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1. Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials

Author

Maurer, Marcus, primary, Ensina, Luis Felipe, additional, Gimenez-Arnau, Ana Maria, additional, Sussman, Gordon, additional, Hide, Michihiro, additional, Saini, Sarbjit, additional, Grattan, Clive, additional, Fomina, Daria, additional, Rigopoulos, Dimitrios, additional, Berard, Frederic, additional, Canonica, Giorgio Walter, additional, Rockmann, Heike, additional, Irani, Carla, additional, Szepietowski, Jacek C, additional, Leflein, Jeffrey, additional, Bernstein, Jonathan A, additional, Peter, Jonny G, additional, Kulthanan, Kanokvalai, additional, Godse, Kiran, additional, Ardusso, Ledit, additional, Ukhanova, Olga, additional, Staubach, Petra, additional, Sinclair, Rodney, additional, Gogate, Shaila, additional, Thomsen, Simon Francis, additional, Tanus, Tonny, additional, Ye, Young Min, additional, Burciu, Alis, additional, Barve, Avantika, additional, Modi, Darshna, additional, Scosyrev, Emil, additional, Hua, Eva, additional, Letzelter, Kerstin, additional, Varanasi, Vineeth, additional, Patekar, Manmath, additional, Severin, Thomas, additional, Rosana, Agondi, additional, Ahmed, Al Waily, additional, Fabio, Almerigogna, additional, Miguel Angel Tejedor, Alonso, additional, Alfred, Ammoury, additional, Eng Kim, Anne Goh, additional, Robert, Anolik, additional, Ledit, Ardusso, additional, Petr, Arenberger, additional, Nandini, AS, additional, Mohammad, Asefi, additional, Natalia, Astafieva, additional, Anil, Badhwar, additional, Esther Serra, Baldrich, additional, Christine, Bangert, additional, Annick, Barbaud, additional, Zsuzsanna, Bata-Csorgo, additional, Andrea, Bauer, additional, Frederic, Berard, additional, Beata, Bergler-Czop, additional, Gary D, Berman, additional, Jonathan, Bernstein, additional, Subhash Chandra, Bharija, additional, Ramesh M, Bhat, additional, Isabelle, Boccon-Gibod, additional, Ivan, Botev, additional, Knut, Brockow, additional, Philipp, Buck, additional, Paula, Busse, additional, Regis, Campos, additional, Giorgio Walter, Canonica, additional, Julia Maria Del, Carmen, additional, Jaime Del, Carpio, additional, Mamatha, Chadalavada, additional, Yoon-Seok, Chang, additional, Amarjit, Cheema, additional, Yi Hsing, Chen, additional, Yuko, Chinuki, additional, Soyun, Cho, additional, Jeong-Hee, Choi, additional, Chia-Yu, Chu, additional, Ronit, Confino, additional, Jonathan, Corren, additional, Roberta, Criado, additional, Claudia De La, Cruz, additional, David M, Cypcar, additional, Pramila, Daftary, additional, Inna, Danilycheva, additional, Kenneth, Dawes, additional, Michelle Joy, De Vera, additional, James, Deangelo, additional, Stefano, Del Giacco, additional, Diana, Deleanu, additional, John, Delgado, additional, Richard, DeMera, additional, Mohamed, Denguezli, additional, Heinrich, Dickel, additional, Le Huu, Doanh, additional, Sinan, Dogan, additional, Marie Sylvie, Doutre, additional, Anne Sophie, Dupond, additional, Anton, Edin, additional, Kent, EDWARD, additional, Swarna, Ekanayake-Bohling, additional, Daniel, Elbirt, additional, David, Elkayam, additional, Anne, Ellis, additional, Shaunagh, Emanuel, additional, Alexander, Emeliyanov, additional, Burhan, Engin, additional, Luis Felipe, Ensina, additional, Ignacio Antepara, Ercoreca, additional, Safiye, Ergun, additional, Jose Luis Lopez, Estebaranz, additional, Rustem, Fassakhov, additional, Daria, Fomina, additional, Linda, Ford, additional, Mariangela, Francomano, additional, Todd, Funkhouser, additional, Remi, Gagnon, additional, Ricardo, Galimberti, additional, Cesar Alberto, Galvan Calle, additional, Clovis, Galvao, additional, Gabriel, Gattolin, additional, Pierre-Dominique, Ghislain, additional, Ana Maria, Gimenez