Soramel, Dmitry Budnikov, Jaroslav Adam, Roy Crawford Lemmon, Yajun Mao, Igor Pshenichnov, Domenico Colella, Mona Sharma, Manuel Colocci, Martin Andreas Volkl, Evgeny Karpechev, Markus Keil, Andrea Festanti, Jun Takahashi, Jana Bielcikova, Marton Vargyas, Antonio Di Mauro, I. Das, Camilo Ernesto Lara Martinez, Peter Zahariev Hristov, Jan Figiel, Vladimir Samsonov, Alberto Caliva, Andre Mischke, Jovan Milosevic, Klaus Barth, Christine Nattrass, Sandun Pahula Hewage, P. Cerello, Bjarte Kileng, Rama Chandra Baral, Peter Graham Jones, Rafael Derradi De Souza, Tribeni Mishra, Pradip Kumar Sahu, Rosario Nania, Satyajit Jena, M. Estienne, Anders Garritt Knospe, Alberto Baldisseri, V. Lenti, Ulrich Fuchs, Corrado Gargiulo, Arianna Batista Camejo, Sandro Bjelogrlic, Manoj Bhanudas Jadhav, Ken Oyama, Ali Okatan, Christoph Mayer, Benjamin Andreas Hess, Smbat Grigoryan, Rainer Martin Schicker, Ernesto Calvo Villar, Andrzej Deloff, Wladyslaw Henryk Trzaska, Madalina-Gabriela Tarzila, Lizardo Valencia Palomo, Dezso Varga, Andrew John Lowe, Pedro Gonzalez Zamora, Alex Henri Jean Chauvin, D. De Gruttola, Panagiotis Christakoglou, Jonghan Park, Kyungeon Choi, Paolo Giubellino, Pierre Vande Vyvre, Philippe Crochet, Sona Pochybova, Anatoly Kolozhvari, Austin Vincent Harton, J. Book, Robert Helmut Munzer, Sang Un Ahn, Valentina Zaccolo, Youngil Kwon, Andrey Zarochentsev, Bogdan Theodor Rascanu, Andre Augustinus, Alexandre Alarcon Do Passo Suaide, Annalisa De Caro, Stefan Thomas Heckel, Wanchaloem Poonsawat, Ankita Sharma, Massimiliano Marchisone, Deepa Thomas, Andrey Reshetin, Hans Rudolf Schmidt, Sergey Filchagin, Marco Bregant, Marie Germain, Franco Meddi, Philipp Johannes Luettig, Mihai Petrovici, Ara Grigoryan, Anik Gupta, Pranjal Sarma, Somnath Kar, Ulrich Michael Frankenfeld, Sebastian Rosado Navarro, Maksym Zyzak, Erin Frances Gauger, Yuri Melikyan, Olja Dordic, Dmitry Aleksandrov, Sukalyan Chattopadhyay, Marcello Lunardon, Jogender Saini, Mais Kazim Oglu Suleymanov, Franck Manso, Chinorat Kobdaj, Piotr Jan Gasik, Vikas Singhal, Antonino Zichichi, M. Spyropoulou-Stassinaki, Marcelo Gameiro Munhoz, Ilya Selyuzhenkov, Benedetto Di Ruzza, Alice Elisabeth Ohlson, Zuman Zhang, Marcello Borri, Alexander Vodopyanov, Sudipan De, Ju Hwan Kang, Alexandr Tumkin, Bernd Stefan Windelband, Valeria Muccifora, Lucina Gabriela Espinoza Beltran, Florian Herrmann, Ritsuya Hosokawa, Tyler Harrison Lutz, Saehanseul Oh, Varlen Grabski, Emilia Leogrande, Alexander Szabo, Filip Krizek, Taesoo Kim, Premomoy Ghosh, Konstantin Mikhaylov, Viktor Ratza, Bernhard Skaali, Laurent Ducroux, Pragati Sahoo, Sk Noor Alam, Alexander Vinogradov, Eugen Mudnic, Astrid Vauthier, Amalia Pop, Rachid Guernane, Anisa Khatun, Iwona Anna Sputowska, Camila De Conti, Catherine Micaela Silvestre, Chitrasen Jena, Sun Kun Oh, Fedor Guber, Nur Hussain, Jorn Henning Putschke, Imrich Szarka, Dong Jo Kim, Nicole Bastid, Shyam Kumar, Hanna Paulina Zbroszczyk, Constantinos Loizides, Toru Sugitate, Michele Floris, Jongsik Eum, Oton Vazquez Doce, Vladimir Kaplin, Soren Pontoppidan Sorensen, Vytautas Vislavicius, Oksana Shadura, Marek Kowalski, Rosario Turrisi, Evgeny Kondratyuk, Branislav Sitar, Sanjib Muhuri, Zixuan Song, Friederike Bock, M. A. Lisa, Gyula Bencedi, Matej Oravec, Dmitry Yurevich Peresunko, Hermes Leon Vargas, Alexei Khanzadeev, Jamila Bashir Butt, Jesse Thomas Buxton, Rainer Arno Ernst Renfordt, Andrew Michael Kubera, Petr Nomokonov, Steffen Georg Weber, Jan Cabala, Hikari Murakami, Ankhi Roy, Fabian Ng, Barthelemy von Haller, Catia Petta, Sidharth Kumar Prasad, Katie Leanne Graham, Francesco Bossu, Chaosong Gao, Saikat Biswas, Jean-Luc Fernand Charvet, Latchezar Betev, Alexey Bogdanov, Arild Velure, Antonio Uras, Raphaelle Marie Bailhache, Stefania Beole, Zhuo Zhou, Maitreyee Mukherjee, Kjetil Ullaland, Jørgen André Lien, Jacobus Onderwaater, Luis Manuel Montano Zetina, Lucile Ronflette, Eulogio Serradilla Rodriguez, Greeshma Koyithatta Meethaleveedu, Rishat Sultanov, Hongbo Zhu, Sergey Kiselev, Elisa Incani, Chiara Oppedisano, Yury Kharlov, Junjie Zhu, Luciano Musa, Hector Bello Martinez, Michal Meres, Tiziano Virgili, Christian Claude Kuhn, Peter Braun-Munzinger, A. Nedosekin, Xinye Peng, Bedangadas Mohanty, Andrea Alici, Pietro Cortese, Bruno Espagnon, H. Bøggild, Ian Gardner Bearden, Mohamad Tarhini, Sebastian Lehner, Javier Ernesto Castillo Castellanos, Francesco Riggi, Ali Zaman, Christian Lippmann, Sebastian Klewin, Panagiota Foka, S. Schuchmann, Jerzy Gustaw Bartke, Fatiha Lehas, Peter Chochula, Alexander Kluge, David Horak, Rashmi Raniwala, Redmer Alexander Bertens, A. S. Gonzalez, Oliver Werner Arnold, Christophe Pierre Suire, Mesut Arslandok, Marco Marquard, Gerardo Antonio Herrera Corral, G. Volpe, Inayat Rasool Bhat, Alexey Kuryakin, Antoine Xavier Lardeux, Miguel Martinez Pedreira, Sanjeev Singh Sambyal, Luis Alberto Perez Moreno, Jacopo Margutti, Sergey Nikolaev, Ganesh Jagannath Tambave, Attiq Ur Rehman, Motoi Inaba, Elisa Meninno, Anastasia Maria Barbano, Thorsten Kollegger, Caio Lagana Fernandes, Shakeel Ahmad, Jin Hee Yoon, Richard Daniel Majka, Eugenio Scapparone, Henner Buesching, Erik Brücken, Vladimir Izucheev, Zubayer Ahammed, Giacomo Vito Margagliotti, Lukasz Kamil Graczykowski, Marc Weber, Andrew John Castro, Matteo Lupi, Nikolay Zavyalov, Caio Alves Garcia Prado, Ashik Ikbal Sheikh, Philippe Rosnet, Ralf Keidel, Alice Zimmermann, Lilit Karayan, David H. Evans, T. Breitner, Konstantin Munning, Antonio Carlos Oliveira da Silva, Jorge Mercado-perez, Kunal Garg, Vladimir Belyaev, D. H. Kim, Grigorii Feofilov, Andrey Vasiliev, Sibaji Raha, Filip Erhardt, Gabor Biro, Naghmeh Mohammadi, Vladislav Grigoryev, Giuseppe Bruno, Karel Safarik, Tomoya Tsuji, Dennis Franz Weiser, Peter Levai, Filimon Roukoutakis, Alis Rodriguez Manso, Audrey Francisco, Andry Malala Rakotozafindrabe, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Krzysztof Redlich, Sami Sakari Rasanen, Enrico Scomparin, Arseniy Shabanov, Myunggeun Song, Lucia Leardini, Jurgen Schukraft, Yves Roland Schutz, Ashutosh Pandey, Jubin Mitra, Federica Sozzi, Johan Alme, Luciano Ramello, Liudmila Malinina, Cristian Andrei, Leticia Cunqueiro Mendez, Daicui Zhou, M. E. Connors, Aurora Diozcora Vargas Trevino, Michal Sefcik, Werner Riegler, Chengxin Zhao, Jennifer Lynn Klay, Evgeny Kryshen, Venelin Anguelov, Linda Vickovic, Eliane Epple, Joel Anthony Mazer, Francesca Bellini, Diego Stocco, Victor Trubnikov, Rama Narayana Singaraju, Oleg Karavichev, Mihaela Gheata, Gustavo Conesa Balbastre, Sagarika Swain, Stefan Kirsch, Sergey Nikulin, Mikhail Malaev, Gergely Gabor Barnafoldi, Giuseppe Pappalardo, Ermanno Vercellin, Artem Konevskikh, Tahir Hussain, Debojit Sarkar, Christian Holm Christensen, Cristiane Jahnke, Beomsu Chang, Tatiana Drozhzhova, Catalin-Lucian Ristea, Peter Kalinak, Valery Punin, D. Vranic, S.A. Zaporozhets, Vitaly Loginov, Marianna Mazzilli, Adriana Telesca, Caterina Deplano, Marian Krivda, Julien Faivre, Salvatore De Pasquale, Teodor Siemiarczuk, Zhang Chunhui, Yonghong Zhang, E. G. Ferreiro, Ketil Roeed, Yasser Corrales Morales, I. Erdemir, Adrian Sevcenco, Anatoly Tikhonov, Vladimir V. Isakov, Ramona Lea, Claude Andre Pruneau, Roberto Barbera, Elena Botta, Zhongbao Yin, Alexander Nyanin, Lidia Maria Gorlich, Basanta Kumar Nandi, Svein Lindal, Ping Yang, Christopher Daniel Anson, Kristin Fanebust Hetland, Pooja Pareek, Roberto Preghenella, Pedro Hugo Ferreira Natal Da Luz, Marek Chojnacki, Janet Elizabeth Seger, Andrea Francescon, Mohammad Ahmad Saleh, Jochen Mathias Thaeder, Rathijit Biswas, Subhasis Chattopadhyay, Alina Gabriela Grigoras, Jeremy John Wilkinson, Ester Anna Rita Casula, Jozef Ferencei, Ionut Cristian Arsene, Sarah Julie Porteboeuf, Jitendra Kumar, Davide Francesco Lodato, Kenneth Francis Read, Zaida Conesa del Valle, Tatsuya Chujo, Jan Cepila, Livio Bianchi, Sarah Louise La Pointe, Minjung Kim, Crispin Williams, Paul Stankus, David Dobrigkeit Chinellato, F. Ronchetti, A. Matyja, Min Jung Kweon, Benjamin Audurier, Federico Cindolo, Xiaowen Ren, Janusz Oleniacz, Chiara Zampolli, Boris Polishchuk, Danthasinghe Piyarathna, Alexander Mamonov, Arturo Tauro, Peter Glassel, Fernando Scarlassara, Lukas Nellen, David Olle Rickard Silvermyr, Gennady Zinovjev, Sadhana Dash, Soyeon Cho, Julius Maximilian Gronefeld, Elena Bruna, Jai Samuel Nielsen Salzwedel, L. Šándor, Christian Bourjau, Grzegorz Andrzej Wilk, Matthias Richter, Igor Lakomov, Podist Kurashvili, Dae Sung Hwang, Y. P. Viyogi, Benjamin Donigus, Tomas Vanat, Maciej Slupecki, Jens Joergen Gaardhoeje, G. Puddu, Jan Jadlovsky, James Declan Mulligan, Alberica Toia, Andile Mothegi Whitehead, Danilo Silva De Albuquerque, Martin Poghosyan, A. R. Reolon, Barbara Jacak, Martin Schmidt, Barbara Guerzoni, Peter Christiansen, Francesco Noferini, Lawrence Pinsky, Hugo Denis Antonio Pereira Da Costa, Alexander Akindinov, Magnus Mager, Alexander Philipp Kalweit, Per-Ivar Lønne, Liliet Calero Diaz, Supriya Das, Artur Furs, Helmut Oskar Oeschler, Miguel Angel Diaz Corchero, N. Grion, Mengliang Wang, Esther Montes Prado, Klaus Johannes Reygers, Astrid Morreale, Vladislav Manko, Andrei Ionut Herghelegiu, Heiko Engel, Federico Antinori, Kai Oliver Schweda, Justin Thomas Blair, Sven Gotovac, Bogdan Vulpescu, Francesco Barile, Nachiketa Sarkar, Vladimir Peskov, Enrichetta Maria Fiore, Francesca Carnesecchi, Guy Paic, Yury Sibiryak, D. R. Gangadharan, Preeti Dhankher, Michal Kopcik, Michael Andreas Winn, Tsubasa Okubo, Sonia Parmar, Gerardus Nooren, Gideon Francois Steyn, Jan Musinsky, Ombretta Pinazza, Henrique Jose Correia Zanoli, Sampo Saarinen, M. Mohisin Khan, I. Berceanu, Borge Svane Nielsen, Raul Tonatiuh Jimenez Bustamante, Pietro Antonioli, Hiroki Yokoyama, Zabulon Vilakazi, Luisa Cifarelli, Barbara Ewa Erazmus, Maria Nicassio, Alexander Borissov, Tomas Wilhelm Snellman, Ana Maria Marin, Rajendra Nath Patra, Serpil Yalcin, I. K. Yoo, Arturo Alejandro Menchaca-Rocha, Daniela Fabris, Irais Bautista Guzman, Ewa Gladysz-dziadus, Jan Rak, Alexandre Shabetai, Rahul Ramachandran Nair, Susanta Kumar