207 results on '"M, Winkler"'
Search Results
2. 39. Subcortical Brain Volumes in Social Anxiety Disorder: An Enigma-Anxiety International Mega-Analysis of 37 Samples
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Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Alyssa R. Amod, Max A. Laansma, Laura S. van Velzen, Moji Aghajani, Kevin Hilbert, Christopher R.K. Ching, Sophia I. Thomopoulos, Enigma-Anxiety Working Group members, Ulrike Lueken, Dick J. Veltman, Anderson M. Winkler, Neda Jahanshad, Daniel S. Pine, Paul M. Thompson, Dan J. Stein, and Nic J.A. van der Wee
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Biological Psychiatry - Published
- 2023
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3. In-beam test results of the Super-FRS GEM-TPC detector prototype with relativistic uranium ion beam
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M. Luoma, F. García, J. Äystö, T. Blatz, D. Chokheli, H. Flemming, K. Götzen, T. Grahn, A. Jokinen, C. Karagiannis, N. Kurz, S. Löchner, C. Nociforo, S. Rinta-Antila, C.J. Schmidt, H. Simon, R. Turpeinen, B. Voss, P. Wieczorek, M. Winkler, and Helsinki Institute of Physics
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clusterization ,Nuclear and High Energy Physics ,ilmaisimet ,super-FRS ,tutkimuslaitteet ,tracking ,ydinfysiikka ,114 Physical sciences ,GEM-TPC ,Instrumentation ,FAIR - Abstract
As an essential part of the Super-FRS particle identification, the GEM-TPC detector in a twin field-cage configuration will provide position information at up to 1 MHz counting rate with a spatial resolution < 1 mm and with tracking efficiency >95 %. This detector is designed to provide particle-beam tracking information of projectiles ranging from protons to uranium. The performance of the GEM-TPC detector in a single field-cage configuration and newly integrated AWAGS readout electronics with a differential output was studied at the FRS for the response to the uranium beam at 850 MeV/u with intensity up to 1000 ions/spill. The result shows that a clusterization algorithm developed for this analysis works properly. The spatial resolution of 0.74–0.81 mm, a detection efficiency >99 %, and a tracking efficiency >96 % were found. This work describes the methodology used to achieve such results in detail. peerReviewed
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- 2023
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4. Novel trial designs in localised prostate cancer: Pilot phase results from the prostate pathway embedded comparative trial (ip3-prospect)
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E.J. Bass, F. Fiorentino, M. Szigeti, N. Klimowska-Nassar, T. Sasikaran, P. Jadav, F. Rawlins, M. Oblak, B. Khoubehi, M. Winkler, M. Nasseri, A. Pope, H. Sokhi, T. Dudderidge, N. Arumainayagam, M.R. Sydes, and H.U. Ahmed
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Urology - Published
- 2023
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5. Is immunohistochemistry relevant for the diagnosis of prostate cancer? A 2-year retrospective analysis in a single tertiary centre in the UK
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M. Bertoncelli Tanaka, A. Smith, E. Mannion, M. Yeung, J. Lloyd, A. Silvanto, R. Asakra, M. Winkler, and H.U. Ahmed
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Urology - Published
- 2023
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6. Knowledge Of Chronic Intestinal Failure Among European And United Kingdom Gastroenterologists
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K. Iyer, N. Zubizarreta, M. Nisenholtz, K. Tappenden, M. Tosi, J. Lubarda, and M. Winkler
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism - Published
- 2023
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7. Ion-optical developments tailored for experiments with the Super-FRS at FAIR
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C. Scheidenberger, Bernhard Franczak, Mikhail I. Yavor, Sergey Litvinov, E. Haettner, Wolfgang R. Plaß, Toshiyuki Kubo, Hans Geissel, E. Kazantseva, Helmut Weick, Timo Dickel, S. Ratschow, M. Winkler, J. S. Winfield, and Y.K. Tanaka
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Nuclear reaction ,Nuclear and High Energy Physics ,010308 nuclear & particles physics ,Computer science ,Nuclear engineering ,Mode (statistics) ,Nuclear structure ,01 natural sciences ,Ion ,Rigidity (electromagnetism) ,Magnet ,0103 physical sciences ,Thermal emittance ,Nuclear Experiment ,010306 general physics ,Instrumentation - Abstract
The future Super-FRS separator-spectrometer at FAIR will provide rare-isotope beams for key experiments in nuclear structure, astrophysics and nuclear reactions. The Super-FRS will use large-aperture magnets, which is important for the acceptance of nuclear reaction products with a large transverse and longitudinal emittance. In the standard ion-optical separator mode, magnetic rigidity analysis in combination with atomic energy-loss will be performed for clean isotopic spatial separation, once in the Pre-Separator and second in the Main-Separator. New ion-optical developments, prepared for different categories of experiments, are presented in this article. The operating modes described in the early publications of the project are updated in the first part of the paper. In the second part, special ion-optical modes mainly for the experiments of the Super-FRS Experiment Collaboration are discussed. This collaboration is the succession of the FRS Collaboration which has concentrated on separator-spectrometer experiments with the present facility at GSI since 1990.
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- 2021
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8. Characterization techniques for heterogeneous nucleation from the gas phase
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Paul E. Wagner and Paul M. Winkler
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Fluid Flow and Transfer Processes ,Atmospheric Science ,Environmental Engineering ,Materials science ,Heterogeneous nucleation ,Mechanical Engineering ,Condensation ,Nucleation ,Nanoparticle ,Kelvin equation ,Pollution ,Electric charge ,Line tension ,Characterization (materials science) ,Chemical physics ,Scientific method ,Particle ,Wetting ,Cluster properties ,Microscopic contact angle - Abstract
Heterogeneous nucleation constitutes the initial step in the formation of new aerosol particles that evolve on the surface of pre-existing (seed) particles. To this end the interaction of vapor and seed particle plays a critical role which is governed by the seed particle's size, composition, solubility, electrical charge state as well as the chemical nature of the vapor and the wetting properties of the condensing liquid with the underlying surface. Despite being a process on the nanoscale under most conditions of relevance the effect of heterogeneous nucleation has global implications via the formation of clouds, and is technically utilized in condensation particle counters for the detection of nanoparticles. Proper techniques for the characterization of heterogeneous nucleation thus serve a better fundamental understanding and improve the detectability of nanoparticles. Here we review state-of-the-art experimental and theoretical techniques allowing quantitative analysis of heterogeneous nucleation and providing insight to properties of nucleating clusters. Building upon current knowledge we identify and discuss open questions in the field motivating prospective future research.