Arnau, additional, Elliot, Ginchansky, additional, Francoise, Giordano-Labadie, additional, Stanislav, Givirovsky, additional, Kiran, Godse, additional, Shaila, Gogate, additional, Alan, Goldsobel, additional, Francisca, Gomez, additional, Rene Maximiliano, Gomez, additional, Erika, Gonzalez, additional, Paula Ribo, Gonzalez, additional, Dimitar, Gospodinov, additional, Clive, Grattan, additional, Martine, Grosber, additional, Gary, Gross, additional, Francisco Jose Gomez, Guimera Martin-Neda, additional, Rolland, Gyulai, additional, Svetlana, Hadvabova, additional, Suzana Ljubojevic, Hadzavdic, additional, Hadi, Hamam, additional, Daniela, Hasicova, additional, Koremasa, Hayama, additional, Pravin, Hissaria, additional, Anna, Hjerppe, additional, Ivan, Hlinka, additional, Moises Labrador, Horrillo, additional, Connie, Hsu, additional, Yu-Huei, Huang, additional, Iftikhar, Hussain, additional, Atsuyuki, Igarashi, additional, Beata, IMKO-WALCZUK, additional, Huseyin Serhat, Inaloz, additional, Rossella, Intravaia, additional, Neal, Jain, additional, Sanjeev, Jain, additional, Thilo, Jakob, additional, Ruth Cerino, Javier, additional, Antonio, João, additional, Luiza Marek, Jozefowicz, additional, Chang-Gyu, Jung, additional, Martin, Kaatz, additional, Nida, Kacar, additional, Henry, Kanarek, additional, Iva, Karlova, additional, Alexander, Kastanayan, additional, Jana, Kazandjieva, additional, Johannes, Kern, additional, Aharon, Kessel, additional, Neena, Khanna, additional, HeeJoo, Kim, additional, Nancy, Kim, additional, Sang-Ha, Kim, additional, Tae-bum, Kim, additional, Kulli, Kingo, additional, Andreas, Kleinheinz, additional, Janka, Komova, additional, Evangelia, Kompoti, additional, Tomas, Kopal, additional, Peter, Kozub, additional, Dorota, Krasowska, additional, Beata, Krecisz, additional, Burkhard, Kreft, additional, Satsuki, Kubota, additional, Hitoshi, Kudo, additional, Teja, Kulkarni, additional, Kanokvalai, Kulthanan, additional, Akihiro, Kume, additional, Maciej, Kupczyk, additional, Edward, Lain, additional, Bobby, Lanier, additional, Hilde, Lapeere, additional, Griselle Ortiz, Lasanta, additional, Svetlana, Lazareva, additional, Laura, Lazzeri, additional, Dennis, Ledford, additional, Donghun, Lee, additional, Haur Yueh, Lee, additional, Jeffrey, Leflein, additional, Nicolas, Leitz, additional, Nancy, Levin, additional, Hermenio, Lima, additional, Undine, Lippert, additional, Brian, Lipson, additional, Paula, Luna, additional, Gabriel, Magarinos, additional, Satyaprakash, Mahajan, additional, Michail, Makris, additional, Alejandro, Malbran, additional, Ahmed Manjra, Manjra, additional, Michael, Manning, additional, Maria, Manrique, additional, Adriana, Marcipar, additional, Mariano, Marini, additional, Veronique Del, Marmol, additional, Jorge, Maspero, additional, Tomoko, Matsuda, additional, Jonathan, Matz, additional, Marcus, Maurer, additional, Wendy, McFalda, additional, Anne, Mclaughlin, additional, Iris, Medina, additional, Rajesh Dutt, Mehta, additional, Stephan, Meller, additional, Steven, MELTZER, additional, Raisa, Meshkova, additional, Dorin, Mihalache, additional, Francisco Javier, Miquel, additional, Mourad, Mokni, additional, J, Molhoek, additional, Efrain, Montano, additional, Sabine, Mueller, additional, Javier Pedraz, Munoz, additional, Toshikazu, Nagakura, additional, Joanna, Narbutt, additional, Ignasi Figueras, Nart, additional, Ma. Lourdes M, Nebrida-Idea, additional, Trong Hao, Nguyen, additional, Johannes, Niesmann, additional, Violeta Zaragoza, Ninet, additional, Hiromitsu, Noguchi, additional, Yuko Chinuki, Nomura, additional, Roman, Nowicki, additional, Tokuya, Omi, additional, Robert, Onder, additional, Ivan, Orojan, additional, Francisco Javier, Ortiz de Frutos, additional, Kim, Papp, additional, Claudio, Parisi, additional, Chun