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630 results on '"Michel, G."'

3. Long-term trajectories of densely reported depressive symptoms during an extended period of the COVID-19 pandemic in Switzerland: Social worries matter

Author

Probst-Hensch, N., primary, Imboden, M., additional, Jeong, A., additional, Keidel, D., additional, Vermes, T., additional, Witzig, M., additional, Cullati, S., additional, Tancredi, S., additional, Noor, N., additional, Rodondi, P.-Y., additional, Harju, E., additional, Michel, G., additional, Frank, I., additional, Kahlert, C., additional, Cusini, A., additional, Rodondi, N., additional, Chocano-Bedoya, P.O., additional, Bardoczi, J.B., additional, Stuber, M.J., additional, Vollrath, F., additional, Fehr, J., additional, Frei, A., additional, Kaufmann, M., additional, Geigges, M., additional, von Wyl, V., additional, Puhan, M.A., additional, Albanese, E., additional, Crivelli, L., additional, and Lovison, G.F., additional

Published
2024
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5. Transthyretin amyloid cardiomyopathy among patients hospitalized for heart failure and performance of an adapted wild-type ATTR-CM machine learning model: Findings from GWTG-HF

Author

Peters, Anthony E., primary, Solomon, Nicole, additional, Chiswell, Karen, additional, Fonarow, Gregg C., additional, Khouri, Michel G., additional, Baylor, Lori, additional, Alvir, Jose, additional, Bruno, Marianna, additional, Huda, Ahsan, additional, Allen, Larry A., additional, Sharma, Kavita, additional, DeVore, Adam D., additional, and Greene, Stephen J., additional

Published
2023
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9. Relative cerebral blood volume as response predictor in the treatment of recurrent glioblastoma with anti-angiogenic therapy

Author

Breda-Yepes, Michele, primary, Rodríguez-Hernández, Luis A., additional, Gómez-Figueroa, Enrique, additional, Mondragón-Soto, Michel G., additional, Arellano-Flores, Gerardo, additional, Hernández-Hernández, Alan, additional, Rodríguez-Rubio, Héctor A., additional, Martínez, Pablo, additional, Reyes-Moreno, Ignacio, additional, Álvaro-Heredia, Juan A., additional, Gutiérrez Aceves, Guillermo A., additional, Villanueva-Castro, Eliezer, additional, Sangrador-Deitos, Marcos V., additional, Alonso-Vanegas, Mario, additional, Guerrero-Juárez, Vicente, additional, and González-Aguilar, Alberto, additional

Published
2023
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11. A systematic review of tools for predicting complications in patients with acute infectious diarrhea

Author

Tania Marx, Claudia Vincent-Boulay, Laurance Marquis-Gendron, Kathryn Bareil, Samuel Leduc, Gabrielle Lefebvre, Catherine Côté, Myriam Mallet, Emmanuelle Paquette-Raynard, Maurice Boissinot, Michel G. Bergeron, and Simon Berthelot

Subjects
Emergency Medicine, General Medicine
Abstract

To identify tools that predict the risk of complications in patients presenting to outpatient clinics or emergency departments (ED) with acute infectious diarrhea.Medline, Embase, Cochrane Library, Web of Science and CINAHL were searched from inception to July 2021. Articles reporting on the derivation or validation of a score to stratify the risk of intravenous rehydration or hospitalization among patients with acute infectious diarrhea in the ED or outpatient clinic were retained for analysis.Five articles reporting on two different tools were identified. Developed to assess the risk of hospitalization of children, the EsVida scale has not been externally validated. Developed originally to assess the level of dehydration in children, the Clinical Dehydration Scale (CDS) was evaluated as a risk stratification tool. For predicting intravenous rehydration, a CDS score ≥ 1 showed a sensitivity between 0.73 and 0.88 and specificity between 0.38 and 0.69, whereas a CDS score ≥ 5 showed a sensitivity between 0.06 and 0.32 and specificity between 0.94 and 0.99. For predicting hospitalization, a CDS score ≥ 1 showed a sensitivity between 0.74 and 1.00 and specificity between 0.34 and 0.38, whereas a CDS score ≥ 5 showed a sensitivity between 0.26 and 0.62 and specificity between 0.66 and 0.96. High heterogeneity among studies and unclear risk of bias precluded meta-analysis.As a risk-stratification tool, the CDS has been validated only for children. Further research is needed to develop and validate a tool suitable for adults in the ED.

Published
2023

12. Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution

Author

Andrew D. Grotzinger, Javier de la Fuente, Florian Privé, Michel G. Nivard, Elliot M. Tucker-Drob, Biological Psychology, APH - Mental Health, and APH - Methodology

Subjects
Case-control GWAS, SNP-based heritability, Multifactorial Inheritance, Ascertainment correction, Phenotype, Bias, Case-Control Studies, Effective sample size, Liability-scale, Polymorphism, Single Nucleotide, Article, Biological Psychiatry, Genome-Wide Association Study
Abstract

BACKGROUND: Single nucleotide polymorphism-based heritability is a fundamental quantity in the genetic analysis of complex traits. For case-control phenotypes, for which the continuous distribution of risk in the population is unobserved, observed-scale heritability estimates must be transformed to the more interpretable liability scale. This article describes how the field standard approach incorrectly performs the liability correction in that it does not appropriately account for variation in the proportion of cases across the cohorts comprising the meta-analysis. We propose a simple solution that incorporates cohort-specific ascertainment using the summation of effective sample sizes across cohorts. This solution is applied at the stage of single nucleotide polymorphism-based heritability estimation and does not require generating updated meta-analytic genome-wide association study summary statistics.METHODS: We began by performing a series of simulations to examine the ability of the standard approach and our proposed approach to recapture liability-scale heritability in the population. We went on to examine the differences in estimates obtained from these 2 approaches for real data for 12 major case-control genome-wide association studies of psychiatric and neurologic traits.RESULTS: We found that the field standard approach for performing the liability conversion can downwardly bias estimates by as much as approximately 50% in simulation and approximately 30% in real data.CONCLUSIONS: Prior estimates of liability-scale heritability for genome-wide association study meta-analysis may be drastically underestimated. To this end, we strongly recommend using our proposed approach of using the sum of effective sample sizes across contributing cohorts to obtain unbiased estimates.

