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5. Interventions for the discharge of older people to their home from the emergency department: a systematic review.

Author

Elliott, R, Mei, J, Wormleaton, N, Fry, M, Elliott, R, Mei, J, Wormleaton, N, and Fry, M

Abstract

Background

Clinicians have limited evidence on which to base their practice to effectively discharge older people from emergency. The aim of the review was to assess the effectiveness of interventions used for the discharge of older people from the emergency department to their home in the community by emergency clinicians.

Methods

The PRISMA guidelines were followed. The search comprised seven databases including CINAHL Complete, Medline and EMBASE, and additionally unpublished literature sources including trial registries and theses databases. The results were presented for three outcomes: mortality; emergency department representation after the index visit; and physical function. A narrative analysis was performed.

Results

Twenty-five studies met the inclusion criteria; 13 RCTs and 12 quasi-experimental. Risk of bias was moderate to high. There was a trend towards reduced probability of representing to the emergency department within 3 months of the index visit for individualised focussed elder discharge health interventions. Results were equivocal for other outcomes.

Conclusions

Greater clarity and consensus is needed to determine the most appropriate discharge measures, screening tools, information sources and discharge roles for the emergency setting. Rigorous multicentre trials to improve the evidence on which to base this aspect of emergency care are required.

Published
2021

6. Rivaroxaban Compared with Standard Anticoagulants for the Treatment of Acute Venous Thromboembolism in Children: a Randomised, Controlled, Phase 3 Trial