Wook, Park, additional, Heungwoo, Park, additional, Jungwon, Park, additional, Young Min, Park, additional, Viviana, Parra, additional, Thierry, Passeron, additional, Justine, Pasteur, additional, Shivakumar, Patil, additional, Vergil, Patrascu, additional, Sylvia, Pauser, additional, Anna Wojas, Pelc, additional, Jonathan Grant, Peter, additional, Wolfgang, Pfuetzner, additional, Nicola, Pimpinelli, additional, Andreas, Pinter, additional, Cristian, Pizarro, additional, Karel, Pizinger, additional, Jarmila, Plutinska, additional, Todor, Popov, additional, Veronika, Popova, additional, Marta Ferrer, Puga, additional, Lara Ferrandiz, Pulido, additional, Anca, Purcaru, additional, Ulrike, Raap, additional, Anna, Rajchel, additional, John, Ramey, additional, Ma Deanna Santos, Ramiscal, additional, German Dario, Ramon, additional, Syed, Rehman, additional, Adam, Reich, additional, Norbert, Reider, additional, Krista, Ress, additional, Dimitrios, Rigopoulos, additional, Enrique, Rivas, additional, Heike, Rockmann, additional, Pierre-Paul, Roquet-Gravy, additional, Menachem, Rottem, additional, Vermen Verallo, Rowell, additional, Franziska, Rueff, additional, Juan Alberto Ruano, Ruiz, additional, Juan, Russo, additional, Ronald, Saff, additional, Sarbjit, Saini, additional, Maria, Salazar, additional, Juan Francisco Silvestre, Salvador, additional, Jorge, Sanchez, additional, Florica, Sandru, additional, Mark, Scarupa, additional, Knut, Schaekel, additional, Sibylle, Schliemann, additional, Rik, Schrijvers, additional, Beate, Schwarz, additional, Andreas, Schwinn, additional, Sudhir, Sekhsaria, additional, Nilgun, Senturk, additional, Seong Jun, Seo, additional, Mercedes Rodriguez, Serna, additional, Faradiba, Serpa, additional, Paul A, Shapero, additional, Eriko, Shinkawa, additional, Jan-Christoph, Simon, additional, Rodney, Sinclair, additional, Ralfi, Singer, additional, Dareen D, Siri, additional, Karl, Sitz, additional, Adam, Smialowski, additional, Andrew, Smith, additional, Morten, Soerensen, additional, Wiebke, Sondermann, additional, Haejun, Song, additional, Dmitrii, Sonin, additional, Weily, Soong, additional, Daniel, Soteres, additional, Maria, Staevska-Kotasheva, additional, Petra, Staubach-Renz, additional, Nisha Su Yien, Subash, additional, Gordon, Sussman, additional, Ake Svensson, Svensson, additional, Ekaterini, Syrigou, additional, Andrea, Szegedi, additional, Jacek, Szepietowski, additional, Shunsuke, Takahagi, additional, Yuval, Tal, additional, Neetu, Talreja, additional, Wooi Chiang, Tan, additional, Ricardo, Tan, additional, Jyh Jong, Tang, additional, Tonny, Tanus, additional, Martha, Tarpay, additional, Shang Ian, Tee, additional, Craig, Teller, additional, Florence, Tetart, additional, Aurelie Du, Thanh, additional, Suganthi, Thevarajah, additional, Simon Francis, Thomsen, additional, Carl, Thornblade, additional, Milan, Tjioe, additional, Alberto, Tolcachier, additional, Celeste, Tolentino, additional, Athanasios, Tsianakas, additional, Ilia, Tsingov, additional, Hamida, Turki, additional, Olga, Ukhanova, additional, Jens, Ulrich, additional, Meltem, Uslu, additional, Fernando, Valenzuela, additional, Solange, Valle, additional, Martijn, van Doorn, additional, Jirina, Vankova, additional, Suneel, Vartak, additional, Christine, Vidouria, additional, Sebastian, Volc, additional, Gerald, Volcheck, additional, Nicola, Wagner, additional, Irena, Walecka-Herniczek, additional, Penpun, Wattanakrai, additional, Bettina, Wedi, additional, Steven, Weinstein, additional, Vesarat, Wessagowit, additional, Hugh, Windom, additional, Akiko, Yagami, additional, Aisaku, Yamamoto, additional, Shinichiro, Yasumoto, additional, Young Min, Ye, additional, Jose Cevallos, Yepez, additional, Sang Woong, Youn, additional, Hana, Zelenkova, additional, Oleg, Ziganshin, additional, and Matthew, Zook, additional

