1. O efeito de epinefrina, norepinefrina e fenilefrina no tratamento da hipotensão pós‐raquianestesia: estudo clínico comparativo
- Author
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Mete Sucu, Ebru Biricik, İlker Ünal, Feride Karacaer, and Hakkı Ünlügenç
- Subjects
business.industry ,medicine.medical_treatment ,Norepinephrine (medication) ,Anesthesiology and Pain Medicine ,Epinephrine ,Blood pressure ,Maternal Hypotension ,Anesthesia ,medicine ,Elective Cesarean Delivery ,Ephedrine ,business ,Phenylephrine ,Saline ,medicine.drug - Abstract
Background and objectives: Limited data are present on safety and efficiency of epinephrine for the prophylaxis and treatment of spinal-hypotension. This was conducted to compare the effect of epinephrine with norepinephrine and phenylephrine on the treatment of spinal-hypotension and ephedrine requirement during cesarean delivery. Methods: 160 parturient with uncomplicated pregnancies undergoing elective cesarean delivery under spinal anesthesia were recruited. They were allocated randomly to receive norepinephrine 5 μg.mL-1 (n = 40), epinephrine 5 μg.mL-1 (n = 40), phenylephrine 100 μg.mL-1 (n = 40) or 0.9% saline infusions (n = 40) immediately after induction of spinal anesthesia. Whenever systolic blood pressure drops to less than 80% of baseline, 5 mg of IV ephedrine was administered as rescue vasopressor. The incidence of hypotension, total number of hypotension episodes, the number of patients requiring ephedrine, the mean amount of ephedrine consumption and side effects were recorded. Results: There was no statistically significant difference in incidence of maternal hypotension between groups. The number of patients requiring ephedrine was significantly greater in group saline than in group phenylephrine (p Conclusion: There is no statistically significant difference in incidence of hypotension and ephedrine consumption during spinal anesthesia for cesarean delivery with the use of epinephrine when compared to norepinephrine or phenylephrine. Epinephrine can be considered as an alternative agent for management of spinal hypotension.
- Published
- 2020