Pal, Cristina Terrevoli, M. Ivanov, Ismael Cortes Maldonado, Aditya Nath Mishra, Roberto Divia, W. Park, Michal Broz, Jana Crkovská, Jan de Cuveland, Jinjin Pan, Massimo Masera, Mikhail Zhalov, Evert Anders Stenlund, Andrea Dubla, Leonardo Milano, Marek Bombara, Ernst Hellbar, Maria Vasileiou, Sanjay K. Ghosh, V. Paticchio, Sarita Sahoo, Yvonne Chiara Pachmayer, Vladimir Kovalenko, Boris Batyunya, R. Varma, Edith Zinhle Buthelezi, Diego Mauricio Gomez Coral, A. K. Bhati, Adela Kravcakova, Juan Carlos Cabanillas Noris, Laura Fabbietti, Artem Shangaraev, Mario Ivan Martinez Hernandez, Paola La Rocca, Edmundo Javier Garcia-Solis, Petra Riedler, Ranjit Nayak, Bastian Bathen, Guido Alexander Willems, Prabhat Ranjan Pujahari, Peter Strmen, Xiaoming Zhang, Henrik Qvigstad, Alessandro Feliciello, Katherin Shtejer Diaz, ShinIchi Esumi, Mario Fusco Girard, Giuseppe Simonetti, Orlando Villalobos Baillie, Jan Fiete Grosse-Oetringhaus, Nicole Alice Martin, Vladimir Vechernin, M. Sano, Xu Cai, Anders Nils Erik Oskarsson, Nikolai Smirnov, Mohd Danish Azmi, Maurizio Basile, Slavka Jadlovska, Peter Malzacher, Andreas Morsch, Ivan Ravasenga, D. Domenicis Gimenez, J. Pluta, Evgeny Ryabinkin, Yongwook Baek, Hyungtaik Jung, Daiki Sekihata, Shingo Sakai, Tome Anticic, L. Gruber, Ralf Peter Averbeck, Uwe Westerhoff, Jacobus Willem Van Hoorne, Biswarup Paul, Joakim Nystrand, Hendrik Poppenborg, R. Orava, Se Yong Kim, Sumit Basu, Jussi Samuli Viinikainen, Dmitry Finogeev, Raphael Noel Tieulent, Cynthia Marie Hadjidakis, Igor Altsybeev, Davide Pagano, Natalia Kondratyeva, Mateusz Andrzej Ploskon, Jiri Mares, Marcel Araujo Silva Figueredo, Kgotlaesele Senosi, Michal Sumbera, Jesus Guillermo Contreras Nuno, Eugenio Nappi, Jeremi Niedziela, Dario Berzano, Anju Bhasin, Rene Bellwied, M. Kim, Annika Passfeld, Sedat Altinpinar, Valerii Kondratev, Kristjan Herlache Gulbrandsen, J. W. Harris, Alexey Kurepin, Rigoberto Cruz Albino, Charalampos Kouzinopoulos, T. K. Nayak, Mauro Gallio, Gines Martinez-Garcia, Riccardo Russo, Johannes Peter Wessels, Renato Angelo Ricci, Udo Wolfgang Kebschull, Taku Gunji, Pascal Dupieux, Andrea Dainese, Maciej Pawel Szymanski, Filippo Costa, Sergey Fokin, Lais Ozelin De Lima Pimentel, Michael Linus Knichel, Suh-urk Chung, Paolo Pagano, Sergey Sadovskiy, Dmitry Blau, C. Roy, M. Vala, Alessandra Maria Mazzoni, Antonio Ortiz Velasquez, Francesco Prino, Yury Ryabov, Antonio Juan Rubio Montero, Torsten Alt, Ernesto Belmont Moreno, Mikolaj Krzewicki, M. An, Mahmut Ozdemir, Monika Joanna Jakubowska, Nikola Poljak, Torsten Dahms, Giulio Usai, Dirk Hutter, Sergey Gorbunov, Yuko Sekiguchi, Silvia Masciocchi, Sibaliso Mhlanga, Eric Endress, Shu Li, Sonia Rajput, Ruben Shahoyan, Janka Vrlakova, Anton Alkin, Miljenko Suljic, Julien Charles Hamon, Grazia Luparello, Paraskevi Ganoti, Suharyo Sumowidagdo, Monika Kofarago, Jens Wiechula, Theo Alexander Broker, J. Cerkala, Alexandru Bercuci, Hyeonjoong Kim, Despina Hatzifotiadou, Salvatore Aiola, Raymond James Ehlers, Shuaib Ahmad Khan, A. B. Kurepin, Harald Appelshaeuser, R. Belmont, A. Rachevski, Edgar Perez Lezama, Linus Feldkamp, Andres Sandoval, Arturo Fernandez Tellez, Eleuterio Spiriti, D. Watanabe, Sergio Vergara Limon, Thomas Humanic, Uzma Tabassam, Maximiliano Puccio, Raimond Snellings, Kenta Shigaki, Giuseppe Trombetta, Rune Langøy, Roberta Arnaldi, Ayben Karasu Uysal, Renato Aparecido Negrao De Oliveira, Peter Martin Jacobs, Jon Christopher Wikne, Stefania Bufalino, Alessandro De Falco, Vladimir Nikulin, Maria Haiduc, Boris Hippolyte, Mihai Niculescu, Charles E. Hughes, Ramni Gupta, Predrag Buncic, Laszlo Boldizsar, O. A. Grachov, S. Balasubramanian, Paola Gianotti, Annelies Marianne Veen, Vito Manzari, Alexandru Florin Dobrin, Renaud Vernet, Dhananjaya Thakur, Eleazar Cuautle Flores, Jasper Van Der Maarel, Viktor Riabov, Alexander Deisting, Bharati Naik, Darius Keijdener, Paulus Gerardus Kuijer, Francesco Carena, Victor Gonzalez, Jose Ruben Alfaro Molina, Sean Murray, Giulio Eulisse, Jan Wagner, Kishora Nayak, Goran Simatovic, Ernesto Lopez Torres, Kilian Eberhard Schwarz, Matthias Bonora, Gilda Scioli, Felix Reidt, Pradip Kumar Roy, Raghunath Sahoo, Leonid Vinogradov, Gabor Kiss, Abraham Villatoro Tello, Johanna Stachel, Katarina Krizkova Gajdosova, Valerie Ramillien Barret, Stefano Piano, Serhiy Senyukov, Dmitry Mal'kevich, A. Rossi, Pascal Dillenseger, Oeystein Djuvsland, Cvetan Valeriev Cheshkov, Ildefonso Leon Monzon, Radiy Ilkaev, Kohei Terasaki, Mohammad Tariq, Oliver Busch, V. Petrov, Fouad Rami, Domenico Elia, S. Mahajan, Prabhakar Palni, Vardanush Papikyan, Sorin Ion Zgura, R. Scott, Marielle Chartier, Gyulnara Eyyubova, H. Zhang, Gergoe Hamar, Dagmar Adamová, Michael Henry Oliver, Laurent Bernard Aphecetche, Herve Borel, Hongkai Wang, Bruno Alessandro, H. Caines, Sudhir Raniwala, Tatiana Karavicheva, Subikash Choudhury, Denise Aparecida Moreira De Godoy, Mario Rodriguez Cahuantzi, Nima Zardoshti, Philippe Pillot, Rudiger Haake, Stefano Trogolo, Patrick Simon Reichelt, Sergey Nazarenko, A. Szczepankiewicz, Vasco Miguel Chibante Barroso, Brigitte Cheynis, Carsten Klein, Jihyun Bhom, Hideki Hamagaki, Anselmo Margotti, Petr Zavada, Deepika Rathee, Annalisa Mastroserio, Debasish Das, Pedro Ladron de Guevara, Christina Markert, Ranbir Singh, Mandeep Kour, Krzysztof Marek Sielewicz, Paul Christoph Bätzing, Malgorzata Anna Janik, Boris Teyssier, Do-Won Kim, Ante Bilandzic, Pedro Luis Manuel Podesta Lerma, Alberto Martin Gago Medina, Elisa Laudi, R Jefferson Porter, Oleksandr Kovalenko, Jacek Tomasz Otwinowski, M. R. Cosentino, B. Grynyov, M. Fasel, Alessandra Fantoni, Angela Badala, Andres Gomez Ramirez, Claudiu Cornel Schiaua, Sandra Moretto, Andrea Danu, Guillaume Batigne, Christian Klein-Boesing, Ajay Kumar Dash, Xiaomei Li, Volodymyr Yurchenko, Antonija Utrobicic, Renu Bala, Hartmut Hillemanns, Yosuke Watanabe, Anand Kumar Dubey, David Michael Rohr, Yasuo Miake, Vojtech Petracek, Jose Garabatos Cuadrado, Fabio Filippo Colamaria, Haavard Helstrup, Giacinto de Cataldo, Hans Peter Beck, Hans Martin Ljunggren, Iouri Belikov, Thomas Dietel, R. Grosso, Roman Lietava, Palash Khan, You Zhou, Sohail Musa Mahmood, Christoph Blume, Andrzej Rybicki, Monika Sharma, Vit Kucera, Ciprian Mihai Mitu, Esther Bartsch, Paolo Bartalini, Natasha Sharma, Mikhail Ippolitov, Natalia Zhigareva, Davide Caffarri, Stefano Bagnasco, Johannes Hendrik Stiller, C. Ceballos Sanchez, Jan Pospíšil, Yury Pestov, Sylvain Chapeland, Volodymyr Chelnokov, Rinaldo Rui, Qiye Shou, A. Maire, Anton Jusko, Ivan Kralik, Miroslav Pikna, Mario Sitta, Nicolo Jacazio, Sergey Evdokimov, Michelangelo Agnello, Satoshi Yano, C. Bedda, Daniel Berenyi, Paolo Martinengo, Alessandro Ferretti, Ivonne Alicia Maldonado Cervantes, Anthony Robert Timmins, Adam Ryszard Kisiel, Alberto Collu, Samrangy Sadhu, Guillermo Tejeda Munoz, Costin Grigoras, Gianluca Aglieri Rinella, Daniel Michael Muhlheim, Carlos Duarte Galvan, Naoto Tanaka, Sabyasachi Siddhanta, Buddhadeb Bhattacharjee, Boris Wagner, Alberto Masoni, Chiara Bianchin, Tyler Allen Browning, Fiorella Fionda, Harry Arthur Andrews, Thomas Peitzmann, Marco H. D. van Leeuwen, Shinichi Hayashi, Seongjoo Lee, M. Cherney, Matti Mikael Mieskolainen, Rosi Reed, Alla Maevskaya, Lee Stuart Barnby, Thomas Michael Cormier, Lokesh Kumar, Marco Leoncino, Hua Pei, Piero Giubilato, Xavier Bernard Lopez, Jaroslav Bielcik, Mirko Planinic, Elena Rogochaya, Kirill Lapidus, Enrico Fragiacomo, Anton Andronic, Baldo Sahlmuller, C.J. Schmidt, Yaroslav Berdnikov, Kirill Voloshin, Tinku Sarkar Sinha, Ivan Vorobyev, Victor Jose Gaston Feuillard, Vladimir Ivanov, Didier Alexandre, Alessandro Grelli, Ajay Kumar, Siegfried Valentin Foertsch, Dieter Roehrich, Muhammad Umair Naru, Jaime Norman, Ji-Young Kim, Nicola Bianchi, Madan M. Aggarwal, Neelima Agrawal, Corrado Cicalo, Alexis Jean-michel Mas, Wisla Carena, Martino Gagliardi, Nirbhay Kumar Behera, D. Di Bari, Jihye Song, and M. Irfan
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Physics ,Nuclear and High Energy Physics ,Particle physics ,Muon ,Meson ,010308 nuclear & particles physics ,01 natural sciences ,Nuclear physics ,0103 physical sciences ,Quark–gluon plasma ,High Energy Physics::Experiment ,Rapidity ,Production (computer science) ,Impact parameter ,Nuclear Experiment ,010306 general physics ,Nucleon ,Energy (signal processing) - Abstract
The inclusive J/$\psi$ production has been studied in Pn-Pb and pp collisions at the centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}=5.02$ TeV, using the ALICE detector at the CERN LHC. The J/$\psi$ meson is reconstructed, in the centre-of-mass rapidity interval $2.5
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- 2017
18. Allogeneic Transplantation for Relapsed Waldenström Macroglobulinemia and Lymphoplasmacytic Lymphoma
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Hillard M. Lazarus, Mehdi Hamadani, Rammurti T. Kamble, Anita D'Souza, Tomer M Mark, Parameswaran Hari, Yago Nieto, Siddhartha Ganguly, Gerhard C. Hildebrandt, Saad Z. Usmani, Robert F. Cornell, Tamila L. Kindwall-Keller, Ayman Saad, Richard F. Olsson, Jean Yared, Mohamed A. Kharfan-Dabaja, Edward A. Copelan, Miguel Angel Diaz, Jiaxing Huang, A. Samer Al-Homsi, Michael Martens, Kwang Woo-Ahn, Cesar O. Freytes, Veronika Bachanova, David I. Marks, Robert Peter Gale, David H. Vesole, Saurabh Chhabra, and Taiga Nishihori
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Adult ,medicine.medical_specialty ,Transplantation Conditioning ,Allogeneic transplantation ,Databases, Factual ,Lymphoma ,Graft vs Host Disease ,Disease ,Gastroenterology ,Article ,Time-to-Treatment ,Lymphoplasmacytic Lymphoma ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Relapsed lymphoma ,Lymph node ,Aged ,Transplantation ,business.industry ,Hematopoietic Stem Cell Transplantation ,Waldenstrom macroglobulinemia ,Hematology ,Middle Aged ,medicine.disease ,Survival Analysis ,Allogeneic stem cell transplant ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Bone marrow ,Waldenstrom Macroglobulinemia ,business ,Progressive disease ,030215 immunology - Abstract
Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) is characterized by lymphoplasmacytic proliferation, lymph node and spleen enlargement, bone marrow involvement, and immunoglobulin M production. Treatment varies based on the extent and biology of disease. In some patients, the use of allogeneic hematopoietic cell transplantation (alloHCT) may have curative potential. We evaluated long-term outcomes of 144 patients that received adult alloHCT for WM/LPL. Data was obtained from the Center for International Blood and Marrow Transplant Research database (2001-2013). Patients received myeloablative (n=67) or reduced intensity conditioning (RIC; n=67). Median age at alloHCT was 53 years, and median time from diagnosis to transplantation was 41 months. Thirteen percent (n=18) failed prior autologous hematopoietic cell transplantation. About half (n=82, 57%) had chemo-sensitive disease at the time of transplantation, while 22% had progressive disease. Progression free survival, overall survival, rate of relapse, and non-relapse mortality at 5-years were 46%, 52%, 24%, and 30% respectively. Patients with chemo-sensitive disease and better pre-transplant disease status experienced significantly superior overall survival. There were no significant differences in progression-free survival based on conditioning (myeloablative 50% vs. RIC 41%) or graft source. Conditioning intensity did not impact treatment-related mortality or relapse. The most common causes of death were primary disease and graft-versus-host disease (GVHD). AlloHCT yielded durable survival in select patients with WM/LPL. Strategies to reduce mortality from GVHD and post-transplant relapse are necessary to improve this approach.
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- 2017
19. European Group for Blood and Marrow Transplantation Centers with FACT-JACIE Accreditation Have Significantly Better Compliance with Related Donor Care Standards
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Paul O'Donnell, Chloe Anthias, Deidre M. Kiefer, Jean A. Yared, Galen E. Switzer, Maxim Norkin, Bipin N. Savani, Bronwen E. Shaw, Menachem Bitan, Joerg Halter, Michael A. Pulsipher, Dennis L. Confer, Brent R. Logan, Miguel Angel Diaz, and Paolo Anderlini
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JACIE ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Best practice ,Population ,education ,Hematopoietic stem cell transplantation ,Article ,Accreditation ,Donor Selection ,03 medical and health sciences ,0302 clinical medicine ,Health care ,medicine ,Humans ,Related donor ,Adverse effect ,health care economics and organizations ,Retrospective Studies ,education.field_of_study ,Transplantation ,business.industry ,Donor selection ,Hematopoietic Stem Cell Transplantation ,Retrospective cohort study ,Hematology ,Hematopoietic cell donation ,3. Good health ,Surgery ,Europe ,030220 oncology & carcinogenesis ,Family medicine ,Female ,Guideline Adherence ,Unrelated Donors ,business ,030215 immunology - Abstract
Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to Foundation for the Accreditation of Cellular Therapy/The Joint Accreditation Committee ISCT and EBMT (FACT-JACIE) Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of European Group for Blood and Marrow Transplantation member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared with nonaccredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P = .02), and a lower percentage have a single physician simultaneously responsible for an RD and their recipient (14% versus 35%; P = .008). In contrast, where regulatory standards do not exist, both accredited and nonaccredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care.
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- 2016
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20. Ocular toxocariasis in a pediatric patient undergoing a bone marrow transplantation
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Blanca Molina, Miguel Angel Diaz, Isabel Valls, and Marta González-Vicent
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Male ,Microbiology (medical) ,Ocular toxocariasis ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Bone marrow transplantation ,Anemia ,Antibodies, Helminth ,MEDLINE ,Albendazole ,Immunocompromised Host ,Dogs ,Pharmacotherapy ,Adrenal Cortex Hormones ,medicine ,Animals ,Humans ,Eye Infections, Parasitic ,Bone Marrow Transplantation ,Anthelmintics ,Toxocariasis ,business.industry ,Anemia, Aplastic ,Toxocara canis ,Eye infection ,medicine.disease ,Pediatric patient ,Socioeconomic Factors ,Drug Therapy, Combination ,Emergencies ,business ,Immunosuppressive Agents - Published
- 2019
21. CD45 RA Depletion As an Allogeneic Hematopoietic Transplantation Platform in Children from HLA-Identical Donors
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Elena Sebastián, Eva M. Galvez, Julián Sevilla, Blanca Molina, Miguel Angel Diaz, Josune Zubicaray, and Marta González Vicent
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Transplantation ,Allogeneic transplantation ,Acute myeloblastic leukemia ,business.industry ,Hematology ,Human leukocyte antigen ,ThioTEPA ,medicine.disease ,Donor Lymphocytes ,Fludarabine ,surgical procedures, operative ,Immunology ,medicine ,business ,Busulfan ,medicine.drug - Abstract
Background In hematopoietic transplantation, graft T lymphocytes play a determining role in promoting hematopoiesis, transferring immunity to pathogens and acting as mediators of the graft-versus-leukemia effect (GVL). However, they are also responsible for graft-versus-host disease (GVHD), the main cause of post-transplant morbidity and mortality. Depletion of CD45 RA lymphocytes, by eliminating naive T lymphocytes from inoculum, aims to conserve GVL without GVHD. Methods Since April 2016, 20 patients (12 boys and 8 girls), with a median age of 8 years, have undergone an allogeneic hematopoietic transplant from an HLA identical donor with CD45 RA depletion. Indication for transplant was: acute lymphoblastic leukemia (n=7), acute myeloblastic leukemia (n=7) and myelodysplasia (n=6). Donor was familiar in 7 cases and unrelated in 13. Conditioning regimen consisted on fludarabine, busulfan and thiotepa. Median of CD34 + cells infused was 6.82 × 106/ Kg. On day 0, +15 and +30 a programmed infusion of 1 × 106 / Kg lymphocytes CD45RA- was performed. Results All patients grafted with a median neutrophil (> 0.5 × 109/ L) and platelet (> 20 × 109/ L) engraftment time of 15 and 10 days, respectively. Only one patient has developed acute GVHD grade I and another patient has developed moderate chronic GVHD. Immune reconstitution was early and rapid in all lymphocyte subsets (see Figure 1). Four patient have relapsed so far. There was no case of toxic mortality. Overall survival was 77 ± 10% with a median follow-up of 1 year (2 months-2 years). At present, 17 patients are alive and doing well (Figure 2). Conclusions Allogeneic transplantation with CD45 lymphocytes RA depletion resulted on encouraging results, with a very low incidence of acute and chronic GVHD, but preserving the GVL effect by infusing CD45 RA- donor lymphocytes. Conflict of interest Miguel Angel Diaz, Marta Gonzalez-Vicent, Blanca Molina, Elena Sebastian, Josune Zubicaray, Julian Sevilla: Nothing to disclose. Keywords CD45RA depletion, Allogeneic transplant, Children
- Published
- 2019
22. A phase I/II trial of interleukin-15–stimulated natural killer cell infusion after haplo-identical stem cell transplantation for pediatric refractory solid tumors
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Miguel Angel Diaz, Inmaculada de Prada, María Dolores Corral, Sandra Santamaría, Jose L. Vicario, Lucía Fernández, Antonio Pérez-Martínez, Jaime Valentín, Lorea Abad, Sara Sirvent, Manuel Ramírez, Isabel Martínez-Romera, Julián Sevilla, and Marta González-Vicent
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Adoptive cell transfer ,Adolescent ,T-Lymphocytes ,Immunology ,Population ,Graft vs Host Disease ,Gastroenterology ,Natural killer cell ,Neoplasms ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Immunology and Allergy ,Lymphocyte Count ,Child ,education ,Genetics (clinical) ,Interleukin-15 ,Transplantation ,education.field_of_study ,business.industry ,Interleukin ,Cell Biology ,medicine.disease ,Killer Cells, Natural ,Treatment Outcome ,medicine.anatomical_structure ,Oncology ,Interleukin 15 ,Female ,Stem cell ,business ,Progressive disease ,Stem Cell Transplantation - Abstract
Background aims Preliminary data suggest that T-cell–depleted haplo-identical stem cell transplantation (haplo-SCT) has a clinically beneficial allograft-versus-tumor effect associated with natural killer (NK) cell immune reconstitution. Methods This phase I/II trial descriptively evaluates the feasibility of interleukin (IL)-15–stimulated NK cell infusion after haplo-SCT in pediatric patients with refractory solid tumors. Results Six patients received an IL-15–stimulated NK cell infusion at 30 days after haplo-SCT. The mean number of infused NK cells per product was 11.3 × 10 6 /kg (range, 3–27 × 10 6 /kg). The T-cell count was 3 /kg in all patients (range, 0–0.75 × 10 3 /kg). No toxic effects related to IL-15–stimulated NK cell infusion were observed. Four of the six patients showed a clinical response (one achieved very good partial remission, two achieved partial remission and one had stable disease). One patient had progressive disease, and the response was not evaluated in the remaining patient. After a median follow-up period of 310 days, all patients had died: four of cancer relapse, one of cancer-associated thrombotic micro-angiopathy and one of acute graft-versus-host disease. Conclusions The adoptive transfer of allogeneic IL-15–stimulated NK cells might be feasible and safe in heavily pretreated pediatric patients with refractory solid tumors, though the advanced stage of disease and toxic effects of haplo-SCT may limit the efficacy of NK cell infusion in this population.
