383 results on '"M, Park"'
Search Results
2. Acute Macular Neuroretinopathy and Coronavirus Disease 2019
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Russel H. Dinh, Edmund Tsui, Matthew S. Wieder, Alexander Barash, Michael M. Park, Ehsan Rahimy, Prithvi Mruthyunjaya, Louise J. Lu, Suzanne M. Michalak, Rohan J. Shah, David Sierpina, Timothy W. Winter, Ryan A. Shields, Eduardo Uchiyama, Gregory D. Lee, Rahul Komati, Eric Lee, Sundeep K. Kasi, and Brian K. Do
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Ophthalmology - Published
- 2023
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3. Analysis of local invasion and regional spread in malignant sublingual gland tumour: Implications for surgical planning
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H.-S. Jeong, Woong-Yang Park, Ki Hong Choi, Y. Heo, M. Park, Junhun Cho, Young-Hyeh Ko, and S.Y. Choi
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Pathology ,medicine.medical_specialty ,Adenoid cystic carcinoma ,Surgical planning ,03 medical and health sciences ,0302 clinical medicine ,Mucoepidermoid carcinoma ,medicine ,Humans ,Pathological ,Lingual nerve ,business.industry ,Sublingual Gland Neoplasms ,Sublingual gland ,030206 dentistry ,Salivary Gland Neoplasms ,medicine.disease ,Carcinoma, Adenoid Cystic ,Submandibular gland ,stomatognathic diseases ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Neck Dissection ,Carcinoma, Mucoepidermoid ,Surgery ,Lymph ,Oral Surgery ,business - Abstract
Malignant tumours arising from the sublingual glands are very rare, and the extent and frequency of local invasion or regional spread in malignant sublingual gland tumour (MSLT) has not been fully studied due to the disease rarity. To provide comprehensive features of local and regional spread of MSLT, we reviewed 20 surgical cases for detailed pathological analyses among 26 cases diagnosed as having primary MSLT. Adenoid cystic carcinoma (ACC) was the most common pathological subtype, followed by mucoepidermoid carcinoma. Disease-free and overall survivals at 5 years were 76.1 % and 77.7 %, respectively. High-grade malignant tumours and grade 2-3 ACC accounted for 41.7 % and 85.7 %. Clinical and pathological extraparenchymal extensions were found in 34.6 % and 80.0 %, respectively. Tumour invasion to the lingual nerve and submandibular gland/ductal system were also detected in 40.0 % and 28.6 %. The incidences of lingual nerve invasion in ACC and ACC ≥4 cm were 30.8 % and 42.9 %. Regional nodal involvement occurred in seven of 26 cases, and all metastatic lymph nodes were found in neck levels Ib and IIa. In summary, a significant portion of MSLT cases consisted of high-grade tumours and grade 2-3 ACC; therefore local invasion into adjacent structures should be cautiously evaluated in cases of MSLT.
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- 2021
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4. Geographic Atrophy Growth Is Strongly Related to Lesion Perimeter
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Aneesha Ahluwalia, Liangbo Shen, Lucian V. Del Priore, Michael M. Park, Benjamin K Young, and Mengyuan Sun
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0303 health sciences ,medicine.medical_specialty ,business.industry ,Eye disease ,Macular degeneration ,Lesion Number ,Fundus (eye) ,medicine.disease ,Perimeter ,Lesion ,Geographic atrophy ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,030221 ophthalmology & optometry ,medicine ,Growth rate ,medicine.symptom ,business ,030304 developmental biology - Abstract
Purpose To investigate the underlying reason for the previously observed impact of baseline lesion size, number, and circularity on geographic atrophy (GA) growth rate. Design Retrospective analysis of a multicenter, prospective, randomized controlled trial. Participants Age-Related Eye Disease Study participants with GA secondary to nonexudative age-related macular degeneration. Methods We manually delineated atrophic lesions on color fundus photographs of 318 eyes with GA followed up over at least 2 visits (mean follow-up duration, 5.1 ± 3.0 years). We calculated GA area growth rate for each eye based on the first and last visit. GA perimeter-adjusted growth rate was defined as the ratio between GA area growth rate and mean GA perimeter between the first and last visit for each eye. Main Outcome Measures GA area growth rate, growth rate of the square root of GA area, and GA perimeter-adjusted growth rate. Results GA area growth rate was correlated strongly with mean GA perimeter (r2 = 0.66). GA area growth rate was associated with baseline GA area (r2 = 0.39; P Conclusions The growth rate of GA area is associated strongly with lesion perimeter. This relationship explains the previously observed influences of baseline GA size, lesion number, and circularity on GA growth rate. GA perimeter-adjusted growth rate is uncorrelated with the 3 morphologic factors and may serve as a surrogate outcome measure to monitor GA progression in future studies.
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- 2021
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5. (677) Serum and BAL Fluid Aspergillus Galactomannan Titers in Lung Transplant Recipients
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M. Park, S. Yong, H. Paik, J. Lee, S. Kim, H. Kim, A. Woo, and E. Kim
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Pulmonary and Respiratory Medicine ,Transplantation ,Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
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6. Implementation of a Psychiatry Consultation-Liaison Service 'Conseminar'
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Nate A. Sowa, Donald L. Rosenstein, Rishika Reddy, Gary J. Gala, Sarah L. Laughon, Rebekah P. Nash, Eliza M. Park, and Jonathan S. Gerkin
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Psychiatry ,Service (systems architecture) ,medicine.medical_specialty ,Process (engineering) ,Best practice ,education ,Group exercise ,Field (computer science) ,Clinical trial ,Psychiatry and Mental health ,Clinical Psychology ,medicine ,Single institution ,Clinical care ,Psychology ,Referral and Consultation - Abstract
Background The field of consultation-liaison psychiatry has generated a relatively small number of rigorous clinical trials that guide clinical care. Consequently, there is a need for a consensus-building process to inform best practices for common clinical dilemmas in consultation-liaison psychiatry. Objective We review several consensus-building approaches in academic medicine and describe a novel educational process called a “conseminar,” which is intended to minimize the variability in teaching and practice on a service staffed by multiple faculty members. Methods The conseminar is an iterative group exercise among faculty who attend on a consultation-liaison service. Faculty members generate a list of candidate topics and then prioritize those topics for a focused and critical literature review, aided by a librarian. In the absence of definitive clinical trial data or established practice guidelines, the faculty articulates a consensus “best-practice” approach and creates a brief document that summarizes specific recommendations for learners on the service. Conclusions The conseminar process can minimize variability among consultation-liaison faculty within a single institution with respect to the diagnostic and treatment recommendations conveyed to trainees. Furthermore, conseminar documents can be shared across institutions to promote more consistent teaching and practice within consultation-liaison psychiatry.