Author

Male, C., Lensing, A. W. A., Palumbo, J. S., Kumar, R., Nurmeev, I., Hege, K., Bonnet, D., Connor, P., Hooimeijer, H. L., Torres, M., Chan, A. K. C., Kenet, G., Holzhauer, S., Santamaría, A., Amedro, P., Chalmers, E., Simioni, P., Bhat, R. V., Yee, D. L., Lvova, O., Beyer-Westendorf, J., Biss, T. T., Martinelli, I., Saracco, P., Peters, M., Kállay, K., Gauger, C. A., Massicotte, M. P., Young, G., Pap, A. F., Majumder, M., Smith, W. T., Heubach, J. F., Berkowitz, S. D., Thelen, K., Kubitza, D., Crowther, M., Prins, M. H., Monagle, P., Molinari, A. C., Nowak, Göttl, U., Chain, J., Robertson, J., Thom, K., Streif, W., Schwarz, R., Schmitt, K., Grangl, G., Van Damme, A., Maes, P., Labarque, V., Petrilli, A., Loggeto, S., Azeka, E., Brandao, L., Le, D., Sabapathy, C., Giordano, P., Wu, R., Ding, J., Huang, W., Mao, J., Lähteenmäki, P., Decramer, S., Bernig, T., Chada, M., Chan, G., Kally, K., Nolan, B., Revel-Vilk, S., Tamary, H., Levin, C., Tormene, D., Abbattista, M., Artoni, A., Ikeyama, T., Inuzuka, R., Yasukochi, S., Morales Soto, M., Solis Labastida, K. A., Suijker, M. H., Bartels, M., Tamminga, R. Y., Van Ommen, C. H., Te Loo, D. M., Anjos, R., Zubarovskaya, L., Popova, N., Samochatova, E., Belogurova, M., Svirin, P., Shutova, T., Lebedev, V., Barbarash, O., Koh, P. L., Mei, J. C., Podracka, L., Berrueco, R., Fernandez, M. F., Frisk, T., Grunt, S., Rischewski, J., Albisetti-Pedroni, M., Antmen, A., Tokgoz, H., Karakas, Z., Motwani, J., Williams, M., Grainger, J., Payne, J., Richards, M., Baird, S., Bhatnagar, N., Aramburo, A., Crary, S., Wynn, T., Carpenter, S., Ahuja, S., Goldenberg, N., Woods, G., Godder, K., Scott-Emuakpor, A., Roach, G., Raffini, L., Shah, N., Shah, S., Thornburg, C., Zia, A., Berkow, R., Male, C., Lensing, A. W. A., Palumbo, J. S., Kumar, R., Nurmeev, I., Hege, K., Bonnet, D., Connor, P., Hooimeijer, H. L., Torres, M., Chan, A. K. C., Kenet, G., Holzhauer, S., Santamaría, A., Amedro, P., Chalmers, E., Simioni, P., Bhat, R. V., Yee, D. L., Lvova, O., Beyer-Westendorf, J., Biss, T. T., Martinelli, I., Saracco, P., Peters, M., Kállay, K., Gauger, C. A., Massicotte, M. P., Young, G., Pap, A. F., Majumder, M., Smith, W. T., Heubach, J. F., Berkowitz, S. D., Thelen, K., Kubitza, D., Crowther, M., Prins, M. H., Monagle, P., Molinari, A. C., Nowak, Göttl, U., Chain, J., Robertson, J., Thom, K., Streif, W., Schwarz, R., Schmitt, K., Grangl, G., Van Damme, A., Maes, P., Labarque, V., Petrilli, A., Loggeto, S., Azeka, E., Brandao, L., Le, D., Sabapathy, C., Giordano, P., Wu, R., Ding, J., Huang, W., Mao, J., Lähteenmäki, P., Decramer, S., Bernig, T., Chada, M., Chan, G., Kally, K., Nolan, B., Revel-Vilk, S., Tamary, H., Levin, C., Tormene, D., Abbattista, M., Artoni, A., Ikeyama, T., Inuzuka, R., Yasukochi, S., Morales Soto, M., Solis Labastida, K. A., Suijker, M. H., Bartels, M., Tamminga, R. Y., Van Ommen, C. H., Te Loo, D. M., Anjos, R., Zubarovskaya, L., Popova, N., Samochatova, E., Belogurova, M., Svirin, P., Shutova, T., Lebedev, V., Barbarash, O., Koh, P. L., Mei, J. C., Podracka, L., Berrueco, R., Fernandez, M. F., Frisk, T., Grunt, S., Rischewski, J., Albisetti-Pedroni, M., Antmen, A., Tokgoz, H., Karakas, Z., Motwani, J., Williams, M., Grainger, J., Payne, J., Richards, M., Baird, S., Bhatnagar, N., Aramburo, A., Crary, S., Wynn, T., Carpenter, S., Ahuja, S., Goldenberg, N., Woods, G., Godder, K., Scott-Emuakpor, A., Roach, G., Raffini, L., Shah, N., Shah, S., Thornburg, C., Zia, A., and Berkow, R.

Abstract

Background: Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. The aim of our study was to compare the efficacy and safety of rivaroxaban versus standard anticoagulants in children with venous thromboembolism. Methods: In a multicentre, parallel-group, open-label, randomised study, children (aged 0–17 years) attending 107 paediatric hospitals in 28 countries with documented acute venous thromboembolism who had started heparinisation were assigned (2:1) to bodyweight-adjusted rivaroxaban (tablets or suspension) in a 20-mg equivalent dose or standard anticoagulants (heparin or switched to vitamin K antagonist). Randomisation was stratified by age and venous thromboembolism site. The main treatment period was 3 months (1 month in children <2 years of age with catheter-related venous thromboembolism). The primary efficacy outcome, symptomatic recurrent venous thromboembolism (assessed by intention-to-treat), and the principal safety outcome, major or clinically relevant non-major bleeding (assessed in participants who received ≥1 dose), were centrally assessed by investigators who were unaware of treatment assignment. Repeat imaging was obtained at the end of the main treatment period and compared with baseline imaging tests. This trial is registered with ClinicalTrials.gov, number NCT02234843 and has been completed. Findings: From Nov 14, 2014, to Sept 28, 2018, 500 (96%) of the 520 children screened for eligibility were enrolled. After a median follow-up of 91 days (IQR 87–95) in children who had a study treatment period of 3 months (n=463) and 31 days (IQR 29–35) in children who had a study treatment period of 1 month (n=37), symptomatic recurrent venous thromboembolism occurred in four (1%) of 335 children receiving rivaroxaban and five (3%) of 165 receiving standard anticoagulants (hazard ratio [HR] 0·40, 95% CI 0·11–1·41). Repeat imaging showed an improved eff