Published
2023

13. Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability

Author

Wang, Xiaotong, primary, Walker, Alicia, additional, Revez, Joana A., additional, Ni, Guiyan, additional, Adams, Mark J., additional, McIntosh, Andrew M., additional, Visscher, Peter M., additional, Wray, Naomi R., additional, Ripke, Stephan, additional, Mattheisen, Manuel, additional, Trzaskowski, Maciej, additional, Byrne, Enda M., additional, Abdellaoui, Abdel, additional, Agerbo, Esben, additional, Air, Tracy M., additional, Andlauer, Till F.M., additional, Bacanu, Silviu-Alin, additional, Bækvad-Hansen, Marie, additional, Beekman, Aartjan T.F., additional, Bigdeli, Tim B., additional, Binder, Elisabeth B., additional, Bryois, Julien, additional, Buttenschøn, Henriette N., additional, Bybjerg-Grauholm, Jonas, additional, Cai, Na, additional, Castelao, Enrique, additional, Christensen, Jane Hvarregaard, additional, Clarke, Toni-Kim, additional, Coleman, Jonathan R.I., additional, Colodro-Conde, Lucía, additional, Couvy-Duchesne, Baptiste, additional, Craddock, Nick, additional, Crawford, Gregory E., additional, Davies, Gail, additional, Degenhardt, Franziska, additional, Derks, Eske M., additional, Direk, Nese, additional, Dolan, Conor V., additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Escott-Price, Valentina, additional, Kiadeh, Farnush Farhadi Hassan, additional, Finucane, Hilary K., additional, Foo, Jerome C., additional, Forstner, Andreas J., additional, Frank, Josef, additional, Gaspar, Héléna A., additional, Gill, Michael, additional, Goes, Fernando S., additional, Gordon, Scott D., additional, Grove, Jakob, additional, Hall, Lynsey S., additional, Søholm Hansen, Christine, additional, Hansen, Thomas F., additional, Herms, Stefan, additional, Hickie, Ian B., additional, Hoffmann, Per, additional, Homuth, Georg, additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Hougaard, David M., additional, Howard, David M., additional, Ising, Marcus, additional, Jansen, Rick, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jorgenson, Eric, additional, Knowles, James A., additional, Kohane, Isaac S., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Kutalik, Zoltán, additional, Li, Yihan, additional, Lind, Penelope A., additional, MacIntyre, Donald J., additional, MacKinnon, Dean F., additional, Maier, Robert M., additional, Maier, Wolfgang, additional, Marchini, Jonathan, additional, Mbarek, Hamdi, additional, McGrath, Patrick, additional, McGuffin, Peter, additional, Medland, Sarah E., additional, Mehta, Divya, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Milaneschi, Yuri, additional, Milani, Lili, additional, Mondimore, Francis M., additional, Montgomery, Grant W., additional, Mostafavi, Sara, additional, Mullins, Niamh, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nivard, Michel G., additional, Nyholt, Dale R., additional, O'Reilly, Paul F., additional, Oskarsson, Hogni, additional, Owen, Michael J., additional, Painter, Jodie N., additional, Bøcker Pedersen, Carsten, additional, Giørtz Pedersen, Marianne, additional, Peterson, Roseann E., additional, Peyrot, Wouter J., additional, Pistis, Giorgio, additional, Posthuma, Danielle, additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Rice, John P., additional, Riley, Brien P., additional, Rivera, Margarita, additional, Saeed Mirza, Saira, additional, Schoevers, Robert, additional, Schulte, Eva C., additional, Shen, Ling, additional, Shi, Jianxin, additional, Shyn, Stanley I., additional, Sigurdsson, Engilbert, additional, Sinnamon, Grant C.B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Teumer, Alexander, additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Thorgeirsson, Thorgeir E., additional, Traylor, Matthew, additional, Treutlein, Jens, additional, Trubetskoy, Vassily, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, Van der Auwera, Sandra, additional, van Hemert, Albert M., additional, Viktorin, Alexander, additional, Wang, Yunpeng, additional, Webb, Bradley T., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Willemsen, Gonneke, additional, Witt, Stephanie H., additional, Wu, Yang, additional, Xi, Hualin S., additional, Yang, Jian, additional, Zhang, Futao, additional, Arolt, Volker, additional, Baune, Bernhard T., additional, Berger, Klaus, additional, Boomsma, Dorret I., additional, Cichon, Sven, additional, Dannlowski, Udo, additional, de Geus, E.J.C., additional, DePaulo, J. Raymond, additional, Domenici, Enrico, additional, Domschke, Katharina, additional, Esko, Tõnu, additional, Grabe, Hans J., additional, Hamilton, Steven P., additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Kendler, Kenneth S., additional, Kloiber, Stefan, additional, Lewis, Glyn, additional, Li, Qingqin S., additional, Lucae, Susanne, additional, Madden, Pamela A.F., additional, Magnusson, Patrik K., additional, Martin, Nicholas G., additional, Metspalu, Andres, additional, Mors, Ole, additional, Bo Mortensen, Preben, additional, Müller-Myhsok, Bertram, additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O'Donovan, Michael C., additional, Paciga, Sara A., additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J.H., additional, Perlis, Roy H., additional, Porteous, David J., additional, Potash, James B., additional, Preisig, Martin, additional, Rietschel, Marcella, additional, Schaefer, Catherine, additional, Schulze, Thomas G., additional, Smoller, Jordan W., additional, Stefansson, Kari, additional, Tiemeier, Henning, additional, Uher, Rudolf, additional, Völzke, Henry, additional, Weissman, Myrna M., additional, Werge, Thomas, additional, Lewis, Cathryn M., additional, Levinson, Douglas F., additional, Breen, Gerome, additional, Børglum, Anders D., additional, and Sullivan, Patrick F., additional

Published
2023
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18. Direct and Indirect Genetic Effects on Aggression

Author

van der Laan, Camiel M., primary, van de Weijer, Steve G.A., additional, Pool, René, additional, Hottenga, Jouke-Jan, additional, van Beijsterveldt, Toos C.E.M., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, Nivard, Michel G., additional, and Boomsma, Dorret I., additional

Published
2023
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20. A systematic review of tools for predicting complications in patients with acute infectious diarrhea

Author

Marx, Tania, primary, Vincent-Boulay, Claudia, additional, Marquis-Gendron, Laurance, additional, Bareil, Kathryn, additional, Leduc, Samuel, additional, Lefebvre, Gabrielle, additional, Côté, Catherine, additional, Mallet, Myriam, additional, Paquette-Raynard, Emmanuelle, additional, Boissinot, Maurice, additional, Bergeron, Michel G., additional, and Berthelot, Simon, additional

Published
2023
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21. The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

Author

Wendt, Frank R., primary, Garcia-Argibay, Miguel, additional, Cabrera-Mendoza, Brenda, additional, Valdimarsdóttir, Unnur A., additional, Gelernter, Joel, additional, Stein, Murray B., additional, Nivard, Michel G., additional, Maihofer, Adam X., additional, Nievergelt, Caroline M., additional, Larsson, Henrik, additional, Mattheisen, Manuel, additional, Polimanti, Renato, additional, Meier, Sandra M., additional, Choi, Karmel W., additional, Coleman, Jonathan R.I., additional, Daskalakis, Nikolaos P., additional, Denckla, Christy A., additional, Ketema, Elizabeth, additional, Morey, Rajendra A., additional, Ratanatharathorn, Andrew, additional, Torres, Katy, additional, Wingo, Aliza P., additional, Zai, Clement C., additional, Aiello, Allison E., additional, Almli, Lynn M., additional, Amstadter, Ananda B., additional, Andersen, Soren B., additional, Andreassen, Ole A., additional, Arbisi, Paul A., additional, Ashley-Koch, Allison E., additional, Austin, S. Bryn, additional, Avdibegovic, Esmina, additional, Borglum, Anders D., additional, Babic, Dragan, additional, Bækvad-Hansen, Marie, additional, Baker, Dewleen G., additional, Beckham, Jean C., additional, Bierut, Laura J., additional, Bisson, Jonathan I., additional, Boks, Marco P., additional, Bolger, Elizabeth A., additional, Bradley, Bekh, additional, Brashear, Meghan, additional, Breen, Gerome, additional, Bryant, Richard A., additional, Bustamante, Angela C., additional, Bybjerg-Grauholm, Jonas, additional, Calabrese, Joseph R., additional, Caldas-de-Almeida, Jose Miguel, additional, Chen, Chia-Yen, additional, Dale, Anders M., additional, Dalvie, Shareefa, additional, Deckert, Jürgen, additional, Delahanty, Douglas L., additional, Dennis, Michelle F., additional, Disner, Seth G., additional, Domschke, Katharina, additional, Duncan, Laramie E., additional, Kulenovic, Alma Dzubur, additional, Erbes, Christopher R., additional, Evans, Alexandra, additional, Farrer, Lindsay A., additional, Feeny, Norah C., additional, Flory, Janine D., additional, Forbes, David, additional, Franz, Carol E., additional, Galea, Sandro, additional, Garrett, Melanie E., additional, Gautam, Aarti, additional, Gelaye, Bizu, additional, Geuze, Elbert, additional, Gillespie, Charles F., additional, Uka, Aferdita Goci, additional, Gordon, Scott D., additional, Guffanti, Guia, additional, Hammamieh, Rasha, additional, Hauser, Michael A., additional, Heath, Andrew C., additional, Hemmings, Sian M.J., additional, Hougaard, David Michael, additional, Jakovljevic, Miro, additional, Jett, Marti, additional, Johnson, Eric Otto, additional, Jones, Ian, additional, Jovanovic, Tanja, additional, Qin, Xue-Jun, additional, Karstoft, Karen-Inge, additional, Kaufman, Milissa L., additional, Kessler, Ronald C., additional, Khan, Alaptagin, additional, Kimbrel, Nathan A., additional, King, Anthony P., additional, Koen, Nastassja, additional, Kranzler, Henry R., additional, Kremen, William S., additional, Lawford, Bruce R., additional, Lebois, Lauren A.M., additional, Lewis, Catrin, additional, Liberzon, Israel, additional, Linnstaedt, Sarah D., additional, Logue, Mark W., additional, Lori, Adriana, additional, Lugonja, Bozo, additional, Luykx, Jurjen J., additional, Lyons, Michael J., additional, Maples-Keller, Jessica L., additional, Marmar, Charles, additional, Martin, Nicholas G., additional, Maurer, Douglas, additional, Mavissakalian, Matig R., additional, McFarlane, Alexander, additional, McGlinchey, Regina E., additional, McLaughlin, Katie A., additional, McLean, Samuel A., additional, Mehta, Divya, additional, Mellor, Rebecca, additional, Michopoulos, Vasiliki, additional, Milberg, William, additional, Miller, Mark W., additional, Morris, Charles Phillip, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Nelson, Elliot C., additional, Nordentoft, Merete, additional, Norman, Sonya B., additional, O’Donnell, Meaghan, additional, Orcutt, Holly K., additional, Panizzon, Matthew S., additional, Peters, Edward S., additional, Peterson, Alan L., additional, Peverill, Matthew, additional, Pietrzak, Robert H., additional, Polusny, Melissa A., additional, Rice, John P., additional, Risbrough, Victoria B., additional, Roberts, Andrea L., additional, Rothbaum, Alex O., additional, Rothbaum, Barbara O., additional, Roy-Byrne, Peter, additional, Ruggiero, Kenneth J., additional, Rung, Ariane, additional, Rutten, Bart P.F., additional, Saccone, Nancy L., additional, Sanchez, Sixto E., additional, Schijven, Dick, additional, Seedat, Soraya, additional, Seligowski, Antonia V., additional, Seng, Julia S., additional, Sheerin, Christina M., additional, Silove, Derrick, additional, Smith, Alicia K., additional, Smoller, Jordan W., additional, Sponheim, Scott R., additional, Stein, Dan J., additional, Stevens, Jennifer S., additional, Teicher, Martin H., additional, Thompson, Wesley K., additional, Trapido, Edward, additional, Uddin, Monica, additional, Ursano, Robert J., additional, Luella van den Heuvel, Leigh, additional, Van Hooff, Miranda, additional, Vermetten, Eric, additional, Vinkers, Christiaan, additional, Voisey, Joanne, additional, Wang, Yunpeng, additional, Wang, Zhewu, additional, Werge, Thomas, additional, Williams, Michelle A., additional, Williamson, Douglas E., additional, Winternitz, Sherry, additional, Wolf, Christiane, additional, Wolf, Erika J., additional, Yehuda, Rachel, additional, Young, Keith A., additional, Young, Ross McD., additional, Zhao, Hongyu, additional, Zoellner, Lori A., additional, Haas, Magali, additional, Lasseter, Heather, additional, Provost, Allison C., additional, Salem, Rany M., additional, Sebat, Jonathan, additional, Shaffer, Richard, additional, Wu, Tianying, additional, Ripke, Stephan, additional, Daly, Mark J., additional, Ressler, Kerry J., additional, and Koenen, Karestan C., additional