- Published
- 2015
23. Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers
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Bronwen E. Shaw, Raquel M. Schears, Rammurti T. Kamble, Brent R. Logan, James Gajewski, Andrew S. Artz, Paul O'Donnell, Miguel Angel Diaz, David F. Stroncek, Deidre M. Kiefer, Muneer H. Abidi, Peiman Hematti, Michael A. Pulsipher, Pintip Chitphakdithai, Jane L. Liesveld, Eric Williams, Kimberley A. Kasow, Christopher E. Dandoy, Tanya L. Pedersen, Bipin N. Savani, Hillard M. Lazarus, Hisham Abdel-Azim, Baldeep Wirk, Richard F. Olsson, John R. Wingard, Galen E. Switzer, Navneet S. Majhail, Gorgun Akpek, and Dennis L. Confer
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Male ,Black male ,Body Mass Index ,0302 clinical medicine ,Anesthesia ,Donor center ,Bone Marrow Transplantation ,2. Zero hunger ,Continental Population Groups ,Hematology ,Middle Aged ,Tissue Donors ,3. Good health ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Donation ,Socioeconomic status ,Cytomegalovirus Infections ,Income ,Tissue and Organ Harvesting ,Female ,Donor toxicities ,PBSC ,Adult ,Unrelated donor ,medicine.medical_specialty ,Race ,Hospitals, Low-Volume ,Adolescent ,Filgrastim ,Pain ,Young Adult ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Bone marrow ,Peripheral Blood Stem Cell Transplantation ,Transplantation ,business.industry ,Bone Marrow Collection ,Peripheral blood ,Blood Cell Count ,Surgery ,Low volume ,Social Class ,business ,Body mass index ,Hospitals, High-Volume ,030215 immunology - Abstract
Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.
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- 2015
24. Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell–mediated cytotoxicity against neuroblastoma in vitro and in vivo
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Lucía Fernández, Matthias Pfeiffer, Enrique Hernández-Jiménez, Petra Zerbes, Fernando Nuñez, Rupert Handgretinger, Hannah Sallis, Antonio Pérez-Martínez, Eduardo López-Collazo, Jaime Valentín, Inmaculada Génesis Martín, Miguel Angel Diaz, Ellen Schwörer, Sociedad Española de Hematología y Oncología Pediátricas, Fundación CRIS contra el Cáncer, Fundación de la Sociedad Española de Hematología y Oncología Pediátricas, Instituto de Salud Carlos III, Josep Carreras Leukemia Foundation, and German Childhood Cancer Foundation
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Cytotoxicity, Immunologic ,Lipopolysaccharides ,Cancer Research ,Immunology ,Mice, SCID ,Biology ,Lymphocyte Activation ,Jurkat cells ,Fluorescence ,Immunophenotyping ,Natural killer cell ,Neuroblastoma ,Interleukin 21 ,Mice, Inbred NOD ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Immunology and Allergy ,Cytotoxic T cell ,IL-2 receptor ,Genetics (clinical) ,Cell Proliferation ,Transplantation ,Lymphokine-activated killer cell ,Oryza ,Cell Biology ,NKG2D ,Killer Cells, Natural ,Disease Models, Animal ,Kinetics ,medicine.anatomical_structure ,Oncology ,Cell culture ,Cancer research ,Cytokines ,Receptors, Natural Killer Cell ,Xylans - Abstract
et al., [Background aims]: Natural killer cell (NK) cytotoxic activity plays a major role in natural immunologic defences against malignancies. NK cells are emerging as a tool for adoptive cancer immunotherapies. Arabinoxylan rice bran (MGN-3/Biobran) has been described as a biological response modifier that can enhance the cytotoxic activity of NK cells. This study evaluated the effect of MGN-3/Biobran on NK cell activation, expansion and cytotoxicity against neuroblastoma cells. [Methods]: NK cells were enriched with magnetic beads and stimulated with MGN-3/Biobran. NK cell activation was evaluated via analysis of their phenotype, and their expansion capability was tracked. The invitro cytotoxic ability of the activated NK cells was tested against K562, Jurkat, A673, NB1691, A-204, RD and RH-30 cell lines and the invivo cytotoxic ability against the NB1691 cell line. [Results]: MGN-3/Biobran stimulation of NK cells induced a higher expression of the activation-associated receptors CD25 and CD69 than in unstimulated cells (P< 0.05). The expression of NKG2D, DNAM, NCRs and TLRs remained unchanged. Overnight MGN-3/Biobran stimulation increased NK cell cytotoxic activity against all cell lines tested invitro and decelerated neuroblastoma growth invivo. The mechanism is not mediated by lipopolysaccharide contamination in MGN-3/Biobran. Furthermore, the addition of MGN-3/Biobran promoted NK cell expansion and decreased T cells invitro. Conclusions: Our data show that MGN-3/Biobran upregulates NK cell activation markers, stimulates NK cell cytotoxic activity against neuroblastoma invitro and invivo and selectively augments the expansion of NK cells. These results may be useful for future NK cell therapeutic strategies of the treatment of neuroblastoma., This work was supported in part by the National Health Service of Spain grant FIS PI12/01622, Fundación de la Sociedad Española de Hemato-Oncologia Infantil and CRIS Cancer Foundation (http://www.criscancer.org/en/index.php) to Antonio Pérez-Martínez and from the German Jose Carreras Leukemia Foundation and the German Childhood Cancer Foundation (DKS) to Matthias Pfeiffer.
- Published
- 2015
25. Herpes 6 Encephalitis: Clinical and Immunological Characteristics in Pediatric Patients with Leukemia Undergoing Depleted Haploidentical Hematopoietic Transplantation
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Miguel Angel Diaz, Marta González-Vicent, Blanca Molina, and Macarena Oporto
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Transplantation ,Leukemia ,Haematopoiesis ,business.industry ,Immunology ,medicine ,Hematology ,medicine.disease ,business ,Encephalitis - Published
- 2018
26. Using Rheopheresis for stem cell Transplantation-Associated Thrombotic Microangiopathy (TA-TMA)
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Julián Sevilla, Maria Isabel Guillén, Miguel Angel Diaz, Marta González-Vicent, and Blanca Herrero
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Male ,medicine.medical_specialty ,Thrombotic microangiopathy ,Rheopheresis ,Defibrotide ,Venous leg ulcer ,Microcirculation ,Internal medicine ,medicine ,Humans ,Child ,Thrombotic Microangiopathies ,business.industry ,Hematology ,Allografts ,medicine.disease ,Diabetic foot ,Pulmonary hypertension ,Surgery ,Transplantation ,Blood Component Removal ,Cardiology ,business ,Stem Cell Transplantation ,medicine.drug - Abstract
Stem cell Transplantation-Associated Thrombotic Microangiopathy (TA-TMA) is an awful complication with high morbidity and mortality. The reported incidence varies from 0.5% to 75% due to the difficulty of diagnosis in these patients. They do not respond to plasma exchange and despite new treatments, such as defibrotide and rituximab, mortality rate ranges between 60% and 90%. Rheopheresis is a specific application of membrane differential filtration for extracorporeal hemorheotherapy that has been used in the diabetic foot syndrome, venous leg ulcer, pulmonary hypertension, sudden hearing loss, macula degeneration and peripheral arterial occlusive disease. The main therapeutic basis of Rheopheresis is the reduction of blood and plasma viscosity that results in improvements of microcirculation and blood flow. The physiopathologic mechanism associated with TA-TMA is the loss of endothelial cell integrity with hypercoagulability secondary to infections, immunosuppressive therapy and graft-versus-host disease. Because of this, we believe that treatment with Rheoapheresis may improve microcirculation and resolve TA-TMA. We report two patients diagnosed of severe TA-MA successfully treated with Rheopheresis using a selective fibrinogen adsorption system (Rheosorb) with a LIFE-18 apheresis unit (Miltenyi Biotec), an integrated plasma therapy instrument.