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- 2022
9. Predictors of Trial-Without-Catheter (TWOC) outcome in 384 patients treated with Rezum thermotherapy?
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A.K.A.A. Uthman, M.J. Connor, C. Khoo, A. Rai, E.J. Bass, S. Agarwal, R. Dasgupta, M. Winkler, H. Abboudi, T. El-Husseiny, and H.U. Ahmed
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Urology - Published
- 2023
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10. Can we predict when non-targeted systematic prostate biopsies need to be performed? Outcomes from the multicentre RAPIDOnline 3,853 patient cohort
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E.J. Bass, M.J. Connor, I. Adzawoloo-Andersson, M. Bertonelli Tanaka, H. Bhola-Stewart, D. Brown, D. Eldred-Evans, F. Hosking-Jervis, J. Jaipuria, R. Mendoza, E. Pegers, D. Leelamany, L. Powell, S. Ahmad, K. Wong, H. Tam, S. Gordon, H. Qazi, D. Hrouda, S. Mccracken, M. Winkler, and H.U. Ahmed
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Urology - Published
- 2023
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11. Rezum thermotherapy for large prostate volumes (>/= 80 cc): 2-year clinical outcomes
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A.K.A.A. Uthman, M.J. Connor, C. Khoo, A. Rai, E.J. Bass, S. Agarwal, R. Dasgupta, M. Winkler, H. Abboudi, T. El-Husseiny, and H.U. Ahmed
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Urology - Published
- 2023
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12. 403 Comparison Of Iterative Reconstruction And Post Reconstruction Deep Learning Noise Reduction Methods Utilizing Philips Brilliance CT 256 Phantom Data And Clinical Images
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M. Halicek, A. Hasegawa, A. Maghsoodpour, W. Fu, N. Cortese, and M. Winkler
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2022
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13. AWAGS: A single ASIC to identify fast ions from protons to uranium
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E. Rocco, P. Wieczorek, H. Flemming, N. Kurz, S. Löchner, C. Nociforo, C.J. Schmidt, H. Simon, B. Voss, M. Winkler, F. García, T. Grahn, and M. Luoma
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Nuclear and High Energy Physics ,Instrumentation - Published
- 2022
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14. TEMPORARY REMOVAL: VP.47 Interleukin 31 (IL-31) inhibition as a trigger for an immune-mediated myopathy?
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M, Winkler, K, Kappes-Horn, and J, Reimann
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Neurology ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Genetics (clinical) - Abstract
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
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- 2022
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15. PD-0416 Derivation and external validation of a RAPID Risk score for predicting significant prostate cancer
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M. Peters, D. Eldred-Evans, M.J. Connor, M. Bertoncelli Tanaka, H. Bhola-Stewart, T. T Shah, S. Ahmad, M. Noureldin, K. Wong, H. Tam, D. Hrouda, M. Winkler, P. van Rossum, P. Kurver, S. Gordon, H. Qazi, H.U. Ahmed, U. Giovanni Falagario, I. Jambor, A. Briganti, T. Nordström, G. Carrieri, L. Powell, S. Joshi, and E. Pegers
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2022
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16. Assessing the regional variability of a pre-biopsy mpMRI and targeted prostate cancer diagnostic pathway
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D.T. Reddy, D. Eldred-Evans, M. Connor, F. Hosking-Jervis, M. Bertoncelli Tanaka, H. Bhola-Stewart, W. Maynard, C. Khoo, T. Shah, E. Bass, H.J. Lee, S. Ahmad, M. Noureldin, S. Joshi, E. Pegers, K. Wong, H. Tam, D. Hrouda, M. Winkler, S. Gordon, H. Qazi, and H. Ahmed
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Urology - Published
- 2022
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17. An evaluation of screening pathways using a combination of MRI and PSA: Results from the IP1-PROSTAGRAM study
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M.J. Connor, D. Eldred-Evans, H. Tam, H. Sokhi, A.R. Padhani, D. Price, M. Gammon, N. Klimowska-Nassar, P. Burak, E. Day, M. Winkler, F. Fiorentino, and H.U. Ahmed
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Urology - Published
- 2022
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18. The influence on sintering and properties of sodium niobate (NaNbO3) ceramics by 'non-stoichiometric' precursor compositions
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T. Ruf, Christof Megnin, M. Mauck, M. Winkler, H. Hillebrecht, and Thomas Hanemann
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Materials science ,Scanning electron microscope ,Analytical chemistry ,Sintering ,02 engineering and technology ,Dielectric ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Dielectric spectroscopy ,Electrical resistivity and conductivity ,visual_art ,visual_art.visual_art_medium ,Particle ,General Materials Science ,Ceramic ,0210 nano-technology ,Spectroscopy - Abstract
NaNbO3 powders from different processing routes and various near equimolar concentrations of metal ions were sintered to ceramics and investigated concerning their structural and electric properties. The particle sizes obtained from two different conventional solid state reactions and one solvent – based route were in the range of 40 nm - 10 μm and the variation of precursor composition covered 48–52 mol% Na. Sintering temperatures were defined by the deviation from the equimolar composition between 950 and 1375 °C, which is due to the coexistence of second phases Na3NbO4, Na2Nb4O11 and NaNb3O8. Small particle sizes (40 nm–3 μm) on deviation from equimolar composition resulted in higher relative densities at lower sintering temperatures. The coexistence of second phases influences structural and electric characteristics. The former were investigated by X-ray Diffraction (XRD) for phase analysis, Scanning Electron Microscopy (SEM) for defining grain sizes and Energy-Dispersive X-ray (EDX) spectroscopy for deciding the elemental composition. The impact on electrical conductivity and dielectric properties are examined by impedance spectroscopy and the resulting d33 coefficients of 15–29 pC/N are measured by Berlincourt method.
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- 2019
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19. First insight into the heritable variation and potential response to selection of phototaxis and locomotion behavior associated to the light/dark stimuli in the abalone Haliotis discus hannai
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William J. Farías, Federico M. Winkler, Katherina Brokordt, Yohana D. Defranchi, and Christophe M. Herbinger
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0303 health sciences ,education.field_of_study ,biology ,Abalone ,Population ,Zoology ,04 agricultural and veterinary sciences ,Aquatic Science ,Stimulus (physiology) ,Heritability ,biology.organism_classification ,Selective breeding ,Genetic correlation ,03 medical and health sciences ,040102 fisheries ,Haliotis discus ,Phototaxis ,0401 agriculture, forestry, and fisheries ,education ,030304 developmental biology - Abstract
Abalones are especially susceptible to environmental lighting conditions. This factor greatly affects crucial biological process such as feeding rates, energy balance, physiological stress status, and consequently, growth and survival of farmed abalone. Most of these effects have been studied in the economically valuable abalone Haliotis discus hannai. The use of specific photoperiods, and/or light qualities and intensities, have been proposed as managing strategies to increase its production; however, for extensive off-shore or in intensive land-based farming systems, lighting conditions are not likely to be easily managed. Despite the great importance of the biological responses to the light/dark stimuli for abalone farming production, to the best of our knowledge the genetic control upon the variation associated behavioral traits have not been studied. Therefore, the aim of this study was to estimate the heritable variation and potential responses to selection for the phototaxis [i.e., displacement towards (positive) or against (negative) the light source] and locomotion behaviors associated to the intensity of the response (i.e., crawling speed and displacement distance) to the light/dark stimuli in juvenile H. discus hannai. Genetic and phenotypic correlations between these traits were also estimated. Results showed moderate but significant heritable variations for phototaxis (h2 = 0.15) and locomotion responses (h2 = 0.18–0.37); and significant positive genetic correlations among them. Expected gain responses to selection per generation (with a selection intensity of 2.06, i.e., selecting 5% of the individuals from a population) were moderate for phototaxis variation (16%) and high for locomotion responses variation (33–67 or 36–73%, depending on the model used for the estimations). As a consequence, the potential for reducing (or incrementing, depending on the breeding goal) the reactivity or the sensibility to the light stimulus by selective breeding is good, and can be an attractive way of indirectly improving growth, survival and general welfare of farmed H. discus hannai.