Published
2023
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2. International Consensus on the Use of Genetics in the Management of Hereditary Angioedema

Author

Jose Fabiani, Emel Aygören-Pürsün, Sladjana Andrejevic, Christian Drouet, Nóra Veszeli, Matija Rijavec, Georg Dewald, Markus Magerl, Michael Kirschfink, Marco Cicardi, Camila Lopes Veronez, Imola Beatrix Nagy, Massimo Triggiani, Maria Zamanakou, Henrik Halle Boysen, Matthaios Speletas, Maria Bova, Maria Staevska, Maurizio Margaglione, Sandra C. Christiansen, Teresa Caballero, Milos Jesenak, Vesna Grivcheva-Panovska, Allen P. Kaplan, Kinga Viktoria Köhalmi, Anthony J. Castaldo, Roman Hakl, Gaëlle Hardy, Walter A. Wuillemin, Inmaculada Martinez Saguer, Margarita López Trascasa, João Bosco Pesquero, Sven Cichon, Jonathan A. Bernstein, Grzegorz Porebski, Patrik Nordenfelt, C. Katelaris, Anette Bygum, Maria Teresa Gonzalez-Quevedo, Stephen Jolles, Henriette Farkas, Sandra A. Nieto, William R. Lumry, Hilary Longhurst, Spath Peter, Iris Leibovich, Nihal M. Gökmen, Christina Weber, Noemi-Anna Bara, Konrad Bork, Alberto López Lera, Dorottya Csuka, Fotis Psarros, Laurence Bouillet, Marc A. Riedl, Bruce L. Zuraw, Anete Sevciovic Grumach, Farrukh R. Sheikh, Marcin Stobiecki, Anastasios E. Germenis, Ágnes Szilágyi, Avner Reshef, Susan Waserman, and J. Gooi

