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1,513 results on '"Longhi, A"'

1. Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution

Author

Bianchi, G, Mangiagalli, M, Ami, D, Ahmed, J, Lombardi, S, Longhi, S, Natalello, A, Tompa, P, Brocca, S, Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca, Bianchi, G, Mangiagalli, M, Ami, D, Ahmed, J, Lombardi, S, Longhi, S, Natalello, A, Tompa, P, Brocca, S, Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, and Stefania Brocca

Abstract

Liquid-liquid phase separation (LLPS) is pivotal in forming biomolecular condensates, which are crucial in several biological processes. Intrinsically disordered regions (IDRs) are typically responsible for driving LLPS due to their multivalency and high content of charged residues that enable the establishment of electrostatic interactions. In our study, we examined the role of charge distribution in the condensation of the disordered N-terminal domain of human topoisomerase I (hNTD). hNTD is densely charged with oppositely charged residues evenly distributed along the sequence. Its LLPS behavior was compared with that of charge permutants exhibiting varying degrees of charge segregation. At low salt concentrations, hNTD undergoes LLPS. However, LLPS is inhibited by high concentrations of salt and RNA, disrupting electrostatic interactions. Our findings show that, in hNTD, moderate charge segregation promotes the formation of liquid condensates that are sensitive to salt and RNA, whereas marked charge segregation results in the formation of aberrant condensates. Although our study is based on a limited set of protein variants, it supports the applicability of the “stickers-and-spacers” model to biomolecular condensates involving highly charged IDRs. These results may help generate reliable models of the overall LLPS behavior of supercharged polypeptides.

Published
2024

2. Sequential administration of anti-complement component C5 eculizumab and type-2 anti-CD20 obinutuzumab for the treatment of early antibody-mediated rejection after kidney transplantation: A proof of concept

Author

Favi, Evaldo, primary, Cresseri, Donata, additional, Perego, Marta, additional, Ikehata, Masami, additional, Iesari, Samuele, additional, Campise, Maria Rosaria, additional, Morello, William, additional, Testa, Sara, additional, Sioli, Viviana, additional, Mattinzoli, Deborah, additional, Longhi, Elena, additional, Del Gobbo, Alessandro, additional, Castellano, Giuseppe, additional, and Ferraresso, Mariano, additional

Published
2024
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6. Brain diffusion alterations in patients with COVID-19 pathology and neurological manifestations

Author

Caroli, A, Capelli, S, Napolitano, A, Cabrini, G, Arrigoni, A, Pezzetti, G, Previtali, M, Longhi, L, Zangari, R, Lorini, F, Sessa, M, Remuzzi, A, Gerevini, S, Caroli A, Capelli S, Napolitano A, Cabrini G, Arrigoni A, Pezzetti G, Previtali M, Longhi LG, Zangari R, Lorini F, Sessa M, Remuzzi A, Gerevini S., Caroli, A, Capelli, S, Napolitano, A, Cabrini, G, Arrigoni, A, Pezzetti, G, Previtali, M, Longhi, L, Zangari, R, Lorini, F, Sessa, M, Remuzzi, A, Gerevini, S, Caroli A, Capelli S, Napolitano A, Cabrini G, Arrigoni A, Pezzetti G, Previtali M, Longhi LG, Zangari R, Lorini F, Sessa M, Remuzzi A, and Gerevini S.

