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2. Multi analytical technique study of human bones from an archaeological discovery

Author

R. Floris, Joanna Izabela Lachowicz, S. Palomba, Gavino Sanna, Valeria Pusceddu, Paola Meloni, M. Carboni, and Marco Sarigu

Subjects
Adult, Male, Minerals, 060101 anthropology, Chemistry, Bone pathology, Normal population, Human bone, 06 humanities and the arts, Mineral composition, Biochemistry, Archaeology, Bone and Bones, Diagenesis, Inorganic Chemistry, Ossuary, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Spectroscopy, Fourier Transform Infrared, Humans, Molecular Medicine, 0601 history and archaeology
Abstract

In 1953, during the building restoration of San Michele church (Bono, Sardinia, 16th-19th Century), a high number of disarticulated skeletons were recovered. From a group of 412 hip bones, two of these, affected by several pathological lesions, were analysed. The two coxal bones can be referred to the same individual, an adult man. A multi-analytical study, started with the purpose of investigating the bone pathology, was extended to characterize the mineral components of a large representative set of bones from the same ossuary, all attributed to adult men who lived in the region four-two centuries ago. A quantitative ICP-AES analysis for Ca, Fe, Mg, Mn, Na, Pb and Zn was executed, and a chemometric investigation on the results was performed. This approach gave evidence of the effects of diagenesis, allowed some hypothesis of the incidence of the known dietary habits on bone composition, and completely differentiated the pathological bones from those of a normal population on the basis of the mineral composition. Moreover, porosity, crystallinity and FT-IR analysis were conducted on both non- and pathological sample.

Published
2017
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3. Search for diffuse neutrino flux from astrophysical sources with MACRO

Author

Ioannis Katsavounidis, R. Caruso, D. Levin, F. Guarino, G. Sirri, P. Pistilli, B. C. Choudhary, R. Pazzi, S. Petrera, M. Giorgini, D. G. Michael, Maurizio Spurio, A. Surdo, C. W. Walter, F. Cafagna, M. De Vincenzi, E. Kearns, Hyun-Chul Kim, I. De Mitri, F.J. Ronga, C. Satriano, Maximiliano Sioli, C. R. Bower, L. R. Sulak, P. Serra, G. Auriemma, Gregory Tarle, M. Brigida, J. Reynoldson, Teresa Montaruli, C. De Marzo, M. N. Mazziotta, V. Togo, A. Rainò, C. Forti, M. J. Longo, S. Cecchini, Np Longley, R. Steinberg, A. Rrhioua, G. Giacomelli, C. Bemporad, J. A. Musser, C. E. Lane, C. Favuzzi, C. W. Peck, Roberto Bellotti, M. Vakili, D. Martello, L. Patrizii, V. Popa, Yvonne Becherini, A. Di Credico, D. Campana, Fabrizio Cei, R. Antolini, S. Kyriazopoulou, R.M. Heinz, Alec Habig, F. Maaroufi, G. de Cataldo, Donato Nicolo, G. Osteria, G. Battistoni, G. Mancarella, Kate Scholberg, R. C. Webb, M. Ambrosio, E. Lamanna, G. C. Barbarino, C. Bloise, P. Fusco, D. Bakari, R. Nolty, A. Marzari-Chiesa, M. Spinetti, Marco Monteno, Andrea Carlo Marini, L. Perrone, Annarita Margiotta, Eugenio Scapparone, G. Giannini, Barry C. Barish, N. Giglietto, H. Dekhissi, Severino Angelo Maria Bussino, Mario Sitta, C. Gustavino, C. Orth, O. Erriquez, G. Mandrioli, M. Cozzi, A. A. Grillo, S. Coutu, M. Calicchio, Halina Bilokon, Erik Katsavounidis, S. L. Mufson, V. Chiarella, P. Monacelli, M. Carboni, J. L. Stone, F. Loparco, Paolo Lipari, M. Grassi, J. Derkaoui, P. Spinelli, Kael Hanson, P. Bernardini, Vincenzo Patera, A. Sciubba, A. Baldini, O. Palamara, E. Iarocci, Ambrosio M., Antolini R., Auriemma G., Bakari D., Baldini A., Barbarino G.C., Barish B.C., Battistoni G., Becherini Y., Bellotti R., Bemporad C., Bernardini P., Bilokon H., Bloise C., Bower C., Brigida M., Bussino S., Cafagna F., Calicchio M., Campana D., Carboni M., Caruso R., Cecchini S., Cei F., Chiarella V., Choudhary B.C., Coutu S., Cozzi M., de Cataldo G., Dekhissi H., de Marzo C., de Mitri I., Derkaoui J., de Vincenzi M., di Credico A., Erriquez O., Favuzzi C., Forti C., Fusco P., Giacomelli G., Giannini G., Giglietto N., Giorgini M., Grassi M., Grillo A., Guarino F., Gustavino C., Habig A., Hanson K., Heinz R., Iarocci E., Katsavounidis E., Katsavounidis I., Kearns E., Kim H., Kyriazopoulou S., Lamanna E., Lane C., Levin D.S., Lipari P., Longley N.P., Longo M.J., Loparco F., Maaroufi F., Mancarella G., Mandrioli G., Margiotta A., Marini A., Martello D., Marzari-Chiesa A., Mazziotta M.N., Michael D.G., Monacelli P., Montaruli T., Monteno M., Mufson S., Musser J., Nicolo D., Nolty R., Orth C., Osteria G., Palamara O., Patera V., Patrizii L., Pazzi R., Peck C.W., Perrone L., Petrera S., Pistilli P., Popa V., Raino A., Reynoldson J., Ronga F., Rrhioua A., Satriano C., Scapparone E., Scholberg K., Sciubba A., Serra P., Sioli M., Sirri G., Sitta M., Spinelli P., Spinetti M., Spurio M., Steinberg R., Stone J.L., Sulak L.R., Surdo A., Tarle G., Togo V., Vakili M., Walter C.W., Webb R., Ambrosio, M, Antolini, R, Auriemma, G, Bakari, D, Baldini, A, Barbarino, Gc, Barish, Bc, Battistoni, G, Becherini, Y, Bellotti, R, Bemporad, C, Bernardini, P, Bilokon, H, Bloise, C, Bower, C, Brigida, M, Bussino, Severino Angelo Maria, Cafagna, F, Calicchio, M, Campana, D, Carboni, M, Caruso, R, Cecchini, S, Cei, F, Chiarella, V, Choudhary, Bc, Coutu, S, Cozzi, M, De Cataldo, G, Dekhissi, H, De Marzo, C, De Mitri, I, Derkaoui, J, De Vincenzi, M, Di Credico, A, Erriquez, O, Favuzzi, C, Forti, C, Fusco, P, Giacomelli, G, Giannini, G, Giglietto, N, Giorgini, M, Grassi, M, Grillo, A, Guarino, F, Gustavino, C, Habig, A, Hanson, K, Heinz, R, Iarocci, E, Katsavounidis, E, Katsavounidis, I, Kearns, E, Kim, H, Kyriazopoulou, S, Lamanna, E, Lane, C, Levin, D, Lipari, P, Longley, Np, Longo, Mj, Loparco, F, Maaroufi, F, Mancarella, G, Mandrioli, G, Margiotta, A, Marini, A, Martello, D, Marzari Chiesa, A, Mazziotta, Mn, Michael, Dg, Monacelli, P, Montaruli, T, Monteno, M, Mufson, S, Musser, J, Nicolo, D, Nolty, R, Orth, C, Osteria, G, Palamara, O, Patera, V, Patrizii, L, Pazzi, R, Peck, Cw, Perrone, L, Petrera, S, Pistilli, P, Popa, V, Raino, A, Reynoldson, J, Ronga, F, Rrhioua, A, Satriano, C, Scapparone, E, Scholberg, K, Sciubba, A, Serra, P, Sioli, M, Sirri, G, Sitta, M, Spinelli, P, Spinetti, M, Spurio, M, Steinberg, R, Stone, Jl, Sulak, Lr, Surdo, A, Tarle, G, Togo, V, Vakili, M, Walter, Cw, Webb, R., M., Ambrosio, Bernardini, Paolo, Martello, Daniele, DE MITRI, Ivan, Perrone, Lorenzo, Mancarella, Giovanni, Macro, Collaboration, R., Antolini, G., Auriemma, D., Bakari, A., Baldini, Barbarino, Giancarlo, B. C., Barish, G., Battistoni, Y., Becherini, R., Bellotti, C., Bemporad, P., Bernardini, H., Bilokon, C., Bloise, C., Bower, M., Brigida, S., Bussino, F., Cafagna, M., Calicchio, D., Campana, M., Carboni, R., Caruso, S., Cecchini, F., Cei, V., Chiarella, B. C., Choudhary, S., Coutu, M., Cozzi, G. D., Cataldo, H., Dekhissi, C. D., Marzo, I. D., Mitri, J., Derkaoui, M. D., Vincenzi, A. D., Credico, O., Erriquez, C., Favuzzi, C., Forti, P., Fusco, G., Giacomelli, G., Giannini, N., Giglietto, M., Giorgini, M., Grassi, A., Grillo, Guarino, Fausto, C., Gustavino, A., Habig, K., Hanson, R., Heinz, E., Iarocci, E., Katsavounidi, I., Katsavounidi, E., Kearn, H., Kim, S., Kyriazopoulou, E., Lamanna, C., Lane, D. S., Levin, P., Lipari, N. P., Longley, M. J., Longo, F., Loparco, F., Maaroufi, G., Mancarella, G., Mandrioli, A., Margiotta, A., Marini, D., Martello, A., Marzari Chiesa, M. N., Mazziotta, D. G., Michael, P., Monacelli, T., Montaruli, M., Monteno, S., Mufson, J., Musser, D., Nicolo, R., Nolty, C., Orth, G., Osteria, O., Palamara, V., Patera, L., Patrizii, R., Pazzi, C. W., Peck, L., Perrone, S., Petrera, P., Pistilli, V., Popa, A., Raino, J., Reynoldson, F., Ronga, A., Rrhioua, C., Satriano, E., Scapparone, K., Scholberg, A., Sciubba, P., Serra, M., Sioli, G., Sirri, M., Sitta, P., Spinelli, M., Spinetti, M., Spurio, R., Steinberg, J. L., Stone, L. R., Sulak, A., Surdo, G., Tarle, V., Togo, M., Vakili, C. W., Walter, and R., Webb