Published
2023
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22. Direct and Indirect Genetic Effects on Aggression

Author

Camiel M. van der Laan, Steve G.A. van de Weijer, René Pool, Jouke-Jan Hottenga, Toos C.E.M. van Beijsterveldt, Gonneke Willemsen, Meike Bartels, Michel G. Nivard, and Dorret I. Boomsma

Subjects
General Medicine
Published
2023

25. Manifestations ORL de la maladie de Forestier : revue systématique de la littérature

Author

Michel G. Khalaf, Patrick Cherfane, Hussein Smaily, and Antoine E. Melkane

Subjects
Rheumatology
Abstract

Resume Objectifs La maladie de Forestier ou l’hyperostose squelettique idiopathique diffuse (DISH) est une maladie frequente de la population âgee mais peu rapportee dans la litterature. D’un point de vue oto-rhino-laryngologique (ORL) cette maladie peut se manifester par une dysphagie, une dysphonie et meme une dyspnee. Le but de cette etude a ete d’identifier toutes les publications portant sur les manifestations ORL de la maladie de Forestier durant la derniere decennie afin d’etablir un algorithme de prise en charge. Methodes Une revue exhaustive de la litterature a ete menee en mai 2020 sur les bases de donnees Medline et Embase suivant les lignes directrices PRISMA pour l’ecriture et la lecture des revues systematiques et des meta-analyses. Resultats Soixante-trois articles, dont 50 rapports de cas et 13 series de cas, ont repondu aux criteres d’inclusion. Un total de 236 cas de DISH a ete recense de 2010 a ce jour. Une evaluation nasofibroscopique anatomique de la filiere pharyngolaryngee et dynamique de la deglutition est frequemment rapportee. Le traitement chirurgical est la modalite therapeutique la plus adoptee pour la dysphagie (58,9 % des patients), alors que 41,1 % des patients sont traites de facon conservatrice. Une tracheotomie a ete realisee chez 6 % des patients presentant une obstruction des voies aero-digestives superieures. Aucune correlation significative n’a pu etre identifiee entre la modalite therapeutique et l’amelioration de la dysphagie. Conclusions La maladie de Forestier est actuellement une source croissante de complications chez les personnes âgees, essentiellement en raison de la dysphagie et moins souvent en raison de l’obstruction des voies respiratoires. La prise en charge de ces complications necessite une approche multidisciplinaire, ou l’ORL joue un role fondamental.

Published
2022

29. Incidence, Risk Factors, and Outcomes of Rhegmatogenous Retinal Detachment after Intravitreal Injections of Anti-VEGF for Retinal Diseases

