1. Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort
- Author
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Guillaume Bonnet, Gauthier Giordano, Théo Pezel, Delphine Mika, Thomas Delmotte, Louis Potier, Laura Geneste, Pascale Chemaly, Wassima Marsou, Orianne Weizman, Thibaut Pommier, Alexandre Gautier, Maxime Vignac, Aurélie Carlier, Willy Sutter, Pierre Guilleminot, Sophie Ribeyrolles, Charles Fauvel, Sabir Attou, Vassili Panagides, Antoine Deney, Joffrey Cellier, Ronan Roussel, Antonin Trimaille, Ariel Cohen, Audrey Sagnard, Corentin Chaumont, Baptiste Duceau, Clément Karsenty, and Julie Pastier
- Subjects
Male ,Endocrinology, Diabetes and Metabolism ,Comorbidity ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,Endocrinology ,law ,Medicine ,Hospital Mortality ,COVID-19, coronavirus disease 2019 ,Aged, 80 and over ,Propensity score-matching ,Diabetes ,Hazard ratio ,General Medicine ,Middle Aged ,ICU, intensive care unit ,Intensive care unit ,Intensive Care Units ,Cohort ,Female ,Original Article ,France ,Covid-19 ,Cohort study ,Patient Transfer ,medicine.medical_specialty ,030209 endocrinology & metabolism ,SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 ,03 medical and health sciences ,RAS, renin–angiotensin system ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Internal Medicine ,Humans ,Medical history ,PSM, propensity score-matching ,Mortality ,Propensity Score ,Aged ,Retrospective Studies ,SARS-CoV-2 ,business.industry ,Retrospective cohort study ,Length of Stay ,medicine.disease ,Propensity score matching ,business - Abstract
Background Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19. Methods This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients’ characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group). The primary outcome was admission to an intensive care unit (ICU) and/or in-hospital death. Results After PSM, all baseline characteristics were well balanced between those with and without diabetes: mean age was 71.2 years; 61.8% were male; and mean BMI was 29 kg/m2. A history of cardiovascular, chronic kidney and chronic obstructive pulmonary diseases were found in 32.8%, 22.1% and 6.4% of participants, respectively. The risk of experiencing the primary outcome was similar in patients with or without diabetes [hazard ratio (HR): 1.16, 95% confidence interval (CI): 0.95–1.41; P = 0.14], and was 1.29 (95% CI: 0.97–1.69) for in-hospital death, 1.26 (95% CI: 0.9–1.72) for death with no transfer to an ICU and 1.14 (95% CI: 0.88–1.47) with transfer to an ICU. Conclusion In this retrospective study cohort of patients hospitalized for COVID-19, diabetes was not significantly associated with a higher risk of severe outcomes after PSM. Trial registration number NCT04344327.
- Published
- 2021
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