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Your search keyword '"McKeigue, Paul M."' showing total 23 results
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23 results on '"McKeigue, Paul M."'

1. Ongoing burden and recent trends in severe hospitalised hypoglycaemia events in people with type 1 and type 2 diabetes in Scotland: A nationwide cohort study 2016–2022

Author

Berthon, William, primary, McGurnaghan, Stuart J., additional, Blackbourn, Luke A.K., additional, Mellor, Joseph, additional, Gibb, Fraser W., additional, Heller, Simon, additional, Kennon, Brian, additional, McCrimmon, Rory J., additional, Philip, Sam, additional, Sattar, Naveed, additional, McKeigue, Paul M., additional, and Colhoun, Helen M., additional

Published
2024
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3. Can deep learning on retinal images augment known risk factors for cardiovascular disease prediction in diabetes? A prospective cohort study from the national screening programme in Scotland

Author

Mellor, Joseph, primary, Jiang, Wenhua, additional, Fleming, Alan, additional, McGurnaghan, Stuart J, additional, Blackbourn, Luke, additional, Styles, Caroline, additional, Storkey, Amos J, additional, McKeigue, Paul M, additional, and Colhoun, Helen M, additional

Published
2023
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6. Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland

Author

McGurnaghan, Stuart J, primary, Weir, Amanda, additional, Bishop, Jen, additional, Kennedy, Sharon, additional, Blackbourn, Luke A K, additional, McAllister, David A, additional, Hutchinson, Sharon, additional, Caparrotta, Thomas M, additional, Mellor, Joseph, additional, Jeyam, Anita, additional, O'Reilly, Joseph E, additional, Wild, Sarah H, additional, Hatam, Sara, additional, Höhn, Andreas, additional, Colombo, Marco, additional, Robertson, Chris, additional, Lone, Nazir, additional, Murray, Janet, additional, Butterly, Elaine, additional, Petrie, John, additional, Kennon, Brian, additional, McCrimmon, Rory, additional, Lindsay, Robert, additional, Pearson, Ewan, additional, Sattar, Naveed, additional, McKnight, John, additional, Philip, Sam, additional, Collier, Andrew, additional, McMenamin, Jim, additional, Smith-Palmer, Alison, additional, Goldberg, David, additional, McKeigue, Paul M, additional, Colhoun, Helen M, additional, Whettlock, Alice, additional, McLeod, Allan, additional, Gasiorowski, Andrew, additional, Merrick, Andrew, additional, McAuley, Andy, additional, Went, April, additional, Purdie, Calum, additional, Fischbacher, Colin, additional, Ramsey, Colin, additional, Bailey, David, additional, Henderson, David, additional, McDonald, Eisin, additional, Drennan, Genna, additional, Gowans, Graeme, additional, Reid, Graeme, additional, Murdoch, Heather, additional, Carruthers, Jade, additional, Murray, Josie, additional, Heatlie, Karen, additional, Donaldson, Lorraine, additional, Paton, Martin, additional, Reid, Martin, additional, Llano, Melissa, additional, Murphy-Hall, Michelle, additional, Hall, Ross, additional, Cameron, Ross, additional, Brownlie, Susan, additional, Gaffney, Adam, additional, Milne, Aynsley, additional, Sullivan, Christopher, additional, McArdle, Edward, additional, Glass, Elaine, additional, Young, Johanna, additional, Malcolm, William, additional, and McCoubrey, Jodie, additional

Published
2021
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7. COVID-19 Disease in People with Diabetes in Scotland: Incidence, Severity and Risk Stratification Using Matched Case-Control and Prospective Cohort Studies

Author

McGurnaghan, Stuart J, primary, Weir, Amanda, additional, Bishop, Jen, additional, Kennedy, Sharon, additional, Blackbourn, Luke AK, additional, Hutchinson, Sharon, additional, Caparrotta, Thomas M, additional, Mellor, Joseph, additional, Jeyam, Anita, additional, O’Reilly, Joseph E, additional, Wild, Sarah, additional, Hatam, Sara, additional, Höhn, Andreas, additional, Colombo, Marco, additional, Robertson, Chris, additional, Lone, Nazir I., additional, Murray, Janet, additional, Butterly, Elaine, additional, Petrie, John, additional, Kennon, Brian, additional, McCrimmon, Rory, additional, Lindsay, Robert, additional, Pearson, Ewan, additional, Sattar, Naveed, additional, McKnight, John, additional, Samuel, Ashirwad Philip, additional, Collier, Andrew, additional, McMenamin, Jim, additional, Smith-Palmer, Alison, additional, Goldberg, David, additional, McKeigue, Paul M, additional, Colhoun, Helen M, additional, and Group, Scottish Diabetes Research Network, additional

Published
2020
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8. Apolipoprotein CIII and N-terminal prohormone b-type natriuretic peptide as independent predictors for cardiovascular disease in type 2 diabetes