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- 2021
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7. Migratory cortical interneuron-specific transcriptome abnormalities in schizophrenia
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Weihua Huang, Peiyan Ni, Gun-Hoo Park, Changhong Yin, Dongxin Liu, Sangmi Chung, James M. Park, and Haneul Noh
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Induced Pluripotent Stem Cells ,Cell ,virus diseases ,RNA-Seq ,Biology ,medicine.disease ,female genital diseases and pregnancy complications ,Pathogenesis ,Transcriptome ,Extracellular matrix ,Psychiatry and Mental health ,Immune system ,medicine.anatomical_structure ,Interneurons ,Schizophrenia ,medicine ,Humans ,Induced pluripotent stem cell ,neoplasms ,Neuroscience ,Biological Psychiatry - Abstract
Cortical interneurons (cINs) are substantially affected in Schizophrenia (SCZ) and enriched for SCZ heritability during development. To understand SCZ-specific changes in these cells during development, we isolated migratory cINs from cIN spheres derived from 5 healthy control (HC) and 5 SCZ induced pluripotent stem cell lines (iPSCs). Transcriptome analyses show dysregulation in extracellular matrix pathways as the major disturbances in SCZ migratory cINs, whereas sphere cINs show dysregulation in immune pathways. This result suggests the importance of using homogeneous cell populations to identify stage-specific abnormalities and provides a platform to further study the biology of schizophrenia pathogenesis during early development.
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- 2021
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8. C4 article: Implications of COVID-19 in transplantation
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Daniel E. Dulek, Michael G. Ison, Cristiano Amarelli, Atul Humar, Emily A. Blumberg, Maria Irene Bellini, Crystal Truax, Rebecca Pellett Madan, Ekamol Tantisattamo, Marwan M. Azar, Neeraj Singh, Camilla W. Nonterah, Santiago M.C. Lopez, Deepali Kumar, Lara Danziger-Isakov, Lilian M. Abbo, Nicole Theodoropoulos, Annelise Nolan, Marion Hemmersbach-Miller, Felipe Alconchel, Gustavo Fernandes Ferreira, Melissa A. Greenwald, Emmanouil Giorgakis, Alessandro Gambella, James R. Rodrigue, Kenneth J. Woodside, Michelle T Jesse, Jonathan Hand, Patti Niles, Valerie Demekhin, Wendy Balliet, Benito Valdepenas, Kristina L. Goff, Naoka Murakami, Armelle Perez Cortes Villalobos, Benjamin A. Miko, Melissa R. Gitman, Justin G. Aaron, Amany Sholkamy, Monica I. Ardura, Nicole A. Pilch, Kristin Kronsnoble, Andrés Jaramillo, Scott G. Westphal, Krista L. Lentine, Jamil Azzi, John W Baddley, Camille N. Kotton, Dhruva Sharma, Shweta Anjan, Mia Schmiedeskamp-Rahe, Sumit Mohan, Jeong M. Park, Yasemin Tezer, Lisa M. Potter, Heather Bruschwein, James A. Blumenthal, Michael Green, Ricardo M. La Hoz, Marcus R. Pereira, and Deborah Verran
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infection and infectious agents ,medicine.medical_specialty ,infection and infectious agents - viral ,Tissue and Organ Procurement ,Coronavirus disease 2019 (COVID-19) ,infectious disease ,clinical research/practice ,Dexamethasone ,Humans ,Immunology and Allergy ,Medicine ,organ transplantation in general ,Pharmacology (medical) ,Child ,Intensive care medicine ,Transplantation ,business.industry ,infection and infectious agents – viral ,COVID-19 ,Original Articles ,Organ Transplantation ,Tissue Donors ,Clinical research/practice ,viral ,Infectious disease (medical specialty) ,COVID-19 Nucleic Acid Testing ,Original Article ,business - Abstract
A novel coronavirus has had global impact on individual health and health care delivery. In this C4 article, contributors discuss various aspects of transplantation including donor and recipient screening, management of infected patients, and prevention of coronavirus disease (COVID). Donor screening with SARS-CoV-2 nucleic acid testing (NAT) close to the time of procurement is recommended. Many programs are also screening all potential recipients at the time of admission. The management of COVID has evolved with remdesivir emerging as a new potential option for transplant recipients. Dexamethasone has also shown promise and convalescent plasma is under study. Prevention strategies for transplant candidates and recipients are paramount. Pediatric-specific issues are also discussed. Strategies for the psychological well-being of patients and providers are also imperative, in addition to future research priorities for transplantation.