Author

Gabrielle, Pierre-Henry, primary, Nguyen, Vuong, additional, Arnould, Louis, additional, Viola, Francesco, additional, Zarranz-Ventura, Javier, additional, Barthelmes, Daniel, additional, Creuzot-Garcher, Catherine, additional, Gillies, Mark, additional, Squirrell, D., additional, Gilhotra, J., additional, Brooijmans, C., additional, Tigchelaar-Besling, O., additional, Cohn, A., additional, Chen, F., additional, McGeorge, A., additional, Welch, S., additional, Jaross, N., additional, Peters, P., additional, Barry, R., additional, McLean, I., additional, Guillaumie, T., additional, Miri, A., additional, Korobelnik, J., additional, Gabrielle, P., additional, Weber, M., additional, Walid, B., additional, Tick, S., additional, Valen, S., additional, Field, A., additional, Wickremasinghe, S., additional, Dayajeewa, C., additional, Wells, J., additional, Essex, R., additional, Dunlop, A., additional, Michalova, K., additional, Ng, C., additional, Young, S., additional, MIMOUN, G., additional, Generic, C., additional, Guymer, R., additional, Carnota, P., additional, Torres Borrego, C., additional, Dolz Marco, R., additional, Gallego-Pinazo, R., additional, Pareja Esteban, J., additional, García Layana, A., additional, Saenz-de-Viteri, M., additional, Uzzan, J., additional, Ferrier, R., additional, Ah-Chan, J., additional, Chow, L., additional, Steiner, H., additional, Amini, A., additional, Clark, G., additional, Wittles, N., additional, Windle, P., additional, Vingerling, J., additional, Clement, C., additional, Gillies, M., additional, Hunt, A., additional, Beaumont, P., additional, Cottee, L., additional, Lee, K., additional, Mack, H., additional, Louw, Z., additional, Lusthaus, J., additional, Chen, J., additional, Landers, J., additional, Billing, K., additional, Saha, N., additional, Lake, S., additional, Qatarneh, D., additional, Phillips, R., additional, Perks, M., additional, Banon, K., additional, Guarro, M., additional, Londoño, G., additional, Rethati, C., additional, Sararols, L., additional, Suarez, J., additional, Viola, F., additional, Lan Oei, S., additional, Fraser-Bell, S., additional, Montejano Milner, R., additional, Arruabarrena, C., additional, Chong, E., additional, Lal, S., additional, Higueras, A., additional, Ascaso, F., additional, Boned Murillo, A., additional, Díaz, M., additional, Perez Rivases, G., additional, Alforja Castiella, S., additional, Bernal-Morales, C., additional, Casaroli-Marano, R., additional, Figueras-Roca, M., additional, Izquierdo-Serra, J., additional, Moll Udina, A., additional, Parrado-Carrillo, A., additional, Zarranz-Ventura, J., additional, escobar, j., additional, Lavid, F., additional, Alvarez Gil, M., additional, Catalán Muñoz, P., additional, Tena Sempere, M., additional, Cerri, L., additional, RICCI, F., additional, Broc Iturralde, L., additional, Campos Figueroa, P., additional, Gómez Sánchez, S., additional, Valldeperas, X., additional, Vilaplana, F., additional, Carreño, E., additional, Munoz Sanz, N., additional, Ventura Abreu, N., additional, Asencio Duran, M., additional, Calvo, P., additional, Sanchez, J., additional, Almazan Alonso, E., additional, Flores-Moreno, I., additional, Garcia Zamora, M., additional, Ciancas, E., additional, Gonzalez-Lopez, J., additional, de la Fuente, M., additional, Rodriguez Maqueda, M., additional, Cobos, E., additional, Lorenzo, D., additional, Cordoves, L., additional, Acebes, m., additional, Aparicio-Sanchis, S., additional, Fernández Hortelano, A., additional, Zarallo-Gallardo, J., additional, Azrak, C., additional, Piñero Sánchez, A., additional, Almuina-Varela, P., additional, García García, L., additional, Salinas Martínez, E., additional, Castilla Marti, M., additional, Campo Gesto, A., additional, Rodriguez Núñez, M., additional, Furness, G., additional, Ponsioen, T., additional, Wilson, G., additional, Manning, L., additional, McAllister, I., additional, Isaacs, Tim, additional, Invernizzi, A., additional, Castelnovo, L., additional, Michel, G., additional, Wolff, B., additional, Arnold, J., additional, Cass, H., additional, Chan, D., additional, Tan, T., additional, OToole, L., additional, Tang, K., additional, Chung, C., additional, Beylerian, H., additional, DAIEN, V., additional, Banerjee, G., additional, Morgan, M., additional, Reddie, I., additional, Ongkosuwito, J., additional, Verbraak, F., additional, Schlingemann, R., additional, piermarocchi, s., additional, Thompson, A., additional, Game, J., additional, Thompson, C., additional, Chalasani, R., additional, Chilov, M., additional, Fung, A., additional, Nothling, S., additional, Chong, R., additional, Hunyor, A., additional, Younan, C., additional, Barnes, R., additional, Sharp, D., additional, Vincent, A., additional, Murray, N., additional, Ah-Moye, S., additional, Hennings, C., additional, Mehta, H., additional, Monaco, P., additional, Cheung, G., additional, Karia, N., additional, Louis, D., additional, Every, S., additional, Lockie, P., additional, van Hecke, M., additional, van Lith-Verhoeven, J., additional, Wong, J., additional, Grigg, J., additional, Hinchcliffe, P., additional, Barthelmes, D., additional, Diaz De Durana Santa Coloma, E., additional, Garay-Aramburu, G., additional, Vujosevic, S., additional, Brosa Morros, H., additional, Daniell, M., additional, Harper, A., additional, Lim, L., additional, ODay, J., additional, Velazquez Villoria, D., additional, Hooper, C., additional, Klaassen-Broekema, N., additional, and Smit, R., additional

Published
2022
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30. Relative Cerebral Blood Volume as Response Predictor in the Treatment of Recurrent Glioblastoma with Anti-Angiogenic Therapy

Author

Michele Breda-Yepes, Luis A. Rodríguez-Hernández, Enrique Gómez-Figueroa, Michel G. Mondragón-Soto, Gerardo Arellano-Flores, Alan Hernández-Hernández, Héctor A. Rodríguez-Rubio, Pablo Martínez, Ignacio Reyes-Moreno, Juan A. Álvaro-Heredia, Guillermo A. Gutiérrez Aceves, Eliezer Villanueva-Castro, Marcos V. Sangrador-Deitos, Mario Alonso-Vanegas, Vicente Guerrero-Juárez, and Alberto González-Aguilar

Published
2023

31. PHASE 2 KEYNOTE-667 STUDY OF PEMBROLIZUMAB (PEMBRO) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED CLASSICAL HODGKIN LYMPHOMA (Chl) AND SLOW EARLY RESPONSE (SER) TO FRONTLINE CHEMOTHERAPY (CHEMO)

Author

Vinti, L., primary, Daw, Stephen, additional, Alvarez, C., additional, Fagioli, F., additional, Beishuizen, A., additional, Michel, G., additional, Moleti, M., additional, Cepelova, M., additional, Thorwarth, A., additional, Rigaud, C., additional, de Sabando, D., additional, Parker, J., additional, Zhu, Y., additional, Pillai, P., additional, Nahar, A., additional, and Mauz-Koerholz, C., additional

Published
2022
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32. Control of ribosomal RNA synthesis by hematopoietic transcription factors

Author

Antony, Charles, primary, George, Subin S., additional, Blum, Justin, additional, Somers, Patrick, additional, Thorsheim, Chelsea L., additional, Wu-Corts, Dexter J., additional, Ai, Yuxi, additional, Gao, Long, additional, Lv, Kaosheng, additional, Tremblay, Michel G., additional, Moss, Tom, additional, Tan, Kai, additional, Wilusz, Jeremy E., additional, Ganley, Austen R.D., additional, Pimkin, Maxim, additional, and Paralkar, Vikram R., additional

Published
2022
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37. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Author

Jami, Eshim S., primary, Hammerschlag, Anke R., additional, Ip, Hill F., additional, Allegrini, Andrea G., additional, Benyamin, Beben, additional, Border, Richard, additional, Diemer, Elizabeth W., additional, Jiang, Chang, additional, Karhunen, Ville, additional, Lu, Yi, additional, Lu, Qing, additional, Mallard, Travis T., additional, Mishra, Pashupati P., additional, Nolte, Ilja M., additional, Palviainen, Teemu, additional, Peterson, Roseann E., additional, Sallis, Hannah M., additional, Shabalin, Andrey A., additional, Tate, Ashley E., additional, Thiering, Elisabeth, additional, Vilor-Tejedor, Natàlia, additional, Wang, Carol, additional, Zhou, Ang, additional, Adkins, Daniel E., additional, Alemany, Silvia, additional, Ask, Helga, additional, Chen, Qi, additional, Corley, Robin P., additional, Ehli, Erik A., additional, Evans, Luke M., additional, Havdahl, Alexandra, additional, Hagenbeek, Fiona A., additional, Hakulinen, Christian, additional, Henders, Anjali K., additional, Hottenga, Jouke Jan, additional, Korhonen, Tellervo, additional, Mamun, Abdullah, additional, Marrington, Shelby, additional, Neumann, Alexander, additional, Rimfeld, Kaili, additional, Rivadeneira, Fernando, additional, Silberg, Judy L., additional, van Beijsterveldt, Catharina E., additional, Vuoksimaa, Eero, additional, Whipp, Alyce M., additional, Tong, Xiaoran, additional, Andreassen, Ole A., additional, Boomsma, Dorret I., additional, Brown, Sandra A., additional, Burt, S. Alexandra, additional, Copeland, William, additional, Dick, Danielle M., additional, Harden, K. Paige, additional, Harris, Kathleen Mullan, additional, Hartman, Catharina A., additional, Heinrich, Joachim, additional, Hewitt, John K., additional, Hopfer, Christian, additional, Hypponen, Elina, additional, Jarvelin, Marjo-Riitta, additional, Kaprio, Jaakko, additional, Keltikangas-Järvinen, Liisa, additional, Klump, Kelly L., additional, Krauter, Kenneth, additional, Kuja-Halkola, Ralf, additional, Larsson, Henrik, additional, Lehtimäki, Terho, additional, Lichtenstein, Paul, additional, Lundström, Sebastian, additional, Maes, Hermine H., additional, Magnus, Per, additional, Munafò, Marcus R., additional, Najman, Jake M., additional, Njølstad, Pål R., additional, Oldehinkel, Albertine J., additional, Pennell, Craig E., additional, Plomin, Robert, additional, Reichborn-Kjennerud, Ted, additional, Reynolds, Chandra, additional, Rose, Richard J., additional, Smolen, Andrew, additional, Snieder, Harold, additional, Stallings, Michael, additional, Standl, Marie, additional, Sunyer, Jordi, additional, Tiemeier, Henning, additional, Wadsworth, Sally J., additional, Wall, Tamara L., additional, Whitehouse, Andrew J.O., additional, Williams, Gail M., additional, Ystrøm, Eivind, additional, Nivard, Michel G., additional, Bartels, Meike, additional, and Middeldorp, Christel M., additional