Subjects
HIGH-ENERGY NEUTRINOS, Particle physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Solar neutrino, grbs, FOS: Physical sciences, PROPAGATION, Astrophysics, agns, LIMIT, neutrino, AGN, Neutrino oscillation, DETECTOR, Astroparticle physics, Physics, Astrophysics (astro-ph), High Energy Physics::Phenomenology, Astronomy and Astrophysics, GRB, Solar neutrino problem, Neutrino, AGNs, GRBs, Neutrino detector, Measurements of neutrino speed, High Energy Physics::Experiment, Neutrino astronomy
Abstract

Many galactic and extragalactic astrophysical sources are currently considered promising candidates as high energy neutrino emitters. Astrophysical neutrinos can be detected as upward-going muons produced in charged-current interactions with the medium surrounding the detector. The expected neutrino fluxes from various models start to dominate on the atmospheric neutrino background at neutrino energies above some tens of TeV. We present the results of a search for an excess of high energy upward-going muons among the sample of data collected by MACRO during ~5.8 years of effective running time. No significant evidence for this signal was found. As a consequence, an upper limit on the flux of upward-going muons from high-energy neutrinos was set at the level of 1.7 10^(-14) cm^(-2) s^(-1) sr^(-1). The corresponding upper limit for the diffuse neutrino flux was evaluated assuming a neutrino power law spectrum. Our result was compared with theoretical predictions and upper limits from other experiments., 19 pages, 8 figures, 2 tables

Published
2003
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4. Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one

Author

Dolatrai M. Vyas, Krista Menard, Joan M. Carboni, David B. Frennesson, Marco M. Gottardis, Kurt Zimmermann, Ann Greer, Upender Velaparthi, Francis Y. Lee, Saulnier Mark G, Peiying Liu, George L. Trainor, Aixin Li, Mark D. Wittman, Wendy Clarke, and Zheng Yang

Subjects
Benzimidazole, Pyridones, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Administration, Oral, Mice, Nude, Pharmaceutical Science, Biochemistry, Piperazines, Receptor, IGF Type 1, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Insulin-like growth factor, Growth factor receptor, Morpholine, Drug Discovery, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, Insulin-like growth factor 1 receptor, biology, Organic Chemistry, Xenograft Model Antitumor Assays, Rats, Piperazine, chemistry, Enzyme inhibitor, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Benzimidazoles
Abstract

A series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one were synthesized to modulate CYP3A4 inhibition and improve aqueous solubility of our prototypical compound BMS-536924 (1), while maintaining potent IGF-1R inhibitory activity. Structure-activity and structure-solubility studies led to the identification of BMS-577098 (27), which demonstrates oral in vivo efficacy in animal models. The improvement was achieved by replacing morpholine with more polar bio-isoster piperazine and modulating the basicity of distal nitrogen with appropriate substitutions.

Published
2010
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5. BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide

Author

Marie-Claude Beauchamp, Joan M. Carboni, Marco M. Gottardis, Amber Yasmeen, Ariane Knafo, Michael Pollak, and Walter H. Gotlieb

Subjects
Programmed cell death, Pyridones, DNA damage, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase Inhibitor, Receptor, IGF Type 1, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Phosphorylation, Cytotoxicity, Ovarian Neoplasms, Dose-Response Relationship, Drug, business.industry, Ribosomal Protein S6 Kinases, Obstetrics and Gynecology, Drug Synergism, medicine.disease, Molecular biology, Oncogene Protein v-akt, Oncology, Cell culture, Apoptosis, Benzamides, PARP inhibitor, Cancer research, Benzimidazoles, Female, business, Ovarian cancer, DNA Damage
Abstract

Objective To evaluate the anti-neoplastic activity of BMS-536924, an IGF-1R inhibitor, in epithelial ovarian cancer and its capacity to potentiate the effect of a PARP inhibitor, 3-aminobenzamide. Methods OVCAR-3, OVCAR-4, SKOV-3 and TOV-81D cell lines were investigated in low-serum tissue culture conditions (1%FBS). Cytotoxicity assays were performed in quadruplicates using the Alamar colorimetric assay in the presence of BMS-536924 and/or 3-aminobenzamide. The levels of phospho-AKT, phospho-S6, PARP-1 and phospho-H2AX were evaluated by western blotting in the presence of BMS-536924. Results BMS-536924 induced a time and dose inhibitory effect on cell survival. This effect seemed to be mediated by a reduction of pAKT and pS6 in a dose-dependent manner. The drug also provoked cell death by apoptosis as suggested by the increase in PARP-1 cleavage. It also induces DNA damage as demonstrated by the increased phosphorylation of histone H2AX and the augmentation of the comet tail moment. Finally, BMS-536924 sensitized cells to the effect of the PARP inhibitor, 3-aminobenzamide. Conclusion Our study reinforces the concept that IGF-1R is a good therapeutic target in ovarian cancer. Moreover, it suggests that combination therapy using BMS-536924 with a PARP inhibitor might be an effective strategy to circumvent resistance to treatment in clinical settings.

Published
2009
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6. Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

Author

Joan M. Carboni, David R. Langley, Upender Velaparthi, Aixin Li, Saulnier Mark G, Ann Greer, Kurt Zimmermann, Xiaopeng Sang, Zheng Yang, Mark D. Wittman, Ricardo M. Attar, Lorell Discenza, Dolatrai M. Vyas, Praveen Balimane, Marco M. Gottardis, and David B. Frennesson

Subjects
Benzimidazole, Nitrogen, Decarboxylation, Stereochemistry, Chemistry, Pharmaceutical, medicine.medical_treatment, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Receptor, IGF Type 1, Inhibitory Concentration 50, chemistry.chemical_compound, Insulin-like growth factor, Adenosine Triphosphate, Somatomedins, Oral administration, Drug Discovery, medicine, Cytochrome P-450 CYP3A, Humans, Molecular Biology, chemistry.chemical_classification, Kinase, Organic Chemistry, Synthon, Fluorine, Malonate, Enzyme, Models, Chemical, chemistry, Area Under Curve, Drug Design, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Benzimidazoles, Thymidine
Abstract

3-(Benzimidazol-2-yl)-pyridine-2-one-based ATP competitive inhibitors of Insulin-like Growth Factor 1 Kinase (IGF-IR) were optimized for reduced Cyp3A4 inhibition and improved oral exposure. The use of malonate as methyl anion synthon via S(N)Ar reaction and double decarboxylation under mild conditions is demonstrated.

Published
2008
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7. Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

Author

Joan M. Carboni, Aixin Li, Dolatrai M. Vyas, Marco M. Gottardis, Ricardo M. Attar, Upender Velaparthi, Peiying Liu, Mark D. Wittman, Ann Greer, Zoeckler Mary Edson, and Balu Balasubramanian

Subjects
Benzimidazole, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Insulin-Like Growth Factor Receptor, Biochemistry, Chemical synthesis, Receptor, IGF Type 1, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Growth factor receptor, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Moiety, Imidazole, Molecular Biology, Insulin-like growth factor 1 receptor, biology, Organic Chemistry, Imidazoles, Cytochrome P450, chemistry, biology.protein, Molecular Medicine
Abstract

A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.