Author

Colombo, Marco, primary, Looker, Helen C., additional, Farran, Bassam, additional, Agakov, Felix, additional, Brosnan, M.Julia, additional, Welsh, Paul, additional, Sattar, Naveed, additional, Livingstone, Shona, additional, Durrington, Paul N., additional, Betteridge, D.John, additional, McKeigue, Paul M., additional, and Colhoun, Helen M., additional

Published
2018
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9. Biomarkers of rapid chronic kidney disease progression in type 2 diabetes

Author

Looker, Helen C, Colombo, Marco, Hess, Sibylle, Brosnan, Mary J, Farran, Bassam, Dalton, R Neil, Wong, Max C, Turner, Charles, Palmer, Colin NA, Nogoceke, Everson, Groop, Leif, Salomaa, Veikko, Dunger, David B, Agakov, Felix, McKeigue, Paul M, Colhoun, Helen M, SUMMIT Investigators, Dunger, David [0000-0002-2566-9304], and Apollo - University of Cambridge Repository

Subjects
Aged, 80 and over, Male, Time Factors, Reproducibility of Results, Kidney, Logistic Models, Diabetes Mellitus, Type 2, ROC Curve, Scotland, Predictive Value of Tests, Risk Factors, Area Under Curve, Case-Control Studies, Disease Progression, Odds Ratio, Humans, Diabetic Nephropathies, Female, Prospective Studies, Renal Insufficiency, Chronic, Biomarkers, Aged, Glomerular Filtration Rate
Abstract

Here we evaluated the performance of a large set of serum biomarkers for the prediction of rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. We used a case-control design nested within a prospective cohort of patients with baseline eGFR 30-60 ml/min per 1.73 m(2). Within a 3.5-year period of Go-DARTS study patients, 154 had over a 40% eGFR decline and 153 controls maintained over 95% of baseline eGFR. A total of 207 serum biomarkers were measured and logistic regression was used with forward selection to choose a subset that were maximized on top of clinical variables including age, gender, hemoglobin A1c, eGFR, and albuminuria. Nested cross-validation determined the best number of biomarkers to retain and evaluate for predictive performance. Ultimately, 30 biomarkers showed significant associations with rapid progression and adjusted for clinical characteristics. A panel of 14 biomarkers increased the area under the ROC curve from 0.706 (clinical data alone) to 0.868. Biomarkers selected included fibroblast growth factor-21, the symmetric to asymmetric dimethylarginine ratio, β2-microglobulin, C16-acylcarnitine, and kidney injury molecule-1. Use of more extensive clinical data including prebaseline eGFR slope improved prediction but to a lesser extent than biomarkers (area under the ROC curve of 0.793). Thus we identified several novel associations of biomarkers with CKD progression and the utility of a small panel of biomarkers to improve prediction.

Published
2015

10. Biomarkers of rapid chronic kidney disease progression in type 2 diabetes

Author

Looker, Helen C., primary, Colombo, Marco, additional, Hess, Sibylle, additional, Brosnan, Mary J., additional, Farran, Bassam, additional, Dalton, R. Neil, additional, Wong, Max C., additional, Turner, Charles, additional, Palmer, Colin N.A., additional, Nogoceke, Everson, additional, Groop, Leif, additional, Salomaa, Veikko, additional, Dunger, David B., additional, Agakov, Felix, additional, McKeigue, Paul M., additional, and Colhoun, Helen M., additional

Published
2015
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12. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)

Author

Deshmukh, Harshal A., primary, Colhoun, Helen M., additional, Johnson, Toby, additional, McKeigue, Paul M., additional, Betteridge, D. John, additional, Durrington, Paul N., additional, Fuller, John H., additional, Livingstone, Shona, additional, Charlton-Menys, Valentine, additional, Neil, Andrew, additional, Poulter, Neil, additional, Sever, Peter, additional, Shields, Denis C., additional, Stanton, Alice V., additional, Chatterjee, Aurobindo, additional, Hyde, Craig, additional, Calle, Roberto A., additional, DeMicco, David A., additional, Trompet, Stella, additional, Postmus, Iris, additional, Ford, Ian, additional, Jukema, J. Wouter, additional, Caulfield, Mark, additional, and Hitman, Graham A., additional

Published
2012
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13. A Genomewide Admixture Mapping Panel for Hispanic/Latino Populations

Author

Mao, Xianyun, primary, Bigham, Abigail W., additional, Mei, Rui, additional, Gutierrez, Gerardo, additional, Weiss, Ken M., additional, Brutsaert, Tom D., additional, Leon-Velarde, Fabiola, additional, Moore, Lorna G., additional, Vargas, Enrique, additional, McKeigue, Paul M., additional, Shriver, Mark D., additional, and Parra, Esteban J., additional

Published
2007
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