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- 2019
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20. IVIG induces apoptotic cell death in CD56dim NK cells resulting in inhibition of ADCC effector activity of human PBMC
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Heinz Anderle, Corinna Hermann, Mantas Malisauskas, Sebastian Bunk, Friedrich Scheiflinger, Birgit M. Reipert, Azra Trbic, Wolfgang Teschner, Josenato Ilas, H. Arno Butterweck, Anna M. Winkler, Padmapriya Ponnuswamy, and Alfred Weber
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0301 basic medicine ,Antibody-dependent cell-mediated cytotoxicity ,Effector ,business.industry ,Immunology ,Effector cell ,Peripheral blood mononuclear cell ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Apoptosis ,Intravenous Immunoglobulins ,hemic and lymphatic diseases ,Apoptotic cell death ,Immunology and Allergy ,Medicine ,Cell-mediated cytotoxicity ,business ,030215 immunology - Abstract
The mechanism of the efficacy of Intravenous immunoglobulins (IVIG) in autoimmune and inflammatory diseases is not well understood. This study aimed at understanding mechanisms of IVIG-mediated suppression of effector cell activities of peripheral blood mononuclear cells (PBMC) in antibody-dependent cellular cytotoxicity (ADCC). We were particularly interested in CD56dim NK cells, the main ADCC effector cells in PBMC. Exposure of PBMC to IVIG for at least 48 h induced a caspase-3-dependent apoptotic cell death of CD56dim NK cells without affecting CD56bright NK cells. Induction of apoptosis in CD56dim NK cells and concomitant suppression of ADCC effector activities of PBMC was associated with the monomer fraction of IVIG. Moreover, it was independent of IgG sialyation, did not depend on engagement of FcγRIII and could not be mimicked by IVIG (Fab’)2 or IVIG Fc preparations. The described effect could contribute to the reduction of peripheral NK cells observed during IVIG therapy in patients.
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- 2019
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21. CONGENITAL MYOPATHIES – CENTRONUCLEAR MYOPATHIES
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M. Winkler, Angela Abicht, Jens Reimann, C. von Landenberg, Cornelia Kornblum, and D. Wolf
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Neurology ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Genetics (clinical) - Published
- 2021
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22. A prospective blinded validation of the rapid prostate cancer risk calculator for patients following initial multiparametric magnetic resonance imaging
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E.J. Bass, M. Bertonelli Tanaka, M.J. Connor, U. Walters, D. Eldred-Evans, P. Sarkar, F. Hosking-Jervis, H. Bhola-Stewart, E. Pegers, L. Powell, D. Leelamany, K. Wong, S. Ahmad, H. Tam, H. Qazi, S. Gordon, D. Hrouda, S. Mccracken, M. Winkler, and H.U. Ahmed
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Urology - Published
- 2022
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23. PROState pathway embedded comparative trial: An update to the IP3-PROSPECT study
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E.J. Bass, N. Klimowska-Nassar, T. Sasikaran, E. Day, F. Fiorentino, M.R. Sydes, N. Arumainayagam, B. Khoubehi, T. Dudderidge, A. Pope, H. Sokhi, M. Winkler, and H.U. Ahmed
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Urology - Published
- 2022
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24. Patient-reported outcome measures and surgical retreatment rates from 181 patients treated with water vapor thermal therapy (Rezūm™)
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M.J. Connor, A. Rai, C. Khoo, E.J. Bass, D. Eldred-Evans, S. Agarwal, M. Winkler, H. Abboudi, R. Dasgupta, T. El-Husseiny, and H.U. Ahmed
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Urology - Published
- 2022
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25. Identifying men affected by changes in PSA screening in the COVID-19 pandemic
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E.J. Bass, M. Bertonelli Tanaka, M.J. Connor, U. Walters, D. Eldred-Evans, P. Sarkar, F. Hosking-Jervis, H. Bhola-Stewart, E. Pegers, L. Powell, D. Leelamany, K. Wong, S. Ahmad, H. Tam, S. Gordon, D. Hrouda, S. Mccracken, M. Winkler, and H.U. Ahmed
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Urology - Published
- 2022
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26. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. 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A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaröe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grässjö, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenström, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S. K., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S. Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Time Factors ,Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF ,030204 cardiovascular system & hematology ,Electrocardiography ,0302 clinical medicine ,Risk Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,Aged ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Prevalence ,Prognosis ,Prospective Studies ,Survival Rate ,Thromboembolism ,Registries ,Risk Assessment ,Medicine ,030212 general & internal medicine ,Prospective cohort study ,Incidence (epidemiology) ,cardiovascular system ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Human ,medicine.medical_specialty ,Time Factor ,RD1-811 ,Prognosi ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Risk factor ,Survival rate ,Fibrillation ,business.industry ,Risk Factor ,ta3121 ,medicine.disease ,Clinical trial ,Prospective Studie ,RC666-701 ,Surgery ,Clinical and Preventive Cardiology ,business - Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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27. Cloning and molecular characterization of two ferritins from red abalone Haliotis rufescens and their expressions in response to bacterial challenge at juvenile and adult life stages
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Byron Morales-Lange, María I. Díaz, Teodoro Coba de la Peña, Katherina Brokordt, Luis Mercado, Claudia B. Cárcamo, and Federico M. Winkler
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0301 basic medicine ,Haliotis rufescens ,Protein subunit ,Gastropoda ,Clone (cell biology) ,Aquatic Science ,03 medical and health sciences ,Complementary DNA ,Animals ,Environmental Chemistry ,Amino Acid Sequence ,Gene ,Phylogeny ,Vibrio ,Cloning ,Base Sequence ,biology ,Gene Expression Profiling ,04 agricultural and veterinary sciences ,General Medicine ,biology.organism_classification ,Molecular biology ,Immunity, Innate ,Ferritin ,Open reading frame ,030104 developmental biology ,Gene Expression Regulation ,Ferritins ,040102 fisheries ,biology.protein ,0401 agriculture, forestry, and fisheries ,Sequence Alignment - Abstract
Ferritins are ubiquitous proteins with a pivotal role in iron storage and homeostasis, and in host defense responses during infection by pathogens in several organisms, including mollusks. In this study, we characterized two ferritin homologues in the red abalone Haliotis rufescens, a species of economic importance for Chile, USA and Mexico. Two ferritin subunits (Hrfer1 and Hrfer2) were cloned. Hrfer1 cDNA is an 807 bp clone containing a 516 bp open reading frame (ORF) that corresponds to a novel ferritin subunit in H. rufescens. Hrfer2 cDNA is an 868 bp clone containing a 516 bp ORF that corresponds to a previously reported ferritin subunit, but in this study 5′- and 3′-UTR sequences were additionally found. We detected a putative Iron Responsive Element (IRE) in the 5′-UTR sequence, suggesting a posttranscriptional regulation of Hrfer2 translation by iron. The deduced protein sequences of both cDNAs possessed the motifs and domains required in functional ferritin subunits. Expression patterns of both ferritins in different tissues, during different developmental stages, and in response to bacterial (Vibrio splendidus) exposure were examined. Both Hrfer1 and Hrfer2 are most expressed in digestive gland and gonad. Hrfer1 mRNA levels increased about 34-fold along with larval developmental process, attaining the highest level in the creeping post-larvae. Exogenous feeding is initiated at the creeping larva stage; thus, the increase of Hrfer1 may suggest and immunity-related role upon exposure to bacteria. Highest Hrfer2 expression levels were detected at trochophore stage; which may be related with early shell formation. Upon challenge with, the bacteria an early mild induction of Hrfer2 (2 h post-challenge), followed by a stronger induction of Hrfer1 at 15 h post-challenge, was observed in haemocytes from adult abalones. While maximal upregulation of both genes in the whole individual occurred at 24 h post-challenge, in juveniles. A significant increase in ferritin protein levels from 6 h to 24 h post-challenge was also detected. Our results suggest an involvement of Hrfer1 and Hrfer2, and of ferritin proteins in the immune response of H. rufescens to bacterial infection.
