1. In vitro PAI-1 inhibitory activity of oxalamide derivatives☆
- Author
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Soma Srivastava, Ajay Sharma, Hiteshkumar Soni, Mehul Raviya, Bhavesh Parmar, Ganes Chakrabarti, Mukul R. Jain, Vrajesh Pandya, Pankaj R. Patel, and Shankar Jayram Shetty
- Subjects
Pharmacology ,chemistry.chemical_classification ,Oxamic Acid ,Serine Proteinase Inhibitors ,biology ,T-plasminogen activator ,Chromogenic ,Stereochemistry ,Organic Chemistry ,Biological activity ,General Medicine ,Inhibitory postsynaptic potential ,Amides ,Chemical synthesis ,In vitro ,Inhibitory Concentration 50 ,Enzyme ,chemistry ,Biochemistry ,Enzyme inhibitor ,Tissue Plasminogen Activator ,Plasminogen Activator Inhibitor 1 ,Drug Discovery ,biology.protein ,Humans - Abstract
A number of oxalamide derivatives have been synthesized and evaluated for PAI-1 inhibitory activity. In vitro PAI-1 inhibitory activities of oxalamide derivatives are evaluated by chromogenic assay. Few compounds have shown significant PAI-1 inhibitory activity.
- Published
- 2008
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