- Published
- 2013
27. Long-range angular correlations on the near and away side in p–Pb collisions at sNN=5.02 TeV
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Betty Abelev, Jaroslav Adam, Dagmar Adamova, Andrew Marshall Adare, Madan Aggarwal, Gianluca Aglieri Rinella, Michelangelo Agnello, Andras Gabor Agocs, Andrea Agostinelli, Zubayer Ahammed, Nazeer Ahmad, Arshad Ahmad, Sul-Ah Ahn, Sang Un Ahn, Muhammad Ajaz, Alexander Akindinov, Dmitry Aleksandrov, Bruno Alessandro, Andrea Alici, Anton Alkin, Erick Jonathan Almaraz Avina, Johan Alme, Torsten Alt, Valerio Altini, Sedat Altinpinar, Igor Altsybeev, Cristian Andrei, Anton Andronic, Venelin Anguelov, Jonas Anielski, Christopher Daniel Anson, Tome Anticic, Federico Antinori, Pietro Antonioli, Laurent Bernard Aphecetche, Harald Appelshauser, Nicolas Arbor, Silvia Arcelli, Andreas Arend, Nestor Armesto, Roberta Arnaldi, Tomas Robert Aronsson, Ionut Cristian Arsene, Mesut Arslandok, Andzhey Asryan, Andre Augustinus, Ralf Peter Averbeck, Terry Awes, Juha Heikki Aysto, Mohd Danish Azmi, Matthias Jakob Bach, Angela Badala, Yong Wook Baek, Raphaelle Marie Bailhache, Renu Bala, Rinaldo Baldini Ferroli, Alberto Baldisseri, Fernando Baltasar Dos Santos Pedrosa, Jaroslav Ban, Rama Chandra Baral, Roberto Barbera, Francesco Barile, Gergely Gabor Barnafoldi, Lee Stuart Barnby, Valerie Barret, Jerzy Gustaw Bartke, Maurizio Basile, Nicole Bastid, Sumit Basu, Bastian Bathen, Guillaume Batigne, Boris Batyunya, Christoph Heinrich Baumann, Ian Gardner Bearden, Hans Beck, Nirbhay Kumar Behera, Iouri Belikov, Francesca Bellini, Rene Bellwied, Ernesto Belmont-Moreno, Gyula Bencedi, Stefania Beole, Ionela Berceanu, Alexandru Bercuci, Yaroslav Berdnikov, Daniel Berenyi, Anais Annick Erica Bergognon, Dario Berzano, Latchezar Betev, Anju Bhasin, Ashok Kumar Bhati, Jihyun Bhom, Livio Bianchi, Nicola Bianchi, Jaroslav Bielcik, Jana Bielcikova, Ante Bilandzic, Sandro Bjelogrlic, Francesco Blanco, F. Blanco, Dmitry Blau, Christoph Blume, Marco Boccioli, Stefan Boettger, Alexey Bogdanov, Hans Boggild, Mikhail Bogolyubsky, Laszlo Boldizsar, Marek Bombara, Julian Book, Herve Borel, Alexander Borissov, Francesco Bossu, Michiel Botje, Elena Botta, Ermes Braidot, Peter Braun-Munzinger, Marco Bregant, Timo Gunther Breitner, Theo Alexander Broker, Tyler Allen Browning, Michal Broz, Rene Brun, Elena Bruna, Giuseppe Eugenio Bruno, Dmitry Budnikov, Henner Buesching, Stefania Bufalino, Predrag Buncic, Oliver Busch, Edith Zinhle Buthelezi, Diego Caballero Orduna, Davide Caffarri, Xu Cai, Helen Louise Caines, Ernesto Calvo Villar, Paolo Camerini, Veronica Canoa Roman, Giovanni Cara Romeo, Wisla Carena, Francesco Carena, Nelson Carlin Filho, Federico Carminati, Amaya Ofelia Casanova Diaz, Javier Ernesto Castillo Castellanos, Juan Francisco Castillo Hernandez, Ester Anna Rita Casula, Vasile Catanescu, Costanza Cavicchioli, Cesar Ceballos Sanchez, Jan Cepila, Piergiaio Cerello, Beomsu Chang, Sylvain Chapeland, Jean-Luc Fernand Charvet, Sukalyan Chattopadhyay, Subhasis Chattopadhyay, Isha Chawla, Michael Gerard Cherney, Cvetan Cheshkov, Brigitte Cheynis, Vasco Miguel Chibante Barroso, David Chinellato, Peter Chochula, Marek Chojnacki, Subikash Choudhury, Panagiotis Christakoglou, Christian Holm Christensen, Peter Christiansen, Tatsuya Chujo, Suh-Urk Chung, Corrado Cicalo, Luisa Cifarelli, Federico Cindolo, Jean Willy Andre Cleymans, Fabrizio Coccetti, Fabio Colamaria, Domenico Colella, Alberto Collu, Gustavo Conesa Balbastre, Zaida Conesa del Valle, Megan Elizabeth Connors, Giacomo Contin, Jesus Guillermo Contreras, Thomas Michael Cormier, Yasser Corrales Morales, Pietro Cortese, Ismael Cortes Maldonado, Mauro Rogerio Cosentino, Filippo Costa, Manuel Enrique Cotallo, Elisabetta Crescio, Philippe Crochet, Emilia Cruz Alaniz, Rigoberto Cruz Albino, Eleazar Cuautle, Leticia Cunqueiro, Andrea Dainese, Hans Hjersing Dalsgaard, Andrea Danu, Indranil Das, Debasish Das, Supriya Das, Kushal Das, Ajay Kumar Dash, Sadhana Dash, Sudipan De, Gabriel de Barros, Annalisa De Caro, Giacinto de Cataldo, Jan de Cuveland, Alessandro De Falco, Daniele De Gruttola, Hugues Delagrange, Andrzej Deloff, Nora De Marco, Ervin Denes, Salvatore De Pasquale, Airton Deppman, Ginevra DʼErasmo, Raoul Stefan de Rooij, Miguel Angel Diaz Corchero, Domenico Di Bari, Thomas Dietel, Carmelo Di Giglio, Sergio Di Liberto, Antonio Di Mauro, Pasquale Di Nezza, Roberto Divia, Oeystein Djuvsland, Alexandru Florin Dobrin, Tadeusz Antoni Dobrowolski, Benjamin Donigus, Olja Dordic, Olga Driga, Anand Kumar Dubey, Andrea Dubla, Laurent Ducroux, Pascal Dupieux, A.K. Dutta Majumdar, Domenico Elia, David Philip Emschermann, Heiko Engel, Barbara Erazmus, Hege Austrheim Erdal, Bruno Espagnon, Magali Danielle Estienne, Shinichi Esumi, David Evans, Gyulnara Eyyubova, Daniela Fabris, Julien Faivre, Davide Falchieri, Alessandra Fantoni, Markus Fasel, Roger Worsley Fearick, Dominik Fehlker, Linus Feldkamp, Daniel Felea, Alessandro Feliciello, Bo Fenton-Olsen, Grigory Feofilov, Arturo Fernandez Tellez, Alessandro Ferretti, Andrea Festanti, Jan Figiel, Marcel Figueredo, Sergey Filchagin, Dmitry Finogeev, Fiorella Fionda, Enrichetta Maria Fiore, Emmanuel Floratos, Michele Floris, Siegfried Valentin Foertsch, Panagiota Foka, Sergey Fokin, Enrico Fragiacomo, Andrea Francescon, Ulrich Michael Frankenfeld, Ulrich Fuchs, Christophe Furget, Mario Fusco Girard, Jens Joergen Gaardhoje, Martino Gagliardi, Alberto Gago, Mauro Gallio, Dhevan Raja Gangadharan, Paraskevi Ganoti, Jose Garabatos, Edmundo Garcia-Solis, Irakli Garishvili, Jochen Gerhard, Marie Germain, Claudio Geuna, Mihaela Gheata, Andrei Geae Gheata, Bruno Ghidini, Premomoy Ghosh, Paola Gianotti, Martin Robert Girard, Paolo Giubellino, Ewa Gladysz-Dziadus, Peter Glassel, Ramon Gomez, Elena Gonzalez Ferreiro, Laura Helena Gonzalez-Trueba, Pedro Gonzalez-Zamora, Sergey Gorbunov, Ankita Goswami, Sven Gotovac, Lukasz Kamil Graczykowski, Robert Grajcarek, Alessandro Grelli, Costin Grigoras, Alina Gabriela Grigoras, Vladislav Grigoriev, Ara Grigoryan, Smbat Grigoryan, Boris Grinyov, Nevio Grion, Philippe Gros, Jan Fiete Grosse-Oetringhaus, Jean-Yves Grossiord, Raffaele Grosso, Fedor Guber, Rachid Guernane, Barbara Guerzoni, Maxime Rene Joseph Guilbaud, Kristjan Herlache Gulbrandsen, Hrant Gulkanyan, Taku Gunji, Anik Gupta, Ramni Gupta, Rudiger Haake, Oystein Senneset Haaland, Cynthia Marie Hadjidakis, Maria Haiduc, Hideki Hamagaki, Gergoe Hamar, Byounghee Han, Luke David Hanratty, Alexander Hansen, Zuzana Harmanova, John William Harris, Matthias Hartig, Austin Harton, Despoina Hatzifotiadou, Shinichi Hayashi, Arsen Hayrapetyan, Stefan Thomas Heckel, Markus Ansgar Heide, Haavard Helstrup, Andrei Ionut Herghelegiu, Gerardo Antonio Herrera Corral, Norbert Herrmann, Benjamin Andreas Hess, Kristin Fanebust Hetland, Bernard Hicks, Boris Hippolyte, Yasuto Hori, Peter Zahariev Hristov, Ivana Hrivnacova, Meidana Huang, Thomas Humanic, Dae Sung Hwang, Raphaelle Ichou, Radiy Ilkaev, Iryna Ilkiv, Motoi Inaba, Elisa Incani, Pier Giaio Innocenti, Gian Michele Innocenti, Mikhail Ippolitov, Muhammad Irfan, Cristian Geae Ivan, Vladimir Ivanov, Andrey Ivanov, Marian Ivanov, Oleksii Ivanytskyi, Adam Wlodzimierz Jacholkowski, Peter Jacobs, Haeng Jin Jang, Malgorzata Anna Janik, Rudolf Janik, Sandun Jayarathna, Satyajit Jena, Deeptanshu Manu Jha, Raul Tonatiuh Jimenez Bustamante, Peter Graham Jones, Hyung Taik Jung, Anton Jusko, Alexei Kaidalov, Sebastian Kalcher, Peter Kalinak, Tuomo Esa Aukusti Kalliokoski, Alexander Philipp Kalweit, Ju Hwan Kang, Vladimir Kaplin, Ayben Karasu Uysal, Oleg Karavichev, Tatiana Karavicheva, Evgeny Karpechev, Andrey Kazantsev, Udo Wolfgang Kebschull, Ralf Keidel, Palash Khan, Shuaib Ahmad Khan, Mohisin Mohammed Khan, Kamal Hussain Khan, Alexei Khanzadeev, Yury Kharlov, Bjarte Kileng, Beomkyu Kim, Jin Sook Kim, Jonghyun Kim, Dong Jo Kim, Do Won Kim, Taesoo Kim, Se Yong Kim, Mimae Kim, Minwoo Kim, Stefan Kirsch, Ivan Kisel, Sergey Kiselev, Adam Ryszard Kisiel, Jennifer Lynn Klay, Jochen Klein, Christian Klein-Bosing, Michael Kliemant, Alexander Kluge, Michael Linus Knichel, Anders Garritt Knospe, Markus Kohler, Thorsten Kollegger, Anatoly Kolojvari, Mikhail Kompaniets, Valery Kondratiev, Natalia Kondratyeva, Artem Konevskih, Vladimir Kovalenko, Marek Kowalski, Serge Kox, Greeshma Koyithatta Meethaleveedu, Jiri Kral, Ivan Kralik, Frederick Kramer, Adela Kravcakova, Tobias Krawutschke, Michal Krelina, Matthias Kretz, Marian Krivda, Filip Krizek, Miroslav Krus, Evgeny Kryshen, Mikolaj Krzewicki, Yury Kucheriaev, Thanushan Kugathasan, Christian Claude Kuhn, Paul Kuijer, Igor Kulakov, Jitendra Kumar, Podist Kurashvili, A. Kurepin, A.B. Kurepin, Alexey Kuryakin, Svetlana Kushpil, Vasily Kushpil, Henning Kvaerno, Min Jung Kweon, Youngil Kwon, Pedro Ladron de Guevara, Igor Lakomov, Rune Langoy, Sarah Louise La Pointe, Camilo Ernesto Lara, Antoine Xavier Lardeux, Paola La Rocca, Ramona Lea, Mateusz Lechman, Ki Sang Lee, Sung Chul Lee, Graham Richard Lee, Iosif Legrand, Joerg Walter Lehnert, Matthieu Laurent Lenhardt, Vito Lenti, Hermes Leon, Ildefonso Leon Monzon, Hermes Leon Vargas, Peter Levai, Shuang Li, Jaen Lien, Roman Lietava, Svein Lindal, Volker Lindenstruth, Christian Lippmann, Michael Annan Lisa, Hans Martin Ljunggren, Per-Ivar Loenne, Vera Loggins, Vitaly Loginov, Daniel Lohner, Constantinos Loizides, Kai Krister Loo, Xavier Bernard Lopez, Ernesto Lopez Torres, Gunnar Lovhoiden, Xianguo Lu, Philipp Luettig, Marcello Lunardon, Jiebin Luo, Grazia Luparello, Cinzia Luzzi, Rongrong Ma, Ke Ma, Dilan Minthaka Madagodahettige-Don, Alla Maevskaya, Magnus Mager, Durga Prasad Mahapatra, Antonin Maire, Mikhail Malaev, Ivonne Alicia Maldonado Cervantes, Ludmila Malinina, Dmitry MalʼKevich, Peter Malzacher, Alexander Mamonov, Loic Henri Antoine Manceau, Lalit Kumar Mangotra, Vladislav Manko, Franck Manso, Vito Manzari, Yaxian Mao, Massimiliano Marchisone, Jiri Mares, Giacomo Vito Margagliotti, Anselmo Margotti, Ana Maria Marin, Christina Markert, Marco Marquard, Irakli Martashvili, Nicole Alice Martin, Paolo Martinengo, Mario Ivan Martinez, Arnulfo Martinez Davalos, Gines Martinez Garcia, Yevgen Martynov, Alexis Jean-Michel Mas, Silvia Masciocchi, Massimo Masera, Alberto Masoni, Laure Marie Massacrier, Annalisa Mastroserio, Adam Tomasz Matyja, Christoph Mayer, Joel Mazer, Alessandra Maria Mazzoni, Franco Meddi, Arturo Alejandro Menchaca-Rocha, Jae Mercado Perez, Michal Meres, Yasuo Miake, Leonardo Milano, Jovan Milosevic, Andre Mischke, Aditya Nath Mishra, Dariusz Miskowiec, Ciprian Mihai Mitu, Sanshiro Mizuno, Jocelyn Mlynarz, Bedangadas Mohanty, Levente Molnar, Luis Manuel Montano Zetina, Marco Monteno, Esther Montes, Taebong Moon, Maurizio Morando, Denise Aparecida Moreira De Godoy, Sandra Moretto, Astrid Morreale, Andreas Morsch, Valeria Muccifora, Eugen Mudnic, Sanjib Muhuri, Maitreyee Mukherjee, Hans Muller, Marcelo Munhoz, Sean Murray, Luciano Musa, Jan Musinsky, Alfredo Musso, Basanta Kumar Nandi, Rosario Nania, Eugenio Nappi, Christine Nattrass, Tapan Kumar Nayak, Sergey Nazarenko, Alexander Nedosekin, Maria Nicassio, Mihai Niculescu, Bae Svane Nielsen, Takafumi Niida, Sergey