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Your search keyword '"M. Alù"' showing total 4 results
Start Over Author "M. Alù" Publisher elsevier bv
4 results on '"M. Alù"'

1. The role of second and third line tyrosine kinase inhibitor monotherapy in EGFR wild-type (and unknown mutational status) advanced non-small-cell lung cancer patients: Findings from a retrospective analysis

Author

R. Alessandro, Giovanni Sortino, Sergio Rizzo, Francesco Passiglia, L. Blasi, Tindara Franchina, Antonio Picone, M. Alù, L. Agata, Alessandro Russo, Claudia Celesia, S. Giuseppina, Vincenzo Adamo, and Giuseppe Bronte

Subjects
Oncology, medicine.medical_specialty, business.industry, medicine.drug_class, Wild type, Hematology, medicine.disease, Tyrosine-kinase inhibitor, Third line, Internal medicine, medicine, Retrospective analysis, Mutational status, Non small cell, business, Lung cancer
Published
2015
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2. G.P.15.08 High genetic variability in European population: The FSHD complex puzzle

Author

Monica Govi, Lucia Santoro, Giuliano Tomelleri, Laura Palmucci, E. Signaroldi, G. Ferri, Emanuela Bonifazi, Francesca Greco, S. Bennardo, Isabella Scionti, C. Angelini, Gabriele Siciliano, Carmelo Rodolico, G. Fabbri, Rossella Tupler, Maurizio Moggio, and M. Alù

Subjects
Genetics, Neurology, Pediatrics, Perinatology and Child Health, Neurology (clinical), European population, Genetic variability, Biology, Genetics (clinical)
Published
2009
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4. Genetics of addiction in legal medicine and forensic investigation: SNPs variations associated with nicotine and cannabis dependence

Author

Giovanni Beduschi, D. Vandelli, Susi Pelotti, Gianmarco Ferri, M. Licata, Milena Alù, L. Picchini, Beatrice Corradini, G. Ferri, M. Alù, B. Corradini, L. Picchini, M. Licata, S. Pelotti, D. Vandelli, and G. Beduschi

Subjects
Drug, Genetics, medicine.medical_specialty, biology, business.industry, Addiction, media_common.quotation_subject, Medical jurisprudence, SNP, Heritability, biology.organism_classification, Pathology and Forensic Medicine, Nicotine, FORENSIC GENETICS, DRUG ADDICTION, DEPENDENCE, Epidemiology, medicine, Cannabis, Cannabis Dependence, business, media_common, medicine.drug
Abstract

Substance addiction is a complex chronic brain disorder, characterized by neurobiological changes leading to compulsive drug seeking and taking. Although environmental factors contribute to drug addiction, evidence showed that genetic factors with multiple genes also play a significant role. Cannabis and tobacco result as the most common widely abused substances. Epidemiological studies have strongly implicated genetics in nicotine and marijuana consuming and vulnerability to subsequent dependence, estimating the range of heritability from 34% to 78% for cannabis and approximately from 50% to 70% for nicotine. Furthermore, varying aspects of impulsive personality and principal psychiatric disorders co-occur with tobacco and cannabis dependence status. We evaluate the possibility of identifying an individual's risk probability to become an addict, based on a genotype analysis and the different possible applications in legal medicine and forensic genetics.

Published
2009
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