1. The inflammatory markers sST2, HSP27 and hsCRP as a prognostic biomarker panel in chronic heart failure patients
- Author
-
Elisabeth Simader, Matthias Zimmermann, Bernhard Moser, Mitja Lainscak, Denise Traxler, Varius Dannenberg, Borut Jug, Michael Mildner, Thomas Mueller, Cecilia Veraar, and Hendrik Jan Ankersmit
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Clinical Biochemistry ,HSP27 Heat-Shock Proteins ,Independent predictor ,Biochemistry ,Cardiovascular death ,03 medical and health sciences ,0302 clinical medicine ,Median follow-up ,Internal medicine ,medicine ,Humans ,Prognostic biomarker ,Receptors, Immunologic ,Heat-Shock Proteins ,Retrospective Studies ,Cardiovascular mortality ,Heart Failure ,Proportional hazards model ,business.industry ,Biochemistry (medical) ,General Medicine ,Prognosis ,medicine.disease ,Interleukin-1 Receptor-Like 1 Protein ,C-Reactive Protein ,030104 developmental biology ,030220 oncology & carcinogenesis ,Heart failure ,business ,Risk assessment ,Biomarkers ,Molecular Chaperones - Abstract
The inflammatory markers sST2, HSP27 and hsCRP have already been identified as prognostic markers in chronic heart failure (HF). Though individual biomarkers have proven their value in mortality risk prediction, the role of a multimarker strategy needs further evaluation.This is an exploratory reanalysis in chronic HF patients. Plasma HSP27, sST2 and hsCRP in outpatients with chronic HF were analysed. Patients were followed for a minimum of twelve months for the endpoint cardiovascular mortality and unplanned HF associated hospitalisation (=event). 15 year overall mortality was assessed retrospectively. The prognostic impact was assessed using a Cox proportional hazard model.113 chronic HF patients were included. Median follow up time was 614 days and 37 patients (32.7%) experienced an event. A Kaplan-Meier analysis revealed that patients with increased sST2, HSP27 and hsCRP levels have significantly worse prognosis (p 0.001). The use of a three-biomarker combination was superior in an independent risk prediction of an event (one high vs. two high: HR = 4.5, 95% CI: 1.3-15.5, p = 0.018; and one high vs. all high: HR = 9.8, 95% CI: 2.8-34.3, p 0.001) as shown in a multivariable cox proportional hazard model. However, the biomarker panel did not predict 15 year overall mortality, in contrast to elevated HSP27 levels (p = 0.012).The combination of all three markers is an independent predictor of cardiovascular death and unplanned HF associated hospitalisation but not overall mortality. Our findings suggest that adding those markers in combination to well established risk assessment parameters may improve risk stratification.
- Published
- 2020