Published
2020

10. Hanzhong bronzes and highly radiogenic lead in Shang period China

Author

Chen, K, Mei, J, Rehren, T, Liu, S, Yang, W, Martinón-Torres, M, Zhao, C, Hirao, Y, Chen, J, Liu, Y, Mei, Jianjun [0000-0001-8942-8633], Martinon-Torres, Marcos [0000-0003-2124-2837], and Apollo - University of Cambridge Repository

Subjects
Lead isotopes, China, Regional specialisation, Bronze, Provenance, Shang, Highly radiogenic lead, Multiple-direction exchange
Abstract

© 2018 Elsevier Ltd For decades, the origin of the bronzes with distinct highly radiogenic lead isotopic ratios in Shang period China has been a puzzle. This paper presents new lead isotope data for bronze objects from the Hanzhong region, one of the key regional bronze cultures during Shang period China. On the basis of a synthetical investigation of the typological, chemical and lead isotopic features of Hanzhong bronzes and their relations to other regional bronze cultures, we propose the Qinling area as a potential region of origin for the metals containing highly radiogenic lead used by several contemporaneous but culturally/politically distinct entities across a vast territory. Taking into account both archaeological and geological evidence, this working hypothesis draws attention not merely to the geological provenance of metal resources, but also to the mechanisms of metal production and circulation as well as broader social-economic dynamics.

Published
2019
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11. Meteoritic origin and manufacturing process of iron blades in two Bronze Age bimetallic objects from China

Author

Chen, K, Wang, Y, Liu, Y, Mei, J, Jiang, T, Mei, Jianjun [0000-0001-8942-8633], and Apollo - University of Cambridge Repository

Subjects
Meteoritic iron, Bronze Age China, Bimetallic artefact, Hot-work, Recrystallization
Abstract

It is widely accepted that meteoritic iron was the first iron alloy used by mankind, however, the manufacturing processes of the earliest iron artefacts remain uncertain and sometimes disputed. Here, we present both chemical and microanalytical results of samples from two bimetallic objects from Bronze Age central China. It is confirmed that the blades were made of meteoritic iron. In-situ photomicrograph and detailed microanalysis provides solid evidence for the cast-on and hot-work processes. We also demonstrate that significant information can be extracted through multiple analyses despite the severely corroded condition of ancient iron objects.

Published
2018

13. First-in-human study of the monopolar spindle 1 (Mps1) kinase inhibitor BAY 1161909 in combination with paclitaxel in subjects with advanced malignancies

Author

Lorusso, P., primary, Chawla, S.P., additional, Bendell, J., additional, Shields, A.F., additional, Shapiro, G., additional, Rajagopalan, P., additional, Cyris, C., additional, Bruns, I., additional, Mei, J., additional, Souza, F., additional, Rasco, D., additional, Eder, J.P., additional, and Tolcher, A.W., additional

Published
2018
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16. Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes☆

Author

Yan Ma, Mark J. Nijland, Stephen P. Ford, Bret W. Hess, Peter W. Nathanielsz, Mei J. Zhu, and Adam B. Uthlaut

Subjects
Blood Glucose, CD36 Antigens, Leptin, Male, medicine.medical_specialty, Placenta, medicine.medical_treatment, CD36, Blotting, Western, Biology, Fatty Acid-Binding Proteins, Article, Random Allocation, chemistry.chemical_compound, Fetus, Pregnancy, Internal medicine, medicine, Animals, Insulin, RNA, Messenger, Protein kinase B, Glucose Transporter Type 1, Glucose Transporter Type 4, Sheep, Triglyceride, Reverse Transcriptase Polymerase Chain Reaction, Body Weight, Glucose transporter, Obstetrics and Gynecology, Fatty Acid Transport Proteins, Up-Regulation, Endocrinology, Fetal Weight, Reproductive Medicine, chemistry, biology.protein, Female, GLUT1, Food Deprivation, Signal Transduction, Developmental Biology, GLUT3
Abstract

