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7 results on '"M. Matusiak"'

1. Opioid Prescribing in United States Health Systems, 2015 to 2019

Author

Katie J. Suda, Mina Tadrous, Linda M. Matusiak, and Tumader Khouja

Subjects
medicine.medical_specialty, Databases, Factual, Pharmacy, Opioid prescribing, Fentanyl, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, Practice Patterns, Physicians', Medical prescription, business.industry, 030503 health policy & services, Health Policy, Public Health, Environmental and Occupational Health, United States, Analgesics, Opioid, Opioid, Hydrocodone, Emergency medicine, 0305 other medical science, business, Delivery of Health Care, Oxycodone, medicine.drug, Healthcare system
Abstract

Objectives Health systems (nonfederal hospitals and clinics) are the second major source for drug expenditure in the United States. Opioids prescribed in these healthcare settings are commonly short-acting opioids that can lead to persistent opioid use. Nevertheless, there are no national data that describe trends in opioid use and the associated expenditure in health systems. Therefore, the objective of this article was to describe opioid use and expenditures in US health systems from 2015 to 2019. Methods We used data from IQVIA National Sales Perspectives to describe prescription opioid expenditure and use in health systems (nonfederal hospitals and clinics). Results Over the 5-year study period, health systems dispensed a total of 6.55 billion units of opioids (26.88% decrease) with an associated expenditure of $3.33 billion (26.78% decrease). Relative to all opioid formulations in our study, oxycodone, hydrocodone, and fentanyl were the opioids with the highest use in US health systems. All opioid prescriptions decreased except fentanyl use, which increased by 29.80% in clinics. The use of abuse-deterrent formulations of opioids decreased by 51.00% over the study period, although the decrease seems to be driven mainly by long-acting oxycodone (brand name Oxycontin). Conclusions Opioid use and expenditures in health systems have been decreasing following national trends from retail pharmacies. Nevertheless, fentanyl use increased in clinics and was prescribed at higher proportions in nonfederal hospitals than other opioids, which warrants further investigation.

Published
2021

2. Positron production using a 9 MeV electron linac for the GBAR experiment

Author

B. Radics, Alexei Voronin, L. Dodd, S. Niang, Bruno Mansoulie, Ferdinand Schmidt-Kaler, Valery Nesvizhevsky, P.-P. Crépin, Paul Indelicato, A. Husson, K.-H. Yoo, T. Kosinski, B. Latacz, A. Welker, Eun-San Kim, P. Debu, Laszlo Liszkay, André Rubbia, J. Rzadkiewicz, R. Nishi, Pierre Cladé, D. Lunney, G. Janka, Y. Sacquin, Paolo Crivelli, D. P. van der Werf, O. Rousselle, Jaison Lee, J.-M. Rey, D. Won, B.H. Kim, Paul-Antoine Hervieux, Naofumi Kuroda, S. Wolf, P. Lotrus, E. Lim, P. Pérez, Giuseppe Mornacchi, Jean-Philippe Karr, O. D. Dalkarov, M. Charlton, C. Regenfus, S. Guellati-Khélifa, S. Nourbaksh, Serge Reynaud, A. Douillet, Svante Jonsell, J.-M. Reymond, S. K. Kim, F. Nez, J.-Y. Roussé, M. Staszczak, K.H. Park, Giovanni Manfredi, Hyo-Suk Lee, JJ Choi, Young Ju Ko, M. Matusiak, N. Paul, Laurent Hilico, Moses Chung, S. Wronka, B. Tuchming, Yasunori Yamazaki, K. Lévêque, B. Vallage, T Louvradoux, P. Comini, A. M. M. Leite, S. Procureur, Laboratoire Kastler Brossel (LKB [Collège de France]), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Laue-Langevin (ILL), ILL, Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

Subjects
safety, Antimatter, Nuclear and High Energy Physics, CERN Lab, Physics - Instrumentation and Detectors, tungsten, Positron, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Electron, 01 natural sciences, 7. Clean energy, Linear particle accelerator, positron: particle source, 010305 fluids & plasmas, electron: pair production, Nuclear physics, electron: linear accelerator, Linear accelerator, Antihydrogen, Gravitation, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, Nuclear Experiment, 010306 general physics, physics.ins-det, Instrumentation, energy: low, antihydrogen, Physics, Large Hadron Collider, gravitation 2, Instrumentation and Detectors (physics.ins-det), linear accelerator, Antiproton Decelerator, Pair production, radioactivity, gravitation: acceleration, Physics::Accelerator Physics, High Energy Physics::Experiment, performance, positron: yield
Abstract

For the GBAR (Gravitational Behaviour of Antihydrogen at Rest) experiment at CERN's Antiproton Decelerator (AD) facility we have constructed a source of slow positrons, which uses a low-energy electron linear accelerator (linac). The driver linac produces electrons of 9 MeV kinetic energy that create positrons from bremsstrahlung-induced pair production. Staying below 10 MeV ensures no persistent radioactive activation in the target zone and that the radiation level outside the biological shield is safe for public access. An annealed tungsten-mesh assembly placed directly behind the target acts as a positron moderator. The system produces $5\times10^7$ slow positrons per second, a performance demonstrating that a low-energy electron linac is a superior choice over positron-emitting radioactive sources for high positron flux., published in NIM A. 33 pages 9 figures