Subjects
Consensus, Genetic counseling, Genetic Counseling, Disease, C1-inhibitor, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Humans, Immunology and Allergy, Genetic Testing, 030212 general & internal medicine, Angioedema, Disease management (health), Genotyping, Genetic testing, Hereditary angioedema, biology, medicine.diagnostic_test, ClinVar, Variant pathogenicity curation, business.industry, Angioedemas, Hereditary, medicine.disease, 030228 respiratory system, biology.protein, medicine.symptom, business, Complement C1 Inhibitor Protein
Abstract

Hereditary angioedema (HAE) is becoming much more genetically complex than was initially considered. Thus, the role of HAE genetics is expanding beyond research laboratories, and the genotyping of subjects suffering from HAE has become diagnostically indispensable in clinical practice. The synthesis and interpretation of the clinical and biochemical analyses to facilitate appropriate genetic test selection has thus also become significantly more complex. With this in mind, an international multidisciplinary group of 14 experts in HAE genetics and disease management was convened in October 2018. The objective was to develop clear, actionable, evidence- and consensus-based statements aiming to facilitate the communication between physicians treating patients with HAE and clinical geneticists, and thus promote the effective use of genetics in the management of the disease. Eleven consensus statements were generated, encompassing considerations regarding the clinical indications for genotyping patients with angioedema, the methods of detection of HAE-causative variants, the variant pathogenicity curation, the genotyping of patients with HAE in the clinic, and genetic counseling. These statements are intended both to guide clinicians and to serve as a framework for future educational and further genetic testing developments as the field continues to evolve rapidly.

Published
2020
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3. Efficacy And Safety Of Bradykinin B2 Receptor Inhibition With Oral PHVS416 In Treating Hereditary Angioedema Attacks: Results Of RAPIDe-1 Phase 2 Trial

Author

Marcus Maurer, John Anderson, Emel Aygören-Pürsün, Laurence Bouillet, María Luisa Baeza, Hugo Chapdelaine, Danny Cohn, Aurélie Du-Thanh, Olivier Fain, Henriette Farkas, Jens Greve, Mar Guilarte, David Hagin, Roman Hakl, Joshua Jacobs, Aharon Kessell, Sorena Kiani-Alikhan, Pavlína Králíčková, Huamin Li, Ramon Lleonart Bellfill, Markus Magerl, Michael Manning, Avner Reshef, Bruce Ritchie, Giuseppe Spadaro, Maria Staevska, Petra Staubach, Marcin Stobiecki, Gordon Sussman, Michael Tarzi, Anna Valerieva, William Yang, Marie-Helene Jouvin, Rafael Crabbé, Simone van Leeuwen, Huaihou Chen, Li Zhu, Jochen Knolle, Anne Lesage, Peng Lu, and Marc Riedl

Subjects
Immunology, Immunology and Allergy
Published
2023
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4. Recombinant human C1 esterase inhibitor as short-term prophylaxis in patients with hereditary angioedema

Author

Tobias M. Suiter, Radana Zachova, Sladjana Andrejevic, Anna Valerieva, Ralph Shapiro, Katarina Hrubiskova, Ljerka Karadza-Lapic, Roman Hakl, Vesna Grivcheva-Panovska, Maria Staevska, D. Soteres, Vinay Mehta, Milos Jesenak, Marta Sobotkova, F. Ida Hsu, Jeffrey Rumbyrt, Andrea Zanichelli, and Raffi Tachdjian

Subjects
medicine.medical_specialty, biology, business.industry, Angioedemas, Hereditary, Esterases, Complement C1 Inactivator Proteins, medicine.disease, Dermatology, Recombinant Proteins, 3. Good health, C1 esterase, C1-inhibitor, 03 medical and health sciences, HUMAN C1-ESTERASE INHIBITOR, 0302 clinical medicine, 030228 respiratory system, Hereditary angioedema, biology.protein, Humans, Immunology and Allergy, Medicine, In patient, 030212 general & internal medicine, business, Complement C1 Inhibitor Protein
Abstract

Hereditary angioedema (HAE), an inherited deficiency offunctional C1 esterase inhibitor (C1-INH), is characterized byrecurrent episodes of disabling and often painful swelling insubcutaneous and/or submucosal tissues.1HAE attacks aregenerally unpredictable, but triggers for an attack can includehaving a dental or medical procedure (eg, surgery), other trauma,or stress. A preemptive management plan for patients under-going these types of situations may reduce the risk of HAE at-tacks. Recommendations include administration of short-termprophylaxis in patients with HAE before invasive medical pro-cedures, especially those involving the upper airways or digestivetract, with C1-INH concentrate typically the medication ofchoice.

