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Your search keyword '"Meyer, Pablo"' showing total 11 results
Start Over Author "Meyer, Pablo" Publisher elsevier bv
11 results on '"Meyer, Pablo"'

1. Informing clinical assessment by contextualizing post-hoc explanations of risk prediction models in type-2 diabetes

Author

Chari, Shruthi, primary, Acharya, Prasant, additional, Gruen, Daniel M., additional, Zhang, Olivia, additional, Eyigoz, Elif K., additional, Ghalwash, Mohamed, additional, Seneviratne, Oshani, additional, Saiz, Fernando Suarez, additional, Meyer, Pablo, additional, Chakraborty, Prithwish, additional, and McGuinness, Deborah L., additional

Published
2023
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3. Benchmarked approaches for reconstruction of in vitro cell lineages and in silico models of C. elegans and M. musculus developmental trees

Author

Gong, Wuming, Granados, Alejandro A., Hu, Jingyuan, Jones, Matthew G., Raz, Ofir, Salvador-Martínez, Irepan, Zhang, Hanrui, Chow, Ke-Huan K., Kwak, Il-Youp, Retkute, Renata, Alis Prusoke, Prusokas, Augustinas, Khodaverdian, Alex, Zhang, Richard, Rao, Suhas, Wang, Robert, Rennert, Phil, Saipradeep, Vangala G., Sivadasan, Naveen, Rao, Aditya, Joseph, Thomas, Srinivasan, Rajgopal, Peng, Jiajie, Han, Lu, Shang, Xuequn, Garry, Daniel J., Yu, Thomas, Chung, Verena, Mason, Michael, Liu, Zhandong, Guan, Yuanfang, Yosef, Nir, Shendure, Jay, Telford, Maximilian J., Shapiro, Ehud, Elowitz, Michael B., and Meyer, Pablo

Subjects
M. musculus, simulation, Benchmarking, Mice, intmemoir, machine learning, lineage reconstruction, CRISPR, C. elegans, Animals, cell lineage tracing, crowdsourcing, Cell Lineage, Computer Simulation, Caenorhabditis elegans, Algorithms
Abstract

The recent advent of CRISPR and other molecular tools enabled the reconstruction of cell lineages based on induced DNA mutations and promises to solve the ones of more complex organisms. To date, no lineage reconstruction algorithms have been rigorously examined for their performance and robustness across dataset types and number of cells. To benchmark such methods, we decided to organize a DREAM challenge using in vitro experimental intMEMOIR recordings and in silico data for a C. elegans lineage tree of about 1,000 cells and a Mus musculus tree of 10,000 cells. Some of the 22 approaches submitted had excellent performance, but structural features of the trees prevented optimal reconstructions. Using smaller sub-trees as training sets proved to be a good approach for tuning algorithms to reconstruct larger trees. The simulation and reconstruction methods here generated delineate a potential way forward for solving larger cell lineage trees such as in mouse.

Published
2021
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4. Benchmarked approaches for reconstruction of in vitro cell lineages and in silico models of C. elegans and M. musculus developmental trees

Author

Gong, Wuming, primary, Granados, Alejandro A., additional, Hu, Jingyuan, additional, Jones, Matthew G., additional, Raz, Ofir, additional, Salvador-Martínez, Irepan, additional, Zhang, Hanrui, additional, Chow, Ke-Huan K., additional, Kwak, Il-Youp, additional, Retkute, Renata, additional, Prusokas, Alidivinas, additional, Prusokas, Augustinas, additional, Khodaverdian, Alex, additional, Zhang, Richard, additional, Rao, Suhas, additional, Wang, Robert, additional, Rennert, Phil, additional, Saipradeep, Vangala G., additional, Sivadasan, Naveen, additional, Rao, Aditya, additional, Joseph, Thomas, additional, Srinivasan, Rajgopal, additional, Peng, Jiajie, additional, Han, Lu, additional, Shang, Xuequn, additional, Garry, Daniel J., additional, Yu, Thomas, additional, Chung, Verena, additional, Mason, Michael, additional, Liu, Zhandong, additional, Guan, Yuanfang, additional, Yosef, Nir, additional, Shendure, Jay, additional, Telford, Maximilian J., additional, Shapiro, Ehud, additional, Elowitz, Michael B., additional, and Meyer, Pablo, additional

Published
2021
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