Published
2021

3. Electron transport and magnetic properties of semimetallic LuAs

Author

Ryszard Wawryk, O.J. Żogał, M. Matusiak, and Zygmunt Henkie

Subjects
Condensed matter physics, Chemistry, Mechanical Engineering, Metals and Alloys, Analytical chemistry, Resonance, Knight shift, Residual resistivity, Magnetization, Mechanics of Materials, Electrical resistivity and conductivity, Hall effect, Seebeck coefficient, Materials Chemistry, Charge carrier
Abstract

Polycrystalline samples of LuAs with a residual resistivity ratio (RRR) between 2.52 and 3.38 were examined by: X-ray diffraction, magnetisation, resistivity, magnetoresistivity, Hall coefficient and thermoelectric power S(T), in addition to the nuclear magnetic resonance (NMR) of 75As and 175Lu nuclei. The density and mobility of carriers for the valence and conduction bands were determined for the RRR = 2.52 sample and used for the calculation of thermoelectric power, Sc(T). The value of Sc(T) fits well with that determined by experiment. The sample shows a charge imbalance with the number of electrons n, (holes, p) equal to 1.52 × 1020 (1.12 × 1020) e/cm3 at 4 K. This imbalance decreases with temperature, reversing after passing a minimum at ∼80 K and then increasing to n (p) = 9.4 × 1019 (1.42 × 1020) e/cm3 at 300 K. The 75As NMR Knight shift is found to be temperature independent and equal to 0.102% and the 175Lu NMR resonance frequency is shifted to higher values by ca. 0.011% with respect to that of LuSb. All data indicate that LuAs belongs to semimetals and the clearly observed 175Lu NMR multiquadrupolar echoes suggest the existence of defects in the cubic structure of the investigated samples.

Published
2014

4. Infrared dispersion of liquid Benzylidenemethylamine and o-Hydroxybenzylidenemethylamine

Author

Teresa Dziembowska, M. Pajdowska, W. Wrzeszcz, Jerzy P. Hawranek, and M. Matusiak-Kucharska

Subjects
Permittivity, Infrared, Chemistry, Organic Chemistry, Near-infrared spectroscopy, Analytical chemistry, Astrophysics::Cosmology and Extragalactic Astrophysics, Polarization (waves), Spectral line, Analytical Chemistry, Inorganic Chemistry, Polarizability, Intramolecular force, Refractive index, Astrophysics::Galaxy Astrophysics, Spectroscopy
Abstract

The spectra of the real and imaginary components of the complex refractive index were determined in the NIR and MIR regions for liquid Benzylidenemethylamine and intramolecularly hydrogen-bonded o-Hydroxybenzylidenemethylamine from transmission studies using a method, which takes into account the dispersion of the refractive index in the Visible range and requires integration over the entire NIR and MIR region. From these data the spectra of both components of the complex electric permittivity and complex polarizability of both liquids were determined in the Visible, Near Infrared, and Mid Infrared spectral regions (25,000–600 cm−1). The molar vibrational polarization related to various spectral ranges has been determined. The considerable contribution due to the formed intramolecular H-bonding has been evaluated and discussed.

Published
2010

5. Fischer synthesis of isomeric thienopyrrole LHRH antagonists

Author

Zbegniew M. Matusiak, Benedicte Delouvrie, Craig S. Harris, Christine Lambert-van der Brempt, Maryannick Lamorlette, Jean-Claude Arnould, Kevin Michael Foote, Christian Delvare, David M. Andrews, Annie Hamon, and Pascal Boutron

Subjects
chemistry.chemical_compound, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Thienopyrrole, Biochemistry, Thiophene derivatives, Pyrrole
Abstract

As part of a structure–activity exploration into LHRH antagonists, structures containing the thieno[2,3-b]pyrrole core were identified as potent antagonists. This letter describes the employment of the Fischer synthesis to access this thienopyrrole and isomeric final compounds.

Published
2009

7. Thin-film transmission spectra of liquid benzylidenemethylamine and o-hydroxybenzylidenemethylamine in the infrared region

Author

M Matusiak, W. Wrzeszcz, Jerzy P. Hawranek, and Teresa Dziembowska

Subjects
Thin layers, Infrared, Chemistry, Organic Chemistry, Analytical chemistry, Spectral line, Analytical Chemistry, Inorganic Chemistry, symbols.namesake, Transmission (telecommunications), Near infrared spectra, symbols, Thin film, Raman spectroscopy, Refractive index, Spectroscopy
Abstract

The spectrum of the complex refractive index in the NIR and MIR regions was determined for liquid benzylidenemethylamine and intramolecularly hydrogen-bonded 2-hydroxybenzylidenemethylamine from transmission studies. In the MIR region very thin layers with thicknesses of a few micrometers had to be used to obtain reliable data. FT-Raman spectra of the liquids are also reported. Numerous bands were identified in both liquids basing on literature data and results of calculations. The effect of H-bond formation on the shift and intensity changes of bands were discusssed.

Published
2004

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