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- 2021
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9. Posterior vitreous cortex hyalocytes visualization in asymmetric pigmented paravenous chorioretinal atrophy (PPCRA) using en face OCT
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Julia Fallon, Sofia Ahsanuddin, Oscar Otero-Marquez, Hernan Andres Rios, Michael M. Park, Toco Y.P. Chui, and Richard B. Rosen
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Ophthalmology - Published
- 2023
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10. PO-02-193 A COMPARISON OF THIRD GENERATION CRYOABLATION VERSUS X3 LASER BALLOON SYSTEMS FOR PULMONARY VEIN ISOLATION FOR TREATMENT OF ATRIAL FIBRILLATION
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Michael Dietrich, Cicely Dye, Jeanne M. du Fay de Lavallaz, David N. Kenigsberg, Luke R. Detloff, Aaron M. Park, Alexander Mazur, Erica D. Engelstein, Jeremiah Wasserlauf, Timothy R. Larsen, Parikshit S. Sharma, and Henry D. Huang
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
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11. 1340 Basal keratinocytes exhibit age-related epigenetic and transcriptomic alterations resulting in an altered metabolic profile
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L. Sutton, E. Sulvaran-Guel, M. Park, and D. Chen
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Cell Biology ,Dermatology ,Molecular Biology ,Biochemistry - Published
- 2023
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12. Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk: From the American Society of Echocardiography
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Harald Becher, Margaret M. Park, Esther S.H. Kim, Amer M. Johri, Henrik Sillesen, Tasneem Z. Naqvi, Steven B. Feinstein, and Vijay Nambi
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Carotid ultrasound ,medicine.medical_specialty ,business.industry ,Ultrasound ,Composition analysis ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Risk stratification ,cardiovascular system ,medicine ,Disease risk ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Ultrasound image - Abstract
Atherosclerotic plaque detection by carotid ultrasound provides cardiovascular disease risk stratification. The advantages and disadvantages of two-dimensional (2D) and three-dimensional (3D) ultrasound methods for carotid arterial plaque quantification are reviewed. Advanced and emerging methods of carotid arterial plaque activity and composition analysis by ultrasound are considered. Recommendations for the standardization of focused 2D and 3D carotid arterial plaque ultrasound image acquisition and measurement for the purpose of cardiovascular disease stratification are formulated. Potential clinical application towards cardiovascular risk stratification of recommended focused carotid arterial plaque quantification approaches are summarized.
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- 2020
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13. (912) Impact of Donor Lung Quality on Outcomes of Lung Transplantation: Clinical Reality of Extended Criteria Donors
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H. Kim, Y. Yang, W. Ara, S. Kim, M. Park, and J. Lee
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Pulmonary and Respiratory Medicine ,Transplantation ,Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
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14. Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition
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Qian Zhu, Akanksha Mishra, Joy S. Park, Dongxin Liu, Derek T. Le, Sasha Z. Gonzalez, Morgan Anderson-Crannage, James M. Park, Gun-Hoo Park, Laura Tarbay, Kamron Daneshvar, Matthew Brandenburg, Christina Signoretti, Amy Zinski, Edward-James Gardner, Kelvin L. Zheng, Chiderah P. Abani, Carla Hu, Cameron P. Beaudreault, Xiao-Lei Zhang, Patric K. Stanton, Jun-Hyeong Cho, Libor Velíšek, Jana Velíšková, Saqlain Javed, Christopher S. Leonard, Hae-Young Kim, and Sangmi Chung
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General Neuroscience - Published
- 2023
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15. DEFINITION, PREVALENCE AND PATHOPHYSIOLOGIC ROLE OF IRON DEFICIENCY IN PULMONARY VASCULAR DISEASE
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Pieter Martens, Shilin Yu, Samar Farha, Serpil C. Erzurum, Anna Hemnes, Evelyn M. Horn, Franz Rischard, Erika Rosenzweig, Margaret M. Park, Paul Hassoun, and Wai Hong Wilson Tang
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Cardiology and Cardiovascular Medicine - Published
- 2023
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16. 83 An Interim Reporting of Trigger Point Injection for Myofascial Pain Syndrome (T-PIMPS): A 3-Arm, Partially Blinded, Randomized Controlled Trial
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J. Oliver, C. Dougherty, N. Downing, A. Hull, B. Jimenez, D. Ediger, M. Park, B. Scwartz, N. Walther, C. Wolterstorff, and T. Olivera
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Emergency Medicine - Published
- 2022
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17. 311P Differences in stromal component of chordoma are associated with contrast enhancement in MRI and differential gene expression in RNA sequencing
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Y.J. Cha, M. Park, I. Park, and J.H. Kim
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Oncology ,Hematology - Published
- 2022
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18. Rare presentation of a clear cell renal cell cancer metastasis to the contralateral testicle: A case report
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Alice Thomson, Eric M. Park, Justin du Plessis, Krishna Rachakonda, and Peter Liodakis
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Urology - Published
- 2023
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19. W263 Time-temperature indicators vs. temperature indicators for transfusion practice: Application in the real hospital setting
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M. Park, M. Hur, H. Chung, H. Kim, K. Oh, D. Ko, and Y. Chung
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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20. PO-1822 Ultra-high dose rate FLASH effect on head and neck cancer cells and normal salivary gland in mice
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E. Kim, K. Yang, M. Kim, W.I. Jang, H. Kim, M. Park, and J. Kim
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2022
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21. SEMI-QUANTITATIVE AND QUANTITATIVE CARTILAGE IMPROVEMENT AFTER INTRA-ARTICULAR INJECTION OF ICM-203 IN CANINE OA MODEL
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M. Park, J. Collins, N. Lee, H.-K. Go, S. Shin, C. Jin, T.-W. Jeong, Y. Song, J. Kim, J.-H. Cho, S. Maschek, W. Wirth, A. Guermazi, and D.-W. Kim
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Rheumatology ,Biomedical Engineering ,Orthopedics and Sports Medicine - Published
- 2022
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22. A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4.2 trafficking
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G. Travis Tabor, Jonathan G. Murphy, Jia-Hua Hu, Dax A. Hoffman, and Jung M. Park
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0301 basic medicine ,MAPK/ERK pathway ,Endosome ,media_common.quotation_subject ,Hippocampal formation ,Biology ,Hippocampus ,p38 Mitogen-Activated Protein Kinases ,Article ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Animals ,Humans ,Binding site ,Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ,Internalization ,Protein kinase A ,Protein Kinase Inhibitors ,Molecular Biology ,Cells, Cultured ,media_common ,Mitogen-Activated Protein Kinase Kinases ,Neurons ,Binding Sites ,Kv Channel-Interacting Proteins ,Cell Biology ,Transfection ,Bungarotoxin ,Bungarotoxins ,Rats ,Cell biology ,Protein Transport ,HEK293 Cells ,Shal Potassium Channels ,030104 developmental biology ,cardiovascular system ,030217 neurology & neurosurgery ,Protein Binding - Abstract
Kv4.2 voltage-gated K(+) channel subunits, the primary source of the somatodendritic A-type K(+) current in CA1 pyramidal neurons of the hippocampus, play important roles in regulating dendritic excitability and plasticity. To better study the trafficking and subcellular distribution of Kv4.2, we created and characterized a novel Kv4.2 construct encoding a bungarotoxin binding site in the extracellular S3-S4 linker region of the α-subunit. When expressed, this construct can be visualized in living cells after staining with rhodamine-conjugated bungarotoxin. We validated the utility of this construct by visualizing the spontaneous internalization and insertion of Kv4.2 in HEK 293T cells. We further report that Kv4.2 colocalized with several endosome markers in HEK 293T cells. In addition, Kv4.2 internalization is significantly impaired by mitogen-activated protein kinase (MAPK) inhibitors in transfected primary hippocampal neurons. Therefore, this newly developed BBS-Kv4.2 construct provides a novel and powerful tool for studying surface Kv4.2 channel localization and trafficking.
