1. Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans
- Author
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Julie M. Donohue, Carolyn T. Thorpe, Chester B. Good, Patience Moyo, John Cashy, Florentina E. Sileanu, Maria K. Mor, Xinhua Zhao, Walid F. Gellad, Thomas R. Radomski, Leslie R. M. Hausmann, Joshua M. Thorpe, Jennifer A. Hale, Michael J. Fine, and Joseph T. Hanlon
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Medicare Part D ,Pharmaceutical Science ,Pharmacy ,Drug overdose ,Drug Prescriptions ,Article ,National cohort ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Medical prescription ,Aged ,Veterans ,business.industry ,Middle Aged ,Veterans health ,medicine.disease ,United States ,Analgesics, Opioid ,United States Department of Veterans Affairs ,Opioid ,Prescription opioid ,Emergency medicine ,Female ,Drug Overdose ,Overdose death ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Few studies have assessed prescription opioid supply preceding death in individuals dying from unintentional prescription opioid overdoses, or described the characteristics of these individuals, particularly among Veterans. Objectives To describe the history of prescription opioid supply preceding prescription opioid overdose death among Veterans. Methods In a national cohort of Veterans who filled ≥1 opioid prescriptions from the Veterans Health Administration (VA) or Medicare Part D during 2008–2013, we identified deaths from unintentional or undetermined-intent prescription opioid overdoses in 2012–2013. We captured opioid prescriptions using both linked VA and Part D data, and VA data only. Results Among 1181 decedents, 643 (54.4%) had prescription opioid supply on the day of death, and 735 (62.2%) within 30 days based on linked data, compared to 40.1% and 46.7%, respectively, using VA data alone. Decedents with prescription opioid supply were significantly older and less likely to have alcohol or illicit drugs as co-occurring substances involved in the overdose. Using linked data, 241 (20.4%) decedents lacked prescription opioid supply within a year of death. Conclusions Many VA patients who die from prescription opioid overdose receive opioid prescriptions outside VA or not at all. It is important to supplement VA with non-VA data to more accurately measure prescription opioid exposure and improve opioid medication safety.
- Published
- 2019