Multiparous ewes received 100% (control, C, n = 13) or 50% (nutrient restricted, NR, n = 14) of NRC dietary requirements from d28-d78 of gestation. On d78, 5 C and 6 NR ewes were necropsied. The remaining 8 C and 8 NR ewes were fed to 100% of NRC from d78-d135 and necropsied. Maternal blood was collected at both necropsies and at weekly intervals for assay of glucose, insulin and leptin. Fetal blood was collected at d78 and d135 necropsies for assay of glucose and lipids. Cotyledonary (COT) tissue was evaluated for protein and mRNA expression [fatty acid transporter (FATP)1, FATP4, CD36, glucose transporter (GLUT)1 and GLUT3], mRNA expression only [placenta fatty acid binding protein (FABPpm) and lipoprotein lipase (LPL)], or expression of phosphorylated and total protein forms [AMP kinase (AMPK)α, acetyl-CoA carboxylase (ACC), extracellular signal-regulated kinase (Erk)1/2, mammalian target of rapamycin (mTOR) and protein kinase B (Akt)]. On d78, but not d135, placental and fetal weights were reduced (P < 0.05) in NR vs. C ewes. Maternal circulating glucose, insulin and leptin levels were decreased in NR vs. C ewes on d78 (P < 0.05) but similar at d135. Fetal blood glucose and triglyceride levels were lower in NR vs. C ewes (P < 0.05) on d78, but similar on d135. On d78, GLUT1, FATP4, CD36 mRNA and protein expression levels, FABPpm mRNA level, and leptin protein level were all increased (P < 0.05) in COT of NR vs. C ewes. AMPK, ACC, and Erk1/2 activities were also increased (P < 0.05) in NR vs. C COT on d78. In contrast, only FATP4 was increased (P < 0.05) at both the mRNA and protein levels in COT of NR realimented vs. C ewes on d135. These data demonstrate placental adaptation to maternal NR through increasing nutrient transporter production and growth signaling activity.

Published
2011

17. Cellular signaling pathways regulating the initial stage of adipogenesis and marbling of skeletal muscle

Author

Mei J. Zhu, Min Du, and Jingdong Yin

Subjects
medicine.medical_specialty, Meat, Time Factors, Marbled meat, Adipose tissue, Biology, chemistry.chemical_compound, Adipocyte, Internal medicine, medicine, Animals, Muscle, Skeletal, Bone morphogenesis, Adipogenesis, Wnt signaling pathway, food and beverages, Skeletal muscle, Mesenchymal Stem Cells, Dietary Fats, Endocrinology, medicine.anatomical_structure, chemistry, Animals, Domestic, Intramuscular fat, Signal Transduction, Food Science
Abstract

Due to extensive efforts to increase lean growth, intramuscular fat (marbling) is reducing in beef, pork and chicken breast, which impairs the eating quality of meat. Because fat is the major contributor to meat flavor, the presence of intramuscular fat is indispensible for the high eating quality of meat. However, up to now, our understanding of adipogenesis (formation of fat cells) in skeletal muscle is limited. Adipocyte differentiation in skeletal muscle initiates from multipotent mesenchymal stem cells, which are abundant in skeletal muscle at early developmental stages. In this review, the known cellular mechanisms regulating adipogenesis from multipotent cells are summarized, which include hedgehog, Wingless and Int (Wnt)/beta-catenin, and bone morphogenesis protein (BMP) mediated signaling pathways, as well as AMP-activated protein kinase. Promoting adipogenesis within skeletal muscle will effectively increase intramuscular fat, improving the quality of meat.