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- 2018
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28. Heritability, genetic correlations and genotype-environment interactions for growth and survival of larvae and post-larvae of the Caribbean scallop, Argopecten nucleus (Mollusca: Bivalvia)
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Luz Adriana Velasco, Judith Barros, and Federico M. Winkler
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0106 biological sciences ,Larva ,biology ,010604 marine biology & hydrobiology ,Argopecten nucleus ,fungi ,Zoology ,04 agricultural and veterinary sciences ,Aquatic Science ,Heritability ,Selective breeding ,biology.organism_classification ,01 natural sciences ,Genetic gain ,Genotype ,Scallop ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Mollusca - Abstract
The Caribbean scallop Argopecten nucleus is a species with a great potential for commercial aquaculture in the Caribbean given its fast growth and the availability of culture technology. However, its production relies completely on hatchery-reared seed, and the survival in early stages, particularly during the settling process, is the main limitation for this activity to become cost effective. Thus, in order to assess the feasibility of improving survival of larvae and post-larvae of A. nucleus through genetic selection without affecting growth, it was estimated the heritability and the genotype-environment interactions for such traits, as well as the genetic correlations between them. These parameters were estimated based on intraclass correlations of 40 full-sib families (10 half-sib families) at 1, 11 and 75 days post fertilization. Heritability values were very high for the post-larvae survival (0.49), while it was low and not significant for larvae survival (≤0.07) and medium to high for growth traits of larvae and post-larvae (>0.3). The traits analyzed in post-larvae exhibited significant genotype-environment interactions in relation to culture depth in the sea. No significant genetic correlations between the measured traits were found. The results suggest the existence of an important genetic component in the variation of post-larval survival, and larval and post-larval growth, as well as a high potential response to direct genetic selection, especially for post-larval survival (50% increase per generation), without affecting the growth traits.
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- 2018
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29. Using robust generalized fuzzy modeling and enhanced symbolic regression to model tribological systems
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Michael Kommenda, Andreas Promberger, Susanne Saminger-Platz, Edwin Lughofer, Falk Nickel, Stephan M. Winkler, Gabriel Kronberger, and Michael Affenzeller
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0209 industrial biotechnology ,020901 industrial engineering & automation ,Computer science ,0202 electrical engineering, electronic engineering, information engineering ,Linear model ,020201 artificial intelligence & image processing ,Regression analysis ,Genetic programming ,02 engineering and technology ,Symbolic regression ,Fuzzy logic ,Algorithm ,Software - Abstract
Tribological systems are mechanical systems that rely on friction to transmit forces. The design and dimensioning of such systems requires prediction of various characteristic, such as the coefficient of friction. The core contribution of this paper is the analysis of two data-based modeling techniques which can be used to produce accurate and at the same time interpretable models for friction systems. We focus on two methods for building interpretable and potentially non-linear regression models: (i) robust fuzzy modeling with batch processing and an enhanced regularized learning scheme, and (ii) enhanced symbolic regression using genetic programming. We compare our results of both methods with state-of-the-art methods and found that linear models are insufficient for predicting the coefficient of friction, temperature, wear, and noise-vibration-harshness rating of the tribological systems, while the proposed robust fuzzy modeling and the enhanced symbolic regression approaches, as well as the state-of-the-art regression techniques, are able to generate satisfactory models. However, robust fuzzy modeling and enhanced symbolic regression lead to simpler models with fewer parameters that can be interpreted by domain experts.
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30. Assessment of oxytetracycline baths as therapeutic treatment for the control of the agent of withering syndrome (WS) in red abalone ( Haliotis rufescens )
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Federico M. Winkler, Ricardo M. García, María Vicenta Valdivia, and Karin B. Lohrmann
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0301 basic medicine ,Gonad ,Haliotis rufescens ,Abalone ,medicine.drug_class ,media_common.quotation_subject ,Gastropoda ,Antibiotics ,Rickettsiales ,Oxytetracycline ,03 medical and health sciences ,Animal science ,medicine ,Animals ,Ecology, Evolution, Behavior and Systematics ,media_common ,biology ,Baths ,04 agricultural and veterinary sciences ,biology.organism_classification ,030104 developmental biology ,medicine.anatomical_structure ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Reproduction ,Digestion ,Intramuscular injection ,medicine.drug - Abstract
Withering Syndrome (WS) is a lethal disease that affects abalone species in both wild and farmed populations. This infection, caused by the rickettsial-like intracellular organism (RLO) Candidatus Xenohaliotis californiensis, can severely impair the normal development of affected animals, and ultimately, their survival. The most common line of action against the WS has been the use of antibiotics, specifically oxytetracycline (OTC), administered via intramuscular injection and per os via medicated feed. In the present study, we have assessed the effectiveness of OTC baths as therapeutic treatment for the control of the WS agent in H. rufescens. Clinical signs of infection were monitored for 11 months in treated juveniles, in addition to feed consumption rate, growth patterns and gonad development. Abalones were asymptomatic until the end of the experiment, when a small number of non-treated animals exhibited clinical signs of infection. Gonad maturity was not observed. OTC treated animals grew significantly less than their non-treated counterparts, being 4.3% shorter and 13.6% lighter at the end of the experiment. They also displayed negative allometry, i.e. for the same shell length, they were lighter than non-treated groups. Furthermore, the weight of muscle and soft tissues in OTC treated animals was lighter than in the other groups, while no differences were found in shell weight. The feed consumption rate was the same for all groups, thus the observed growth patterns cannot be attributed to a decreased feed intake. One possible explanation is that antibiotic treatment may have impacted gut microflora, thus preventing efficient nutrient digestion and absorption and, indirectly, reducing growth. Prevalence of RLOs causing WS (WS-RLO) and the variant form (RLOv), infected with a bacteriophague and non virulent, were significantly lower in the OTC-treated group than in the other groups. Similar results were observed for the mean intensity of RLOv, while for WS-RLO, the intensity in the OTC-treated group was higher, although not statistically significant, than the rest of the groups. These observations may be the consequence of an increased bacterial sensitivity to OTC effects associated with the phage infection or faster reproduction of WS-RLOs than RLOv after OTC treatment. Our results let us infer that the prophylactic use of OTC in abalone to avoid the negative effects of WS on abalone farms could have an undesired negative effect on the biological control exerted by the phage on the bacteria after OTC treatment.