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- 2019
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23. Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells
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Kyungjoon Park, Leonard M. Eisenberg, Fatima Arif, Alexander A. Moghadam, Vadim Y. Bolshakov, Clare Faux, John Parnevelas, Zhicheng Shao, Youxin Guan, Joshua J. Park, Haneul Noh, Sangmi Chung, Bill Andrews, Peiyan Ni, Cameron P Beaudreault, John N. Hutchinson, Patric K. Stanton, Elizabeth Berry, James M. Park, Chiderah P Abani, Joy S. Park, and Qian Zhu
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0301 basic medicine ,lcsh:QH426-470 ,Cell ,Population ,Biology ,migration ,Article ,cortical interneurons ,Cell therapy ,GABA ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,medicine ,human pluripotent stem cells ,lcsh:QH573-671 ,Progenitor cell ,Induced pluripotent stem cell ,education ,Molecular Biology ,education.field_of_study ,lcsh:Cytology ,maturation ,Cerebrum ,differentiation ,Phenotype ,female genital diseases and pregnancy complications ,Transplantation ,lcsh:Genetics ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Molecular Medicine ,Neuroscience ,transplantation - Abstract
During development, cortical interneurons (cINs) are generated from the ventral telencephalon, robustly migrate to the dorsal telencephalon, make local synaptic connections, and critically regulate brain circuitry by inhibiting other neurons. Thus, their abnormality is associated with various brain disorders. Human pluripotent stem cell (hPSC)-derived cINs can provide unlimited sources with which to study the pathogenesis mechanism of these disorders as well as provide a platform to develop novel therapeutics. By employing spinner culture, we could obtain a >10-fold higher yield of cIN progenitors compared to conventional culture without affecting their phenotype. Generated cIN spheres can be maintained feeder-free up to 10 months and are optimized for passaging and cryopreservation. In addition, we identified a combination of chemicals that synchronously matures generated progenitors into SOX6+KI67− migratory cINs and extensively characterized their maturation in terms of metabolism, migration, arborization, and electrophysiology. When transplanted into mouse brains, chemically matured migratory cINs generated grafts that efficiently disperse and integrate into the host circuitry without uncontrolled growth, making them an optimal cell population for cell therapy. Efficient large-scale generation of homogeneous migratory cINs without the need of feeder cells will play a critical role in the full realization of hPSC-derived cINs for development of novel therapeutics. Keywords: cortical interneurons, GABA, human pluripotent stem cells, differentiation, transplantation, maturation, migration
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- 2019
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24. 137P Combining protein and mRNA spatial profiles to identify distinct cell population in metaplastic breast cancer
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H. Kuasne, P. Savage, B. Khadang, J. Lai, C. Martinez Ramirez, A. Monast, A-M. Fortier, S. Busque, J. Asselah, N. Bouganim, S. Meterissian, A. Omeroglu, M. Basik, Y. Riazalhosseini, and M. Park
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Oncology ,Hematology - Published
- 2022
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25. 702 Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells
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M. Park, S. Jang, J. Chung, K. Kim, O. Kwon, and S. Jo
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Cell Biology ,Dermatology ,Molecular Biology ,Biochemistry - Published
- 2022
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26. P093 IMMUNE GLOBULIN SUBCUTANEOUS (HUMAN) 20% SOLUTION ADMINISTRATION IN PRIMARY IMMUNODEFICIENCY DISEASES: A RETROSPECTIVE CHART REVIEW
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M. Park, K. Paris, M. Sanchirico, O. Nwose, and K. Rosenbach
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Pulmonary and Respiratory Medicine ,biology ,business.industry ,Immunology ,medicine.disease ,Chart review ,Primary immunodeficiency ,medicine ,biology.protein ,Immunology and Allergy ,Antibody ,business ,Administration (government) - Published
- 2021
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27. The effect of gamma-ray irradiation on the electrical characteristics of sol-gel derived zinc tin oxide thin film transistors
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S. Wang, S. Uprety, V. Mirkhani, D. Hanggi, K. Yapabandara, M.P. Khanal, A.C. Ahyi, M.C. Hamilton, M.H. Sk, and M. Park
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Materials Chemistry ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2022
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28. W264 A survey on RBC transfusion practice in Korea
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M. Park, M. Hur, H. Chung, H. Kim, K. Oh, Y.H. Song, D. Ko, and Y. Chung
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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29. M158 Validation of various equations for calculated serum LDL cholesterol in Korean
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R. Choi, M. Park, Y. Oh, S.H. Kim, S.G. Lee, and E.H. Lee
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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30. M289 Evaluation of two automated immunoassays for the detection of anti-nuclear antibody
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S. Yoon, H. Moon, M. Park, H. Kim, H. Chung, M. Hur, and Y. Yun
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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31. M044 Development of machine learning model for diagnostic disease prediction based on laboratory tests