Published
2022
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39. Cardiometabolic Comorbidities in Cancer Survivors

Author

Zullig, Leah L., primary, Sung, Anthony D., additional, Khouri, Michel G., additional, Jazowski, Shelley, additional, Shah, Nishant P., additional, Sitlinger, Andrea, additional, Blalock, Dan V., additional, Whitney, Colette, additional, Kikuchi, Robin, additional, Bosworth, Hayden B., additional, Crowley, Matthew J., additional, Goldstein, Karen M., additional, Klem, Igor, additional, Oeffinger, Kevin C., additional, and Dent, Susan, additional

Published
2022
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42. Identifying the Common Genetic Basis of Antidepressant Response

Author

Pain, Oliver, primary, Hodgson, Karen, additional, Trubetskoy, Vassily, additional, Ripke, Stephan, additional, Marshe, Victoria S., additional, Adams, Mark J., additional, Byrne, Enda M., additional, Campos, Adrian I., additional, Carrillo-Roa, Tania, additional, Cattaneo, Annamaria, additional, Als, Thomas D., additional, Souery, Daniel, additional, Dernovsek, Mojca Z., additional, Fabbri, Chiara, additional, Hayward, Caroline, additional, Henigsberg, Neven, additional, Hauser, Joanna, additional, Kennedy, James L., additional, Lenze, Eric J., additional, Lewis, Glyn, additional, Müller, Daniel J., additional, Martin, Nicholas G., additional, Mulsant, Benoit H., additional, Mors, Ole, additional, Perroud, Nader, additional, Porteous, David J., additional, Rentería, Miguel E., additional, Reynolds, Charles F., additional, Rietschel, Marcella, additional, Uher, Rudolf, additional, Wigmore, Eleanor M., additional, Maier, Wolfgang, additional, Wray, Naomi R., additional, Aitchison, Katherine J., additional, Arolt, Volker, additional, Baune, Bernhard T., additional, Biernacka, Joanna M., additional, Bondolfi, Guido, additional, Domschke, Katharina, additional, Kato, Masaki, additional, Li, Qingqin S., additional, Liu, Yu-Li, additional, Serretti, Alessandro, additional, Tsai, Shih-Jen, additional, Turecki, Gustavo, additional, Weinshilboum, Richard, additional, McIntosh, Andrew M., additional, Lewis, Cathryn M., additional, Kasper, Siegfried, additional, Zohar, Joseph, additional, Montgomery, Stuart, additional, Albani, Diego, additional, Forloni, Gianluigi, additional, Ferentinos, Panagiotis, additional, Rujescu, Dan, additional, Mendlewicz, Julien, additional, Mattheisen, Manuel, additional, Trzaskowski, Maciej, additional, Abdellaoui, Abdel, additional, Agerbo, Esben, additional, Air, Tracy M., additional, Andlauer, Till F.M., additional, Bacanu, Silviu-Alin, additional, Bækvad-Hansen, Marie, additional, Beekman, Aartjan T.F., additional, Bigdeli, Tim B., additional, Binder, Elisabeth B., additional, Bryois, Julien, additional, Buttenschøn, Henriette N., additional, Bybjerg-Grauholm, Jonas, additional, Cai, Na, additional, Castelao, Enrique, additional, Christensen, Jane Hvarregaard, additional, Clarke, Toni-Kim, additional, Coleman, Jonathan R.I., additional, Colodro-Conde, Lucía, additional, Couvy-Duchesne, Baptiste, additional, Craddock, Nick, additional, Crawford, Gregory E., additional, Davies, Gail, additional, Deary, Ian J., additional, Degenhardt, Franziska, additional, Derks, Eske M., additional, Direk, Nese, additional, Dolan, Conor V., additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Escott-Price, Valentina, additional, Hassan Kiadeh, Farnush Farhadi, additional, Finucane, Hilary K., additional, Foo, Jerome C., additional, Forstner, Andreas J., additional, Frank, Josef, additional, Gaspar, Héléna A., additional, Gill, Michael, additional, Goes, Fernando S., additional, Gordon, Scott D., additional, Grove, Jakob, additional, Hall, Lynsey S., additional, Hansen, Christine Søholm, additional, Hansen, Thomas F., additional, Herms, Stefan, additional, Hickie, Ian B., additional, Hoffmann, Per, additional, Homuth, Georg, additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Hougaard, David M., additional, Howard, David M., additional, Ising, Marcus, additional, Jansen, Rick, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jorgenson, Eric, additional, Knowles, James A., additional, Kohane, Isaac S., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Kutalik, Zoltán, additional, Li, Yihan, additional, Lind, Penelope A., additional, MacIntyre, Donald J., additional, MacKinnon, Dean F., additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Mbarek, Hamdi, additional, McGrath, Patrick, additional, McGuffin, Peter, additional, Medland, Sarah E., additional, Mehta, Divya, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Milaneschi, Yuri, additional, Milani, Lili, additional, Mondimore, Francis M., additional, Montgomery, Grant W., additional, Mostafavi, Sara, additional, Mullins, Niamh, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nivard, Michel G., additional, Nyholt, Dale R., additional, O’Reilly, Paul F., additional, Oskarsson, Hogni, additional, Owen, Michael J., additional, Painter, Jodie N., additional, Pedersen, Carsten Bøcker, additional, Pedersen, Marianne Giørtz, additional, Peterson, Roseann E., additional, Peyrot, Wouter J., additional, Pistis, Giorgio, additional, Posthuma, Danielle, additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Rice, John P., additional, Riley, Brien P., additional, Rivera, Margarita, additional, Mirza, Saira Saeed, additional, Schoevers, Robert, additional, Schulte, Eva C., additional, Shen, Ling, additional, Shi, Jianxin, additional, Shyn, Stanley I., additional, Sigurdsson, Engilbert, additional, Sinnamon, Grant C.B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Teumer, Alexander, additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Thorgeirsson, Thorgeir E., additional, Traylor, Matthew, additional, Treutlein, Jens, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, Van der Auwera, Sandra, additional, van Hemert, Albert M., additional, Viktorin, Alexander, additional, Visscher, Peter M., additional, Wang, Yunpeng, additional, Webb, Bradley T., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Willemsen, Gonneke, additional, Witt, Stephanie H., additional, Wu, Yang, additional, Xi, Hualin S., additional, Yang, Jian, additional, Zhang, Futao, additional, Berger, Klaus, additional, Boomsma, Dorret I., additional, Cichon, Sven, additional, Dannlowski, Udo, additional, de Geus, E.J.C., additional, DePaulo, J. Raymond, additional, Domenici, Enrico, additional, Esko, Tõnu, additional, Grabe, Hans J., additional, Hamilton, Steven P., additional, Heath, Andrew C., additional, Kendler, Kenneth S., additional, Kloiber, Stefan, additional, Lucae, Susanne, additional, Madden, Pamela A.F., additional, Magnusson, Patrik K., additional, Metspalu, Andres, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O’Donovan, Michael C., additional, Paciga, Sara A., additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J.H., additional, Perlis, Roy H., additional, Potash, James B., additional, Preisig, Martin, additional, Schaefer, Catherine, additional, Schulze, Thomas G., additional, Smoller, Jordan W., additional, Stefansson, Kari, additional, Tiemeier, Henning, additional, Völzke, Henry, additional, Weissman, Myrna M., additional, Werge, Thomas, additional, Levinson, Douglas F., additional, Breen, Gerome, additional, Børglum, Anders D., additional, and Sullivan, Patrick F., additional