Nikolaev, Vedran Nikolic, Sergey Nikulin, Vladimir Nikulin, Bjorn Steven Nilsen, Mads Stormo Nilsson, Francesco Noferini, Petr Nomokonov, Gerardus Nooren, Norbert Novitzky, Alexandre Nyanin, Anitha Nyatha, Casper Nygaard, Joakim Ingemar Nystrand, Alexander Ochirov, Helmut Oskar Oeschler, Saehanseul Oh, Sun Kun Oh, Janusz Oleniacz, Antonio Carlos Oliveira Da Silva, Chiara Oppedisano, Antonio Ortiz Velasquez, Anders Nils Erik Oskarsson, Piotr Krystian Ostrowski, Jacek Tomasz Otwinowski, Ken Oyama, Kyoichiro Ozawa, Yvonne Chiara Pachmayer, Milos Pachr, Fatima Padilla, Paola Pagano, Guy Paic, Florian Painke, Carlos Pajares, Susanta Kumar Pal, Arvinder Singh Palaha, Armando Palmeri, Vardanush Papikyan, Giuseppe Pappalardo, Woo Jin Park, Annika Passfeld, Blahoslav Pastircak, Dmitri Ivanovich Patalakha, Vincenzo Paticchio, Biswarup Paul, Alexei Pavlinov, Tomasz Jan Pawlak, Thomas Peitzmann, Hugo Denis Antonio Pereira Da Costa, Elienos Pereira De Oliveira Filho, Dmitri Peresunko, Carlos Eugenio Perez Lara, Diego Perini, Davide Perrino, Wiktor Stanislaw Peryt, Alessandro Pesci, Vladimir Peskov, Yury Pestov, Vojtech Petracek, Michal Petran, Mariana Petris, Plamen Rumenov Petrov, Mihai Petrovici, Catia Petta, Stefano Piano, Miroslav Pikna, Philippe Pillot, Ombretta Pinazza, Lawrence Pinsky, Nora Pitz, Danthasinghe Piyarathna, Mirko Planinic, Mateusz Andrzej Ploskon, Jan Marian Pluta, Timur Pocheptsov, Sona Pochybova, Pedro Luis Manuel Podesta Lerma, Martin Poghosyan, Karel Polak, Boris Polichtchouk, Amalia Pop, Sarah Porteboeuf-Houssais, Vladimir Pospisil, Baba Potukuchi, Sidharth Kumar Prasad, Roberto Preghenella, Francesco Prino, Claude Andre Pruneau, Igor Pshenichnov, Giovanna Puddu, Valery Punin, Marian Putis, Jorn Henning Putschke, Emanuele Quercigh, Henrik Qvigstad, Alexandre Rachevski, Alphonse Rademakers, Tomi Samuli Raiha, Jan Rak, Andry Malala Rakotozafindrabe, Luciano Ramello, Abdiel Ramirez Reyes, Rashmi Raniwala, Sudhir Raniwala, Sami Sakari Rasanen, Bogdan Theodor Rascanu, Deepika Rathee, Kenneth Francis Read, Jean-Sebastien Real, Krzysztof Redlich, Rosi Jan Reed, Attiq Ur Rehman, Patrick Reichelt, Martijn Reicher, Rainer Arno Ernst Renfordt, Anna Rita Reolon, Andrey Reshetin, Felix Vincenz Rettig, Jean-Pierre Revol, Klaus Johannes Reygers, Lodovico Riccati, Renato Angelo Ricci, Tuva Richert, Matthias Rudolph Richter, Petra Riedler, Werner Riegler, Francesco Riggi, Mario Rodriguez Cahuantzi, Alis Rodriguez Manso, Ketil Roed, David Rohr, Dieter Rohrich, Rosa Romita, Federico Ronchetti, Philippe Rosnet, Stefan Rossegger, Andrea Rossi, Christelle Sophie Roy, Pradip Kumar Roy, Antonio Juan Rubio Montero, Rinaldo Rui, Riccardo Russo, Evgeny Ryabinkin, Andrzej Rybicki, Sergey Sadovsky, Karel Safarik, Raghunath Sahoo, Pradip Kumar Sahu, Jogender Saini, Hiroaki Sakaguchi, Shingo Sakai, Dosatsu Sakata, Carlos Albert Salgado, Jai Salzwedel, Sanjeev Singh Sambyal, Vladimir Samsonov, Xitzel Sanchez Castro, Ladislav Sandor, Andres Sandoval, Masato Sano, Gianluca Santagati, Romualdo Santoro, Juho Jaako Sarkamo, Eugenio Scapparone, Fernando Scarlassara, Rolf Paul Scharenberg, Claudiu Cornel Schiaua, Rainer Martin Schicker, Christian Joachim Schmidt, Hans Rudolf Schmidt, Simone Schuchmann, Jurgen Schukraft, Tim Schuster, Yves Roland Schutz, Kilian Eberhard Schwarz, Kai Oliver Schweda, Gilda Scioli, Enrico Scomparin, Patrick Aaron Scott, Rebecca Scott, Gianfranco Segato, Ilya Selyuzhenkov, Serhiy Senyukov, Jeewon Seo, Sergio Serci, Eulogio Serradilla, Adrian Sevcenco, Alexandre Shabetai, Galina Shabratova, Ruben Shahoyan, Natasha Sharma, Satish Sharma, Rohini Sharma, Kenta Shigaki, Katherin Shtejer, Yury Sibiriak, Eva Sicking, Sabyasachi Siddhanta, Teodor Siemiarczuk, David Olle Rickard Silvermyr, Catherine Silvestre, Goran Simatovic, Giuseppe Simonetti, Rama Narayana Singaraju, Ranbir Singh, Subhash Singha, Vikas Singhal, Bikash Sinha, Tinku Sinha, Branislav Sitar, Mario Sitta, Bernhard Skaali, Kyrre Skjerdal, Radek Smakal, Nikolai Smirnov, Raimond Snellings, Carsten Sogaard, Ron Ariel Soltz, Hyungsuk Son, Jihye Song, Myunggeun Song, Csaba Soos, Francesca Soramel, Iwona Sputowska, Martha Spyropoulou-Stassinaki, Brijesh Kumar Srivastava, Johanna Stachel, Ionel Stan, Grzegorz Stefanek, Matthew Steinpreis, Evert Anders Stenlund, Gideon Francois Steyn, Johannes Hendrik Stiller, Diego Stocco, Mikhail Stolpovskiy, Peter Strmen, Alexandre Alarcon do Passo Suaide, Martin Alfonso Subieta Vasquez, Toru Sugitate, Christophe Pierre Suire, Rishat Sultanov, Michal Sumbera, Tatjana Susa, Timothy Symons, Alejandro Szanto de Toledo, Imrich Szarka, Adam Szczepankiewicz, Artur Krzysztof Szostak, Maciej Szymanski, Jun Takahashi, Daniel Jesus Tapia Takaki, Attilio Tarantola Peloni, Alfonso Tarazona Martinez, Arturo Tauro, Guillermo Tejeda Munoz, Adriana Telesca, Cristina Terrevoli, Jochen Mathias Thader, Deepa Thomas, Raphael Noel Tieulent, Anthony Timmins, David Tlusty, Alberica Toia, Hisayuki Torii, Luca Toscano, Victor Trubnikov, David Christopher Truesdale, Wladyslaw Henryk Trzaska, Tomoya Tsuji, Alexandr Tumkin, Rosario Turrisi, Trine Spedstad Tveter, Jason Glyndwr Ulery, Kjetil Ullaland, Jochen Ulrich, Antonio Uras, Jozef Urban, Guido Marie Urciuoli, Gianluca Usai, Michal Vajzer, Martin Vala, Lizardo Valencia Palomo, Sara Vallero, Pierre Vande Vyvre, Marco van Leeuwen, Luigi Vannucci, Aurora Diozcora Vargas, Raghava Varma, Maria Vasileiou, Andrey Vasiliev, Vladimir Vechernin, Misha Veldhoen, Massimo Venaruzzo, Ermanno Vercellin, Sergio Vergara, Renaud Vernet, Marta Verweij, Linda Vickovic, Giuseppe Viesti, Jussi Viinikainen, Zabulon Vilakazi, Orlando Villalobos Baillie, Yury Vinogradov, Alexander Vinogradov, Leonid Vinogradov, Tiziano Virgili, Yogendra Viyogi, Alexander Vodopianov, Sergey Voloshin, Kirill Voloshin, Giacomo Volpe, Barthelemy von Haller, Ivan Vorobyev, Danilo Vranic, Janka Vrlakova, Bogdan Vulpescu, Alexey Vyushin, Boris Wagner, Vladimir Wagner, Renzhuo Wan, Yaping Wang, Yifei Wang, Mengliang Wang, Dong Wang, Kengo Watanabe, Michael Weber, Johannes Wessels, Uwe Westerhoff, Jens Wiechula, Jon Wikne, Martin Rudolf Wilde, Grzegorz Andrzej Wilk, Alexander Wilk, Crispin Williams, Bernd Stefan Windelband, Leonidas Xaplanteris Karampatsos, Chris G. Yaldo, Yorito Yamaguchi, Hongyan Yang, Shiming Yang, Stanislav Yasnopolsky, JunGyu Yi, Zhongbao Yin, In-Kwon Yoo, Jongik Yoon, Weilin Yu, Xianbao Yuan, Igor Yushmanov, Valentina Zaccolo, Cenek Zach, Chiara Zampolli, Sergey Zaporozhets, Andrey Zarochentsev, Petr Zavada, Nikolai Zaviyalov, Hanna Paulina Zbroszczyk, Pierre Zelnicek, Sorin Ion Zgura, Mikhail Zhalov, Haitao Zhang, Xiaoming Zhang, Fengchu Zhou, You Zhou, Daicui Zhou, Hongsheng Zhu, Jianhui Zhu, Jianlin Zhu, Xiangrong Zhu, Antonino Zichichi, Alice Zimmermann, Gennady Zinovjev, Yannick Denis Zoccarato, Mykhaylo Zynovyev, and Maksym Zyzak
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Physics ,Nuclear and High Energy Physics ,Particle physics ,Large Hadron Collider ,010308 nuclear & particles physics ,01 natural sciences ,Nuclear physics ,Azimuth ,Pseudorapidity ,0103 physical sciences ,Transverse momentum ,Angular dependence ,Multiplicity (chemistry) ,Nuclear Experiment ,010306 general physics ,Anisotropy ,Fourier series - Abstract
Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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- 2013
28. Impact of Higher-Dose Total Body Irradiation Conditioning on Outcome of an Allogeneic Hematopoietic Cell Transplant (HCT) in the Modern Era
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Baldeep Wirk, Shahrukh K. Hashmi, Amer Beitinjaneh, Jean A. Yared, Sanghee Hong, Edward A. Copelan, Lori Muffly, Jeffery J. Auletta, Andrew Daly, Aleksandr Lazaryan, Miguel Angel Diaz, Betty K. Hamilton, Hillard M. Lazarus, Minoo Battiwalla, Xiaochun Zhu, Jean-Yves Cahn, Andrew S. Artz, Miguel-Angel Perales, Saurabh Chhabra, Richard F. Olsson, Maxim Norkin, Gerhard C. Hildebrandt, Mitchell Sabloff, Arnon Nagler, Peiman Hematti, Jan Cerny, Allistair Abraham, Rodrigo Martino Bufarull, Marcelo C. Pasquini, Siddhartha Ganguly, Taiga Nishihori, Selina M. Luger, Ajoy Dias, Robert Peter Gale, Armin Rashidi, Shin Mineishi, Leona Holmberg, Cesar O. Freytes, Natasha Kekre, Celalettin Ustun, Christopher Bredeson, Ann E. Woolfrey, Rizwan Romee, Kehinde Adekola, Tao Wang, Matthew L. Ulrickson, Ayman Saad, Sachiko Seo, and Gregory A. Hale
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Oncology ,Transplantation ,medicine.medical_specialty ,Hematopoietic cell ,business.industry ,Internal medicine ,medicine ,Conditioning ,Hematology ,Total body irradiation ,business - Published
- 2017
29. The Autologous Serum Skin Test as a Prognostic Factor for the Severity and Duration of Chronic Urticaria after five years of Follow-up
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Consuelo Fernández Rodríguez, Miguel Angel Diaz, Alicia Enriquez Matas, Karen Milena Lozano Mosquera, Lys Herraez, Ruth Mielgo Ballesteros, and Beatriz Moya Camacho
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medicine.medical_specialty ,Prognostic factor ,business.industry ,Duration (music) ,Internal medicine ,Immunology ,Immunology and Allergy ,Medicine ,Autologous serum skin test ,business ,Gastroenterology ,Chronic urticaria - Published
- 2018
30. Adaptación cultural al español y validación de la escala GSFQ (Gastrointestinal Short Form Questionnaire)
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Mercedes García Vargas, Antonio Pardo Merino, José Manuel Suárez de Parga, Virginia Pascual Renedo, and Miguel Angel Diaz
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Hepatology ,business.industry ,Gastroenterology ,Medicine ,business ,Humanities - Abstract
Resumen Objetivo describir el proceso seguido para la adaptacion cultural y la validacion al espanol del cuestionario GSFQ (Gastrointestinal Short Form Questionnaire) de interferencia de los sintomas asociados con la enfermedad de reflujo gastroesofagico e informar de sus propiedades psicometricas. Material y metodos el proceso de adaptacion fue supervisado por un panel de 5 expertos. Tras la traduccion, revision y retrotraduccion del instrumento se obtuvo un cuestionario en espanol que fue administrado a dos muestras de pacientes: una muestra piloto de 5 pacientes para valorar la comprensibilidad del instrumento y una muestra de 4.000 pacientes para comprobar su validez estructural (analisis factorial y fiabilidad) y la validez de constructo y discriminante. Resultados el cuestionario presenta una unica dimension que se ajusta a la estructura original. La fiabilidad es buena (alfa=0,83) con buena correlacion entre items pares e impares (r=0,69). La puntuacion total correlaciona con las puntuaciones genericas de CVRS medidas por el EQ-5D (r=0,499) y la escala VAS (r=−0,481). La escala discrimina entre los niveles de gravedad (Savary-Miller; p Conclusiones los resultados obtenidos son satisfactorios, demuestran buenas propiedades psicometricas y ponen a disposicion de los profesionales un nuevo instrumento para valorar la interferencia de la sintomatologia de ERGE teniendo en cuenta el punto de vista del paciente.