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D.J. Park, M. Park, Y. Kim, and Y.H. Park
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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32. T077 Laboratory-specific equation for calculated serum LDL concentration
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R. Choi, M. Park, Y. Oh, S.H. Kim, S.G. Lee, and E.H. Lee
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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33. W232 The value of measuring NK cell fraction in Korean women with reproductive failure
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M. Park, E. Pack, S.G. Lee, S. Park, R. Choi, Y. Kim, and M. Min
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Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Published
- 2022
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34. Facile quantization of semiconductor compounds in the zeolite: characterization of quantum dots of Zn4S6+ and Zn2S2+ in zeolite Y
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D.J. Moon, M. Park, and W.T. Lim
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Biomaterials ,Colloid and Surface Chemistry ,Polymers and Plastics ,Materials Chemistry ,Catalysis ,Electronic, Optical and Magnetic Materials - Published
- 2022
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35. Investigating flaviviral genomic cyclization
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Tyler Mrozowich, Sean M. Park, Michael T. Wolfinger, and Trushar R. Patel
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Biophysics - Published
- 2022
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36. Investigating Japanese encephalitis virus long-range terminal region interactions
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Sean M. Park, Tyler Mrozowich, Michael T. Wolfinger, and Trushar R. Patel
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Biophysics - Published
- 2022
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37. Best Core Stabilization for Anticipatory Postural Adjustment and Falls in Hemiparetic Stroke
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Chung H Yi, Bong S Choi, Hye Seon Jeon, Tae H Lee, In T Ryu, Hyun S Yoon, Dong R Lee, Nam G Lee, Joshua Sung H You, and Jae M Park
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Male ,030506 rehabilitation ,medicine.medical_specialty ,medicine.medical_treatment ,education ,Paraspinal Muscles ,Physical Therapy, Sports Therapy and Rehabilitation ,Electromyography ,Fear of falling ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Muscle Stretching Exercises ,medicine ,Humans ,Single-Blind Method ,Postural Balance ,Stroke ,Abdominal Muscles ,Aged ,Balance (ability) ,Core (anatomy) ,Rehabilitation ,medicine.diagnostic_test ,business.industry ,Stroke Rehabilitation ,Torso ,Abdominal Oblique Muscles ,Fear ,Middle Aged ,Anticipation, Psychological ,medicine.disease ,Trunk ,Exercise Therapy ,Paresis ,Treatment Outcome ,Berg Balance Scale ,Chronic Disease ,Accidental Falls ,Female ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
To compare the effects of conventional core stabilization and dynamic neuromuscular stabilization (DNS) on anticipatory postural adjustment (APA) time, balance performance, and fear of falls in chronic hemiparetic stroke.Two-group randomized controlled trial with pretest-posttest design.Hospital rehabilitation center.Adults with chronic hemiparetic stroke (N=28).Participants were randomly divided into either conventional core stabilization (n=14) or DNS (n=14) groups. Both groups received a total of 20 sessions of conventional core stabilization or DNS training for 30 minutes per session 5 times a week during the 4-week period.Electromyography was used to measure the APA time for bilateral external oblique (EO), transverse abdominis (TrA)/internal oblique (IO), and erector spinae (ES) activation during rapid shoulder flexion. Trunk Impairment Scale (TIS), Berg Balance Scale (BBS), and Falls Efficacy Scale (FES) were used to measure trunk movement control, balance performance, and fear of falling.Baseline APA times were delayed and fear of falling was moderately high in both the conventional core stabilization and DNS groups. After the interventions, the APA times for EO, TrA/IO, and ES were shorter in the DNS group than in the conventional core stabilization group (P.008). The BBS and TIS scores (P.008) and the FES score (P.003) were improved compared with baseline in both groups, but FES remained stable through the 2-year follow-up period only in the DNS group (P.003).This is the first clinical evidence highlighting the importance of core stabilization exercises for improving APA control, balance, and fear of falls in individuals with hemiparetic stroke.
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- 2018
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38. Hair Biology
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Jeffrey D. Rawnsley, Sajjad Khan, and Andrea M. Park
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0301 basic medicine ,Natural course ,integumentary system ,Biology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Minoxidil ,otorhinolaryngologic diseases ,medicine ,Surgery ,sense organs ,Neuroscience ,medicine.drug - Abstract
Healthy hair is vital to identity. Understanding the intricate anatomy and physiology of hair provides insight into the aging process and the eventual loss of either hair pigmentation or hair shafts. Several biologics are available that have enabled altering or slowing the aging process of hair, but, unfortunately, no agent exists that can reverse the natural course. The commonly used biologics are discussed.