Published
2022
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45. Cardiac Implantable Electronic Devices

Author

Amanda C. Coniglio, Michel G. Khouri, Sean D. Pokorney, Michael Rehorn, Rahul S. Loungani, Ravi Karra, and Eric Black-Maier

Subjects
Bradycardia, medicine.medical_specialty, Ejection fraction, business.industry, Amyloidosis, Cardiomyopathy, Atrial fibrillation, 030204 cardiovascular system & hematology, medicine.disease, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Cardiac amyloidosis, Internal medicine, Cardiology, Medicine, 030212 general & internal medicine, medicine.symptom, business, Cardiac imaging
Abstract

Objectives This study characterized the relationship between conduction disease and cardiac amyloidosis (CA) through longitudinal analysis of cardiac implantable electronic device (CIED) data. Background Bradyarrhythmias and tachyarrhythmias are commonly reported in CA and may precede a CA diagnosis, although the natural history of conduction disease in CA is not well-described. Methods Patients with CA (transthyretin amyloidosis cardiomyopathy [ATTR-CM] and light-chain amyloidosis [AL-CA]) and a CIED were identified within the Duke University Health System. Patient characteristics at the time of implantation, including demographics and data relevant to CA diagnosis, cardiac imaging, and CIED were recorded. CIED interrogations were analyzed for pacing and atrial fibrillation (AF) burden, activity level, lead parameters, and ventricular arrhythmia incidence and/or therapy. Results Thirty-four patients with CA (7 with AL-CA, 27 with ATTR-CM [78% with wild-type]; 82% men) with median age of 75 years and a mean ejection fraction of 42 ± 13% had a CIED implanted for bradycardia (65%) or prevention of sudden cardiac death (35%). CIED implantation preceded CA diagnosis in 14 patients (41%). Over a mean follow-up of 3.1 ± 4.0 years, right ventricular sensing amplitudes decreased but did not result in device malfunction; lead impedances and capture thresholds remained stable. Between post-implantation years 1 and 5, mean ventricular pacing increased from 56 ± 9% to 96 ± 1% (p = 0.003) and AF burden increased from 2 ± 1.3 to 17 ± 3 h/day (p = 0.0002). Ventricular arrhythmias were common (mean episodes per patient per year: 6.7 ± 2.3 [ATTR-CM] and 5.1 ± 3.2 [AL-CA]) but predominately nonsustained; only 1 patient with AL-CA required implantable cardioverter-defibrillator therapy. Conclusions Longitudinal analysis of CIED data in patients with CA revealed progressive conduction disease, with high AF burden and eventual dependence on ventricular pacing, although lead parameters remained stable. Ventricular arrhythmias were common but predominantly nonsustained, particularly in ATTR-CM.

Published
2020

46. Identification of Undetected Monogenic Cardiovascular Disorders

Author

Fawaz Alenezi, Lauren K. Truby, Lydia Coulter Kwee, Aris Baras, Michel G. Khouri, Andrew Wang, Christopher L. Holley, James P. Daubert, Albert Y. Sun, Robert W. McGarrah, Sreekanth Vemulapalli, Svati H. Shah, Jawan W. Abdulrahim, Teminioluwa A. Ajayi, and Ricardo Henao

Subjects
Male, medicine.medical_specialty, Familial hypercholesterolemia, Disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Exome Sequencing, Prevalence, medicine, Electronic Health Records, Humans, Genetic Testing, 030212 general & internal medicine, Medical diagnosis, Hemochromatosis Protein, Exome sequencing, Sequence Deletion, Genetic testing, Missed Diagnosis, medicine.diagnostic_test, business.industry, Amyloidosis, alpha-Glucosidases, Middle Aged, medicine.disease, United States, Cardiovascular Diseases, Clinical diagnosis, Genomic Structural Variation, Cohort, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background Monogenic diseases are individually rare but collectively common, and are likely underdiagnosed. Objectives The purpose of this study was to estimate the prevalence of monogenic cardiovascular diseases (MCVDs) and potentially missed diagnoses in a cardiovascular cohort. Methods Exomes from 8,574 individuals referred for cardiac catheterization were analyzed. Pathogenic/likely pathogenic (P/LP) variants associated with MCVD (cardiomyopathies, arrhythmias, connective tissue disorders, and familial hypercholesterolemia were identified. Electronic health records (EHRs) were reviewed for individuals harboring P/LP variants who were predicted to develop disease (G+). G+ individuals who did not have a documented relevant diagnosis were classified into groups of whether they may represent missed diagnoses (unknown, unlikely, possible, probable, or definite) based on relevant diagnostic criteria/features for that disease. Results In total, 159 P/LP variants were identified; 2,361 individuals harbored at least 1 P/LP variant, of whom 389 G+ individuals (4.5% of total cohort) were predicted to have at least 1 MCVD. EHR review of 342 G+ individuals predicted to have 1 MCVD with sufficient EHR data revealed that 52 had been given the relevant clinical diagnosis. The remaining 290 individuals were classified as potentially having an MCVD as follows: 193 unlikely (66.6%), 50 possible (17.2%), 30 probable (10.3%), and 17 definite (5.9%). Grouping possible, probable, definite, and known diagnoses, 149 were considered to have an MCVD. Novel MCVD pathogenic variants were identified in 16 individuals. Conclusions Overall, 149 individuals (1.7% of cohort) had MCVDs, but only 35% were diagnosed. These patients represents a “missed opportunity,” which could be addressed by greater use of genetic testing of patients seen by cardiologists.

Published
2020

47. Outcomes following cardioversion for patients with cardiac amyloidosis and atrial fibrillation or atrial flutter

Author

Sean D. Pokorney, Eric Black-Maier, Kyle R. Geurink, Michael Rehorn, Amanda C. Coniglio, Michel G. Khouri, and Rahul S. Loungani

Subjects
Male, Bradycardia, medicine.medical_specialty, Biopsy, medicine.medical_treatment, Electric Countershock, Magnetic Resonance Imaging, Cine, 030204 cardiovascular system & hematology, Cardioversion, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Cause of Death, Internal medicine, Atrial Fibrillation, medicine, Humans, Sinus rhythm, cardiovascular diseases, 030212 general & internal medicine, Aged, Retrospective Studies, business.industry, Myocardium, Amyloidosis, Atrial fibrillation, Retrospective cohort study, Prognosis, medicine.disease, United States, Survival Rate, Atrial Flutter, Cardiac amyloidosis, cardiovascular system, Cardiology, Female, Morbidity, medicine.symptom, Cardiomyopathies, Cardiology and Cardiovascular Medicine, business, Atrial flutter, Follow-Up Studies
Abstract

Atrial arrhythmias commonly occur in patients with cardiac amyloidosis (CA), but there is limited data on safety or efficacy of cardioversion (DCCV) for management of these rhythms in CA. We identified 25 patients with CA (20 with transthyretin (TTR) and 5 with light-chain (AL) amyloidosis) at Duke University who underwent DCCV for atrial arrhythmias and documented procedural success, complications, and long-term morbidity and mortality. While DCCV successfully restored sinus rhythm in 96% of patients, 36% of patients experienced immediate procedural complications (primarily bradycardia and hypotension), 80% had recurrence of atrial arrhythmias at 1 year, and 52% died at 3 years, highlighting short-term safety concerns, long-term inefficacy, and poor prognosis associated with symptomatic atrial arrhythmias requiring DCCV in CA.