Published
2007
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8. Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

Author

Peiying Liu, Yax Sun, Xiaopeng Sang, Upender Velaparthi, Joan M. Carboni, Ann Greer, Dolatrai M. Vyas, Ricardo M. Attar, David R. Langley, ChiehYing Y. Chang, Stoffan Karen M, Kurt Zimmermann, Aixin Li, Balu Balasubramanian, Mark D. Wittman, John S. Sack, Bruce L. Jacobsen, and Marco M. Gottardis

Subjects
Pyridines, Pyridones, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Cell Line, Receptor, IGF Type 1, Inhibitory Concentration 50, Structure-Activity Relationship, Insulin-like growth factor, Growth factor receptor, Drug Discovery, medicine, Humans, Structure–activity relationship, Molecular Biology, Insulin-like growth factor 1 receptor, biology, Chemistry, Organic Chemistry, Biological activity, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Tyrosine kinase
Abstract

The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the enzyme potency. SAR and biological activity of these compounds is presented.

Published
2007
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9. Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

Author

Ann Greer, Stoffan Karen M, Joan M. Carboni, Bruce L. Jacobson, Zoeckler Mary Edson, Marco M. Gottardis, Dolatrai M. Vyas, Ricardo M. Attar, Aixin Li, Steven Hansel, Subramaniam Krishnanathan, Mark D. Wittman, Pieying Liu, Chiehying Chang, Yax Sun, Upender Velaparthi, and Balu Balasubramanian

Subjects
Models, Molecular, Pyridones, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, Insulin-like growth factor, Growth factor receptor, Drug Discovery, medicine, Animals, Structure–activity relationship, Insulin-Like Growth Factor I, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, biology, Kinase, Growth factor, Phosphotransferases, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Indicators and Reagents, Signal transduction, Baculoviridae, Thymidine
Abstract

A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.

Published
2007
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10. The physics of the FLUKA code: Recent developments

Author

F Sommerer, Fabio Cerutti, L. S. Pinsky, Paola Sala, Vincenzo Patera, Maria Vittoria Garzelli, D. A. Scannicchio, Andrea Ottolenghi, Anton Empl, Alberto Fasso, Vasilis Vlachoudis, Stefan Roesler, M. Campanella, S. Trovati, Mattias Lantz, Andrea Mostacci, Arnaud Ferrari, Silvia Muraro, Francesca Ballarini, Markus Brugger, George Smirnov, E. Gadioli, G. Battistoni, Andrea Mairani, M. Carboni, N. Zapp, M. Pelliccioni, T. Wilson, R. Villari, and J. Ranft

Subjects
Physics, Atmospheric Science, Particle physics, Physical model, Photon, monte-carlo simulations, Astrophysics::High Energy Astrophysical Phenomena, Monte Carlo method, Hadron, Aerospace Engineering, heavy-ion interactions, Astronomy and Astrophysics, Interaction model, Cosmic ray, ionization energy loss, space dosimetry, Neutron temperature, Nuclear physics, Geophysics, Space and Planetary Science, General Earth and Planetary Sciences, Generator (mathematics)
Abstract

FLUKA is a Monte-Carlo code able to simulate interaction and transport of hadrons, heavy ions and electromagnetic particles from few keV (or thermal neutron) to cosmic ray energies in whichever material. The highest priority in the design and development of the code has always been the implementation and improvement of sound and modern physical models. A summary of the FLUKA physical models is given, while recent developments are described in detail: among the others, extensions of the intermediate energy hadronic interaction generator, refinements in photon cross sections and interaction models, analytical on-line evolution of radio-activation and remnant dose. In particular, new developments in the nucleus–nucleus interaction models are discussed. Comparisons with experimental data and examples of applications of relevance for space radiation are also provided.

Published
2007
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11. Performance of the MACRO streamer tube system in the search for magnetic monopoles

Author

S. Coutu, E. Kearns, A. Rainò, Np Longley, Lawrence Sulak, Mario Sitta, C. Gustavino, A. Marzari-Chiesa, C. Bemporad, G. Ludlam, C. Orth, V. Chiarella, C. W. Peck, F.J. Ronga, P. Monacelli, L. Patrizii, G. Mandrioli, V. Bisi, E. Lamanna, M. N. Mazziotta, M. Mittelbrunn, R. Baker, Marco Monteno, C. Bloise, M. Goretti, M. Severi, P. Fusco, C. Favuzzi, G. Osteria, S. Parlati, Andrea Carlo Marini, M. G. Castellano, F. Tassoni, G. Battistoni, S. Cecchini, Alec Habig, R.M. Heinz, Roberto Bellotti, C. W. Walter, A. Hawthorne, P. Serra-Lugaresi, R. Nolty, A. Corona, P. Guarnaccia, F. Guarino, Kael Hanson, L. Miller, D. Levin, C. Okada, H. G. Giannini, R. Steinberg, M. Spinetti, J. Reynoldson, Teresa Montaruli, D. G. Michael, Vincenzo Patera, F. Sartogo, C. Forti, C. Eane, M. De Vincenzi, N. D. Pignatano, F. Cafagna, M. J. Longo, Marco Grassi, G. Giacomelli, J. T. Hong, C. Satriano, Donato Nicolo, G. Auriemma, Gregory Tarle, A. A. Grillo, A. Baldini, P. Spinelli, I. De Mitri, S P Mikheyev, C. R. Bower, V. Valente, D. Martello, A. Sciubba, S. Petrera, V. Togo, Paolo Lipari, C. De Marzo, G. C. Barbarino, O. Palamara, M. Ambrosio, Fabrizio Cei, J. A. Musser, Severino Angelo Maria Bussino, Eugenio Scapparone, A. Di Credico, R. Antolini, G. de Cataldo, S. Kyriazopoulou, P. Pistilli, R. Pazzi, V. Popa, R. C. Webb, E. Iarocci, Maurizio Spurio, A. Surdo, D. Campana, M. Carboni, J. L. Stone, Barry C. Barish, L. Satta, H. Dekhissi, N. Giglietto, G. Mancarella, Kate Scholberg, R. Liu, M. Calicchio, U. Rubizzo, Halina Bilokon, O. Erriquez, Erik Katsavounidis, P. Bernardini, S. L. Mufson, A. Margiotta-Neri, A. Sanzgiri, Y. Lu, Ambrosio M., Antolini R., Auriemma G., Baker R., Baldini A., Barbarino G.C., Barish B.C., Battistoni G., Bellotti R., Bemporad C., Bernardini P., Bilokon H., Bisi V., Bloise C., Bower C., Bussino S., Cafagna F., Calicchio M., Campana D., Carboni M., Castellano M., Cecchini S., Cei F., Chiarella V., Corona A., Coutu S., De Cataldo G., Dekhissi H., De Marzo C., De Mitri I., De Vincenzi M., Di Credico A., Erriquez O., Favuzzi C., Forti C., Fusco P., Giacomelli G., Giannini H.G., Giglietto N., Goretti M., Grassi M., Grillo A., Guarino F., Guarnaccia P., Gustavino C., Habig A., Hanson K., Hawthorne A., Heinz R., Hong J.T., Iarocci E., Katsavounidis E., Kearns E., Kyriazopoulou S., Lamanna E., Eane C., Levin D.S., Lipari P., Liu R., Longley N.P., Longo M.J., Lu Y., Ludlam G., Mancarella G., Mandrioli G., Margiotta-Neri A., Marini A., Martello D., Marzari-Chiesa A., Mazziotta M.N., Michael D.G., Mikheyev S., Miller L., Mittelbrunn M., Monacelli P., Montaruli T., Monteno M., Mufson S., Musser J., Nicolo D., Nolty R., Okada C., Orth C., Osteria G., Palamara O., Parlati S., Patera V., Patrizii L., Pazzi R., Peck C.W., Petrera S., Pignatano N.D., Pistilli P., Popa V., Raino A., Reynoldson J., Ronga F., Rubizzo U., Sanzgiri A., Sartogo F., Satriano C., Satta L., Scapparone E., Scholberg K., Sciubba A., Serra-Lugaresi P., Severi M., Sitta M., Spinelli P., Spinetti M., Spurio M., Steinberg R., Stone J.L., Sulak L.R., Surdo A., Tarle G., Tassoni F., Togo V., Valente V., Walter C.W., Webb R., M., Ambrosio, R., Antolini, G., Auriemma, R., Baker, A., Baldini, G. C., Barbarino, B. C., Barish, G., Battistoni, R., Bellotti, C., Bemporad, P., Bernardini, H., Bilokon, V., Bisi, C., Bloise, C., Bower, S., Bussino, F., Cafagna, M., Calicchio, D., Campana, M., Carboni, M., Castellano, S., Cecchini, F., Cei, V., Chiarella, A., Corona, S., Coutu, G., De Cataldo, H., Dekhissi, C., De Marzo, DE MITRI, Ivan, M., De Vincenzi, A., Di Credico, O., Erriquez, C., Favuzzi, C., Forti, P., Fusco, G., Giacomelli, H. G., Giannini, N., Giglietto, M., Goretti, M., Grassi, A., Grillo, F., Guarino, P., Guarnaccia, C., Gustavino, A., Habig, K., Hanson, A., Hawthorne, R., Heinz, J. T., Hong, E., Iarocci, E., Katsavounidi, E., Kearn, S., Kyriazopoulou, E., Lamanna, C., Eane, D. S., Levin, P., Lipari, R., Liu, N. P., Longley, M. J., Longo, Y., Lu, G., Ludlam, Mancarella, Giovanni, G., Mandrioli, A., Margiotta Neri, A., Marini, Martello, Daniele, A., Marzari Chiesa, M. N., Mazziotta, D. G., Michael, S., Mikheyev, L., Miller, M., Mittelbrunn, P., Monacelli, T., Montaruli, M., Monteno, S., Mufson, J., Musser, D., Nicoló, R., Nolty, C., Okada, C., Orth, G., Osteria, O., Palamara, S., Parlati, V., Patera, L., Patrizii, R., Pazzi, C. W., Peck, S., Petrera, N. D., Pignatano, P., Pistilli, V., Popa, A., Rainó, J., Reynoldson, F., Ronga, U., Rubizzo, A., Sanzgiri, F., Sartogo, C., Satriano, L., Satta, E., Scapparone, K., Scholberg, A., Sciubba, P., Serra Lugaresi, M., Severi, M., Sitta, P., Spinelli, M., Spinetti, M., Spurio, R., Steinberg, J. L., Stone, L. R., Sulak, A., Surdo, G., Tarlé, F., Tassoni, V., Togo, V., Valente, C. W., Walter, R., Webb, Ambrosio, M, Antolini, R, Auriemma, G, Baker, R, Baldini, A, Barbarino, Gc, Barish, Bc, Battistoni, G, Bellotti, R, Bemporad, C, Bernardini, P, Bilokon, H, Bisi, V, Bloise, C, Bower, C, Bussino, Severino Angelo Maria, Cafagna, F, Calicchio, M, Campana, D, Carboni, M, Castellano, M, Cecchini, S, Cei, F, Chiarella, V, Corona, A, Coutu, S, Decataldo, G, Dekhissi, H, Demarzo, C, Demitri, I, Devincenzi, M, Dicredico, A, Erriquez, O, Favuzzi, C, Forti, C, Fusco, P, Giacomelli, G, Giannini, G, Giglietto, N, Goretti, M, Grassi, M, Grillo, A, Guarino, F, Guarnaccia, P, Gustavino, C, Habig, A, Hanson, K, Hawthorne, A, Heinz, R, Hong, Jt, Iarocci, E, Katsavounidis, E, Kearns, E, Kyriazopoulou, S, Lamanna, E, Lane, C, Levin, D, Lipari, P, Liu, R, Longley, Np, Longo, Mj, Lu, Y, Ludlam, G, Mancarella, G, Mandrioli, G, Margiottaneri, A, Marini, A, Martello, D, Marzarichiesa, A, Mazziotta, Mn, Michael, Dg, Mikheyev, S, Miller, L, Mittelbrunn, M, Monacelli, P, Montaruli, T, Monteno, M, Mufson, S, Musser, J, Nicolo, D, Nolty, R, Okada, C, Orth, C, Osteria, G, Palamara, O, Parlati, S, Patera, V, Patrizii, L, Pazzi, R, Peck, Cw, Petrera, S, Pignatano, Nd, Pistilli, P, Popa, V, Raino, A, Reynoldson, J, Ronga, F, Rubizzo, U, Sanzgiri, A, Sartogo, F, Satriano, C, Satta, L, Scapparone, E, Scholberg, K, Sciubba, A, Serralugaresi, P, Severi, M, Sitta, M, Spinelli, P, Spinetti, M, Spurio, M, Steinberg, R, Stone, Jl, Sulak, Lr, Surdo, A, Tarle, G, Tassoni, F, Togo, V, Valente, V, Walter, Cw, Webb, R., Barbarino, Giancarlo, and Guarino, Fausto

