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Start Over Author "Lyu, Lyu" Publisher elsevier bv
5 results on '"Lyu, Lyu"'

2. Increased levels of ferritin on admission predicts intensive care unit mortality in patients with COVID-19

Author

Xiao-Rong Ma, Fuxue Deng, Lisha Zhang, Yonghong Guo, Dengfeng Gao, Wei Jiang, Ziwei Lu, Lyu Lyu, Shouping Gong, and Rong Wang

Subjects
Male, ARDS, CK-MB, creatine kinase-MB, WBC, white blood cells, AST, aspartate aminotransferase, Logistic regression, Severity of Illness Index, Hs-TnI, high sensitive troponin I, law.invention, AUC, area under the curve, Patient Admission, 0302 clinical medicine, RR, respiration rate, FiO2, fraction of inspired oxygen, law, DM, diabetes mellitus, Marcadores inflamatorios, Medicine, Hospital Mortality, 030212 general & internal medicine, Aged, 80 and over, TNF, tumor necrosis factor, COVID-19, coronavirus disease-2019, HP, hypertension, HR, heart rate, NT-proBNP, N-terminal pro-B-type natriuretic peptide, biology, RBC, red blood cells, CHD, coronary heart diseases, INR, international normalized ratio, MV, mechanical ventilation, General Medicine, Middle Aged, Prognosis, Laboratory results, ICU, intensive care unit, Intensive care unit, PCT, procalcitonin, Intensive Care Units, CRP, C-reactive protein, Female, Original Article, PaO2, partial pressure of arterial oxygen, Adult, MOF, multiple organ failure, China, medicine.medical_specialty, AOSD, adult-onset Still's disease, Coronavirus disease 2019 (COVID-19), RT-PCR, reverse transcription-polymerase chain reaction, PTA, prothrombin activity, eGFR, ovulated glomerular filtration rate, DBP, diastolic pressure, Sensitivity and Specificity, BUN, urea nitrogen, TT, plasma thrombin time, SpO2, percutaneous oxygen saturation, 03 medical and health sciences, Clinical Decision Rules, PT, prothrombin time, ALT, alanine aminotransferase, Internal medicine, Humans, In patient, SARS, severe acute respiratory syndrome, Mortality, APTT, activated partial thromboplastin time, ARDS, acute respiratory distress syndrome, IQR, interquartile range, Aged, Retrospective Studies, Ferritin, CAPS, catastrophic anti-phospholipid syndrome, Receiver operating characteristic, SARS-CoV-2, Ferritina, business.industry, SBP, systolic blood pressure, MERS, Middle East respiratory syndrome, COVID-19, medicine.disease, IL, interleukin, MAS, macrophage activation syndrome, ROC, receiver operating characteristic, Logistic Models, ROC Curve, Ferritins, Mortalidad, biology.protein, Hyperferritinemia, business, Biomarkers, Inflammation markers
Abstract

The aim of this study was to evaluate hyperferritinemia could be a predicting factor of mortality in hospitalized patients with coronavirus disease-2019 (COVID-19).A total of 100 hospitalized patients with COVID-19 in intensive care unit (ICU) were enrolled and classified into moderate (The amount of ferritin was significantly higher in critical group compared with moderate and severe groups. The median of ferritin concentration was about three times higher in death group than survival group (1722.25 μg/L vs. 501.90 μg/L,The ferritin measured at admission may serve as an independent factor for predicting in-hospital mortality in patients with COVID-19 in ICU.El objetivo de este estudio fue evaluar si la hiperferritinemia podría ser un factor predictivo de la mortalidad en pacientes hospitalizados con enfermedad por coronavirus de 2019 (COVID-19).Se incluyó un total de 100 pacientes hospitalizados con COVID-19 en la unidad de cuidados intensivos (UCI), clasificándose como grupos moderado (n = 17), grave (n = 40) y crítico (n = 43). Se recopiló la información clínica y de laboratorio, comparándose los niveles de ferritina entre los diferentes grupos. Se evaluó la asociación entre ferritina y mortalidad mediante un análisis de regresión logística. Además, se evaluó la eficacia del valor predictivo utilizando la curva ROCLa cantidad de ferritina fue significativamente superior en el grupo de pacientes críticos en comparación con el grupo de pacientes graves. La media de concentración de ferritina fue cerca de 3 veces superior en el grupo de muerte que en el grupo de supervivientes (1.722,25 μg/L vs. 501,90 μg/L, El valor de ferritina medido durante el ingreso puede servir de factor independiente para prevenir la mortalidad intrahospitalaria en los pacientes de COVID-19 en la UCI.

Published
2021
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4. Multiple Biomarkers in the Context of Conventional Risk Factors in Patients With Coronary Artery Disease

Author

Lyu Lyu, Cui Xu, Jie Liu, Han Lina, Hongbin Liu, Yongyi Bai, Huijun Chen, Juan Wang, Haibo Li, and Wei Guo

Subjects
medicine.medical_specialty, Renal function, Context (language use), Inflammation, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Fibrinogen, Severity of Illness Index, Endothelial activation, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Severity of illness, Humans, Medicine, 030212 general & internal medicine, business.industry, Growth differentiation factor, medicine.disease, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Biomarkers, medicine.drug
Abstract

Accurate risk stratification is crucial for the evaluation of patients with coronary artery disease (CAD). We evaluated 8 biomarkers representing inflammation (growth differentiation factor [GDF]-15, fibrinogen), renal function (estimated glomerular filtration rate [eGFR]), endothelial activation (

Published
2017

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