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31. A GEM-TPC in twin configuration for the Super-FRS tracking of heavy ions at FAIR
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C. Caesar, C. Simons, Ari Jokinen, J. Kunkel, Tuomas Grahn, J. Hoffmann, A. Prochazka, H. Heggen, Sami Rinta-Antila, Bernd Voss, R. Turpeinen, M. Winkler, Harvey A. Risch, N. Kurz, C. Kaya, Herbert A. Simon, Francisco Garcia, C. Nociforo, I. Rusanov, C. J. Schmidt, and Juha Äystö
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radioactive ion beam ,Nuclear and High Energy Physics ,Proton ,fragment separator ,Physics::Instrumentation and Detectors ,super-FRS ,chemistry.chemical_element ,Tracking (particle physics) ,01 natural sciences ,7. Clean energy ,Particle identification ,GSI ,Xenon ,Optics ,0103 physical sciences ,seuranta ,Nuclear Experiment ,010306 general physics ,Instrumentation ,Image resolution ,Physics ,Time projection chamber ,ta114 ,010308 nuclear & particles physics ,Projectile ,business.industry ,tracking ,fair ,time projection chamber ,beam adjustment ,chemistry ,gas electron multiplier ,Gas electron multiplier ,business - Abstract
The GEM-TPC [1] described herein will be part of the standard beam-diagnostics equipment of the Super-FRS [2] . This chamber will provide tracking information for particle identification at rates up to 1 MHz on an event-by-event basis. The key requirements of operation for these chambers are: close to 100% tracking efficiency under conditions of high counting rate, spatial resolution below 1 mm and a superb large dynamic range covering projectiles from Z=1 up to Z=92. The current prototype consists of two GEM-TPCs inside a single vessel, which are operating independently and have electrical drift fields in opposite directions. The twin configuration is done by flipping one of the GEM-TPCs on the middle plane with respect to the second one. In order to put this development in context, the evolution of previous prototypes will be described and its performances discussed. Finally, this chamber was tested at the University of Jyväskylä accelerator with proton projectiles and at GSI with Uranium, Xenon, fragments and Carbon beams. The results obtained have shown a position resolution between 120 to 300 μm at moderate counting rate under conditions of full tracking efficiency. peerReviewed
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32. Heritability, genetic correlations and genotype by environment interactions in productive traits of the Caribbean scallop, Argopecten nucleus (Mollusca: Bivalvia)
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Judith Barros, Luz Adriana Velasco, and Federico M. Winkler
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0301 basic medicine ,Animal breeding ,Argopecten nucleus ,Zoology ,Aquatic animal ,04 agricultural and veterinary sciences ,Aquatic Science ,Biology ,Heritability ,Selective breeding ,Fecundity ,biology.organism_classification ,Genetic correlation ,03 medical and health sciences ,030104 developmental biology ,Scallop ,040102 fisheries ,0401 agriculture, forestry, and fisheries - Abstract
Argopecten nucleus is a hermaphroditic scallop native to the Caribbean Sea, whose aquaculture production currently relies on hatchery-produced seed. Although this species exhibits a relatively fast growth, its survival, fecundity and commercial size are lower than those of other economically important pectinids. To assess the feasibility to improve productive traits in this species through selective breeding, heritabilities (h2) and genetic correlations (rG) for survival, fecundity and growth were estimated. The existence of genotype by environment interactions (GEI) associated with the culture depth, i.e. location of culture systems in the water column, ware also examined. Fifty sexually mature individuals were individually spawned, collecting female and male gametes separately. The sperm of one “male” was used to fertilize the eggs of four female individuals randomly chosen from the base population, generating 10 half sibling families and 40 full sibling families, in a nested experimental design. Shell length, height, and width, and total wet weight, were measured in 3.5 (juveniles) and nine (adults) months old progenies. Additionally, at 9 months the adductor muscle and remaining soft tissues wet weight were separately measured, and fecundity and survival recorded. The components of the phenotypic variance and heritabilities were estimated using an animal model. Most of the traits exhibited medium to high heritability (h2 ≥ 0.26), with the exception of shell width in juveniles and survival (h2 ≤ 0.18). h2 estimations were generally higher in juveniles than in adults and h2 for fecundity was not significantly different from zero. The growth related traits exhibit significant positive genetic correlations (rG ≥ 0.69), but were not genetically correlated with fecundity or survival. Interestingly, GEI in relation to culture depth were statistically significant. Results suggest a high potential response to direct and indirect selection, indicating that productive traits can be improved through selective breeding. The differential relative performance of different genotypes at different depths will be an important consideration to take into account in designing selective breeding plans for this species.