Published
2020
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6. Objective approach for fending off the sublingual immunotherapy placebo effect in subjects with pollenosis: double-blinded, placebo-controlled trial

Author

Violina Filipova, Maria Staevska, Vasil Dimitrov, Roxana Mincheva, Tihomir B. Mustakov, Kalina Bacheva, Cvetelina Lazarova, Todor A. Popov, Margarita Koleva, Tanya Kralimarkova, and Rumyana Racheva

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Spirometry, medicine.medical_specialty, Allergen immunotherapy, Adolescent, Visual analogue scale, Immunology, Administration, Sublingual, Placebo-controlled study, Poaceae, Placebo, Gastroenterology, Placebos, Double-Blind Method, Internal medicine, Statistical significance, otorhinolaryngologic diseases, medicine, Humans, Immunology and Allergy, Sublingual immunotherapy, Conjunctivitis, Allergic, Sublingual Immunotherapy, medicine.diagnostic_test, business.industry, Temperature, Rhinitis, Allergic, Seasonal, food and beverages, Allergens, Surgery, Clinical trial, C-Reactive Protein, Exhalation, Pollen, Female, business, Cell Adhesion Molecules, Biomarkers
Abstract

Background Symptom scoring for the assessment of allergen immunotherapy is associated with a substantial placebo effect. Objective To assess the ability of exhaled breath temperature (EBT), a putative marker of airway inflammation, to evaluate objectively the efficacy of grass pollen sublingual immunotherapy in a proof-of-concept study. Methods This was a double-blinded, placebo-controlled clinical trial in 56 subjects (mean ± SD 30 ± 12 years old, 33 men) sensitized to grass pollen. The objective measurements were EBT, spirometry, and periostin and high-sensitivity C-reactive protein in blood. Overall discomfort scored on a visual analog scale was used as a proxy for subjective symptoms. Evaluations were performed before, during, and after the grass pollen season. Results Fifty-one subjects (25 and 26 in the active treatment and placebo groups, respectively) were assessed before and during the pollen season. The mean pre- vs in-season increase in EBT was significantly smaller (by 59.1%) in the active treatment than in the placebo group ( P = .030). Of the other objective markers, only the blood periostin level increased significantly during the pollen season ( P = .047), but without intergroup differences. Subjectively, the mean pre- vs in-season increase in the visual analog scale score was 32.3% smaller in the active treatment than in the placebo group, although this difference did not reach statistical significance ( P = .116). Conclusion These results suggest that the efficacy of grass pollen sublingual immunotherapy can be assessed by EBT, a putative quantitative measurement of airway inflammation, which is superior in its power to discriminate between active and placebo treatment than a subjective assessment of symptoms assessed on a visual analog scale. Trial Registration clinicaltrials.gov Identifier: NCT01785394.