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- 2018
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39. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. 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Y., Angchaisuksiri, P., Chawanadelert, S., Mongkolwongroj, P., Kanokphatcharakun, K., Cheewatanakornkul, S., Laksomya, T., Pattanaprichakul, S., Chantrarat, T., Rungaramsin, S., Silaruks, S., Wongcharoen, W., Siriwattana, K., Likittanasombat, K., Katekangplu, P., Boonyapisit, W., Cholsaringkarl, D., Chatlaong, B., Chattranukulchai, P., Santanakorn, Y., Hutayanon, P., Khunrong, P., Bunyapipat, T., Jai-Aue, S., Kaewsuwanna, P., Bamungpong, P., Gunaparn, S., Hongsuppinyo, S., Inphontan, R., Khattaroek, R., Khunkong, K., Kitmapawanont, U., Kongsin, C., Naratreekoon, B., Ninwaranon, S., Phangyota, J., Phrommintikul, A., Phunpinyosak, P., Pongmorakot, K., Poomiphol, S., Pornnimitthum, N., Pumprueg, S., Ratchasikaew, S., Sanit, K., Sawanyawisuth, K., Silaruks, B., Sirichai, R., Sriwichian, A., Suebjaksing, W., Sukklad, P., Suttana, T., Tangsirira, A., Thangpet, O., Tiyanon, W., Vorasettakarnkij, Y., Wisaratapong, T., Wongtheptien, W., Wutthimanop, A., Yawila, S., Oto, A., Altun, A., Ozdogru, I., Ozdemir, K., Yilmaz, O., Aydinlar, A., Yilmaz, M. 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A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaröe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grässjö, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenström, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S. K., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S. Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
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Registrie ,Male ,Time Factors ,Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF ,030204 cardiovascular system & hematology ,Electrocardiography ,0302 clinical medicine ,Risk Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,Aged ,Atrial Fibrillation ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Prevalence ,Prognosis ,Prospective Studies ,Survival Rate ,Thromboembolism ,Registries ,Risk Assessment ,Medicine ,030212 general & internal medicine ,Prospective cohort study ,Incidence (epidemiology) ,cardiovascular system ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Human ,medicine.medical_specialty ,Time Factor ,RD1-811 ,Prognosi ,Follow-Up Studie ,03 medical and health sciences ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Risk factor ,Survival rate ,Fibrillation ,business.industry ,Risk Factor ,ta3121 ,medicine.disease ,Clinical trial ,Prospective Studie ,RC666-701 ,Surgery ,Clinical and Preventive Cardiology ,business - Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
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40. Mesothelial Stem Cells and Stromal Vascular Fraction
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Andrea M. Park, Greg Chernoff, and Nathan S. Bryan
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0301 basic medicine ,business.industry ,Mesenchymal stem cell ,030204 cardiovascular system & hematology ,Fat transfer ,Stromal vascular fraction ,Nitric oxide ,Cell therapy ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Cancer research ,Medicine ,Surgery ,Stem cell ,business ,Wound healing - Abstract
Autologous human fat-derived mesenchymal stem cells are present in stromal vascular fraction. Stromal vascular fraction can be easily and safely extracted from lipoaspirate. The regenerative, antiinflammatory and immunomodulatory effects of stromal vascular fraction are being documented in ongoing therapeutic response studies.
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- 2018
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41. The adoption of generic immunosuppressant medications in kidney, liver, and heart transplantation among recipients in Colorado or nationally with Medicare part D
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Adam Saulles, Sarah K. Dutcher, Ghalib Bello, Alan B. Leichtman, Sangeeta Goel, Murewa Oguntimein, Marc N. Turenne, Jeong M. Park, Jarcy Zee, Melissa Fava, Rajesh Balkrishnan, Abigail R. Smith, Margaret E. Helmuth, Charlotte A. Beil, Pratima Sharma, and Qian Liu
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Male ,Drug ,medicine.medical_specialty ,Prescription drug ,medicine.medical_treatment ,media_common.quotation_subject ,Medicare Part D ,Pharmacy ,030230 surgery ,Article ,Organ transplantation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Drugs, Generic ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,030212 general & internal medicine ,Kidney transplantation ,media_common ,Heart transplantation ,Transplantation ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Kidney Transplantation ,Transplant Recipients ,United States ,Tacrolimus ,Liver Transplantation ,Heart Transplantation ,Female ,business ,Immunosuppressive Agents ,Follow-Up Studies - Abstract
The transplant community is divided regarding whether substitution with generic immunosuppressants is appropriate for organ transplant recipients. We estimated the rate of uptake over time of generic immunosuppressants using US Medicare Part D Prescription Drug Event (PDE) and Colorado pharmacy claims (including both Part D and non-Part D) data from 2008 to 2013. Data from 26 070 kidney, 15 548 liver, and 6685 heart recipients from Part D, and 1138 kidney and 389 liver recipients from Colorado were analyzed. The proportions of patients with PDEs or claims for generic and brand-name tacrolimus or mycophenolate mofetil were calculated over time by transplanted organ and drug. Among Part D kidney, liver, and heart beneficiaries, the proportion dispensed generic tacrolimus reached 50%−56% at 1 year after first generic approval and 78%−81% by December 2013. The proportion dispensed generic mycophenolate mofetil reached 70%−73% at 1 year after generic market entry and 88%−90% by December 2013. There was wide interstate variability in generic uptake, with faster uptake in Colorado compared with most other states. Overall, generic substitution for tacrolimus and mycophenolate mofetil for organ transplant recipients increased rapidly following first availability, and utilization of generic immunosuppressants exceeded that of brand-name products within a year of market entry.
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- 2018
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42. Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI: Application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging
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Mark M. Schira, Min Tae M. Park, Julie L. Winterburn, Jon Pipitone, Gabriel A. Devenyi, Nancy J. Lobaugh, Aristotle N. Voineskos, Vivian Lynn, Jens C. Pruessner, M. Mallar Chakravarty, Robert S. C. Amaral, and Sofia Chavez
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Adult ,Male ,Aging ,Pathology ,medicine.medical_specialty ,Adolescent ,Cognitive Neuroscience ,Fornix, Brain ,Hippocampus ,Neuroimaging ,Hippocampal formation ,Grey matter ,050105 experimental psychology ,White matter ,Young Adult ,03 medical and health sciences ,Atlases as Topic ,0302 clinical medicine ,Alzheimer Disease ,medicine ,Humans ,Cognitive Dysfunction ,0501 psychology and cognitive sciences ,Segmentation ,Gray Matter ,CA1 Region, Hippocampal ,Pathological ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,05 social sciences ,Fornix ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,White Matter ,medicine.anatomical_structure ,nervous system ,Neurology ,Female ,Psychology ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Recently, much attention has been focused on the definition and structure of the hippocampus and its subfields, while the projections from the hippocampus have been relatively understudied. Here, we derive a reliable protocol for manual segmentation of hippocampal white matter regions (alveus, fimbria, and fornix) using high-resolution magnetic resonance images that are complementary to our previous definitions of the hippocampal subfields, both of which are freely available at https://github.com/cobralab/atlases. Our segmentation methods demonstrated high inter- and intra-rater reliability, were validated as inputs in automated segmentation, and were used to analyze the trajectory of these regions in both healthy aging (OASIS), and Alzheimer's disease (AD) and mild cognitive impairment (MCI; using ADNI). We observed significant bilateral decreases in the fornix in healthy aging while the alveus and cornu ammonis (CA) 1 were well preserved (all p's
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- 2018