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- 2009
31. Risks and methods for peripheral blood progenitor cell collection in small children
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Julián Sevilla, Sandra Fernández-Plaza, Miguel Angel Diaz, Luis Madero, and Marta González-Vicent
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Adult ,medicine.medical_specialty ,business.industry ,Anticoagulants ,Hemodynamics ,Hematology ,Leukapheresis ,Hematopoietic Stem Cells ,Risk Assessment ,Hematopoietic Stem Cell Mobilization ,Blood cell ,Transplantation ,Apheresis ,medicine.anatomical_structure ,Child, Preschool ,Tissue and Organ Harvesting ,Humans ,Medicine ,Progenitor cell ,Stem cell ,Child ,business ,Adverse effect ,Intensive care medicine - Abstract
Peripheral blood progenitor cells (PBPC) are increasingly used as a source of stem cells for either autologous or allogeneic hematopoietic transplantation in children. Although technically similar to adult procedures, apheresis in small children worries some operators and physicians that have little experience in managing pediatric patients or donors. However several published series have showed that these procedures, when performed by experienced teams are safe and can obtain enough amount of PBPC for either autologous or allogeneic hematopoietic transplantation. Some technical aspects must be considered in pediatric apheresis due to the size of the patient/donor. Factors that must be evaluated are extracorporeal circuit volume, blood flow rates, type of anticoagulant and vascular access. Other important issue to be considered is the emotional stress for them and their relatives. Leukaphereses in children may be performed with any of the reported continuous blood cell separator without sedation. Adverse events are mainly related either to vascular access or to metabolic or hemodynamic changes. Anyway, taking all these complications together, they are not higher than those adverse events or toxicities reported after general anesthesia and bone marrow harvesting.
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- 2004
32. Loss of heterozygosity of p16 correlates with minimal residual disease at the end of the induction therapy in non-high risk childhood B-cell precursor acute lymphoblastic leukemia
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Olga Tutor, Patricia Algara, Manuel Ramírez, Luis Madero, Miguel Angel Diaz, and Pedro Javier Gómez Martínez
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Male ,Cancer Research ,Neoplasm, Residual ,medicine.medical_treatment ,Gene Rearrangement, B-Lymphocyte, Heavy Chain ,Loss of Heterozygosity ,Loss of heterozygosity ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,Life Tables ,Child ,Mercaptopurine ,Remission Induction ,Cytarabine ,Receptors, Antigen, T-Cell, gamma-delta ,Hematology ,Prognosis ,Treatment Outcome ,medicine.anatomical_structure ,Oncology ,Vincristine ,Child, Preschool ,Female ,medicine.medical_specialty ,Tumor suppressor gene ,Gene Rearrangement, delta-Chain T-Cell Antigen Receptor ,Biology ,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ,Acute lymphocytic leukemia ,medicine ,Asparaginase ,Humans ,Cyclophosphamide ,Childhood Acute Lymphoblastic Leukemia ,Cyclin-Dependent Kinase Inhibitor p16 ,B cell ,Retrospective Studies ,Chemotherapy ,Genes, p16 ,Cytogenetics ,Infant ,medicine.disease ,Survival Analysis ,Minimal residual disease ,Methotrexate ,Drug Resistance, Neoplasm ,Cancer research ,Prednisone ,Gene Deletion ,Microsatellite Repeats - Abstract
We evaluated the incidence of MTS1 / p16 deletions by loss of heterozygosity (LOH) analysis in 36 non-high risk B-cell precursor childhood acute lymphoblastic leukemia (BCP-ALL) and correlated these results with clinical features and with the presence of minimal residual disease (MRD) at the end of induction therapy. LOH was analyzed using three microsatellite markers flanking the p16 gene. MRD was studied by the polymerase chain reaction (PCR) for IgH and TCRδ genes. All patients were classified and treated according to the BFM-86 protocol. A slower response to the induction treatment (MRD) was associated with LOH of p16 and worse clinical outcome. Thus, LOH of p16 may be a marker of chemotherapy resistance among the children classified as non-high risk BCP-ALL.
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- 2002
33. Outcome and Prognostic Factors for Pediatric Patients Receiving an Haploidentical Transplantation Using CD3/CD19 Depleted Grafts
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Julián Sevilla, Manuel Ramírez, Marta González-Vicent, Antonio Pérez-Martínez, and Miguel Angel Diaz
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Oncology ,medicine.medical_specialty ,Transplantation ,Haploidentical transplantation ,biology ,business.industry ,CD3 ,Ethnic group ,Human leukocyte antigen ,Hematology ,CD19 ,Bone transplantation ,Internal medicine ,biology.protein ,Medicine ,business - Abstract
s / Biol Blood Marrow Transplant 20 (2014) S27eS44 S33 mismatched with the pt, fewer 10/10 donors and increased 4/6 or worse CBUs were used. API pts were more often transplanted with an HLA mismatched source when the source is also race/ethnic mismatched. Conclusion: This study shows that AFA, API, CAU, and HIS pts, transplanted in the past 5 years, most utilized a race/ matched donor. From 2008 to present, greater than 70% of donors and greater than 50% of CBU transplants were race/ ethnic matched between the pt and cell source. In addition, better HLA matching was observed when the pt and cell source were matched for race/ethnicity.
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- 2014
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34. Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder in Children Treated with Rituximab: The Impact of Viral Load and Non-Lymphoid Tissue Involvement
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Simone Cesaro, Petr Hubacek, Jan Styczyński, J Maertens, W.J.F.M. van der Velden, Adriana Balduzzi, Susanne Matthes, K. Kałwak, R de la Cámara, Agnieszka Tomaszewska, Chiara Nozzoli, Koen Theunissen, Maura Faraci, Franca Fagioli, H. Einsele, Miguel Angel Diaz, Maddalena Migliavacca, Rodrigo Martino, J.P. Donnelly, Jennifer Hoek, Per Ljungman, Hamdy Omar, Lidia Gil, and Simona Sica
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Transplantation ,business.industry ,Hematology ,medicine.disease_cause ,medicine.disease ,Epstein–Barr virus ,Virology ,Post-transplant lymphoproliferative disorder ,Lymphatic system ,Immunology ,medicine ,Rituximab ,business ,Viral load ,medicine.drug - Published
- 2012
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35. Outcomes of Allogeneic Cord Blood Transplantation for Leukodystrophies; A Joint Study of Eurocord and 'Inborn Errors WP-EBMT'
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Robbert G. M. Bredius, Miguel Angel Diaz, Annalisa Ruggeri, Attilio Rovelli, Karl-Walter Sykora, Tracey A. O'Brien, Mouhab Ayas, Eliane Gluckman, Gergely Kriván, Victoria Bordon, Manuel Abecasis, Peter J. Shaw, Marleen Renard, Izaskun Elorza, Tsila Zuckerman, Rik Schots, Andrew R. Gennery, Jaap-Jan Boelens, José M. Moraleda, Reuven Or, Gérard Michel, Vanderson Rocha, Janna Hol, and M. Akif Yesilipek
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Transplantation ,medicine.medical_specialty ,Platelet Engraftment ,business.industry ,medicine.medical_treatment ,Immunology ,Leukodystrophy ,Cell Biology ,Hematopoietic stem cell transplantation ,Hematology ,medicine.disease ,Biochemistry ,Asymptomatic ,Surgery ,Metachromatic leukodystrophy ,Peripheral neuropathy ,Internal medicine ,medicine ,Cumulative incidence ,medicine.symptom ,business ,Cord blood transplantation - Abstract
Background This study aims to describe transplant outcomes and disease-specific clinical outcomes of allogeneic cord blood transplantation (CBT) in leukodystrophies. Leukodystrophies are rare inborn errors of metabolism (IEM) in which the development and maintenance of brain myelin is primarily affected. They are characterized by rapid neurological deterioration. Hematopoietic stem cell transplantation (HSCT) has been shown to halt disease progression for selected leukodystrophies, including adrenoleukodystrophy (ALD), Krabbe disease (globoid cell leukodystrophy) and metachromatic leukodystrophy (MLD). The fast availability of unrelated cord blood (UCB) makes HSCT feasible in leukodystrophy patients who lack an HLA-matched sibling. Patients and methods All patients transplanted for leukodystrophies with related and unrelated umbilical cord blood in EBMT centers between 1996 and 2012 were included. HSCT data were collected from the EUROCORD database. An additional questionnaire on disease-specific clinical outcomes was sent to participating centers. Included in the questionnaire were enzyme- and (for ALD) fatty acid levels, general disease status, performance score, MRI/MRS status, peripheral neuropathy, school attendance and performance, mental development testing, adrenal insufficiency (for ALD only), vision and hearing. Kaplan-Meier estimates were used to calculate overall survival (OS) and cumulative incidence methods for secondary outcomes, including neutrophil and platelet engraftment, incidence of graft-versus-host disease (GvHD), donor chimerism and disease-specific characteristics at most recent follow-up. The two-sided log-rank test was used for univariate comparisons. Results Seventy patients (31 ALD, 5 Krabbe, 34 MLD) were available for analysis, with a median age at transplant of 6.5 years (range 0-43 years). Median follow-up for survivors was 46 months. Overall survival at 4 years was 60% (±6%). Cumulative incidences of neutrophil and platelet engraftment were 88% (±4%) at day 60, and 73% (±6%) at day 180, respectively. Ten patients experienced graft failure and 5 had autologous recovery; 4 received a 2nd HSCT (2 CBT, 1 Haplo, 1 BM) and of those 3 were alive in a median of 60 months after HSCT. Acute-GvHD (grade II-IV) occurred in 16 patients (22% ±5%) at day 100 and chronic GvHD in 9 patients (13% ±5%). Out of the 24 patients who died, 18 (67%) died of transplant-related causes and 6 (33%) died of disease progression. Higher survival was seen in patients who had no or 1 HLA mismatch (OS 81%), compared to patients who received UCBT with 2 HLA mismatches (OS 47%, p 0.02). On 37 patients (53%), information on disease-specific characteristics was available. OS among these patients was 68% (±8), which was not significantly different from patients without disease-specific information (p=0,307). Of the 37 patients, 19 (51%) were asymptomatic at transplant, 14 (38%) had mild disease and 4 (11%) were severely affected. Overall survival was dramatically worse in patients with severe disease at transplant; all 4 severely affected patients died, while 79% of patients with mild disease and 76% of asymptomatic patients survived. At most recent follow-up, disease status was stable in 15 (57.7%), had improved in 2 (7.7%) and worsened in 9 (34.6%) surviving patients. The majority of patients showed abnormalities on MRI-scanning pre-HSCT (n=25, 68%). In patients with normal MRI-scans pre-transplant OS was 69%; in patients with abnormal MRI-scans 75%. At most recent follow-up, MRI-scans were stable in 12 (43.9%), improved in 5 (17.8%) and worsened in 11 (39.3%) patients. Eighteen patients (50%) showed peripheral neuropathy pre-HSCT, of which 13 were mildly affected and 5 severely affected. Of patients who had no signs of peripheral neuropathy pre-HSCT, 70% survived, versus 77% of patients who were mildly affected and 40% of those severely affected. At most recent follow-up, peripheral neuropathy was stable in 14 (56%), had improved in 3 (12%) and worsened in 8 (32%) patients. Conclusion We found an overall survival of 60% at 4 years after CBT for leukodystrophies, with relatively low rates of GvHD. Use of a mismatched donor (>1 HLA mismatch) negatively impacts survival. Data on clinical characteristics suggest that overall survival is strongly influenced by disease status at transplant. Disclosures: No relevant conflicts of interest to declare.