Published
2014
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7. RECOMBINANT C1 ESTERASE INHIBITOR FOR SHORT-TERM PROPHYLAXIS IN PATIENTS WITH HEREDITARY ANGIOEDEMA

Author

Anna Valerieva, Raffi Tachdjian, Sladjana Andrejevic, Katarina Hrubiskova, Maria Staevska, V. Mehta, Ljerka Karadza-Lapic, D. Soteres, Ralph Shapiro, Roman Hakl, F. Hsu, Andrea Zanichelli, Milos Jesenak, Tobias M. Suiter, Radana Zachova, J. Rumbyrt, Marta Sobotkova, and Vesna Grivcheva-Panovska

Subjects
Pulmonary and Respiratory Medicine, Danazol, medicine.diagnostic_test, Angioedema, business.industry, Immunology, medicine.disease, Endoscopy, Anesthesia, Hereditary angioedema, Immunology and Allergy, Medicine, In patient, medicine.symptom, business, Adverse effect, Recombinant C1 esterase inhibitor, Tranexamic acid, medicine.drug
Abstract

Introduction Patients with hereditary angioedema (HAE) are at risk for an acute attack after medical procedures. Short-term prophylaxis may minimize this risk. This study evaluated recombinant C1 esterase inhibitor (rhC1-INH) as short-term prophylaxis. Methods Patients with angioedema were treated with rhC1-INH prior to medical procedures/stressful life events; HAE attacks were recorded through 2 days and >2-7 days postprocedure. Results Fifty-one patients (median age, 44 years [range, 17-73 years]; 62.7% female; 92.2% HAE type 1) were included. A median rhC1-INH dose of 3075 IU (range, 2100-4200 IU) was administered as prophylaxis, median of 60 minutes prior, for 70 procedures (52.9% [n=37] dental [median, 60 minutes preprocedure]); 30.0% [n=21] surgical [median, 45 minutes preprocedure]; 15.7% [n=11] endoscopy [median, 30 minutes preprocedure, and 1.4% [n=1] stressful life event). Majority (n=48; 68.6%) of 70 cases had rhC1-INH administered 10-65 minutes preprocedure: 25 of 48 (52.1%) dental, 16 (33.3%) surgical, and 7 (14.6%) endoscopy. Nineteen (27.1%) cases involved long-term prophylaxis (danazol/tranexamic acid). Overall, 97.1% (68/70) of cases did not have an HAE attack within 2 days postprocedure; 91.4% (64/70) during >2-7 days postprocedure. For 2 attacks occurring within 2 days, rhC1-INH was administered 230 minutes and ≥24 hours preprocedure, respectively. No adverse events were reported. As a self-control group, 76.9% of 26 cases with no long-term/short-term prophylaxis preprocedure had an attack within 2 days postprocedure. Conclusions Short-term prophylaxis with rhC1-INH, administered within several hours preprocedure, was efficacious and safe in adolescents/adults and reduced the risk of an HAE attack postprocedure.

Published
2018
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8. P180 Results from an interim analysis of a recombinant human C1 inhibitor treatment registry in Europe

Author

Anurag Relan, L. Bellizzi, Anna Valerieva, Maria Staevska, Katarina Hrubiskova, Milos Jesenak, Henriette Farkas, Marco Cicardi, Andrea Zanichelli, and Roman Hakl

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, Internal medicine, Immunology, Recombinant human C1 inhibitor, medicine, Immunology and Allergy, business, Interim analysis
Published
2017
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9. Recombinant Human C1 Esterase Inhibitor as Short-Term Prophylaxis for Dental Procedures in Patients With Angioedema: A Case Series

Author

Florence Ida Hsu, Ralph Shapiro, Katarina Hrubiskova, Andrea Zanichelli, Tobias M. Suiter, Radana Zachova, Sladjana Andrejevic, Vesna Grivcheva-Panovska, Milos Jesenak, Marta Sobotkova, Ljerka Karadza-Lapic, Anna Valerieva, Roman Hakl, and Maria Staevska

Subjects
medicine.medical_specialty, Angioedema, business.industry, Immunology, Dental procedures, Dermatology, law.invention, HUMAN C1-ESTERASE INHIBITOR, law, medicine, Recombinant DNA, Immunology and Allergy, In patient, medicine.symptom, business
Published
2019
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10. Long-Term Prophylaxis with Recombinant Human C1 Inhibitor in Patients with Hereditary Angioedema: Is Intramuscular Administration an Option?