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43. Oral rigidity and xerostomia in a 46-year-old man
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Chan M Park, Jeffrey A Elo, Fernando Rodriguez-Paris, Ho-Hyun (Brian) Sun, and Sally Sun
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Male ,030203 arthritis & rheumatology ,business.industry ,MEDLINE ,Dentistry ,Rigidity (psychology) ,Middle Aged ,Xerostomia ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Humans ,Medicine ,business ,General Dentistry - Published
- 2018
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44. Not All AI are Equal: Exploring the Accessibility of AI-Mediated Communication Technology
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Jennifer M. Park, Hannah Mieczkowski, Jeffrey T. Hancock, Sunny Xun Liu, and Emma Goldenthal
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Knowledge management ,business.product_category ,business.industry ,Computer science ,media_common.quotation_subject ,Mediated communication ,Interpersonal communication ,Language acquisition ,computer.software_genre ,Literacy ,Disadvantaged ,Human-Computer Interaction ,Intelligent agent ,Arts and Humanities (miscellaneous) ,Internet access ,Transcription (software) ,business ,computer ,General Psychology ,media_common - Abstract
While AI technologies and tools offer various potential benefits to their users, it is not clear whether opportunities to access these benefits are equally accessible to all. We examine this gap between availability and accessibility as it relates to the adoption of AI-Mediated Communication (AI-MC) tools, which enable interpersonal communication where an intelligent agent operates on behalf of a communicator. Upon defining six functional AI-MC types (voice-assisted communication, language correction, predictive text suggestion, transcription, translation, personalized language learning) we conducted an online survey of 519 U.S. participants that combined closed- and open-ended measures. Our quantitative results revealed how AI-MC adoption is related to software, device, and internet access for tools such as voice-assisted communication; demographic factors such as age, education and income in the case of translation and transcription tools; and some components of AI-MC literacy for specific functional tools. Our qualitative analyses provide additional nuance for these findings, and we articulate a number of barriers to access, understanding, and usage of AI-MC tools, which we suggest hinder AI-MC accessibility for user groups traditionally disadvantaged by one-size-fits-all technological tools. We end with a call for broadly addressing accessibility concerns within the digital technology industry.
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- 2021
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45. The Effect of Disease Type on Changes in Total Lung Volume after Lung Transplantation Measured by Three-Dimensional (3D) CT Reconstruction
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Junwoo Lee, Hyo Chae Paik, Jon Suh, Sun Bean Kim, M. Park, N. Son, and S. Jeong
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Pulmonary and Respiratory Medicine ,Transplantation ,medicine.medical_specialty ,Lung ,Thoracic cavity ,business.industry ,medicine.medical_treatment ,Lung volume measurement ,Disease ,respiratory system ,medicine.anatomical_structure ,medicine ,Lung transplantation ,Surgery ,Lung volumes ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Ct reconstruction - Abstract
Purpose It is accepted that a donor's predicted total lung capacity (pTLC) can be 75-125% of the recipient's pTLC in lung transplantation; however, ‘optimal graft size’ is not clearly defined, especially in restricted lung disease (RD) patients. These disagreements exist as it is difficult to accurately measure lung size before and after transplantation and it is also difficult to predict and evaluate the extent of re-expansion of the restricted thoracic cavity after transplantation. This study examined changes in lung volume after lung transplantation using a 3D lung volume measurement from CT scans before and after surgery under the assumption that the patient's thoracic cavity would return to the size of the patient without underlying lung disease after surgery. Methods A total of 113 patients, who underwent lung transplantation between September 2012 and April 2019 in our institute, and met the inclusion criteria were enrolled in the study. This included 88 patients who were diagnosed with RD and 25 patients who were diagnosed with non-RD. Patients were further divided into oversized and undersized groups according to the donor and recipient pTLC ratio, and a total of 4 groups were studied. Preoperative and postoperative lung volume on CT scans were measured using the synapse 3D program (Fuji film, Japan). Results RD patients showed a significant increase in total lung volume (TLV) after surgery, while non-RD patients showed a decrease in TLV. These changes showed the greatest increase in the RD group within 1 year and continuously increased up to 5 years. In the non-RD group, TLV decreased within 3 months of surgery. These changes were not related to graft size. Conclusion In lung transplant patients, the thoracic cavity re-expanded in RD patients and reduced in the non-RD patients, returning to healthy values without lung disease status in terms of TLV.
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- 2021
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46. Treatment Strategy for Hyperammonemia in Lung Transplantation
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Sun Bean Kim, H.J. Kim, Hyo Chae Paik, M. Park, Junwoo Lee, and S. Jeong
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Pulmonary and Respiratory Medicine ,Transplantation ,Treatment response ,medicine.medical_specialty ,biology ,medicine.drug_class ,business.industry ,medicine.medical_treatment ,Antibiotics ,Hyperammonemia ,biology.organism_classification ,medicine.disease ,Gastroenterology ,Ureaplasma ,Internal medicine ,medicine ,Lung transplantation ,Treatment strategy ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Complication ,Dialysis - Abstract
Purpose Idiopathic hyperammonemia syndrome (IHS) is a rare, often fatal complication following lung transplantation. Multiple treatment strategies have been documented including dialysis, although no definite treatments exist so far, and mortality remains high. In this study, we analyzed the current treatment strategy to determine the better treatment option in patients with hyperammonemia. Methods 283 patients who underwent lung transplantation from January 2013 to June 2020 were retrospectively reviewed. We defined non-severe hyperammonemia as serum ammonia >38umol/L, severe hyperammonemia as >75umol/L, and HIS >200umol/L at least one occasion. Elevated serum ammonia was detected in 134 patients. For the assessment of the treatment response, patients with severe hyperammonemia were divided into subgroups; the resolved group in which was treated successfully, and the failed group in which had failed to resolve. Results Among 134 patients with hyperammonemia, 38 (28.4%) showed severe hyperammonemia and 10 of 38 have failed to resolve. Mean peak ammonia level was 52.7umol/L in non-severe patients, 111.6umol/L in resolved patients, and 356.6umol/L in the failed group (p=0.001). The peak level was detected on median postoperative 16.7day in non-severe patients, 42.8day in the resolved group, and 25.4day in the failed group (p=0.001). 16 (16.8%) were symptomatic in non-severe patients, 12 (46.2%) in the resolved group and all patients in the failed group were symptomatic (p=0.001). Total amount of transfusion within postoperative 48 hours is greater in the failed group (2912.5ml) than the resolved group (1655.7ml, p=0.040), especially, the tendency was remarkable for red blood cell transfusion (1945.0ml vs. 799.0ml; p=0.018). The proportions of applying renal replacement, nitrogen scavengers, and bowel decontaminant were not significantly different. Although not statistically significant, only the resolved group patients had received empirical antibiotics such as fluoroquinolone (37.5%, p=0.063). All the patients in the failed group died during follow up, 4 of them died due to IHS. Conclusion None of the current treatment was optimally effective for hyperammonemia. However, certain combinations of antibiotics might have potential to lower serum ammonia, which is consistent with recent findings that microbes such as Ureaplasma spp. can cause hyperammonemia after lung transplantation.