Abstract

Background and objective: COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity in COVID-19 patients, as assessed by morphologic evaluation of brain DWI scans only. The aim of this study was to assess and quantify brain diffusion alterations in COVID-19 patients with neurological manifestations. Methods: 215 COVID-19 patients with neurological manifestations (olfactory and/or other neurological disorders) and 36 normal controls were compared and studied with DWI and T1-weighted MRI scans. MRI scans were processed by a semi-automatic processing procedure specifically developed for the purpose of this study, and the Apparent Diffusion Coefficient (ADC) was quantified in different brain tissues and individual white matter (WM) and gray matter (GM) regions. Differences in ADC values were assessed between COVID-19 patients and normal controls, as well as in the COVID-19 patient population grouped by hospitalization and neurological symptoms. Results: Among COVID-19 patients (median [IQR] = 52 [42 – 60] years of age, 58 % females), 91 were hospitalized and 26 needed intensive care. 84 patients had hyposmia/ageusia only, while 131 ones showed other neurological disorders. COVID-19 patients showed significantly increased ADC values in the WM and in several GM regions (p < 0.001). ADC values were significantly correlated with MRI time from disease onset (p < 0.05). Hospitalized patients showed significantly higher ADC alteration than non-hospitalized patients in all brain tissues; similarly, COVID-19 patients with neurological disorders showed significantly higher ADC values than those with olfactory loss only. ADC alteration was highest in patients with cognitive or memory disorder and in those with encephalitis or meningitis. ADC values were neither associated

Published
2023

7. Diagnostic pathways to wild-type transthyretin amyloid cardiomyopathy: a multicentre network study

Author

Tini, G, Milani, P, Zampieri, M, Caponetti, A, Fabris, F, Foli, A, Argiro, A, Mazzoni, C, Gagliardi, C, Longhi, S, Saturi, G, Vergaro, G, Aimo, A, Russo, D, Varra, G, Serenelli, M, Fabbri, G, De Michieli, L, Palmiero, G, Ciliberti, G, Carigi, S, Sessarego, E, Mandoli, G, Ricci Lucchi, G, Rella, V, Monti, E, Gardini, E, Bartolotti, M, Crotti, L, Merli, E, Mussinelli, R, Vianello, P, Cameli, M, Marzo, F, Guerra, F, Limongelli, G, Cipriani, A, Perlini, S, Obici, L, Perfetto, F, Autore, C, Porto, I, Rapezzi, C, Sinagra, G, Merlo, M, Musumeci, B, Emdin, M, Biagini, E, Cappelli, F, Palladini, G, Canepa, M, Tini G., Milani P., Zampieri M., Caponetti A. G., Fabris F., Foli A., Argiro A., Mazzoni C., Gagliardi C., Longhi S., Saturi G., Vergaro G., Aimo A., Russo D., Varra G. G., Serenelli M., Fabbri G., De Michieli L., Palmiero G., Ciliberti G., Carigi S., Sessarego E., Mandoli G. E., Ricci Lucchi G., Rella V., Monti E., Gardini E., Bartolotti M., Crotti L., Merli E., Mussinelli R., Vianello P. F., Cameli M., Marzo F., Guerra F., Limongelli G., Cipriani A., Perlini S., Obici L., Perfetto F., Autore C., Porto I., Rapezzi C., Sinagra G., Merlo M., Musumeci B., Emdin M., Biagini E., Cappelli F., Palladini G., Canepa M., Tini, G, Milani, P, Zampieri, M, Caponetti, A, Fabris, F, Foli, A, Argiro, A, Mazzoni, C, Gagliardi, C, Longhi, S, Saturi, G, Vergaro, G, Aimo, A, Russo, D, Varra, G, Serenelli, M, Fabbri, G, De Michieli, L, Palmiero, G, Ciliberti, G, Carigi, S, Sessarego, E, Mandoli, G, Ricci Lucchi, G, Rella, V, Monti, E, Gardini, E, Bartolotti, M, Crotti, L, Merli, E, Mussinelli, R, Vianello, P, Cameli, M, Marzo, F, Guerra, F, Limongelli, G, Cipriani, A, Perlini, S, Obici, L, Perfetto, F, Autore, C, Porto, I, Rapezzi, C, Sinagra, G, Merlo, M, Musumeci, B, Emdin, M, Biagini, E, Cappelli, F, Palladini, G, Canepa, M, Tini G., Milani P., Zampieri M., Caponetti A. G., Fabris F., Foli A., Argiro A., Mazzoni C., Gagliardi C., Longhi S., Saturi G., Vergaro G., Aimo A., Russo D., Varra G. G., Serenelli M., Fabbri G., De Michieli L., Palmiero G., Ciliberti G., Carigi S., Sessarego E., Mandoli G. E., Ricci Lucchi G., Rella V., Monti E., Gardini E., Bartolotti M., Crotti L., Merli E., Mussinelli R., Vianello P. F., Cameli M., Marzo F., Guerra F., Limongelli G., Cipriani A., Perlini S., Obici L., Perfetto F., Autore C., Porto I., Rapezzi C., Sinagra G., Merlo M., Musumeci B., Emdin M., Biagini E., Cappelli F., Palladini G., and Canepa M.

