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Your search keyword '"Massimo, L"' showing total 22 results
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22 results on '"Massimo, L"'

1. Anti-cancer activity of di- and tri-organotin(IV) compounds with D-(+)-Galacturonic acid on human tumor cells

Author

Attanzio, Alessandro, primary, Ippolito, Maristella, additional, Girasolo, Maria Assunta, additional, Saiano, Filippo, additional, Rotondo, Archimede, additional, Rubino, Simona, additional, Mondello, Luigi, additional, Capobianco, Massimo L., additional, Sabatino, Piera, additional, Tesoriere, Luisa, additional, and Casella, Girolamo, additional

Published
2018
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3. Monoelectronic reduction of dihydroartemsisinin (DHA): pH dependence and product analysis

Author

Giancarlo Marconi, Maria Luisa Navacchia, Mila D'Angelantonio, and Massimo L. Capobianco

Subjects
Chemistry, medicine.medical_treatment, Organic Chemistry, Dihydroartemisinin, Solvated electron, Photochemistry, Biochemistry, Product analysis, Malaria, gamma-Radiolysis, Reduction, Alkoxyl radicals, Drug Discovery, Radiolysis, medicine, Ph dependence
Abstract

The reaction of dihydroartemisinin (DHA) with solvated electrons (e(solv)(-)) generated under radiolytic conditions showed high pH dependence. The reduction performed under neutral conditions led to the formation of compound P1 deriving from the initial alkoxyl radical as the only detectable product. (C) 2013 Elsevier Ltd. All rights reserved.

Published
2013

4. Graphene oxide doped polysulfone membrane adsorbers for the removal of organic contaminants from water

Author

Zambianchi, Massimo, primary, Durso, Margherita, additional, Liscio, Andrea, additional, Treossi, Emanuele, additional, Bettini, Cristian, additional, Capobianco, Massimo L., additional, Aluigi, Annalisa, additional, Kovtun, Alessandro, additional, Ruani, Giampiero, additional, Corticelli, Franco, additional, Brucale, Marco, additional, Palermo, Vincenzo, additional, Navacchia, Maria Luisa, additional, and Melucci, Manuela, additional

Published
2017
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5. A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-l-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

Author

Girasolo, Maria Assunta, primary, Tesoriere, Luisa, additional, Casella, Girolamo, additional, Attanzio, Alessandro, additional, Capobianco, Massimo L., additional, Sabatino, Piera, additional, Barone, Giampaolo, additional, Rubino, Simona, additional, and Bonsignore, Riccardo, additional

Published
2017
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6. Interactions between Morpholinyl Anthracyclines and DNA

Author

Giovanni Ughetto, Francesco Paolo Colonna, Massimo L. Capobianco, Fiorella Bachechi, and Maurizio Cirilli

Subjects
Morpholino, Stereochemistry, Intercalation (chemistry), Random hexamer, chemistry.chemical_compound, chemistry, Structural Biology, Duplex (building), medicine, Moiety, Doxorubicin, Binding site, Molecular Biology, DNA, medicine.drug
Abstract

Anthracycline antibiotics daunomycin and adriamycin are among the most widely used in cancer chemotherapy and DNA is believed to be the primary target of their biological action. The crystal structure of a morpholino derivative of adriamycin bound to the DNA hexamer d(CGTACG) has been determined at 1.5 A resolution. The complex crystallizes in space group P1 with unit cell dimensions a = 18.01 A, b = 18.83 A, c = 27.65 A, alpha = 92.6 degrees, beta = 100.5 degrees, gamma = 94.9 degrees and there are two drug molecules bound per duplex. Morpholino derivatives differ greatly from their parent compounds in their biological and pharmacological properties. Structural comparison of this complex with the series of previously reported anthracycline-DNA complexes offers an opportunity for studying relationships between structure and function. The anthracycline chromophore intercalates at the CpG step and DNA distortions from a B-type conformation are similar to those observed in the other DNA-anthracycline complexes. Interactions between drug and DNA show no differences at the intercalation site, while in the minor groove they are significantly affected by the presence of the bulky morpholinyl moiety on the anthracycline amino sugar. The binding site involves four base-pairs and the absence of a positive charge on the amino sugar appears to influence the hydration pattern on both grooves. The two halves of the duplex are symmetrically related by a non-crystallographic 2-fold axis but they are not equivalent. In one half, one magnesium cluster bridges both drug and DNA, further stabilizing the complex.

Published
1993

15. Prostanoids from D-glucose. Palladium-catalyzed alkylation of 1,2-0-isopropylidene-3-deoxy-5-acetoxy-α-D-erythro-pent-5-en-furanose

Author

Achille Umani-Ronchi, Emilio Tagliavini, Diego Savoia, Elisabetta Mezzina, Massimo L. Capobianco, and Claudio Trombini

Subjects
chemistry.chemical_classification, Allylic rearrangement, Stereochemistry, Organic Chemistry, Diastereomer, chemistry.chemical_element, Alkylation, Furanose, Biochemistry, Catalysis, chemistry.chemical_compound, chemistry, Aldose, D-Glucose, Drug Discovery, Palladium
Abstract

Pd-Catalyzed CC bond forming reactions on an allylic acetate derived from D-glucose are performed to prepare potentially useful precursors of (R)-4-hydroxycyclopent-2-en-1-ones.

Published
1986

22. VINCRISTINE PLUS VINBLASTINE IN ACUTE CHILDHOOD LEUKqMIA

Author

Fossati-Guglielmoni A, Mori Pg, Massimo L, and Cottafava F

Subjects
Oncology, Vincristine, medicine.medical_specialty, Leukemia, business.industry, General Medicine, Vinblastine, Leukemia, Lymphoid, Childhood leukaemia, Leukemia, Myeloid, Acute, Internal medicine, Acute Disease, Humans, Medicine, Child, business, medicine.drug
Published
1969

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