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Your search keyword '"M’kacher, Radhia"' showing total 11 results
Start Over Author "M’kacher, Radhia" Publisher elsevier bv
11 results on '"M’kacher, Radhia"'

1. Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

Author

Gentien, David, primary, Saberi-Ansari, Elnaz, additional, Servant, Nicolas, additional, Jolly, Ariane, additional, de la Grange, Pierre, additional, Némati, Fariba, additional, Liot, Géraldine, additional, Saule, Simon, additional, Teissandier, Aurélie, additional, Bourc’his, Deborah, additional, Girard, Elodie, additional, Wong, Jennifer, additional, Masliah-Planchon, Julien, additional, Narmanli, Erkan, additional, Liu, Yuanlong, additional, Torun, Emma, additional, Goulancourt, Rebecca, additional, Rodrigues, Manuel, additional, Gaudé, Laure Villoing, additional, Reyes, Cécile, additional, Bazire, Matéo, additional, Chenegros, Thomas, additional, Henry, Emilie, additional, Rapinat, Audrey, additional, Bohec, Mylene, additional, Baulande, Sylvain, additional, M’kacher, Radhia, additional, Jeandidier, Eric, additional, Nicolas, André, additional, Ciriello, Giovanni, additional, Margueron, Raphael, additional, Decaudin, Didier, additional, Cassoux, Nathalie, additional, Piperno-Neumann, Sophie, additional, Stern, Marc-Henri, additional, Gibcus, Johan Harmen, additional, Dekker, Job, additional, Heard, Edith, additional, Roman-Roman, Sergio, additional, and Waterfall, Joshua J., additional

Published
2023
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3. Telomere aberrations, including telomere loss, doublets, and extreme shortening, are increased in patients with infertility

Author

M’kacher, Radhia, primary, Colicchio, Bruno, additional, Marquet, Valentine, additional, Borie, Claire, additional, Najar, Wala, additional, Hempel, William M., additional, Heidingsfelder, Leonhard, additional, Oudrhiri, Noufissa, additional, Al Jawhari, Mustafa, additional, Wilhelm-Murer, Nadège, additional, Miguet, Marguerite, additional, Dieterlen, Alain, additional, Deschênes, Georges, additional, Tabet, Anne-Claude, additional, Junker, Steffen, additional, Grynberg, Michael, additional, Fenech, Michael, additional, Bennaceur-Griscelli, Annelise, additional, Voisin, Philippe, additional, Carde, Patrice, additional, Jeandidier, Eric, additional, and Yardin, Catherine, additional

Published
2021
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4. A new tool for genotoxic risk assessment: Reevaluation of the cytokinesis-block micronucleus assay using semi-automated scoring following telomere and centromere staining

Author

Zaguia, Narjes, primary, Laplagne, Eric, additional, Colicchio, Bruno, additional, Cariou, Olivier, additional, Al Jawhari, Mustafa, additional, Heidingsfelder, Leonhard, additional, Hempel, William M., additional, Jrad, Besma Bel Hadj, additional, Jeandidier, Eric, additional, Dieterlen, Alain, additional, Carde, Patrice, additional, Voisin, Philippe, additional, and M’kacher, Radhia, additional

Published
2020
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6. Detection and Automated Scoring of Dicentric Chromosomes in Nonstimulated Lymphocyte Prematurely Condensed Chromosomes After Telomere and Centromere Staining

Author

M'kacher, Radhia, primary, El Maalouf, Elie, additional, Terzoudi, Georgia, additional, Ricoul, Michelle, additional, Heidingsfelder, Leonhard, additional, Karachristou, Ionna, additional, Laplagne, Eric, additional, Hempel, William M., additional, Colicchio, Bruno, additional, Dieterlen, Alain, additional, Pantelias, Gabriel, additional, and Sabatier, Laure, additional

Published
2015
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8. Prospective Coronary Heart Disease Screening in Asymptomatic Hodgkin Lymphoma Patients Using Coronary Computed Tomography Angiography: Results and Risk Factor Analysis

Author

Girinsky, Theodore, primary, M’Kacher, Radhia, additional, Lessard, Nathalie, additional, Koscielny, Serge, additional, Elfassy, Eric, additional, Raoux, François, additional, Carde, Patrice, additional, Santos, Marcos Dos, additional, Margainaud, Jean-Pierre, additional, Sabatier, Laure, additional, Ghalibafian, Mithra, additional, and Paul, Jean-François, additional