Published
2020

50. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Author

Blokland, Gabriëlla A.M., primary, Grove, Jakob, additional, Chen, Chia-Yen, additional, Cotsapas, Chris, additional, Tobet, Stuart, additional, Handa, Robert, additional, St Clair, David, additional, Lencz, Todd, additional, Mowry, Bryan J., additional, Periyasamy, Sathish, additional, Cairns, Murray J., additional, Tooney, Paul A., additional, Wu, Jing Qin, additional, Kelly, Brian, additional, Kirov, George, additional, Sullivan, Patrick F., additional, Corvin, Aiden, additional, Riley, Brien P., additional, Esko, Tõnu, additional, Milani, Lili, additional, Jönsson, Erik G., additional, Palotie, Aarno, additional, Ehrenreich, Hannelore, additional, Begemann, Martin, additional, Steixner-Kumar, Agnes, additional, Sham, Pak C., additional, Iwata, Nakao, additional, Weinberger, Daniel R., additional, Gejman, Pablo V., additional, Sanders, Alan R., additional, Buxbaum, Joseph D., additional, Rujescu, Dan, additional, Giegling, Ina, additional, Konte, Bettina, additional, Hartmann, Annette M., additional, Bramon, Elvira, additional, Murray, Robin M., additional, Pato, Michele T., additional, Lee, Jimmy, additional, Melle, Ingrid, additional, Molden, Espen, additional, Ophoff, Roel A., additional, McQuillin, Andrew, additional, Bass, Nicholas J., additional, Adolfsson, Rolf, additional, Malhotra, Anil K., additional, Martin, Nicholas G., additional, Fullerton, Janice M., additional, Mitchell, Philip B., additional, Schofield, Peter R., additional, Forstner, Andreas J., additional, Degenhardt, Franziska, additional, Schaupp, Sabrina, additional, Comes, Ashley L., additional, Kogevinas, Manolis, additional, Guzman-Parra, José, additional, Reif, Andreas, additional, Streit, Fabian, additional, Sirignano, Lea, additional, Cichon, Sven, additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Lissowska, Jolanta, additional, Mayoral, Fermin, additional, Müller-Myhsok, Bertram, additional, Świątkowska, Beata, additional, Schulze, Thomas G., additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Kelsoe, John, additional, Leboyer, Marion, additional, Jamain, Stéphane, additional, Etain, Bruno, additional, Bellivier, Frank, additional, Vincent, John B., additional, Alda, Martin, additional, O’Donovan, Claire, additional, Cervantes, Pablo, additional, Biernacka, Joanna M., additional, Frye, Mark, additional, McElroy, Susan L., additional, Scott, Laura J., additional, Stahl, Eli A., additional, Landén, Mikael, additional, Hamshere, Marian L., additional, Smeland, Olav B., additional, Djurovic, Srdjan, additional, Vaaler, Arne E., additional, Andreassen, Ole A., additional, Baune, Bernhard T., additional, Air, Tracy, additional, Preisig, Martin, additional, Uher, Rudolf, additional, Levinson, Douglas F., additional, Weissman, Myrna M., additional, Potash, James B., additional, Shi, Jianxin, additional, Knowles, James A., additional, Perlis, Roy H., additional, Lucae, Susanne, additional, Boomsma, Dorret I., additional, Penninx, Brenda W.J.H., additional, Hottenga, Jouke-Jan, additional, de Geus, Eco J.C., additional, Willemsen, Gonneke, additional, Milaneschi, Yuri, additional, Tiemeier, Henning, additional, Grabe, Hans J., additional, Teumer, Alexander, additional, Van der Auwera, Sandra, additional, Völker, Uwe, additional, Hamilton, Steven P., additional, Magnusson, Patrik K.E., additional, Viktorin, Alexander, additional, Mehta, Divya, additional, Mullins, Niamh, additional, Adams, Mark J., additional, Breen, Gerome, additional, McIntosh, Andrew M., additional, Lewis, Cathryn M., additional, Hougaard, David M., additional, Nordentoft, Merete, additional, Mors, Ole, additional, Mortensen, Preben B., additional, Werge, Thomas, additional, Als, Thomas D., additional, Børglum, Anders D., additional, Petryshen, Tracey L., additional, Smoller, Jordan W., additional, Goldstein, Jill M., additional, Ripke, Stephan, additional, Neale, Benjamin M., additional, Walters, James T.R., additional, Farh, Kai-How, additional, Holmans, Peter A., additional, Lee, Phil, additional, Bulik-Sullivan, Brendan, additional, Collier, David A., additional, Huang, Hailiang, additional, Pers, Tune H., additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Albus, Margot, additional, Alexander, Madeline, additional, Amin, Farooq, additional, Bacanu, Silviu A., additional, Belliveau, Richard A., additional, Bene, Judit, additional, Bergen, Sarah E., additional, Bevilacqua, Elizabeth, additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Catts, Stanley V., additional, Chambert, Kimberly D., additional, Chan, Raymond C.K., additional, Chen, Ronald Y.L., additional, Chen, Eric Y.H., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Cormican, Paul, additional, Craddock, Nick, additional, Crowley, James J., additional, Curtis, David, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, Del Favero, Jurgen, additional, Demontis, Ditte, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Durmishi, Naser, additional, Eichhammer, Peter, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Essioux, Laurent, additional, Fanous, Ayman H., additional, Farrell, Martilias S., additional, Frank, Josef, additional, Franke, Lude, additional, Freedman, Robert, additional, Freimer, Nelson B., additional, Friedl, Marion, additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Giusti-Rodríguez, Paola, additional, Godard, Stephanie, additional, Goldstein, Jacqueline I., additional, Golimbet, Vera, additional, Gopal, Srihari, additional, Gratten, Jacob, additional, de Haan, Lieuwe, additional, Hammer, Christian, additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hofman, Andrea, additional, Hollegaard, Mads V., additional, Ikeda, Masashi, additional, Joa, Inge, additional, Julià, Antonio, additional, Kahn, René S., additional, Kalaydjieva, Luba, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Klovins, Janis, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kuzelova-Ptackova, Hana, additional, Kähler, Anna K., additional, Laurent, Claudine, additional, Lee Chee Keong, Jimmy, additional, Lee, S. Hong, additional, Legge, Sophie E., additional, Lerer, Bernard, additional, Li, Miaoxin, additional, Li, Tao, additional, Liang, Kung-Yee, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lönnqvist, Jouko, additional, Macek, Milan, additional, Maher, Brion S., additional, Maier, Wolfgang, additional, Mallet, Jacques, additional, Marsal, Sara, additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, McCarley, Robert W., additional, McDonald, Colm, additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milanova, Vihra, additional, Mokrab, Younes, additional, Morris, Derek W., additional, Murphy, Kieran C., additional, Myin-Germeys, Inez, additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nikitina-Zake, Liene, additional, Nisenbaum, Laura, additional, Nordin, Annelie, additional, O’Callaghan, Eadbhard, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Van Os, Jim, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Papiol, Sergi, additional, Parkhomenko, Elena, additional, Paunio, Tiina, additional, Pejovic-Milovancevic, Milica, additional, Perkins, Diana O., additional, Pietiläinen, Olli, additional, Pimm, Jonathan, additional, Pocklington, Andrew J., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Rasmussen, Henrik B., additional, Reichenberg, Abraham, additional, Reimers, Mark A., additional, Richards, Alexander L., additional, Roffman, Joshua L., additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Salomaa, Veikko, additional, Schall, Ulrich, additional, Schubert, Christian R., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Sigurdsson, Engilbert, additional, Silagadze, Teimuraz, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slominsky, Petr, additional, So, Hon-Cheong, additional, Spencer, Chris C.A., additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Straub, Richard E., additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Söderman, Erik, additional, Thirumalai, Srinivas, additional, Toncheva, Draga, additional, Tosato, Sarah, additional, Veijola, Juha, additional, Waddington, John, additional, Walsh, Dermot, additional, Wang, Dai, additional, Wang, Qiang, additional, Webb, Bradley T., additional, Weiser, Mark, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wormley, Brandon K., additional, Xi, Hualin Simon, additional, Zai, Clement C., additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Wray, Naomi R., additional, Stefansson, Kari, additional, Visscher, Peter M., additional, Blackwood, Douglas H.R., additional, Darvasi, Ariel, additional, Domenici, Enrico, additional, Gill, Michael, additional, Gurling, Hugh, additional, Hultman, Christina M., additional, Jablensky, Assen V., additional, Kendler, Kenneth S., additional, Knight, Jo, additional, Li, Qingqin