1. Rearrangement routes to selectively fluorinated compounds
- Author
-
Michael E. Prime and Jonathan M. Percy
- Subjects
Allylic rearrangement ,Organic Chemistry ,chemistry.chemical_element ,Sigmatropic reaction ,Vinyl ether ,Biochemistry ,Combinatorial chemistry ,Inorganic Chemistry ,chemistry ,medicine ,Fluorine ,Environmental Chemistry ,Physical and Theoretical Chemistry ,Carbon ,medicine.drug - Abstract
Fluoroallylic alcohols are easy to synthesise by a variety of routes using one or two carbon fluorinated building blocks. Sigmatropic rearrangement then transforms these intermediates into species in which the fluorine atom (or atoms) is borne on an sp3-hybridised carbon. Alternatively, allylic alcohols can be transformed into fluorinated vinyl ether derivatives; rearrangement then affords products in which the fluorine atoms occupy a different and complementary location with respect to a carbonyl function.
- Published
- 1999