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33. MRI and targeted biopsies compared to transperineal mapping biopsies for targeted ablation in recurrent prostate cancer after radiotherapy: Primary outcomes of the FORECAST trial
- Author
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Norman R. Williams, Shonit Punwani, A. Nikapota, J. Bomanji, H. Payne, A. Mitra, Chris Brew-Graves, Francesco Giganti, Tim Dudderidge, Alex Freeman, Abi Kanthabalan, Jaspal Virdi, Caroline M. Moore, Manit Arya, Athar Haroon, Harbir S. Sidhu, Hashim U. Ahmed, Mark Emberton, M. Pavlou, M. Winkler, R. Hindley, Clement Orczyk, S. Adeleke, Taimur T. Shah, and Gail Horan
- Subjects
Radiation therapy ,medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,medicine ,Recurrent prostate cancer ,Radiology ,business ,Ablation - Published
- 2021
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34. The CADMUS trial: A paired cohort, blinded study comparing multiparametric ultrasound targeted biopsies with multiparametric MRI targeted biopsies in the detection of clinically significant prostate cancer
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Sami Hamid, A. Chapman, T. Collins, A. Karatziotou, Alex Freeman, B. Shah, L. Mcleavy, S. Liyanage, Hashim U. Ahmed, R. Omar, P. Acher, Mark Emberton, Maneesh Ghei, Frank Chinegwundoh, R. Scott, M. Pavlou, M. Winkler, N. Arumainayagam, P. Patki, Chris Brew-Graves, Taimur T. Shah, Z. Alsaadi, Alistair Grey, and David Eldred-Evans
- Subjects
Prostate cancer ,medicine.medical_specialty ,business.industry ,Urology ,Cohort ,Ultrasound ,medicine ,Multiparametric MRI ,Radiology ,medicine.disease ,business ,Blinded study - Published
- 2021
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35. Focal ablative salvage therapy for radio-recurrent prostate cancer: 6 year oncological and safety outcomes
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Arnas Rakauskas, Saiful Miah, Max Peters, Rajendra Persad, Stuart McCracken, Stephanie Guillaumier, Hashim U. Ahmed, Clement Orczyk, Deepika Reddy, M. Van Son, Feargus Hosking-Jervis, Caroline M. Moore, Philipp M. Huber, Mark Emberton, Manit Arya, M. Bertoncelli Tanaka, Derek Lomas, David Eldred-Evans, M. Winkler, Raj Nigam, A. Emara, Tim Dudderidge, R. Hindley, Taimur T. Shah, and Jaspal Virdi
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medicine.medical_specialty ,business.industry ,Urology ,Ablative case ,Salvage therapy ,Medicine ,Recurrent prostate cancer ,Radiology ,business - Published
- 2021
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36. Metastatic prostate cancer patients’ Attitudes towards Treatment of the local Tumour and metastasis Evaluative Research (IP5-MATTER): A multicentre, discrete choice experiment trial-in-progress
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T. Pokrovska, Michael Gonzalez, K. Thippu Jayaprakash, Johanna Sukumar, Naveed Sarwar, M. Winkler, Gail Horan, Natalia Klimowska-Nassar, Hashim U. Ahmed, Angus Robinson, Alison Falconer, Verity Watson, Martin J. Connor, Mesfin G Genie, Dolan Basak, Vincent Khoo, Feargus Hosking-Jervis, Stephen Mangar, Bhavan Prasad Rai, Mark Beresford, and Tim Dudderidge
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Oncology ,medicine.medical_specialty ,Prostate cancer ,business.industry ,Urology ,Internal medicine ,medicine ,Discrete choice experiment ,Evaluative research ,medicine.disease ,business ,Metastasis - Published
- 2021
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37. Cancer control outcomes following focal therapy using HIFU in 1,829 men with non-metastatic prostate cancer treated over 15 years
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Stephanie Guillaumier, Arnas Rakauskas, Manit Arya, Mark Emberton, Raj Nigam, Hashim U. Ahmed, M. Van Son, Derek Lomas, Jaspal Virdi, Caroline M. Moore, Saiful Miah, Max Peters, Taimur T. Shah, Henry Lewi, Naveed Afzal, Chris Ogden, Deepika Reddy, R. Hindley, Philipp M. Huber, M. Winkler, M. Valerio, A. Emara, Tim Dudderidge, Clement Orczyk, and Rajendra Persad
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Oncology ,Focal therapy ,Prostate cancer ,medicine.medical_specialty ,Cancer control ,business.industry ,Urology ,Internal medicine ,Non metastatic ,Medicine ,business ,medicine.disease - Published
- 2021
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38. Impact of non-targeted prostate sampling histology on the probability of receiving invasive local treatment in an mpMRI-targeted pathway – analysis of 1,719 men
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M.J. Connor, M. Van Son, D. Eldred-Evans, E.J. Bass, M. Bertoncelli Tanaka, U. Walters, P. Sakar, F. Hosking-Jervis, H. Bhola-Stewart, E. Pegers, L. Powell, D. Leelamany, K. Wong, S. Ahmad, H. Tam, S. Mccracken, D. Hrouda, H. Qasi, S. Gordon, M. Winkler, and H.U. Ahmed
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Urology - Published
- 2021
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39. Focal spot optimization through scattering media in multiphoton lithography
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Bianca Buchegger, Stephan M. Winkler, D. Höglinger, Armin Hochreiner, Jaroslaw Jacak, and Andreas Haghofer
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Wavefront ,Materials science ,Spatial light modulator ,Scattering ,business.industry ,Mechanical Engineering ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Multiphoton lithography ,Laser ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,010309 optics ,Optics ,law ,0103 physical sciences ,Microscopy ,Electrical and Electronic Engineering ,Photolithography ,0210 nano-technology ,business ,Focus (optics) - Abstract
Shaping the optical wavefront utilizing spatial light modulators (SLMs) is a valuable methodology for modification of a focal spot. It has numerous applications in microscopy, particularly in scattering media. Optical lithography techniques, i.e. multiphoton lithography, can also benefit from wavefront shaping. In this contribution, we present focus optimization in multiphoton lithography through a scattering medium. Beam shaping of a femtosecond-pulsed laser pulse was achieved using a liquid-crystal SLM. For the feedback system a low-cost approach, using a Raspberry Pi-camera in Bayer-mode was applied. Images of the focal spot were used as input for an evolutionary algorithm to improve focus quality.
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- 2021
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40. Technology: Is There Sufficient Evidence to Change Practice in Point-of-Care Management of Coagulopathy?
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Jerrold H. Levy, Michael Fabbro, and Anne M. Winkler
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medicine.medical_specialty ,Blood transfusion ,Point-of-Care Systems ,Point-of-care testing ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,medicine ,Coagulopathy ,Coagulation testing ,Humans ,Blood Transfusion ,Cardiac Surgical Procedures ,Intensive care medicine ,Blood Coagulation ,Randomized Controlled Trials as Topic ,Point of care ,Hemostasis ,Perioperative medicine ,business.industry ,Disease Management ,Blood Coagulation Disorders ,medicine.disease ,Anesthesiology and Pain Medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Currently, hemostasis is one of the most widely researched topics in perioperative medicine. As investigators learn more about the complexity of coagulation, developing tests with the ability to rapidly monitor coagulation and guide targeted therapy is the key to optimizing hemostasis management. There is mounting evidence that algorithmic transfusion using point-of-care (POC) testing can reduce red cell and platelet transfusions and major bleeding after cardiac surgery. Integrating these tests during cardiac surgery and trauma management is especially important because these groups use the most blood products within a health system and the risks of transfusion are well documented. Currently, numerous POC tests are available for evaluating hemostasis. The purpose of this review is to provide a comprehensive evaluation of the current evidence surrounding the most common POC testing devices in practice for managing coagulation.
