1. Increased protein expression of VEGF-A, VEGF-B, VEGF-C and their receptors in the temporal neocortex of pharmacoresistant temporal lobe epilepsy patients
- Author
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Monica E. Ureña-Guerrero, Sandra Orozco-Suárez, Mario Alonso-Vanegas, Rosalinda Guevara-Guzmán, Carlos Beas-Zarate, Luisa Rocha-Arrieta, and José Luis Castañeda-Cabral
- Subjects
Adult ,Male ,Vascular Endothelial Growth Factor A ,0301 basic medicine ,Drug Resistant Epilepsy ,Neuropilins ,Immunology ,Neocortex ,Biology ,behavioral disciplines and activities ,Temporal lobe ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Epilepsy ,0302 clinical medicine ,medicine ,Humans ,Immunology and Allergy ,Receptor ,Protein kinase B ,Aged ,Kinase ,Middle Aged ,medicine.disease ,nervous system diseases ,Vascular endothelial growth factor ,Receptors, Vascular Endothelial Growth Factor ,030104 developmental biology ,medicine.anatomical_structure ,Epilepsy, Temporal Lobe ,nervous system ,Neurology ,chemistry ,Cancer research ,Female ,Neurology (clinical) ,psychological phenomena and processes ,030217 neurology & neurosurgery - Abstract
The vascular endothelial growth factor (VEGF) system has been shown to play a crucial role in several neuropathological processes. Temporal lobe epilepsy (TLE) is the most common focal epilepsy type in adult humans. We assessed the protein expression levels of VEGF-A, VEGF-B, and VEGF-C, their specific receptors VEGFR-2 and -3, their accessory receptors neuropilins 1 and 2, and PI3 and Akt kinases, in temporal neocortex from pharmacoresistant TLE (PR-TLE) patients and control subjects by western blotting. All proteins were found to be significantly overexpressed in samples of PR-TLE patients, indicating that the VEGF system contributes to PR-TLE pathogenesis and should be further studied.
- Published
- 2019
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