Author

Borislava Krusheva, Anna Valerieva, and Maria Staevska

Subjects
medicine.medical_specialty, business.industry, Immunology, Long term prophylaxis, medicine.disease, Gastroenterology, Internal medicine, Recombinant human C1 inhibitor, Hereditary angioedema, Immunology and Allergy, Medicine, In patient, business, Administration (government)
Published
2018
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12. Real-Life Study on the Effect of Micronized Cellulose Powder As Add-on to Intranasal As-Needed Treatment of Subjects with Pollen Allergic Rhinitis

Author

Elitsa Valerieva, Tsvetelina Lazarova, Anna Valerieva, Vasil Dimitrov, Todor A. Popov, Martin K. Church, Maria Staevska, Tanya Kralimarkova, and Elena Petkova

Subjects
Traditional medicine, business.industry, Immunology, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030228 respiratory system, chemistry, Pollen, medicine, Immunology and Allergy, Nasal administration, Cellulose, 030223 otorhinolaryngology, business, Life study
Published
2016
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13. Persistent asthma and rhinitis co-morbidity and allergic sensitization in a sample of 317 Bulgarian patients

Author

Vasil Dimitrov, Maria Staevska, D.N. Popova, and Mariana A. Mandajieva

Subjects
medicine.medical_specialty, biology, business.industry, Immunology, medicine.disease, Alternaria, biology.organism_classification, medicine.disease_cause, Dermatology, respiratory tract diseases, Allergic sensitization, medicine.anatomical_structure, Allergen, immune system diseases, Concomitant, otorhinolaryngologic diseases, medicine, Immunology and Allergy, Nasal polyps, Sinusitis, business, Sensitization, Asthma
Abstract

Rationale Since there is no data about persistent allergic and non-allergic asthma and rhinitis association as well as sensitization among Bulgarian patient population, we assessed this co-morbidity and the major allergen sensitization in our country. Methods A sample of 317 proven perennial asthma and/or rhinitis patients underwent skin prick testing (SPT) to house dust mites, cockroaches, moulds, dog, cat and pollens with commercially available allergen extracts (Allerbio). Results The majority of patients in our series 185 (58%) were atopic and had at least one positive skin test to major inhalant allergens. The mean age of the patients in allergic group was 34,8 (from 5 to 59) with 43%:56% men:women ratio versus 44,1 (from 6 to 79) in the non-allergic group with 30%:70% men:women ratio. In the allergic group 87% of asthmatics suffered from accompanying rhinitis versus 79% in the non-allergic group. A subgroup of 9 (5,3%) asthmatics had nasal polyps and aspirin sensitivity and 11 (6,5%) had only polyps as a concomitant disorder. Accompanying seasonal rhinoconjunctivitis proven with positive SPT to pollens was assessed in 55% of atopic patients. The sensitization to the inhalant allergens in the allergic group was as follows: D. pteronyssinus 60%, D. farinae 52%, dog 34%, cat 31%, Blatella germanica 26%, Periplaneta americana 22%, Alternaria mix 19%, Fusarium moniliforme 18%, Penicillium digihetum 10%. Conclusions Both persistent allergic rhinitis and non-allergic rhino(sinusitis) showed a frequent association with persistent asthma. Polysensitization was a characteristic feature for 82% of patient sample and house dust mites and pets were among the most common allergens causing sensitization.

Published
2004
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14. Prevalence of the sensitization to snails and shrimps in patients allergic to house dust mites (HDM) a prospective European multicenter study

Author

Jean-Marc Rame, Brigitte Adessi, Maria Staevska, P. Girardin, M. Vigan, André Dubiez, F. Lavaud, and Dominique A. Vuitton

Subjects
Veterinary medicine, medicine.medical_specialty, medicine.anatomical_structure, Multicenter study, business.industry, Immunology, medicine, Immunology and Allergy, In patient, Dust mites, business, Dermatology, Sensitization
Published
2002
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