Subjects
Physics, Physics::Instrumentation and Detectors, High Energy Physics::Lattice, Detector, Magnetic monopole, Astronomy and Astrophysics, Cosmic ray, Time resolution, MACRO, Gran Sasso, Computational physics, Nuclear physics, Tube (fluid conveyance), Macro
Abstract

We describe the techniques chosen to search tor magnetic monopoles using the MACRO streamer tube sub-system. The hardware and the details of the analysis procedures will be discussed also. The results for slowly moving monopoles are reported from a first data taking period using only part of the detector. © 1995 Elsevier Science B.V. All rights reserved.

Published
1995
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12. The fluka code for space applications: recent developments

Author

Andrea Ottolenghi, V. Andersen, Johannes Ranft, M. Pelliccioni, Kerry Lee, Anton Empl, Lawrence S. Pinsky, Maria Vittoria Garzelli, Francesco Cerutti, Stefan Roesler, T. Wilson, A. Fassò, M. Campanella, Paola Sala, Francesca Ballarini, E. Gadioli, M. Carboni, A. Ferrari, and G. Battistoni

Subjects
Atmospheric Science, Extraterrestrial Environment, Monte Carlo method, Inelastic collision, Aerospace Engineering, Cosmic ray, Nuclear physics, symbols.namesake, Master equation, Computer Simulation, Heavy Ions, Neutron, Statistical physics, Solar Activity, Nuclear Physics, Neutrons, Physics, Range (particle radiation), Committee on Space Research, Astronomy and Astrophysics, Models, Theoretical, Space Flight, Elementary Particle Interactions, Geophysics, Space and Planetary Science, Boltzmann constant, symbols, General Earth and Planetary Sciences, Monte Carlo Method, Cosmic Radiation, Mathematics
Abstract

The FLUKA Monte Carlo transport code is widely used for fundamental research, radioprotection and dosimetry, hybrid nuclear energy system and cosmic ray calculations. The validity of its physical models has been benchmarked against a variety of experimental data over a wide range of energies, ranging from accelerator data to cosmic ray showers in the earth atmosphere. The code is presently undergoing several developments in order to better fit the needs of space applications. The generation of particle spectra according to up-to-date cosmic ray data as well as the effect of the solar and geomagnetic modulation have been implemented and already successfully applied to a variety of problems. The implementation of suitable models for heavy ion nuclear interactions has reached an operational stage. At medium/high energy FLUKA is using the DPMJET model. The major task of incorporating heavy ion interactions from a few GeV/n down to the threshold for inelastic collisions is also progressing and promising results have been obtained using a modified version of the RQMD-2.4 code. This interim solution is now fully operational, while waiting for the development of new models based on the FLUKA hadron-nucleus interaction code, a newly developed QMD code, and the implementation of the Boltzmann master equation theory for low energy ion interactions. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

Published
2004
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13. Atmospheric neutrino oscillations from upward throughgoing muon multiple scattering in MACRO