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- 2017
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41. The Role of the Laboratory and Transfusion Service in the Management of Ebola Virus Disease
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John D. Roback, Scott A. Koepsell, and Anne M. Winkler
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medicine.medical_specialty ,Resuscitation ,Convalescent plasma ,Clinical Biochemistry ,Ebola virus disease ,Disease ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Article ,Virus ,ABO Blood-Group System ,Disease Outbreaks ,Laboratory testing ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Blood Transfusion ,Ethics, Medical ,030212 general & internal medicine ,Adverse effect ,Intensive care medicine ,Transfusion service ,Rh-Hr Blood-Group System ,Ebola virus ,business.industry ,Biochemistry (medical) ,Outbreak ,Hematology ,Hemorrhagic Fever, Ebola ,United States ,Europe ,Africa, Western ,Immunology ,Patient Safety ,Centers for Disease Control and Prevention, U.S ,Laboratories ,business - Abstract
The Ebola outbreak that began in 2013 infected and killed record numbers of individuals and created unprecedented challenges, including containment and treatment of the virus in resource-strained West Africa as well as the repatriation and treatment for patients in the United States and Europe. Valuable lessons were learned, especially the important role that the laboratory and transfusion service plays in the treatment for patients with Ebola virus disease (EVD) by providing data for supportive care and fluid resuscitation as well as the generation of investigational therapies such as convalescent plasma (CP). To provide treatment support, laboratories had to evaluate and update procedures to ensure the safety of laboratory personnel. Because there is no licensed EVD-specific treatment, CP was used in more than 99 patients with only 1 possible severe adverse event reported. However, given the biologic variability inherent in CP as well as the small number of patient treated in a nonrandomized fashion, the efficacy of CP in the treatment of EVD remains unknown., Highlights • Patients with Ebola virus disease were treated in the United States and Europe for the first time. • Laboratories played a vital role in supportive care and experimental therapies for Ebola virus disease. • Convalescent plasma has unknown efficacy in treating Ebola virus disease.
- Published
- 2017
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42. Genotype by environment interactions, heritabilities and genetic correlations for productive traits of Haliotis rufescens
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William J. Farías, Katherina Brokordt, and Federico M. Winkler
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0106 biological sciences ,Haliotis rufescens ,biology ,Abalone ,Ecology ,010604 marine biology & hydrobiology ,04 agricultural and veterinary sciences ,Aquatic Science ,Heritability ,biology.organism_classification ,Selective breeding ,01 natural sciences ,Genetic correlation ,Agronomy ,040102 fisheries ,Trait ,0401 agriculture, forestry, and fisheries ,Gene–environment interaction ,Selection (genetic algorithm) - Abstract
A critical aspect of a selective breeding program is whether responses of traits of interest are similar in different environments. The magnitude of the genotype by environment interaction (GEI) together with heritability ( h 2 ) accounts for this aspect. Despite the economic significance of abalones and the interest in genetic improvement programs for their cultivation, only one previous study has reported GEI estimations for this group of mollusks. The objective of the present study was to estimate h 2 and the existence of GEI for growth traits of Haliotis rufescens cultivated in Chilean farms with different environmental and management conditions. A total of 2 cohorts (2007 and 2009) of 50 and 42 families of full sibs (FS), respectively, were used. Replicates of each FS family of the 2007 cohort were distributed in two farms in the northern region of the country and were evaluated after 1 and 2 years of cultivation. For the 2009 cohort, replicates of each family were distributed in a farm in the northern region and a farm in the southern region of the country. The estimated h 2 values were significant for all traits, with the length and width of the shell and total weight varying primarily by cohort between 0.22–0.62, 0.16–0.58 and 0.40–0.53, respectively. The genetic correlations ( r G ) between traits were all higher than 0.82. The expected correlated responses for improving the total weight using the shell length as a selection criterion predict a selection gain (14–51%) similar to what would be obtained by selecting directly for weight (16–51%) in all environments examined. Thus, indirect selection by shell length and the direct use of total weight as a selection criterion would yield similar effects in terms of the increase in weight. High r G , not significantly different from 1, were observed for the analyzed traits between replicates of the families in any of the farms compared, both within the northern region and between the northern and southern regions of the country. These high r G were indicative of non-significant GEI for the analyzed traits. Therefore, results suggest that one selective breeding program could provide improved red abalone for the industry in Chile with consistent results between farms located in different environments. Statement of relevance Abalones are one of the most important mollusks in aquaculture due to their commercial value in international markets, especially in Asia; as such there are several efforts to develop abalone breeding programs in different countries. In this work we addressed a critical aspect for a selective breeding program, which is to know whether responses of productive traits are similar in different environments. Considering that the magnitude of the genotype by environment interaction (GEI) together with heritability ( h 2 ) accounts for this aspect, we estimated these genetic quantitative parameters for growth traits (total mass, shell length and width) in two cohorts of the red abalone, Haliotis rufescens , cultivated throughout Chile. Results indicated that the application of selection by the shell length at age of harvest has the greatest potential for improving the production of H. rufescens . These improvements are practical (ease and accuracy in measurement), have indirect effects on the objective trait of selection (weight), and consist of a trait that is not significantly affected by genotype-environment interactions. In addition, the results obtained suggest that a single selective breeding program would be sufficient for the red abalone industry in Chile, as the response to selection of traits associated with growth would be similar in different environments. Red abalone is naturally distributed in California and Baja California coasts, and this information can be especially useful in planning breeding programs also in the west coast of USA and Mexico.
