1. Novel family GH3 β-glucosidases or β-xylosidases of unknown function found in various animal groups, including birds and reptiles
- Author
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Štefan Janeček and Marek Gabriško
- Subjects
Models, Molecular ,endocrine system ,CAZy ,endocrine system diseases ,In silico ,Biochemistry ,Substrate Specificity ,Analytical Chemistry ,Birds ,Molecular evolution ,Catalytic Domain ,Animals ,Humans ,Computer Simulation ,Phylogeny ,Genetics ,biology ,Gene Expression Profiling ,Organic Chemistry ,Glycoside hydrolase family 3 ,Computational Biology ,Reptiles ,General Medicine ,Xylosidases ,Protein tertiary structure ,Protein Structure, Tertiary ,biology.protein ,Glucosidases ,hormones, hormone substitutes, and hormone antagonists ,Function (biology) - Abstract
Proteins from the glycoside hydrolase family 3 (GH3) are important bacterial, fungal and plant enzymes involved in cell wall remodeling, energy metabolism and pathogen defense but no animal GH3 proteins have been reported so far. In presented work we use the in silico approach to describe putative GH3 proteins of animals. Based on tertiary structure modeling, domain organization and transcriptomics data analysis, presence of catalytic and substrate binding residues and evolutionary relationship inference, we assume that there is a monophyletic group of GH3 enzymes (probably β-xylosidases) found in various animal taxa with possible role in development.
- Published
- 2015
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