Author

M. Carboni, D. Campana, A. Surdo, M. Giorgini, Vincenzo Patera, G. Giannini, C. Bloise, E. Kearns, C. Forti, M. Spinetti, A. Sciubba, S. Cecchini, C. Favuzzi, A. Baldini, A. Rrhioua, G. Giacomelli, M. De Vincenzi, J. L. Stone, O. Palamara, B. C. Barish, N. Giglietto, Mario Sitta, R.M. Heinz, E. Iarocci, C. Satriano, A. Di Credico, Annarita Margiotta, L. R. Sulak, Gregory Tarle, C. Gustavino, S P Mikheyev, Ashavani Kumar, F. Loparco, S. Kyriazopoulou, G. de Cataldo, D. Bakari, A. Rainò, D. Levin, C. Bemporad, R. Caruso, R. C. Webb, E. Katsavounidis, C. Orth, Severino Angelo Maria Bussino, P. Serra, V. Popa, P. Bernardini, G. Mandrioli, Tommaso Chiarusi, M. Grassi, Yvonne Becherini, Fabrizio Cei, G. Sirri, C. W. Walter, M. Brigida, Michael J. Longo, Donato Nicolo, Giuseppe Osteria, Kate Scholberg, F. Cafagna, M. N. Mazziotta, D. Martello, Hyun-Chul Kim, A. Marzari-Chiesa, Marco Monteno, A. A. Grillo, Alec Habig, I. De Mitri, M. Cozzi, J. Derkaoui, Ioannis Katsavounidis, F. Maaroufi, G. C. Barbarino, P. Spinelli, Kael Hanson, P. Fusco, C. R. Bower, L. Perrone, Maximiliano Sioli, C. De Marzo, Eugenio Scapparone, R. Antolini, V. Togo, J. A. Musser, H. Dekhissi, Andrea Carlo Marini, Paolo Lipari, M. Vakili, Roberto Bellotti, G. Mancarella, R. Nolty, C. W. Peck, J. Reynoldson, Teresa Montaruli, R. Pazzi, S. Coutu, Frederic Jean Ronga, S. L. Mufson, B. C. Choudhary, Shahid Manzoor, D. G. Michael, S. Petrera, Maurizio Spurio, R. Steinberg, M. Ambrosio, V. Chiarella, M. Calicchio, Halina Bilokon, P. Monacelli, E. Lamanna, G Battistoni, C. E. Lane, L. Patrizii, Barbarino, Giancarlo, Ambrosio, M, Antolini, R, Bakari, D, Baldini, A, Barbarino, Gc, Barish, Bc, Battistoni, G, Becherini, Y, Bellotti, R, Bemporad, C, Bernardini, P, Bilokon, H, Bloise, C, Bower, C, Brigida, M, Bussino, Severino Angelo Maria, Cafagna, E, Calicchio, M, Campana, D, Carboni, M, Caruso, R, Cecchini, S, Cei, F, Chiarella, V, Chiarusi, T, Choudhary, Bc, Coutu, S, Cozzi, M, De Cataldo, G, Dekhissi, H, De Marzo, C, De Mitri, I, Derkaoui, J, De Vincenzi, M, Di Credico, A, Favuzzi, C, Forti, C, Fusco, P, Giacomelli, G, Giannini, G, Giglietto, N, Giorgini, M, Grassi, M, Grillo, A, Gustavino, C, Habig, A, Hanson, K, Heinz, R, Iarocci, E, Katsavounidis, E, Katsavounidis, I, Kearns, E, Kim, H, Kumar, A, Kyriazopoulou, S, Lamanna, E, Lane, C, Levin, D, Lipari, P, Longo, Mj, Loparco, F, Maaroufi, F, Mancarella, G, Mandrioli, G, Manzoor, S, Margiotta, A, Marini, A, Martello, D, Marzari Chiesa, A, Mazziotta, Mn, Michael, Dg, Mikheyev, S, Monacelli, P, Montaruli, T, Monteno, M, Mufson, S, Musser, J, Nicolo, D, Nolty, R, Orth, C, Osteria, G, Palamara, O, Patera, V, Patrizii, L, Pazzi, R, Peck, Cw, Perrone, L, Petrera, S, Popa, V, Raino, A, Reynoldson, J, Ronga, F, Rrhioua, A, Satriano, C, Scapparone, E, Scholberg, K, Sciubba, A, Serra, P, Sioli, M, Sirri, G, Sitta, M, Spinelli, P, Spinetti, M, Spurio, M, Steinberg, R, Stone, Jl, Sulak, Lr, Surdo, A, Tarle, G, Togo, V, Vakili, M, Walter, Cw, Webb, R., Ambrosio M., Antolini R., Bakari D., Baldini A., Barbarino G.C., Barish B.C., Battistoni G., Becherini Y., Bellotti R., Bemporad C., Bernardini P., Bilokon H., Bloise C., Bower C., Brigida M., Bussino S., Cafagna F., Calicchio M., Campana D., Carboni M., Caruso R., Cecchini S., Cei F., Chiarella V., Chiarusi T., Choudhary B.C., Coutu S., Cozzi M., de Cataldo G., Dekhissi H., de Marzo C., de Mitri I., Derkaoui J., de Vincenzi M., di Credico A., Favuzzi C., Forti C., Fusco P., Giacomelli G., Giannini G., Giglietto N., Giorgini M., Grassi M., Grillo A., Gustavino C., Habig A., Hanson K., Heinz R., Iarocci E., Katsavounidis E., Katsavounidis I., Kearns E., Kim H., Kumar A., Kyriazopoulou S., Lamanna E., Lane C., Levin D.S., Lipari P., Longo M.J., Loparco F., Maaroufi F., Mancarella G., Mandrioli G., Manzoor S., Margiotta A., Marini A., Martello D., Marzari-Chiesa A., Mazziotta M.N., Michael D.G., Mikheyev S., Monacelli P., Montaruli T., Monteno M., Mufson S., Musser J., Nicolo D., Nolty R., Orth C., Osteria G., Palamara O., Patera V., Patrizii L., Pazzi R., Peck C.W., Perrone L., Petrera S., Popa V., Raino A., Reynoldson J., Ronga F., Rrhioua A., Satriano C., Scapparone E., Scholberg K., Sciubba A., Serra P., Sioli M., Sirri G., Sitta M., Spinelli P., Spinetti M., Spurio M., Steinberg R., Stone J.L., Sulak L.R., Surdo A., Tarle G., Togo V., Vakili M., Walter C.W., Webb R., Bernardini, Paolo, Martello, Daniele, DE MITRI, Ivan, Mancarella, Giovanni, Perrone, Lorenzo, and Macro, Collaboration

Subjects
Astroparticle physics, Physics, Elastic scattering, Particle physics, Nuclear and High Energy Physics, Muon, Scattering, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, MACRO, Gran Sasso, High Energy Physics - Experiment, Massless particle, Nuclear physics, High Energy Physics - Experiment (hep-ex), Physique des particules élémentaires, High Energy Physics::Experiment, Neutrino, Neutrino oscillation, Lepton
Abstract

The energy of atmospheric neutrinos detected by MACRO was estimated using multiple coulomb scattering of upward throughgoing muons. This analysis allows a test of atmospheric neutrino oscillations, relying on the distortion of the muon energy distribution. These results have been combined with those coming from the upward throughgoing muon angular distribution only. Both analyses are independent of the neutrino flux normalization and provide strong evidence, above the 4 sigma level, in favour of neutrino oscillations., 10 pages, 7 figures, submitted to Physics Letters B

Published
2003
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14. The KLOE detector and physics program

Author

L. Tortora, M. Adinolfi, F. Ambrosino, A. Aloisio, A. Andryakov, A. Angeletti, A. Antonelli, C. Bacci, R. Baldini-Ferroli, G. Barbiellini, G. Bencivenni, S. Bertolucci, C. Bini, C. Bloise, V. Bocci, F. Bossi, P. Branchini, L. Bucci, G. Cabibbo, A. Calcaterra, R. Caloi, G. Carboni, P. Campana, G. Capon, M. Carboni, C. Carusotti, G. Cataldi, F. Ceradini, F. Cervelli, F. Cevenini, G. Chiefari, P. Ciam brone, S. Conticelli, E. De Lucia, R. De Sangro, P. De Zorzi, S. Dell'Agnello, A. Denig, A. Di Domenico, S. Di Falco, A. Doria, F. Donno, E. Drago, V. Elia, L. Entesano, O. Erriquez, A. Farilla, G. Felici, A. Ferrari, M.L. Ferrer, G. Finocchiaro, D. Fiore, C. Forti, G. Foti, A. Franceschi, P. Franzini, A. Galli, M.L. Gao, C. Gatti, P. Gauzzi, S. Giovannella, V. Golovatyuk, E. Gorini, F. Grancagnolo, E. Graziani, P. Guarnaccia, U.v. Hagel, H.G. Han, S.W. Han, M. Incagli, L. Ingrosso, W. Kim, W. Kluge, V. Kulikov, F. Lacava, G. Lanfranchi, J. Lee-Franzini, T. Lomtadze, C. Luisi, A. Martini, W. Mei, L. Merola, R. Messi, S. Miscetti, A. Moalem, S. Moccia, F. Murtas, M. Napolitano, A. Nedosekin, P. Pagès, M. Palutan, L. Paoluzi, E. Pasqualucci, L. Passalacqua, M. Passaseo, A. Passeri, V. Patera, E. Petrolo, G. Petrucci, D. Picca, M. Piccolo, A. Pintus, G. Pirozzi, L. Pontecorvo, M. Primavera, F. Ruggieri, P. Santangelo, E. Santovetti, G. Saracino, R.D. Schamberger, C. Schwick, B. Sciascia, A. Sciubba, F. Scuri, I. Sfiligoi, S. Sinibaldi, T. Spadaro, S. Spagnolo, E. Spiriti, C. Stanescu, E. Valente, P. Valente, G. Venanzoni, S. Veneziano, D. Vettoretti, S. Weseler, Y.G. Xie, C.D. Zhang, J.Q. Zhang, and P.P. Zhao

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Detector, Measure (physics), CP violation, Atomic and Molecular Physics, and Optics
Abstract

The KLOE detector, mainly designed to measure the R ( ϵ′ ϵ ) parameter of CP violation in KL decay to an absolute precision of ≈ 10−4, is completed and will start data taking by spring 1999 at the e+ e− Φ-factory DAΦNE in Frascati. The primary K-meson physics and the experimental requirements at DAΦNE are summarized. The design strategies, the salient features and the main physics performances of all components of the experimental apparatus are reviewed.

