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Linkage between clinical databases and population-based cancer registries may serve to evaluate European Reference Networks' (ERNs) activity, by monitoring the proportion of patients benefiting from these and their impact on survival at a population level. To test this, a study targeting neuroblastoma (Nb) was conducted in Spain by the European Joint Action on Rare Cancers.Subjects: Nb cases, incident 1999-2017, aged 15 years. Linkage included: Spanish Neuroblastoma Clinical Database (NbCDB) (1217 cases); Spanish Registry of Childhood Tumours (RETI) (1514 cases); and 10 regional population-based registries (RPBCRs) which cover 33% of the childhood population (332 cases). Linkage was semiautomatic. We estimated completeness, incidence, contribution, deficit, and 5-year survival in the databases and specific subsets.National completeness estimates for RETI and NbCDB were 91% and 72% respectively, using the Spanish RPBCRs on International Incidence of Childhood Cancer (https://iicc.iarc.fr/) as reference. RPBCRs' specific contribution was 1.6%. Linkage required manual crossover in 54% of the semiautomatic matches. Five-year survival was 74% (0-14 years) and 90% (0-18 months).All three databases were incomplete as regards Spain as a whole and should therefore be combined to achieve full childhood cancer registration. A unique personal patient identifier could facilitate such linkage. Most children have access to Nb clinical trials. Consolidated interconnections between the national registry and clinical registries (including ERNs and paediatric oncology clinical groups) should be established to evaluate outcomes.

The extended first-principles molecular dynamics (Extended FPMD) model introduced by Zhang et al. [2] , based on an analytical single plane wave description of electronic orbitals for high energy electrons , has been implemented within the ab initio DFT software package Abinit and is now available. This model allows quantum simulations to be done smoothly on the full range of temperatures from cold condensed matter to hot dense plasmas passing through the warm dense matter regime which was currently not possible within the same ab initio model due to numerical limitations. In addition to presenting a brief theoretical background of the Zhang et al. method, we propose some improvements to the model. We then present the details of the implementation, and finally offer an application to the aluminum simulations for multiple densities, from room temperature to hot (thousands of eVs) temperature ranges, with a resulting Hugoniot equation of state that we compare with other methods.

In the assessment of lung cancer, computed tomography guides the use of bronchoscopy and establishes whether local treatment may be appropriate for the NSCLC or whether it is at an advanced stage. Percutaneous biopsy of a lesion suspected to be a metastasis can provide histological confirmation, allowing staging to be carried out at the same time. The initial presentation depends on the staging and histological type, ranging from an isolated nodule or mass to atelectasis or obstructive pneumonia, isolated lymph node disease or isolated pleural effusion to miliary metastasis in tumors showing EGFR mutation. Tumor (T) status depends on tumor size, distance from the carina, and invasion of the chest wall and mediastinal organs. PET-CT is superior to CT in identifying lymph node invasion (N2 for ipsilateral mediastinal disease and N3 for contralateral or supraclavicular disease). As a general rule, all contraindications for surgery should be confirmed via histological examination, with the exception of cerebral metastases.

Resume Le scanner, dans le bilan d’un cancer bronchique, guide la realisation de la bronchoscopie et precise si le cancer bronchique non a petites cellules (CBNPC) est potentiellement accessible a un traitement local ou s’il s’agit d’un stade avance. Si une lesion suspecte de metastase est objectivee, sa ponction premiere permet la confirmation histologique et le staging. La presentation initiale est polymorphe, fonction du stade et du type histologique : nodule ou masse isoles, atelectasie ou pneumonie obstructive, atteinte ganglionnaire ou epanchement pleural isoles, miliaire dans les formes avec mutation epithelial growth factor receptor (EGFR). Le statut T depend de la taille tumorale, de la distance a la carene, de l’envahissement parietal et aux organes du mediastin. Le TEP est plus performant que le scanner pour l’extension ganglionnaire, N2 si elle est mediastinale homolaterale, N3 si elle est controlaterale ou sus-claviculaire. La regle doit etre de valider toute contre-indication chirurgicale par une preuve histologique, metastases cerebrales mises a part.

A model is presented to calculate the stopping power of ions propagating in dense matter. Comparisons with experiment in the cold dense regime are presented and discussed. Further, we present results from the warm dense matter regime and the field of high energy density physics.