S., additional, Liu, Jianjun, additional, McCarroll, Steven A., additional, Moran, Jennifer L., additional, Owen, Michael J., additional, Pato, Carlos N., additional, Posthuma, Danielle, additional, Sklar, Pamela, additional, Wendland, Jens R., additional, Daly, Mark J., additional, O’Donovan, Michael C., additional, Donnelly, Peter, additional, Barroso, Ines, additional, Blackwell, Jenefer M., additional, Brown, Matthew A., additional, Casas, Juan P., additional, Deloukas, Panos, additional, Duncanson, Audrey, additional, Jankowski, Janusz, additional, Markus, Hugh S., additional, Mathew, Christopher G., additional, Palmer, Colin N.A., additional, Plomin, Robert, additional, Rautanen, Anna, additional, Sawcer, Stephen J., additional, Trembath, Richard C., additional, Viswanathan, Ananth C., additional, Wood, Nicholas W., additional, Band, Gavin, additional, Bellenguez, Céline, additional, Freeman, Colin, additional, Giannoulatou, Eleni, additional, Hellenthal, Garrett, additional, Pearson, Richard, additional, Pirinen, Matti, additional, Strange, Amy, additional, Su, Zhan, additional, Vukcevic, Damjan, additional, Langford, Cordelia, additional, Blackburn, Hannah, additional, Bumpstead, Suzannah J., additional, Dronov, Serge, additional, Edkins, Sarah, additional, Gillman, Matthew, additional, Gray, Emma, additional, Gwilliam, Rhian, additional, Hammond, Naomi, additional, Hunt, Sarah E., additional, Jayakumar, Alagurevathi, additional, Liddle, Jennifer, additional, McCann, Owen T., additional, Potter, Simon C., additional, Ravindrarajah, Radhi, additional, Ricketts, Michelle, additional, Tashakkori-Ghanbaria, Avazeh, additional, Waller, Matthew, additional, Weston, Paul, additional, Whittaker, Pamela, additional, Widaa, Sara, additional, McCarthy, Mark I., additional, Arranz, Maria J., additional, Bakker, Steven, additional, Bender, Stephan, additional, Crespo-Facorro, Benedicto, additional, Hall, Jeremy, additional, Iyegbe, Conrad, additional, Lawrie, Stephen, additional, Lin, Kuang, additional, Linszen, Don H., additional, Mata, Ignacio, additional, Walshe, Muriel, additional, Weisbrod, Matthias, additional, Wiersma, Durk, additional, Trubetskoy, Vassily, additional, Wang, Yunpeng, additional, Coleman, Jonathan R.I., additional, Gaspar, Héléna A., additional, de Leeuw, Christiaan A., additional, Whitehead Pavlides, Jennifer M., additional, Trzaskowski, Maciej, additional, Byrne, Enda M., additional, Abbott, Liam, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Awasthi, Swapnil, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Belliveau, Richard, additional, Pedersen, Carsten Bøcker, additional, Bøen, Erlend, additional, Boks, Marco P., additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Bybjerg-Grauholm, Jonas, additional, Casas, Miquel, additional, Cerrato, Felecia, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Churchhouse, Claire, additional, Clarke, Toni-Kim, additional, Coryell, William, additional, Craig, David W., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, de Jong, Simone, additional, Del-Favero, Jurgen, additional, DePaulo, J. Raymond, additional, Dobbyn, Amanda L., additional, Dumont, Ashley, additional, Elvsåshagen, Torbjørn, additional, Fan, Chun Chieh, additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Fraser, Christine, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Pedersen, Marianne Giørtz, additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Guan, Weihua, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hipolito, Maria, additional, Holland, Dominic, additional, Huckins, Laura, additional, Johnson, Jessica S., additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kittel-Schneider, Sarah, additional, Koller, Anna C., additional, Kupka, Ralph, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Liu, Chunyu, additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, Mahon, Pamela B., additional, Martinsson, Lina, additional, McCarroll, Steve, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Meng, Fan, additional, Montgomery, Grant W., additional, Mühleisen, Thomas W., additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Adolfsson, Annelie Nordin, additional, Nwulia, Evaristus A., additional, O'Donovan, Claire, additional, Olde Loohuis, Loes M., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Perry, Amy, additional, Pfennig, Andrea, additional, Regeer, Eline J., additional, Reinbold, Céline S., additional, Rice, John P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schork, Nicholas J., additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shilling, Paul D., additional, Slaney, Claire, additional, Sobell, Janet L., additional, Hansen, Christine Søholm, additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Szelinger, Szabolcs, additional, Thompson, Robert C., additional, Thorgeirsson, Thorgeir E., additional, Treutlein, Jens, additional, Vedder, Helmut, additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Weickert, Thomas W., additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zöllner, Sebastian, additional, Abdellaoui, Abdel, additional, Air, Tracy M., additional, Andlauer, Till F.M., additional, Bacanu, Silviu-Alin, additional, Beekman, Aartjan T.F., additional, Binder, Elisabeth B., additional, Bryois, Julien, additional, Buttenschøn, Henriette N., additional, Cai, Na, additional, Castelao, Enrique, additional, Christensen, Jane Hvarregaard, additional, Colodro-Conde, Lucía, additional, Couvy-Duchesne, Baptiste, additional, Crawford, Gregory E., additional, Davies, Gail, additional, Deary, Ian J., additional, Derks, Eske M., additional, Direk, Nese, additional, Dolan, Conor V., additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Hassan Kiadeh, Farnush Farhadi, additional, Finucane, Hilary K., additional, Foo, Jerome C., additional, Goes, Fernando S., additional, Hall, Lynsey S., additional, Hansen, Thomas F., additional, Hickie, Ian B., additional, Homuth, Georg, additional, Horn, Carsten, additional, Howard, David M., additional, Ising, Marcus, additional, Jansen, Rick, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jorgenson, Eric, additional, Kohane, Isaac S., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Kutalik, Zoltán, additional, Li, Yihan, additional, Lind, Penelope A., additional, MacKinnon, Dean F., additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Mbarek, Hamdi, additional, McGrath, Patrick, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Mondimore, Francis M., additional, Mostafavi, Sara, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nivard, Michel G., additional, Nyholt, Dale R., additional, O'Reilly, Paul F., additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Peterson, Roseann E., additional, Peyrot, Wouter J., additional, Pistis, Giorgio, additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Mirza, Saira Saeed, additional, Schoevers, Robert, additional, Schulte, Eva C., additional, Shen, Ling, additional, Shyn, Stanley I., additional, Sinnamon, Grant C.B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Traylor, Matthew, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, van Hemert, Albert M., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Wu, Yang, additional, Xi, Hualin S., additional, Yang, Jian, additional, Zhang, Futao, additional, Arolt, Volker, additional, Berger, Klaus, additional, Dannlowski, Udo, additional, Domschke, Katharina, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Kloiber, Stefan, additional, Lewis, Glyn, additional, Madden, Pamela AF., additional, Magnusson, Patrik K., additional, Mortensen, Preben Bo, additional, O'Donovan, Michael C., additional, Paciga, Sara A., additional, Pedersen, Nancy L., additional, Porteous, David J., additional, Schaefer, Catherine, additional, Völzke, Henry, additional, Blokland, Gabriëlla A.M., additional, Bortolato, Marco, additional, Bralten, Janita, additional, Bulik, Cynthia M., additional, Burton, Christie L., additional, Carey, Caitlin E., additional, Davis, Lea K., additional, Duncan, Laramie E., additional, Edenberg, Howard J., additional, Erdman, Lauren, additional, Faraone, Stephen V., additional, Goleva, Slavina B., additional, Guo, Wei, additional, Hübel, Christopher, additional, Huckins, Laura M., additional, Khramtsova, Ekaterina A., additional, Martin, Joanna, additional, Mathews, Carol A., additional, Robinson, Elise, additional, Stahl, Eli, additional, Stranger, Barbara E., additional, Traglia, Michela, additional, Walters, Raymond K., additional, Weiss, Lauren A., additional, Winham, Stacey J., additional, Yao, Yin, additional, Skajaa, Kristjar, additional, Nöthen, Markus, additional, Owen, Michael, additional, Yolken, Robert H., additional, Plath, Niels, additional, Mill, Jonathan, additional, and Geschwind, Daniel, additional

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2022
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