Published
1999
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15. The measurement of upward going muons using the MACRO detector

Author

D. Martello, D. Campana, A. M. Baldini, P. Lipari, P. Pistilli, Kate Scholberg, Kael Hanson, Shahid Manzoor, C.W. Peck, P. Monacelli, L. De Benedictis, D.G. Michael, J. Musser, M. Ambrosio, O. Erriquez, S. L. Mufson, M. Sitta, L.R. Sulak, G. Giannini, G. Battistoni, M. Carboni, G. Giacomelli, O. Palamara, F. Cafagna, E. Iarocci, C. Gustavino, Marco Grassi, M. Calicchio, R. Pazzi, L. Gray, A. Sciubba, G. Tarle, L. Satta, S P Mikheyev, G.C. Barbarino, E. Lamanna, G. Osteria, S. Kyriazopoulou, S. Coutu, C. Orth, A. Marini, A. Sanzgiri, S. Cecchini, U. Rubizzo, Maurizio Spurio, C. Mazzotta, P. Bernardini, M. Castellano, J. Reynoldson, A. Di Credico, C. Aramo, N.P. Longley, F. Guarino, P. Spinelli, Teresa Montaruli, A. Marzari-Chiesa, F. Ronga, N. Giglietto, A. Hawthorne, G. Auriemma, G. Cunti, M. J. Longo, A. Habig, R.M. Heinz, Donato Nicolo, V. Bisi, C. W. Walter, E. Kearns, H. Bilokon, H. Dekhissi, V. Pugliese, V. Chiarella, P. Serra-Lugaresi, C. Favuzzi, M. Spinetti, M. Monteno, M.N. Mazziotta, L. Miller, D. Levin, C. Okada, R. Steinberg, Vincenzo Patera, E. Katsavounidis, A. Rainó, S. Petrera, S. Bussino, R. C. Webb, C. Bemporad, R. Nolty, G. Mandrioli, M. Severi, G. Mancarella, B.C. Barish, A. A. Grillo, C. Lane, C. Forti, V. Togo, G. De Cataldo, Eugenio Scapparone, M. De Vincenzi, V. Popa, P. Fusco, J.L. Stone, Maximiliano Sioli, C. R. Bower, C. Satriano, A. Surdo, A. Margiotta Neri, P. Guarnaccia, C. Bloise, C. De Marzo, R. Antolini, F. Maaroufi, L. Patrizii, I De Mitri, Fabrizio Cei, and R. Bellotti

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, Solar neutrino problem, Atomic and Molecular Physics, and Optics, Neutrino detector, High Energy Physics::Experiment, Neutrino astronomy, Neutrino, Neutrino oscillation, Zenith
Abstract

The upward-going muon flux (Eμ > 1 GeV) has been measured with the underground detector MACRO at LNGS. The total number of measured events is compatible at the 8% c.l. with the expected one. Moreover, the zenith angular distribution of the measured flux does not match the expectation showing a deficit in the vertical direction where the apparatus performance is best known. Assuming an oscillation hypothesis with parameters in the range recently suggested to solve the atmospheric neutrino problem, the agreement increases, but not significantly. The results of an indirect dark matter search for a signal of WIMPs from the core of the Sun and of the Earth are given. Neutrino astronomy with MACRO is giving interesting results regarding possible high energy neutrino emission from pointlike sources and coincidences of neutrino events with γ-ray bursts.

Published
1999
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16. Status of the KLOE experiment at the ø-factory DAΦNE

Author

Margherita Primavera, Paolo Franzini, R. Caloi, P. De Simone, S. Miscetti, L. Ingrosso, Alberto Aloisio, A. Moalem, W. Mei, E. Spiriti, Leonardo Merola, H.G. Han, Ashlie Martini, Vincenzo Patera, Cristian Stanescu, P. Branchini, A. Sciubba, P. Campana, Enrico Pasqualucci, G. Felici, R. D. Schamberger, Stefania Spagnolo, E. Valente, G. Cataldi, G. Di Cosimo, S. Weseler, C. De Lucia, A. Nedosekin, G.F. Palama, S. Dell'Angnello, M. Piccolo, L. Paoluzi, G. Cheifari, G. Lanfranchi, Stefano Veneziano, A. G. Denig, P.P. Zhao, C. Forti, G. Corti, F.M. Favero, D. Picca, F. Bossi, A. Pintus, A. Antonelli, Edoardo Gorini, G. Bencivenni, D. Fiore, G. Barbiellini, F. Donno, M.M. Massai, F. Grancagnolo, A. Zott, C. Bloise, Christoph Schwick, A. Passeri, Chao Zhang, E. Drago, Cesare Bini, G. Carboni, C. Bacci, M. Napolitano, Francesco Lacava, U. v. Hagel, L. Tortora, P. Valente, Emilio Petrolo, F. Cervelli, C. Luisi, W. Kluge, S. Di Falco, A. Ferrari, M. Carboni, J.Q. Zhang, P. Guazzi, R. Baldini-Ferroli, O. Erriquez, L. Bucci, R. de Sangro, Andrea Doria, W. Grandegger, R. Messi, G. Venanzoni, A. Andryakov, S. Bertolucci, A. Farilla, F. Ruggieri, G. Capon, A. Galli, M. L. Ferrer, Igor Sfiligoi, S. Conticelli, I. Cohen, V. Bocci, A. Calcaterra, G. De Zorzi, D. Vettoretti, Yuehong Xie, G. Petrucci, G. Cabibbo, C. Curosotti, A. Franceschi, G. Saracino, F. Cevenini, G. Forti, F. Murtas, V. Elia, C. Colantuono, Ludovico Pontecorvo, M. Panareo, Marina Passaseo, A. Di Domenico, V. V. Kulikov, Filippo Ceradini, W. Kim, L. Passalacqua, Teimuraz Lomtadze, M.L. Gao, Paolo Ciambrone, C. Gatto, S.W. Han, G. Finocchiaro, P. Guarnaccia, A. Adinolfi, A. di Benedetto, L. Entesano, E. Graziani, A. Angeletti, V.M. Golovatyuk, G. Pirozz, M. Incagli, Fabrizio Scuri, Juliet Lee-Franzini, S. Giovannella, S. Moccia, E. Santovetti, and S. Conetti

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Detector, CP violation, Factory (object-oriented programming), Current (fluid), Atomic and Molecular Physics, and Optics
Abstract

The CP violation physics program and the detector design are described. The current status of KLOE is summarized.

Published
1998
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17. Aberrant Regulation of Transforming Growth Factor-α during the Establishment of Growth Arrest and Quiescence of Growth Factor Independent Cells

Author

Joan M. Carboni, Rana A. Awwad, Wenhui Li, Lisa E. Humphrey, Degeng Wang, Basker Periyasamy, Junhua Yang, James K V Willson, Michael G. Brattain, Alan Koterba, Kevin G. Coleman, Mark Lynch, Barry L. Ziober, and Gillian M. Howell

Subjects
Chloramphenicol O-Acetyltransferase, Transcription, Genetic, Recombinant Fusion Proteins, medicine.medical_treatment, Molecular Sequence Data, Regulatory Sequences, Nucleic Acid, Biology, Transfection, Biochemistry, Cell Line, Downregulation and upregulation, Leukocytes, Tumor Cells, Cultured, medicine, Humans, Insulin, RNA, Messenger, Cloning, Molecular, Promoter Regions, Genetic, Autocrine signalling, Molecular Biology, Genomic Library, Messenger RNA, Base Sequence, Epidermal Growth Factor, Effector, Growth factor, Cell Cycle, Cell Biology, Transforming Growth Factor alpha, Phenotype, Clone Cells, Cell biology, Gene Expression Regulation, Neoplastic, Kinetics, Cell culture, Colonic Neoplasms, Cell Division, Transforming growth factor
Abstract

Autocrine transforming growth factor alpha (TGFalpha) is an important positive growth effector in malignant cells and plays a significant role in generating the growth factor-independent phenotype associated with malignant progression. However, the molecular mechanisms by which TGFalpha confers a growth advantage in progression is poorly understood. The highly tumorigenic cell line HCT116 up-regulates TGFalpha mRNA expression during growth arrest, whereas the poorly tumorigenic growth factor-dependent FET cell line down-regulates TGFalpha mRNA expression as it becomes quiescent. We have identified a 25-bp sequence at -201 to -225 within the TGFalpha promoter which mediates the differential regulation of TGFalpha expression during quiescence establishment in these two cell lines. This same sequence confers TGFalpha promoter responsiveness to exogenous growth factor or autocrine TGFalpha. The abberant upregulation of TGFalpha mRNA in quiescent HCT116 cells may allow them to return to the dividing state under more stringent conditions (nutrient replenishment alone) then quiescent FET cells (requires nutrients and growth factors). Antisense TGFalpha approaches showed that the dysregulated TGFalpha expression in quiescent HCT116 cells is a function of the strong TGFalpha autocrine loop (not inhibited by blocking antibodies) in these cells.

