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Your search keyword '"Mannina L"' showing total 10 results
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10 results on '"Mannina L"'

1. Corrigendum to “Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression” [Food Chem. Toxicol. 129 (2019) 434–443]

Author

Di Lorenzo, A., primary, Sobolev, A.P., additional, Nabavi, S.F., additional, Sureda, A., additional, Moghaddam, A.H., additional, Khanjani, S., additional, Di Giovanni, C., additional, Xiao, J., additional, Shirooie, S., additional, Tsetegho Sokeng, A.J., additional, Baldi, A., additional, Mannina, L., additional, Nabavi, S.M., additional, and Daglia, M., additional

Published
2019
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2. A functional metagenomics investigation of cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy

Author

Gregorio, V.D.I., primary, Iebba, V., additional, Guerrieri, F., additional, Levrero, M., additional, Gagliardi, A., additional, Santangelo, F., additional, Sobolev, A.P., additional, Circi, S., additional, Giannelli, V., additional, Mannina, L., additional, Schippa, S., additional, and Merli, M., additional

Published
2018
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10. Novel thermosensitive calcium alginate microspheres: Physico-chemical characterization and delivery properties

Author

Serena De Santis, Letizia Oddo, Franco Alhaique, Chiara Di Meo, Raffaele Lamanna, Tommasina Coviello, Luisa Mannina, Pietro Matricardi, Donatella Capitani, Giancarlo Masci, Oddo, L., Masci, G., Di Meo, C., Capitani, D., Mannina, L., Lamanna, R., De Santis, S., Alhaique, F., Coviello, T., and Matricardi, P.

Subjects
Microsphere, Magnetic Resonance Spectroscopy, Calcium alginate, Optical Phenomena, Hexuronic Acid, Biochemistry, Horseradish peroxidase, chemistry.chemical_compound, Colloid, Drug Delivery Systems, Glucuronic Acid, Stimuli-responsive material, Materials Testing, Horseradish Peroxidase, Acrylamide, Aqueous solution, biology, Atom-transfer radical-polymerization, Hexuronic Acids, Temperature, Hydrogels, Dextrans, alginate, hydrogels, stimuli-responsive materials, microspheres, drug delivery, General Medicine, Microspheres, Self-healing hydrogels, Drug delivery, Hydrophobic and Hydrophilic Interactions, Fluorescein-5-isothiocyanate, Human, Biotechnology, Materials science, Alginates, Biomedical Engineering, Lower critical solution temperature, Biomaterials, Hydrophobic and Hydrophilic Interaction, Polymer chemistry, Stimuli-responsive materials, Humans, Dextran, Molecular Biology, Acrylamides, Alginate, Hydrogel, chemistry, Chemical engineering, Microscopy, Electron, Scanning, biology.protein, Drug Delivery System
Abstract

The system described in this paper was obtained by soaking calcium alginate (CaAlg) microspheres in a water solution of poly-[(3-acrylamidopropyl)- trimethylammonium chloride-b-N-isopropylacrylamide] [poly(AMPTMA-b-NIPAAM)], a new block co-polymer recently synthesized by atom transfer radical polymerization (ATRP). The block co-polymer is characterized by a lower critical solution temperature (LCST) of 41 °C in aqueous 0.1 M NaCl solution, and can be anchored on the CaAlg microspheres by means of polyion interactions. Polycations (permanently positively charged blocks) and polyanions (free alginate carboxylic groups) interact, leading to microspheres with thermosensitive properties. As an effect of interaction with the microspheres the LCST of the co-polymer is lowered to 36-38 °C. In this temperature range a colloidal water suspension of the microspheres collapses, forming macroscopic aggregates. The new system shows, at human body temperature, an improved ability to carry and deliver both hydrophobic and hydrophilic molecules in comparison with unmodified CaAlg microspheres. The release properties of the microspheres loaded with different model drugs can be appropriately modulated by the amount of the poly(AMPTMA-b-NIPAAM). Furthermore, the microspheres show the interesting capability of retaining the activity of a loaded enzyme (horseradish peroxidase), used as a model protein. The results obtained indicate that the proposed drug delivery system may be suitable for drug depot applications. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Published
2010

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