Published
2010

18. Average values of L-functions in characteristic two

Author

Yen Mei J. Chen

Subjects
Discrete mathematics, Pure mathematics, Quadratic function fields, Algebra and Number Theory, Gauss, Quadratic function, Function (mathematics), Algebraic number field, Lipschitz continuity, Quadratic equation, L-functions, Orders, Binary quadratic form, Quadratic field, Mathematics, Class numbers
Abstract

Gauss made two conjectures about average values of class numbers of orders in quadratic number fields, later on proven by Lipschitz and Siegel. A version for function fields of odd characteristic was established by Hoffstein and Rosen. In this paper, we extend their results to the case of even characteristic. More precisely, we obtain formulas of average values of L -functions associated to orders in quadratic function fields over a constant field of characteristic two, and then derive formulas of average class numbers of these orders.

Published
2008
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22. On Primitive Roots of One-Dimensional Tori

Author

Yen Mei J. Chen

Subjects
primitive roots, density, Algebra and Number Theory, Conjecture, Modulo, torus, Torus, Artin's conjecture on primitive roots, Algebra, Combinatorics, Riemann hypothesis, symbols.namesake, symbols, Point (geometry), quadratic fields, Primitive root modulo n, Mathematics
Abstract

We exploit an analogue of Artin's primitive roots conjecture for one-dimensional tori over Q. Let T be a one-dimensional torus over Q, and let P∈T(Q) be a nontorsion point. Under Generalized Riemann Hypothesis, we derive an explicit density formula for the set of rational primes ℓ such that P modulo ℓ generates T(Fℓ).

Published
2002

23. A study on the α-amylase fermentation performed by Bacillus amyloliquefaciens

Author

Mei J. Syu and Yu H. Chen

Subjects
chemistry.chemical_classification, biology, Bacillus amyloliquefaciens, Starch, General Chemical Engineering, food and beverages, Substrate (chemistry), General Chemistry, biology.organism_classification, Industrial and Manufacturing Engineering, Reducing sugar, chemistry.chemical_compound, Hydrolysis, chemistry, Biochemistry, biology.protein, Environmental Chemistry, Fermentation, Amylase, Food science, Aeration
Abstract

α -Amylase fermentation with soluble starch as the limiting substrate was performed by Bacillus amyloliquefaciens . We investigated the influence, of the presence of α -amylase, on the hydrolysis of different starch concentrations. Both the initial and average rates for the hydrolysis of starch under different initial conditions were compared and calculated. The time for the completion of starch hydrolysis was also obtained. Effects of kinetic factors, such as pH of 5.5, 6.3, 7.0 and temperature of 30 °C and 37 °C, on the performance of α -amylase fermentation were studied. The influence of the dynamic variables, such as agitation speed and aeration rate, on this fermentation were also evaluated and are discussed. The variations of cell mass, α -amylase activity, and reducing sugar with regard to the step changes of aeration rates during a batch fermentation are also discussed. The optimal conditions of these variables have been determined.

Published
1997

24. Impact of Immunoglobulin (Ig) D Subtype on the Efficacy and Safety of Lenalidomide Plus Low-Dose Dexamethasone (Rd) in Chinese Patients (Pts) With Relapsed/Refractory Multiple Myeloma (RRMM): MM-021 Trial

Author

Cai, Z., primary, Jin, J., additional, Du, X., additional, Chen, F., additional, Zhou, D.-b., additional, Yu, L., additional, Ke, X., additional, Li, X., additional, Wu, D., additional, Meng, F., additional, DeMarco, D., additional, Zhang, J., additional, Mei, J., additional, and Hou, J., additional

Published
2015
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25. Efficacy and Safety of Lenalidomide (LEN) Plus Low-Dose Dexamethasone (DEX; Rd) in Chinese Patients (Pts) With Relapsed/Refractory Multiple Myeloma (RRMM) According to Disease Stage (International Staging System [ISS]): Results From the MM-021 Trial and MM-024 Extended Access Program (EAP)