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- 2021
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47. Manganese and neurobehavioral impairment. A preliminary risk assessment
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Robert M. Park and Shannon L. Berg
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Percentile ,chemistry.chemical_element ,Air Pollutants, Occupational ,Manganese ,Neuropsychological Tests ,Toxicology ,Risk Assessment ,Article ,03 medical and health sciences ,0302 clinical medicine ,Occupational Exposure ,Environmental health ,Humans ,Medicine ,Welding ,Manganese Poisoning ,Small particles ,Exposure response ,business.industry ,General Neuroscience ,Metallurgy ,Absolute risk reduction ,030210 environmental & occupational health ,Neurological effects ,chemistry ,Risk assessment ,business ,030217 neurology & neurosurgery - Abstract
Similar patterns of cognitive and motor deficits have been widely reported from manganese exposures in welding, metallurgical and chemical industry workers. A risk assessment was performed based on studies reported in the literature, extending some earlier work, and deriving new estimates of exposure response and excess risk. Many investigations of manganese neurological effects in humans have insufficient information to derive an exposure response; however, findings from a chemical manufacturer, two smelter and two welder populations permitted application of the benchmark dose procedure for continuous end-points. Small particles and aggregates of condensation fume (condensing vaporized metal, 1.0 μm). Consideration was given to long-term effects of continuous low exposures that instead of producing increasing toxicity attain a steady-state condition. Impairment was defined as excursions beyond the 5th percentile in a normal population and the concentrations of manganese predicted to result in 1% excess prevalence of impairment over different time periods were calculated. Over five years, exposures resulting in 1% excess prevalence of impairment (for purposes of discussion) were in the vicinity of 10 μg/m3 for manganese fume and 25 μg/m3 for larger particle dusts. These levels are below current recommendations for occupational limits on manganese exposure in the United States.
- Published
- 2018
- Full Text
- View/download PDF
48. CN7 Prediction of onset timing of breakthrough pain using deep learning model
- Author
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Y.H. Choi, S-Y. Shin, G. Lee, M. Park, S.J. Kim, and Yeonghak Bang
- Subjects
medicine.medical_specialty ,Physical medicine and rehabilitation ,Oncology ,business.industry ,Deep learning ,Breakthrough Pain ,Medicine ,Hematology ,Artificial intelligence ,business ,Onset timing - Published
- 2021
- Full Text
- View/download PDF
49. Psychiatric Care of the Radiation Oncology Patient
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Jordan A. Holmes, Eliza M. Park, and Emily G. Holmes
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Neuropsychiatry ,Article ,03 medical and health sciences ,0302 clinical medicine ,Arts and Humanities (miscellaneous) ,Neoplasms ,Radiation oncology ,medicine ,Humans ,030212 general & internal medicine ,Psychiatry ,Adverse effect ,Applied Psychology ,business.industry ,Mental Disorders ,Cancer ,medicine.disease ,Radiation therapy ,Psychiatry and Mental health ,030220 oncology & carcinogenesis ,Claustrophobia ,Anxiety ,medicine.symptom ,business ,Neurocognitive - Abstract
Background In recent decades, psychiatrists have become increasingly involved in the care of patients with cancer. Psychiatrists are often less familiar with the field of radiation oncology than with other medical specialties. Objective Therefore, it is beneficial for consulting psychiatrists to be familiar with the basic principles of radiation therapy (RT) and its potential neuropsychiatric sequelae. Methods We performed a PubMed search to identify articles describing neuropsychiatric symptoms resulting from RT, including anxiety, claustrophobia, posttraumatic stress disorder, and neurocognitive impairment. We also searched for other sequelae of RT that may produce psychiatric symptoms, such as radiation necrosis and endocrinopathies. We provide a basic introduction to the delivery of RT. Results Psychiatrists may be involved in the treatment of patients before, during, or after RT, and each phase of treatment produces unique considerations. Anxiety about the treatment, especially the need for immobilization with a mask, can be treatment-limiting. Adverse effects from treatment, including cognitive impairment and endocrinopathies, can result in psychiatric symptoms. Conclusions Consulting psychiatrists should be familiar with the basic principles of RT and the neuropsychiatric sequelae that may result from the treatment. Further research is needed to identify strategies to help patients tolerate RT and to identify additional preventive and therapeutic options for RT-induced cognitive impairment.
- Published
- 2017
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50. 1377P Exploratory analyses of efficacy from a phase III study comparing SB8, a proposed bevacizumab biosimilar, and reference bevacizumab in patients with metastatic or recurrent non-squamous NSCLC
- Author
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M. Reck, Jihye Choi, M. Park, Y. Seo, Dong Wook Shin, David Planchard, and J.A. Jung
- Subjects
Oncology ,medicine.medical_specialty ,Bevacizumab ,business.industry ,Non squamous ,Internal medicine ,medicine ,Biosimilar ,In patient ,Hematology ,business ,medicine.drug - Published
- 2020
- Full Text
- View/download PDF
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