1. Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development
- Author
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Zhonggui He, Yixin Sun, Gang Wang, Linlin Cao, Yang Wang, Qikun Jiang, Jin Sun, and Dongyang Zhao
- Subjects
HIF-1α, hypoxia-inducible factor-1α ,H2O, water ,3O2, molecular oxygen ,medicine.medical_treatment ,Photodynamic therapy ,Review ,MDR1, multidrug resistance 1 ,0302 clinical medicine ,DC, dendritic cells ,polycyclic compounds ,General Pharmacology, Toxicology and Pharmaceutics ,Hypoxia ,Cancer ,0303 health sciences ,Oxygen supply ,Ce6, chlorin e6 ,DDS, drug delivery system ,CeO2, cerium oxide ,HIF, hypoxia-inducible factor ,PDT, photodynamic therapy ,H2O2, hydrogen peroxide ,030220 oncology & carcinogenesis ,APCs, antigen-presenting cells ,medicine.symptom ,therapeutics ,PFC, perfluorocarbon ,PS, photosensitizers ,PFH, perfluoroethane ,Tumor cells ,NMR - Nuclear magnetic resonance ,TAM, tumor-associated macrophages ,03 medical and health sciences ,ROS, reactive oxygen species ,AQ4N, banoxantrone ,O2.−, superoxide anion ,medicine ,NMR, nuclear magnetic resonance ,EPR, enhanced permeability and retention ,MB, methylene blue ,CaO2, calcium dioxide ,030304 developmental biology ,Tumor hypoxia ,OH., hydroxyl radical ,business.industry ,lcsh:RM1-950 ,Mn-CDs, magnetofluorescent manganese-carbon dots ,Nanomedicine delivery systems ,Hypoxia (medical) ,Hb - Hemoglobin ,DOX, doxorubicin ,eye diseases ,Oxygen ,FDA, U.S. Food and Drug Administration ,MDSC, myeloid derived suppressive cells ,lcsh:Therapeutics. Pharmacology ,TPZ, tirapazamine ,RBCs, red blood cells ,Cancer research ,MnO2, manganese dioxide ,business ,H2O2 - Hydrogen peroxide ,HSA, human serum albumin ,Hb, hemoglobin - Abstract
Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment. In this review, the mechanism and relationship of tumor hypoxia and PDT are discussed. Moreover, we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT, such as oxygen supply systems, down-regulation of oxygen consumption and hypoxia utilization. Finally, the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT., Graphical abstract Review of mechanisms and relationships of tumor hypoxia and photodynamic therapy as well as four nanomedicine delivery systems for manipulating tumor hypoxia to enhance the photodynamic therapy.Image 1
- Published
- 2020
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