Published
1998
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18. Searches for magnetic monopoles with the MACRO detector at Gran Sasso

Author

Vincenzo Patera, A. Sciubba, O. Palamara, M. Carboni, B. C. Barish, J. Musser, P. Bernardini, James R. Stone, Ana Maria Marin, A. Hawthorne, M. G. Castellano, G. Battistoni, C. W. Peck, C. Rossi, J. L. Stone, Kael Hanson, M. Ambrosio, S. L. Mufson, L. Satta, Severino Angelo Maria Bussino, G. Tarle, A. Margiotta-Neri, P. Pistilli, M. Severi, V. Valente, A. Rainò, R. Nolty, R. Pazzi, V. Chiarella, Marco Grassi, P. Serra Lugaresi, P. Guarnaccia, Edward Diehl, F. Sartogo, A. Sanzgiri, J. Petrakis, L. R. Sulak, G. Osteria, P. Monacelli, C. Bemporad, S. Coutu, V. Bisi, J. T. Hong, S. P. Ahlen, J. Reynoldson, R. Baker, Roberto Bellotti, F. Cafagna, R.M. Heinz, Y. Lu, Fabrizio Cei, Np Longley, G. C. Barbarino, Mario Sitta, D. G. Michael, C. Gustavino, Donato Nicolo, A. Di Credico, Maurizio Spurio, A. Surdo, M. Mittelbrun, E. Katsavounidis, S. Parlati, S. Kyriazopoulou, Paolo Lipari, M. Spinetti, C. Forti, Eugenio Scapparone, C. E. Lane, V. Popa, G. Ludlam, R. C. Webb, Marco Monteno, S. Petrera, T. Bosio, P. F. Spada, R. Fantini, M. Sioli, G. Giacomelli, I. De Mitri, A. M. Baldini, C. Orth, C. R. Bower, C. Favuzzi, M. De Vincenzi, G.L. Sanzani, C. De Marzo, C. Satriano, M. Calicchio, G. Auriemma, M. J. Longo, F. Guarino, D. Campana, Halina Bilokon, G. Liu, S P Mikheyev, Mn Mazziotta, D. Martello, Kate Scholberg, R. Liu, W. A. Worstell, E. Iarocci, C. W. Walter, Robert A. Cormack, H. Dekhissi, A. A. Grillo, U. Rubizzo, B. Pavesi, T. Montaruli, O. Erriquez, L. Patrizii, G. Mandrioli, F.J. Ronga, M. Goretti, A. Corona, R. Antolini, G. de Cataldo, L. Miller, D. Levin, G. Giannini, N. D. Pignatano, N. Giglietto, V. Togo, P. Matteuzzi, S. Cecchini, Alec Habig, G. Mamcarella, C. Okada, E. Kearns, A. Marzari-Chiesa, E. Lamanna, P. Spinelli, R. Steinberg, C. Bloise, P. Fusco, Andrea Carlo Marini, Paul J. Green, Ahlen, S, Ambrosio, M, Antolini, R, Auriemma, G, Baker, R, Baldini, A, Barbarino, Gc, Barish, Bc, Battistoni, G, Bellotti, R, Bemporad, C, Bernardini, P, Bilokon, H, Bisi, V, Bloise, C, Bosio, T, Bower, C, Bussino, Severino Angelo Maria, Cafagna, F, Calicchio, M, Campana, D, Castellano, M, Carboni, M, Cecchini, S, Cei, F, Chiarella, V, Cormak, R, Corona, A, Coutu, S, De Cataldo, G, Dekhissi, H, De Marzo, C, De Mitri, I, De Vincenzi, M, Di Credico, A, Diehl, E, Erriquez, O, Fantini, R, Favuzzi, C, Forti, C, Fusco, P, Giacomelli, G, Giannini, G, Giglietto, N, Goretti, M, Grassi, M, Green, P, Grillo, A, Guarino, F, Gustavino, C, Habig, A, Hanson, K, Hawthorne, A, Heinz, R, Hong, Jt, Iarocci, E, Katsavounidis, E, Kearns, E, Kyriazopoulou, S, Lamanna, E, Lane, C, Levin, D, Lipari, P, Liu, G, Liu, R, Longley, Np, Longo, Mj, Lu, Y, Ludlam, G, Mancarella, G, Mandrioli, G, Margiotta Neri, A, Marin, A, Marini, A, Martello, D, Marzari Chiesa, A, Matteuzzi, P, Mazziotta, Mn, Michael, Dg, Mikheyev, S, Miller, L, Mittelbrun, M, Monacelli, P, Montaruli, T, Monteno, M, Mufson, S, Musser, J, Nicolo, D, Nolty, R, Okada, C, Orth, C, Osteria, G, Palamara, O, Parlati, S, Patera, V, Patrizii, L, Pazzi, R, Peck, Cw, Petrakis, J, Petrera, S, Pignatano, N, Pistilli, P, Popa, V, Raino, A, Reynoldson, J, Ronga, F, Rossi, C, Rubizzo, U, Sanzani, G, Sanzgiri, A, Sartogo, F, Satriano, C, Satta, L, Scapparone, E, Scholberg, K, Sciubba, A, Serra Luganesi, P, Severi, M, Sioli, M, Sitta, M, Spada, Pf, Spinelli, P, Spinetti, M, Spurio, M, Steinberg, R, Stone, Jl, Sulak, Lr, Surdo, A, Tarle, G, Togo, V, Valente, V, Walter, Cw, Webb, R, and Worstell, W.

Subjects
Physics, Nuclear and High Energy Physics, Range (particle radiation), Magnetic monopole, Physics::Instrumentation and Detectors, Detector, Flux, MACRO, Scintillator, Atomic and Molecular Physics, and Optics, Relativistic particle, Nuclear physics, Planar, Macro, Underground detector
Abstract

MACRO is a large area multiple component detector located deep underground in Hall B of the Laboratori Nazionali del Gran Sasso in Italy. Its active components consist of tanks of liquid scintillator and planes of limited streamer tubes. In addition, there are two planar areas covered with passive track-etch plastics. The full detector measures 72 m × 12 m × 9.6 m providing a large sensitive area for the detection of penetrating particles. Multiple electronics systems provide triggering on particles over a wide range of velocities, in particular, for slowly moving massive particles such as grand unified magnetic monopoles. MACRO is sensitive to relativistic particles as well as ones whose velocities are as low as 10 −4 c. Various portions of the MACRO detector have been operational since 1989. Various data sets have been analyzed and although no monopoles have been found, stringent flux limits have been set using a variety of techniques. This paper summarizes the capabilities of MACRO for monopole detection and presents some experimental results which have been obtained to date.

Published
1996
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19. Novel C-4 paclitaxel (Taxol®) analogs: potent antitumor agents

Author

John F. Kadow, Dolatrai M. Vyas, Joan M. Carboni, William C. Rose, Vittorio Farina, Jianmei Wei, S. W. Mamber, Kathy A. Johnston, Shu-Hui Chen, Byron H. Long, Craig Fairchild, Anna Maria Casazza, and Terrence W. Doyle

Subjects
Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, In vitro toxicology, Pharmaceutical Science, Biochemistry, In vitro, chemistry.chemical_compound, Paclitaxel, Cell culture, In vivo, Drug Discovery, Side chain, Molecular Medicine, Cytotoxicity, Molecular Biology, Derivative (chemistry)
Abstract

A large number of C-4 paclitaxel analogs have been prepared in the course of our systematic C-4 modification. These include C-4 esters, carbonates, carbamates as well as a C-4 deacetyl derivative. All of these analogs were evaluated in a tubulin polymerization assay as well as in a cytotoxicity assay against a human colon cancer cell line. The potent analogs emerging from these in vitro assays were further evaluated in vivo. With the exception of paclitaxel side chain bearing C-4 carbamates and C-4 aromatic esters, most of the C-4 aliphatic esters and carbonates were found to possess comparable or superior activity to paclitaxel in vitro. Several C-4 aliphatic esters and carbonates also exhibited in vivo activities against i.p. implanted murine M-109 lung carcinoma.

Published
1995
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20. Environmental protection in space: a quantitative policy study

Author

Ted L. Napier and Silvana M. Carboni

Subjects
Economics and Econometrics, Economic growth, Sociology and Political Science, Public economics, Space and Planetary Science, Environmental safety, Control (management), Survey data collection, Sample (statistics), Business, Space (commercial competition), Test (assessment)
Abstract

Survey data were collected in the USA from a national sample of chief executive officers. The first goal of the research was to identify national policies and strategies to control orbital debris, without imposing undue negative impacts on the US private and governmental space sectors. The second goal was to test a theoretical model, developed to predict the willingness of respondents to accept a national space environmental safety programme. National and International implications were drawn.