Author

Hou, J., primary, Cai, Z., additional, Jin, J., additional, Chen, F., additional, Zhou, D.B., additional, Yu, L., additional, Ke, X., additional, Li, X., additional, Wu, D., additional, Meng, F., additional, DeMarco, D., additional, Zhang, J., additional, Mei, J., additional, and Du, X., additional

Published
2015
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26. Safety of Lenalidomide (LEN) Plus Low-Dose Dexamethasone (DEX; Rd) in Chinese Patients (Pts) With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With Prior Thalidomide (THAL) and Bortezomib (BORT): Subanalysis of the MM-024 Extended Access Program (EAP)

Author

Yu, L., primary, Cai, Z., additional, Jin, J., additional, Du, X., additional, Chen, F., additional, Zhou, D.-b., additional, Ke, X., additional, Li, X., additional, Wu, D., additional, Meng, F., additional, DeMarco, D., additional, Zhang, J., additional, Mei, J., additional, and Hou, J., additional

Published
2015
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29. Determination of the parahydrogen fraction in a liquid hydrogen target using energy-dependent slow neutron transmission

Author

Barrón-Palos, L., primary, Alarcon, R., additional, Balascuta, S., additional, Blessinger, C., additional, Bowman, J.D., additional, Chupp, T.E., additional, Covrig, S., additional, Crawford, C.B., additional, Dabaghyan, M., additional, Dadras, J., additional, Dawkins, M., additional, Fox, W., additional, Gericke, M.T., additional, Gillis, R.C., additional, Lauss, B., additional, Leuschner, M.B., additional, Lozowski, B., additional, Mahurin, R., additional, Mason, M., additional, Mei, J., additional, Nann, H., additional, Penttilä, S.I., additional, Ramsay, W.D., additional, Salas-Bacci, A., additional, Santra, S., additional, Seo, P.-N., additional, Sharma, M., additional, Smith, T., additional, Snow, W.M., additional, Wilburn, W.S., additional, and Yuan, V., additional

Published
2011
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37. A liquid parahydrogen target for the measurement of a parity-violating gamma asymmetry in

Author

Santra, S., primary, Barrón Palos, L., additional, Blessinger, C., additional, Bowman, J.D., additional, Chupp, T.E., additional, Covrig, S., additional, Crawford, C., additional, Dabaghyan, M., additional, Dadras, J., additional, Dawkins, M., additional, Gericke, M.T., additional, Fox, W., additional, Gillis, R.C., additional, Leuschner, M.B., additional, Lozowski, B., additional, Mahurin, R., additional, Mason, M., additional, Mei, J., additional, Nann, H., additional, Penttila, S.I., additional, Salas-Bacci, A., additional, Sharma, M., additional, Snow, W.M., additional, and Wilburn, W.S., additional

Published
2010
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39. Parity violation in neutron–proton capture—The NPDGamma experiment

Author

Gericke, Michael, primary, Page, S., additional, Ramsay, D., additional, Alarcon, R., additional, Balascuta, S., additional, Barron, L., additional, Bowman, J.D., additional, Carlini, R.D., additional, Chen, W., additional, Chupp, T.E., additional, Crawford, C., additional, Covrig, S., additional, Dabaghyan, M., additional, Freedman, S.J., additional, Gentile, T.R., additional, Gillis, R.C., additional, Greene, G.L., additional, Hersman, F.W., additional, Ino, T., additional, Jones, G.L., additional, Lauss, B., additional, Leuschner, M., additional, Losowki, B., additional, Mahurin, R., additional, Masuda, Y., additional, Mei, J., additional, Mitchell, G.S., additional, Muto, S., additional, Nann, H., additional, Penttilä, S.I., additional, Salas-Bacci, A., additional, Santra, S., additional, Seo, P.-N., additional, Sharapov, E., additional, Sharma, M., additional, Smith, T., additional, Snow, W.M., additional, Wilburn, W.S., additional, and Yuan, V., additional

Published
2009
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