Search

Your search keyword '"Martin, Sheree D"' showing total 6 results
Start Over Author "Martin, Sheree D" Publisher elsevier bv
6 results on '"Martin, Sheree D"'

2. Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Author

Gaur, Vidhi, primary, Connor, Timothy, additional, Sanigorski, Andrew, additional, Martin, Sheree D., additional, Bruce, Clinton R., additional, Henstridge, Darren C., additional, Bond, Simon T., additional, McEwen, Kevin A., additional, Kerr-Bayles, Lyndal, additional, Ashton, Trent D., additional, Fleming, Cassandra, additional, Wu, Min, additional, Pike Winer, Lisa S., additional, Chen, Denise, additional, Hudson, Gregg M., additional, Schwabe, John W.R., additional, Baar, Keith, additional, Febbraio, Mark A., additional, Gregorevic, Paul, additional, Pfeffer, Frederick M., additional, Walder, Ken R., additional, Hargreaves, Mark, additional, and McGee, Sean L., additional

Published
2016
Full Text
View/download PDF

3. Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

Author

Martin, Sheree D, Morrison, Shona, Konstantopoulos, Nciky, McGee, Sean L, Martin, Sheree D, Morrison, Shona, Konstantopoulos, Nciky, and McGee, Sean L

Abstract

The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to multiple forms of insulin resistance. However, some models of mitochondrial dysfunction fail to induce insulin resistance, suggesting greater complexity describes mitochondrial regulation of insulin action. We report that mitochondrial dysfunction is not necessary for cellular models of insulin resistance. However, impairment of mitochondrial function is sufficient for insulin resistance in a cell type-dependent manner, with impaired mitochondrial function inducing insulin resistance in adipocytes, but having no effect, or insulin sensitising effects in hepatocytes. The mechanism of mitochondrial impairment was important in determining the impact on insulin action, but was independent of mitochondrial ROS production. These data can account for opposing findings on this issue and highlight the complexity of mitochondrial regulation of cell type-specific insulin action, which is not described by current reductionist paradigms.

Published
2014

6. Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling

Author

Fernández-Rojo, Manuel A., primary, Gongora, Milena, additional, Fitzsimmons, Rebecca L., additional, Martel, Nick, additional, Martin, Sheree D., additional, Nixon, Susan J., additional, Brooks, Andrew J., additional, Ikonomopoulou, Maria P., additional, Martin, Sally, additional, Lo, Harriet P., additional, Myers, Stephen A., additional, Restall, Christina, additional, Ferguson, Charles, additional, Pilch, Paul F., additional, McGee, Sean L., additional, Anderson, Robin L., additional, Waters, Michael J., additional, Hancock, John F., additional, Grimmond, Sean M., additional, Muscat, George E.O., additional, and Parton, Robert G., additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results