Published
1994
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22. Estimate of the primary cosmic ray composition from a multi-parametric fit of MACRO multimuon events

Author

Valente, Paolo Lipari, J. Musser, Jl Stone, G. Ludlam, Marco Grassi, A. M. Baldini, F. Cafagna, Am Neri, F.J. Ronga, P. Pistilli, L. Patrizii, G. Mandrioli, Mn Mazziotta, P. Bernardini, R. Pazzi, J. T. Hong, D. G. Michael, Np Longley, M. Calicchio, Halina Bilokon, Marco Monteno, C. E. Lane, M. Goretti, S. Kyriazopoulou, Bisi, S. Cecchini, Alec Habig, Maurizio Spurio, A. Surdo, L. R. Sulak, C. Okada, M. Severi, G. C. Barbarino, E. Kearns, R. C. Webb, P. F. Spada, R. Steinberg, C. R. Bower, A. Corona, Y. Lu, M. Spinetti, C. W. Peck, R. Baker, Eugenio Scapparone, A. Marzari-Chiesa, O. Erriquez, G. Tarle, E. Lamanna, P. Spinelli, C. Bloise, P. Fusco, S. Petrera, Andrea Carlo Marini, Giovanni Mancarella, C. Satriano, G. Auriemma, M. J. Longo, L. Miller, D. Levin, D. Martello, A. Sciubba, G. Osteria, S. Parlati, T. Bosio, M. Mittelbrunn, R. Fantini, O. Palamara, N. D. Pignatano, P. Serra-Lugaresi, B. C. Barish, S. L. Mufson, E. Katsavounidis, I DeMitri, Kate Scholberg, A. Sanzgiri, L. Satta, Kael Hanson, P Guamaccia, Roberto Bellotti, R. Liu, A DiCredico, M. Carboni, M. Ambrosio, F. Guarino, G. Liu, R.M. Heinz, U. Rubizzo, D. Campana, A. Hawthorne, Patera, Severino Angelo Maria Bussino, M. Devincenzi, Donato Nicolo, C. Orth, J. Reynoldson, C. W. Walter, H. Dekhissi, Popa, Chiarella, C. Forti, Fabrizio Cei, M. G. Castellano, G. Giacomelli, G. Battistoni, A. Rainò, R. Nolty, C. Bemporad, F. Sartogo, S P Mikheyev, C. DeMarzo, P. Monacelli, G. Giannini, N. Giglietto, Togo, S. Coutu, R. Antolini, G. DeCataldo, Mario Sitta, C. Gustavino, C. Favuzzi, A. A. Grillo, E. Iarocci, T. Montaruli, Ambrosio, M, Antolini, R, Auriemma, G, Baker, R, Baldini, A, Barbarino, Gc, Barish, Bc, Battistoni, G, Bellotti, R, Bemporad, C, Bernardini, P, Bilokon, H, Bisi, V, Bloise, C, Bosio, T, Bower, C, Bussino, Severino Angelo Maria, Cafagna, F, Calicchio, M, Campana, D, Carboni, M, Castellano, M, Cecchini, S, Cei, F, Chiarella, V, Corona, A, Coutu, S, Decataldo, G, Dekhissi, H, Demarzo, C, Demitri, I, Devincenzi, M, Dicredico, A, Erriquez, O, Fantini, R, Favuzzi, C, Forti, C, Fusco, P, Giacomelli, G, Giannini, G, Giglietto, N, Goretti, M, Grassi, M, Grillo, A, Guarino, F, Guamaccia, P, Gustavino, C, Habig, A, Hanson, K, Hawthorne, A, Heinz, R, Hong, Jt, Iarocci, E, Katsavounidis, E, Kearns, E, Kyriazopoulou, S, Lamanna, E, Lane, C, Levin, D, Lipari, P, Liu, G, Liu, R, Longley, Np, Longo, Mj, Lu, Y, Ludlam, G, Mancarella, G, Mandrioli, G, Neri, Am, Marini, A, Martello, D, Marzarichiesa, A, Mazziotta, Mn, Michael, Dg, Mikheyev, S, Miller, L, Mittelbrunn, M, Monacelli, P, Montaruli, T, Monteno, M, Mufson, S, Musser, J, Nicolo, D, Nolty, R, Okada, C, Orth, C, Osteria, G, Palamara, O, Parlati, S, Patera, V, Patrizii, L, Pazzi, R, Peck, Cw, Petrera, S, Pignatano, Nd, Pistilli, P, Popa, V, Raino, A, Reynoldson, J, Ronga, F, Rubizzo, U, Sanzgiri, A, Sartogo, F, Satriano, C, Satta, L, Scapparone, E, Scholberg, K, Sciubba, A, Serralugaresi, P, Severi, M, Sitta, M, Spada, Pf, Spinelli, P, Spinetti, M, Spurio, M, Steinberg, R, Stone, Jl, Sulak, Lr, Surdo, A, Tarle, G, Togo, V, Valente, V, Walter, Cw, and Webb, R.

Subjects
Physics, Nuclear and High Energy Physics, Multi parametric, Primary (astronomy), Astrophysics::High Energy Astrophysical Phenomena, Cosmic ray, MACRO, Composition (combinatorics), Macro, Muon underground, Atomic and Molecular Physics, and Optics, Computational physics
Abstract

Multimuon data from the MACRO experiment at Gran Sasso have been analysed using a new method which allows one to estimate the primary cosmic ray fluxes. The estimated all-particle spectrum is higher and flatter than the one obtained from direct measurements but is consistent with EAS measurements. The average mass number shows a weak dependence on the primary energy below 10^{6} GeV. Even within large uncertainties our data support a possible increase of the average mass number at higher energies.

Published
1996
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24. Localization of villin, a cytoskeletal protein specific to microvilli, in human ileum and colon and in colonic neoplasms

Author

Catherine A. Isaac, Kenneth W. Barwick, Jon S. Morrow, Mark S. Mooseker, Joan M. Carboni, and A. Brian West

Subjects
Adenoma, Adult, Male, Pathology, medicine.medical_specialty, Brush border, Colon, Crypt, Ileum, macromolecular substances, Adenocarcinoma, digestive system, Basement Membrane, medicine, Animals, Humans, Intestinal Mucosa, Aged, Epithelial polarity, Aged, 80 and over, Immunoassay, Microvilli, Hepatology, biology, Microfilament Proteins, Gastroenterology, Antibodies, Monoclonal, Middle Aged, Immunohistochemistry, Epithelium, medicine.anatomical_structure, Colonic Neoplasms, biology.protein, Female, Enterocyte differentiation, Carrier Proteins, Villin, Chickens
Abstract

Villin is a cytoskeletal protein of microvilli of epithelial cell brush borders found principally in absorptive cells of the intestine and proximal renal tubule. A marker of both enterocyte differentiation and epithelial cell polarity, it has been studied mainly in experimental animals. We raised monoclonal antibodies to villin and used them to localize it in human ileum and colon and in 22 colonic neoplasms. Villin is localized in the brush border of normal ileum and in the luminal border of normal colon and is expressed with increasing staining intensity as cells migrate from crypt to surface. It was present in the luminal border in all five adenomas and in 16 of 17 adenocarcinomas studied. In addition, villin staining was observed in the cytoplasm of 10 tumors, and in the basement membrane area surrounding tumor in 10 cases. In "transitional" mucosa adjacent to carcinomas it was confined to the luminal border. Abnormal expression of villin by a significant proportion of colonic tumors suggests that it may have a role as a marker of colorectal neoplasia.

Published
1988
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25. Surgical treatment of gastric cancer

Author

F. Gossetti, M. Carboni, M. Catarci, S. Guadagni, and P Negro

Subjects
Cancer Research, medicine.medical_specialty, Oncology, business.industry, Medicine, Cancer, Surgical treatment, business, medicine.disease, Surgery
Published
1989
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26. A bioreactor for the electromechanical stress of cells to address towards the cardiac phenotype

Author

Emanuele Giordano, Marco Carboni, Gabriele Vassura, Marco Govoni, Fabrizio Lotti, Claudio Marcello Caldarera, Silvio Cavalcanti, Claudio Muscari, Claudio Melchiorri, L. Biagotti, Francesca Bonafè, A. CARPI, F. Lotti, G. Vassura, C. Melchiorri, L. Biagiotti, C. Muscari, E. Giordano, M. Govoni, F. Bonafè, M. Carboni, C.M. Caldarera, and S. Cavalcanti

Subjects
Pharmacology, business.industry, technology, industry, and agriculture, General Medicine, Biology, equipment and supplies, complex mixtures, Biotechnology, Cell biology, Stress (mechanics), Bioreactor, CELL CULTURES, business, Cardiac phenotype, BIOREACTOR
Abstract

In this paper, a bioreactor for cell cultures is presented. Main features of the bioreactor are the possibility of applying controlled movements of the substrate during the culture of cells, reproducing the typical cardio movements and stresses.

Published
2006
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