Both neurological and immunological systems are vulnerable to early life exposures. Neurological disorders and atopy have been related in animals and humans. Our main objective was to assess whether multiple exposures to early life determinants remain associated with neurodevelopment after considering the potential intermediate role of atopy. A second objective was to assess whether genes associated with atopy may inform about the potential neurotoxical mechanisms. Children were members of the AMICS birth cohort in Menorca (n=418, 87% of the recruited). General cognition was measured with the McCarthy Scales at age 4 and atopy through specific IgE at age 4 and prick test at age 6; 85 single nucleotide polymorphisms (SNPs) in 16 atopy and detoxification genes were genotyped. Among the 27 risk factors assessed, lower maternal social class, maternal smoking during pregnancy, being first born, shorter breastfeeding, higher DDT levels in cord blood, and higher indoor levels of NO2 (among the non-detoxifiers by GSTP1 polymorphism) were independently associated with poorer cognition. These associations were apparently not mediated by the relation between atopy and general cognition. Among the candidate atopic genes, variants in NQ01 (a detoxification gene) and NPRS1 (related with affective disorders like anxiety and stress management) had a significant association with general cognition (p-value0.001). However, adjustment for the corresponding SNPs did not change the association between the early life determinants and general cognition. Multiple environmental pre-natal exposures were associated with neurodevelopment independently of their role in the immunological system. Atopic genes related to neurodevelopment suggest some potential mechanisms.

La histiocitosis de células de Langerhans (HCL), anteriormente conocida como histiocitosis X, es una enfermedad poco frecuente caracterizada por la acumulación y proliferación de histiocitos, eosinófilos y células de Langerhans, con inclusión de gránulos de Birbeck detectables por microscopia electrónica, afectando órganos y sistemas de forma aislada o múltiple. Las distintas formas de presentación producen distinto enfoque terapéutico y pronóstico, desde formas benignas, autolimitadas, con resolución espontánea hasta otras de curso tórpido o maligno. Se presentan 5 casos de HCL exponentes de esta entidad, con la misma base histopatológica, pero diferente evolución. : Langerhans' cell histiocytosis (LCH), previously known as histiocytosis X, is a rare disease. It is characterized by the accumulation and proliferation of histiocytes, eosinophils and Langerhans' cells with Birbeck granules detected by electron microscopy. It involves single organs or systems or can present as a multisystem disease. The clinical presentation may vary widely, ranging from benign self-limiting types with spontaneous regression to slowlyprogressive malignant disease. We report five cases of LCH with the same histopathologic basis but different outcome.

A quantitative analysis of the changes induced by solvation and static uniform electric fields on the potential energy surface of the SN2 Menshutkin-type reaction between ammonia and methyl chloride has been performed with the help of different indexes. These indexes have been defined to account for the structural and electronic degree of advance of the transition state with respect to the reactant complex and ion pair product through the use of geometrical parameters, dipole moments and electron density distributions. Indexes reveal that external perturbations yield transition states which are both electronically and structurally advanced as compared to the transition state in the gas phase. The overall study is complemented with HOMO-LUMO orbital considerations, quantification of the global charge density redistributions by means of quantum molecular self-similarity measures and an analysis of the topological features of electron density distributions.

Resumen Objetivo Conocer la incidencia, mortalidad y supervivencia del cancer de pulmon en la isla de Menorca entre los anos 1990 y 1993. Metodos Recogida de todos los casos ocurridos en el periodo de estudio, utilizando la metodologia habitual de los registros poblacionales de cancer, factible en nuestro entorno dadas sus caracteristicas geograficas y demograficas. Resultados La incidencia observada fue de 47,7 casos por 100.000 habitantes y ano y la mortalidad de 44,2 fallecimientos por 100.000 habitantes y ano. La edad media de los pacientes estudiados fue de 67,5 anos, siendo el 90% hombres. El tipo histologico mas frecuentemente observado fue el carcinoma epider-moide (43%), seguido del carcinoma de celulas pequenas (20%) y del adenocarcinoma (19%). La supervivencia media sobre un total de 141 casos fue de 281 dias (9,3 meses). Conclusion Las tasas ajustadas por la poblacion mundial muestran que Menorca se encuentra en el rango superior de la incidencia de cancer de pulmon en Espana.