- Published
- 2017
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43. AUTOIMMUNE MYOPATHIES
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M. Winkler, C. von Landenberg, C. Kornblum, and J. Reimann
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Neurology ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Genetics (clinical) - Published
- 2020
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44. Deconstructing Irritability Phenotypically and Neurally
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Anderson M. Winkler, Melissa A. Brotman, Ellen Leibenluft, Julia Linke, Katharina Kircanski, Elise M. Cardinale, and Daniel S. Pine
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business.industry ,medicine ,medicine.symptom ,Irritability ,business ,Biological Psychiatry ,Clinical psychology - Published
- 2020
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45. Switching from sedation to local anaesthetic transperineal prostate biopsies: A cost-benefit analysis
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U. Walters, M.J. Connor, E.J. Bass, D. Eldred-Evans, W. Maynard, P. Sarkar, M. Bertoncelli Tanaka, F. Hosking-Jervis, H. Bhola-Stewart, E. Pegers, L. Powell, D. Leelamany, K. Wong, S. Ahmad, H. Tam, S. Mccracken, S. Gordon, D. Hrouda, H. Qazi, M. Winkler, and H.U. Ahmed
- Subjects
Urology - Published
- 2021
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46. Niche overlap among anglers, fishers and cormorants and their removals of fish biomass: A case from brackish lagoon ecosystems in the southern Baltic Sea
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Helmut M. Winkler, Jorrit Lucas, Carsten Kühn, Harry Vincent Strehlow, Robert Arlinghaus, Dieter Kömle, Marc Simon Weltersbach, and Carsten Riepe
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0106 biological sciences ,Perch ,Fish migration ,biology ,010604 marine biology & hydrobiology ,Cormorant ,04 agricultural and veterinary sciences ,Clupea ,Aquatic Science ,biology.organism_classification ,01 natural sciences ,Commercial fishing ,Fishery ,Herring ,Geography ,biology.animal ,040102 fisheries ,Freshwater fish ,0401 agriculture, forestry, and fisheries ,Rutilus - Abstract
We used time series, diet studies and angler surveys to examine the potential for conflict in brackish lagoon fisheries of the southern Baltic Sea in Germany, specifically focusing on interactions among commercial and recreational fisheries as well as fisheries and cormorants (Phalacrocorax carbo sinensis). For the time period between 2011 and 2015, commercial fisheries were responsible for the largest total fish biomass extraction (5,300 t per year), followed by cormorants (2,394 t per year) and recreational fishers (966 t per year). Commercial fishing dominated the removals of most marine and diadromous fish, specifically herring (Clupea harengus), while cormorants dominated the biomass extraction of smaller-bodied coastal freshwater fish, specifically perch (Perca fluviatilis) and roach (Rutilus rutilus). Pike (Esox lucius) as large-bodied freshwater fish was the only species where recreational fisheries were responsible for the major fraction of the annual biomass extraction. A strong trophic overlap and hence a similar foraging niche was documented among commercial fishers and recreational anglers and among non-resident and resident anglers, indicating that the aversion expressed by anglers against commercial fisheries in a survey had an objective underpinning related to resource competition. By contrast, the foraging niches of cormorants and of both fishers and anglers differed strongly as evidenced by largely non-overlapping sets of species that were caught and removed by cormorants and by commercial as well as recreational fishers. However, for individual species of commercial and recreational interest, specifically perch, cormorants were responsible for a major fraction of total biomass extraction, suggesting that at the individual fish species level competition with fishers and anglers may still occur. In an angler survey, respondents expressed a preference for cormorant control, indicating the existence of conflict between fisheries and cormorants. We recommend that conflicts in the lagoon fisheries be proactively managed, e.g., through improved communication, zoning, predator control and outreach. Further research should clarify the population-level impacts of cormorants on target species of commercial and recreational fisheries as well as the relative impact of commercial and recreational fisheries on selected species of joint interest.
- Published
- 2021
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47. Prostate pathway embedded comparative trial: The ip3-prospect study
- Author
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E.J. Bass, F. Fransesca, M. Winkler, Matthew R. Sydes, A. Pope, Nimalan Arumainayagam, Emily Day, Natalia Klimowska-Nassar, Tim Dudderidge, Heminder Sokhi, B. Khoubehi, and Thiagarajah Sasikaran
- Subjects
Oncology ,medicine.medical_specialty ,medicine.anatomical_structure ,Prostate ,business.industry ,Urology ,Internal medicine ,medicine ,Comparative trial ,business - Published
- 2021
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48. Functional Connectivity Relates to Electrophysiological Markers of Attention in Infancy
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Anderson M. Winkler, Courtney A. Filippi, Nathan A. Fox, Daniel S. Pine, Santiago Morales, Maya Bracy, Sanjana Ravi, George A. Buzzell, and Stephanie C. Leach
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Functional connectivity ,Electrophysiological markers ,Biology ,Neuroscience ,Biological Psychiatry - Published
- 2021
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49. Allocentric representation in the human amygdala and ventral visual stream
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Richard F. Betzel, Tor Ivar Hansen, Hallvard Røe Evensmoen, Lars M. Rimol, Anderson M. Winkler, Asta Håberg, and Hamed Nili
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Male ,0301 basic medicine ,Hippocampus ,Amygdala ,General Biochemistry, Genetics and Molecular Biology ,Temporal lobe ,03 medical and health sciences ,0302 clinical medicine ,Cortex (anatomy) ,Perirhinal cortex ,medicine ,Humans ,Vision, Ocular ,Cognitive map ,medicine.diagnostic_test ,Entorhinal cortex ,Magnetic Resonance Imaging ,Temporal Lobe ,030104 developmental biology ,medicine.anatomical_structure ,nervous system ,Psychology ,Functional magnetic resonance imaging ,Neuroscience ,psychological phenomena and processes ,030217 neurology & neurosurgery - Abstract
The hippocampus and the entorhinal cortex are considered the main brain structures for allocentric representation of the external environment. Here, we show that the amygdala and the ventral visual stream are involved in allocentric representation. Thirty-one young men explored 35 virtual environments during high-resolution functional magnetic resonance imaging (fMRI) of the medial temporal lobe (MTL) and were subsequently tested on recall of the allocentric pattern of the objects in each environment—in other words, the positions of the objects relative to each other and to the outer perimeter. We find increasingly unique brain activation patterns associated with increasing allocentric accuracy in distinct neural populations in the perirhinal cortex, parahippocampal cortex, fusiform cortex, amygdala, hippocampus, and entorhinal cortex. In contrast to the traditional view of a hierarchical MTL network with the hippocampus at the top, we demonstrate, using recently developed graph analyses, a hierarchical allocentric MTL network without a main connector hub. Cell Reports 34, 108658, January 19, 2021 ª 2021 The Authors. 1 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Published
- 2021
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50. A heuristic and evolutionary algorithm to optimize the coefficients of curve parametrizations
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J. Rafael Sendra, Stephan M. Winkler, and Universidad de Alcalá. Departamento de Física y Matemáticas. Unidad docente Matemáticas
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Rational curve ,Mathematical optimization ,Matemáticas ,Heuristic (computer science) ,Applied Mathematics ,010102 general mathematics ,Evolutionary algorithm ,Parametrization height ,010103 numerical & computational mathematics ,Heuristic algorithm ,01 natural sciences ,Arithmetic optimality ,Computational Mathematics ,0101 mathematics ,Computational problem ,Parametrization ,Mathematics ,Integer (computer science) ,Parametric statistics - Abstract
A major part of this work was developed while S. M. Winkler was visiting J.R. Sendra at the Universidad de Alcalá in the frame of the project Giner de los Rios. J.R. Sendra is member of the Research Group ASYNACS (Ref.CT-CE2019/683)., Parametric representations may have unnecessarily huge integer coefficients. This can be a computational problem in practical applications. In this paper we present an evolutionary algorithm that reduces the maximum length of the coefficients for a proper curve parametrization with integer coefficients. This method is tested with different families of parametrizations, and as we show the results are very satisfactory in terms of achievable quality and runtime consumption. According to our knowledge, this is the first algorithmic approach to this problem., Ministerio de Economía y Competitividad, The Austrian Research Promotion Agency
- Published
- 2016
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