Published
2014
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9. Telomere Shortening and Associated Chromosomal Instability in Peripheral Blood Lymphocytes of Patients With Hodgkin’s Lymphoma Prior to Any Treatment Are Predictive of Second Cancers

Author

M’kacher, Radhia, primary, Bennaceur-Griscelli, Annelise, additional, Girinsky, Theodore, additional, Koscielny, Serge, additional, Delhommeau, François, additional, Dossou, Julien, additional, Violot, Dominique, additional, Leclercq, Evelyne, additional, Courtier, Marie Hélène, additional, Béron-Gaillard, Nadine, additional, Assaf, Elias, additional, Ribrag, Vincent, additional, Bourhis, Jean, additional, Feneux, Daniele, additional, Bernheim, Alain, additional, Parmentier, Claude, additional, and Carde, Patrice, additional

Published
2007
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11. Telomere aberrations, including telomere loss, doublets, and extreme shortening, are increased in patients with infertility

Author

Catherine Yardin, Anne-Claude Tabet, Michael Fenech, Wala Najar, Georges Deschenes, Claire Borie, Marguerite Miguet, Alain Dieterlen, Noufissa Oudrhiri, Radhia M'kacher, Valentine Marquet, Michael Grynberg, Leonhard Heidingsfelder, Nadège Wilhelm-Murer, Annelise Bennaceur-Griscelli, Steffen Junker, Bruno Colicchio, Philippe Voisin, Patrice Carde, William M. Hempel, Mustafa Al Jawhari, Eric Jeandidier, M'kacher, Radhia, Colicchio, Bruno, Marquet, Valentine, Borie, Claire, Fenech, Michael, and Yardin, Catherine

Subjects
Adult, Male, 0301 basic medicine, Infertility, Oncology, medicine.medical_specialty, media_common.quotation_subject, Fertility, Young Adult, 03 medical and health sciences, Dicentric chromosome, 0302 clinical medicine, Chromosomal Instability, Internal medicine, Chromosome instability, chromosomal aberrations, Chromosome Duplication, medicine, Retrospective analysis, Humans, In patient, telomere doublets, In Situ Hybridization, Fluorescence, Telomere Shortening, Retrospective Studies, media_common, Chromosome Aberrations, 030219 obstetrics & reproductive medicine, business.industry, Outcome measures, Obstetrics and Gynecology, Middle Aged, Telomere, medicine.disease, excessive telomere shortening, 030104 developmental biology, Reproductive Medicine, Case-Control Studies, Cytogenetic Analysis, Female, business
Abstract

OBJECTIVE: To test the hypothesis that telomere shortening and/or loss are risk factors for infertility.DESIGN: Retrospective analysis of the telomere status in patients with infertility using conventional cytogenetic data collected prospectively.SETTING: Academic centers.PATIENT(S): Cytogenetic slides with cultured peripheral lymphocytes from 50 patients undergoing fertility treatment and 150 healthy donors, including 100 donors matched for age.INTERVENTION(S): Cytogenetic slides were used to detect chromosomal and telomere aberrations.MAIN OUTCOME MEASURE(S): Telomere length and telomere aberrations were analyzed after telomere and centromere staining.RESULT(S): The mean telomere length of patients consulting for infertility was significantly less than that of healthy donors of similar age. Moreover, patients with infertility showed significantly more extreme telomere loss and telomere doublet formation than healthy controls. Telomere shortening and/or telomere aberrations were more pronounced in patients with structural chromosomal aberrations. Dicentric chromosomes were identified in 6/13 patients, with constitutional chromosomal aberrations leading to chromosomal instability that correlated with chromosomal end-to-end fusions.CONCLUSION(S): Our findings demonstrate the feasibility of analyzing telomere aberrations in addition to chromosomal aberrations, using cytogenetic slides. Telomere attrition and/or dysfunction represent the main common cytogenetic characteristic of patients with infertility, leading to potential implications for fertility assessment. Pending further studies, these techniques that correlate the outcome of assisted reproduction and telomere integrity status may represent a novel and useful diagnostic and/or prognostic tool for medical care in this field.

Published
2021

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