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- 2014
36. 369: Extracorporeal Photochemotherapy (ECP) for Steroid-Refractory Graft-Versus-Host Disease (GVHD) in Low-Weight Pediatric Patients. Changes in L-selectin Expression by T Lymphocytes and Clinical Outcome
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Julián Sevilla, Miguel Angel Diaz, Ariadna Pérez, Marta González-Vicent, and Manuel Ramírez
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Transplantation ,biology ,business.industry ,education ,Hematology ,medicine.disease ,Graft-versus-host disease ,Immunology ,biology.protein ,Extracorporeal photochemotherapy ,Medicine ,L-selectin ,Steroid refractory ,business - Published
- 2008
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37. 347: Intentional induction of mixed hematopoietic chimerism as platform for cellular therapy after HLA-matched allogeneic stem cell transplantation in childhood leukemia patients
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Julián Sevilla, Manuel Ramírez, Ariadna Pérez, Miguel Angel Diaz, and Marcos González
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Cell therapy ,Transplantation ,Haematopoiesis ,Childhood leukemia ,business.industry ,Immunology ,medicine ,Human leukocyte antigen ,Hematology ,Stem cell ,medicine.disease ,business - Published
- 2007
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38. Risk assessment and outcome of chronic graft-versus-host disease after allogeneic peripheral blood progenitor cell transplantation in pediatric patients
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Miguel Angel Diaz, Marta González Vicent, J. Bargay, F de Arriba, J de la Rubia, Marcos González, Amparo Verdeguer, D Caballero, Jose Luis Dı́ez, Salut Brunet, and L Madero
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Graft vs Host Disease ,Peripheral blood progenitor cell transplantation ,Hematopoietic stem cell transplantation ,Lower risk ,Gastroenterology ,Risk Assessment ,Disease-Free Survival ,immune system diseases ,HLA Antigens ,hemic and lymphatic diseases ,Cyclosporin a ,Internal medicine ,Humans ,Transplantation, Homologous ,Medicine ,Risk factor ,Child ,Retrospective Studies ,Univariate analysis ,Transplantation ,business.industry ,Incidence ,Hazard ratio ,Hematopoietic Stem Cell Transplantation ,Infant ,Hematology ,Total body irradiation ,medicine.disease ,Tissue Donors ,Surgery ,Treatment Outcome ,Graft-versus-host disease ,Child, Preschool ,Hematologic Neoplasms ,Chronic Disease ,Female ,business ,Risk assessment ,Follow-Up Studies - Abstract
We retrospectively evaluated the incidence, risk factors for chronic graft-versus-host disease (cGvHD) and outcome in 80 pediatric patients (36 male) (median age 13 years) who underwent allogeneic peripheral blood progenitor cell transplantation. Patients were grafted from an HLA-identical sibling after myeloablative conditioning (total body irradiation (TBI) based 52; non-TBI 28). GvHD prophylaxis used were: cyclosporin A (CsA)+ short methotrexate (MTX) in 52 and CsA+/-prednisone in 28. The median number of CD34+ cells infused were 5.8 x 10(6)/kg (range: 1.4-32.8). The median follow-up was 24 months (range: 3-94). In all, 28 patients had cGvHD (confidence interval (CI): 54.2+/-10%). Factors that were significant on univariate analysis were diagnosis (P=0.03) and GvHD prophylaxis administered (P=0.04). On multivariate analysis, only GvHD prophylaxis used was associated with a significant risk of cGvHD (hazard ratio (HR): 3.94; 95% CI: 1.41-10.91, P=0.009). The CI of cGvHD for patients receiving CsA+MTX was 40.9+/-12 vs 76.5+/-18% for patients who did not (P=0.03). The probability of relapse was 36+/-6% for all patients (12.5+/-8% for patients with cGvHD vs 47.9+/-8% without cGvHD). The probability of disease-free survival was better for patients with cGvHD (69.9+/-10 vs 37.9+/-7%; HR: 3.59, 95% CI: 1.47-5.56; P=0.001). Our data suggest that the GvHD prophylaxis used is the most relevant predictor of cGvHD. Patients with cGvHD had a lower risk of relapse and a better survival.
- Published
- 2004
- Full Text
- View/download PDF
39. Unrelated cord blood transplantation in adolescent and young adults with hematologic malignancies
- Author
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Miguel Angel Diaz and Marta González-Vicent
- Subjects
Adult ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,Adolescent ,business.industry ,Hematology ,Cord Blood Stem Cell Transplantation ,Hematologic Neoplasms ,medicine.disease ,Tissue Donors ,Young Adult ,Leukemia ,Oncology ,Humans ,Medicine ,Young adult ,business ,Cord blood transplantation - Published
- 2012
40. Encouraging citizens to perform basic CPR: Potential usefulness of mobile phone applications
- Author
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Fernando Estévez González, Javier Ignacio Martín López, Raimundo García del Moral, Alberto Fernández Carmona, Aida Díaz Redondo, and Miguel Angel Diaz Castellanos
- Subjects
Multimedia ,business.industry ,Mobile phone ,Emergency Medicine ,Medicine ,Emergency Nursing ,Cardiology and Cardiovascular Medicine ,computer.software_genre ,business ,computer - Published
- 2014
41. Intentional induction of immune-hematopoietic mixed chimerism as a platform for early cellular therapy in pediatric leukemia patients after allogeneic transplantation: Enhancing GvL effect while avoiding GvHD
- Author
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Marta González-Vicent, L Madero, Miguel Angel Diaz, Manuel Ramírez, Antonio Pérez-Martínez, and Javier García-Castro
- Subjects
Pediatric leukemia ,Cell therapy ,Transplantation ,Haematopoiesis ,Immune system ,Allogeneic transplantation ,Mixed chimerism ,business.industry ,Immunology ,Medicine ,sense organs ,Hematology ,business - Published
- 2006
42. Teaching basic life support to citizens. Choosing the most efficient target population
- Author
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Castellanos, Miguel Angel Diaz, primary, Carmona, Alberto Fernández, additional, Redondo, Aida Díaz, additional, Moral, Raimundo García del, additional, and González, Fernando Estévez, additional
- Published
- 2013
- Full Text
- View/download PDF
43. Teaching basic life support to citizens: Choosing the most efficient target population
- Author
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Aida Díaz Redondo, Alberto Fernández Carmona, Raimundo García del Moral, Fernando Estévez González, and Miguel Angel Diaz Castellanos
- Subjects
Medical education ,business.industry ,Emergency Medicine ,Basic life support ,Medicine ,Target population ,Emergency Nursing ,business ,Cardiology and Cardiovascular Medicine - Published
- 2013
44. AP095 Teaching basic life support (BLS) in Spain. Results of “Plan Salvavidas”
- Author
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Castellanos, Miguel Angel Diaz, primary, Cruz, Antonio Cardenas, additional, Redondo, Aida Díaz, additional, Caballero, Maria Angeles Muñoz, additional, Morales, Juan Jose Garcia, additional, Cruz, Dolores Cárdenas, additional, Estevez, Fernando Estevez, additional, and Torné, Mª Mercedes Lopez, additional
- Published
- 2011
- Full Text
- View/download PDF
45. AP101 Teaching basic life support (BLS) to citizens. Impact study
- Author
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Castellanos, Miguel Angel Diaz, primary, Carmona, Alberto Fernandez, additional, Del Moral Garcia, Raimundo, additional, Lopez, Javier Martin, additional, Redondo, Aida Díaz, additional, Navarro, Carmen Gervilla, additional, and Cruz, Antonio Cardenas, additional
- Published
- 2011
- Full Text
- View/download PDF
46. AP095 Teaching basic life support (BLS) in Spain. Results of 'Plan Salvavidas'
- Author
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Miguel Angel Diaz Castellanos, Dolores Cárdenas Cruz, Juan Jose Garcia Morales, Antonio Cárdenas Cruz, Maria Angeles Muñoz Caballero, Aida Díaz Redondo, Mª Mercedes Lopez Torné, and Fernando Estevez Estevez
- Subjects
Medical education ,business.industry ,Emergency Medicine ,Basic life support ,Medicine ,Plan (drawing) ,Emergency Nursing ,Cardiology and Cardiovascular Medicine ,business - Published
- 2011
47. AP101 Teaching basic life support (BLS) to citizens. Impact study
- Author
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Alberto Fernández Carmona, Javier Ignacio Martín López, Miguel Angel Diaz Castellanos, Aida Díaz Redondo, Carmen Gervilla Navarro, Antonio Cárdenas Cruz, and Raimundo García
- Subjects
Medical education ,business.industry ,Emergency Medicine ,Medicine ,Basic life support ,Impact study ,Emergency Nursing ,Cardiology and Cardiovascular Medicine ,business - Published
- 2011
48. A Role For NF-KB Inducing Kinase (NIK) In Graft Versus Host Reactions
- Author
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Marta González-Vicent, Isabel Colmenero, Luis Madero, Miguel Angel Diaz, Manuel Fresno, L. Casanova, Carmen Sánchez-Valdepeñas, and Manuel Ramírez
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Transplantation ,Graft versus host reactions ,Kinase ,business.industry ,hemic and lymphatic diseases ,Cancer research ,Medicine ,Hematology ,business ,Virology - Published
- 2009
49. 162: Fludarabine-based reduced-intensity conditioning for allogeneic transplantation in children with malignant and non-malignant diseases
- Author
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Marcos González, L Madero, Manuel Ramírez, Julián Sevilla, Miguel Angel Diaz, and Ariadna Pérez
- Subjects
Oncology ,Transplantation ,medicine.medical_specialty ,Allogeneic transplantation ,business.industry ,viruses ,virus diseases ,Non malignant ,Hematology ,Fludarabine ,Internal medicine ,Reduced Intensity Conditioning ,medicine ,business ,medicine.drug - Published
- 2007
50. Changes in rat brain muscarinic receptors after inhibitory avoidance learning
- Author
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Ortega, Arturo, primary, Guante, Miguel Angel Diaz del, additional, Prado-Alcalá, Roberto A., additional, and Alemán, Victor, additional
- Published
- 1996
- Full Text
- View/download PDF
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