Abstract

Aim: Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization of pathways leading to ATTRwt-CA diagnosis is of key importance, and potentially informative of disease course and prognosis. The aim of this study was to describe the characteristics of contemporary pathways leading to ATTRwt-CA diagnosis, and their potential association with survival. Methods and results: This was a retrospective study of patients diagnosed with ATTRwt-CA at 17 Italian referral centres for CA. Patients were categorized into different ‘pathways’ according to the medical reason that triggered the diagnosis of ATTRwt-CA (hypertrophic cardiomyopathy [HCM] pathway, heart failure [HF] pathway, incidental imaging or incidental clinical pathway). Prognosis was investigated with all-cause mortality as endpoint. Overall, 1281 ATTRwt-CA patients were included in the study. The diagnostic pathway leading to ATTRwt-CA diagnosis was HCM in 7% of patients, HF in 51%, incidental imaging in 23%, incidental clinical in 19%. Patients in the HF pathway, as compared to the others, were older and had a greater prevalence of New York Heart Association (NYHA) class III–IV and chronic kidney disease. Survival was significantly worse in the HF versus other pathways, but similar among the three others. In multivariate model, older age at diagnosis, NYHA class III–IV and some comorbidities but not the HF pathway were independently associated with worse survival. Conclusions: Half of contemporary ATTRwt-CA diagnoses occur in a HF setting. These patients had worse clinical profile and outcome than those diagnosed either due to suspected HCM or incidentally, although prognosis remained primarily related to age, NYHA functional class and comorbidities rather than the diagnostic pathway itself.

Published
2023

9. Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis

Author

Gao, Li, primary, Zhang, Wei, additional, Zhang, Lina, additional, Gromova, Barbora, additional, Chen, Guanqing, additional, Csizmadia, Eva, additional, Cagle, Cortney, additional, Nastasio, Silvia, additional, Ma, Yun, additional, Bonder, Alan, additional, Patwardhan, Vilas, additional, Robson, Simon C., additional, Jiang, Sizun, additional, and Longhi, Maria Serena, additional

Published
2024
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10. Sigma receptor and aquaporin modulators: chiral resolution, configurational assignment, and preliminary biological profile of RC752 enantiomers

Author

Listro, Roberta, primary, Marra, Annamaria, additional, Cavalloro, Valeria, additional, Rossino, Giacomo, additional, Linciano, Pasquale, additional, Rossi, Daniela, additional, Casali, Emanuele, additional, De Amici, Marco, additional, Mazzeo, Giuseppe, additional, Longhi, Giovanna, additional, Fusè, Marco, additional, Dondio, Giulio, additional, Pellavio, Giorgia, additional, Laforenza, Umberto, additional, Schepmann, Dirk, additional, Wünsch, Bernhard, additional, and Collina, Simona, additional

Published
2024
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17. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

Author

Rovin, Brad H, primary, Barratt, Jonathan, additional, Heerspink, Hiddo J L, additional, Alpers, Charles E, additional, Bieler, Stewart, additional, Chae, Dong-Wan, additional, Diva, Ulysses A, additional, Floege, Jürgen, additional, Gesualdo, Loreto, additional, Inrig, Jula K, additional, Kohan, Donald E, additional, Komers, Radko, additional, Kooienga, Laura Ann, additional, Lafayette, Richard, additional, Maes, Bart, additional, Małecki, Robert, additional, Mercer, Alex, additional, Noronha, Irene L, additional, Oh, Se Won, additional, Peh, Chen Au, additional, Praga, Manuel, additional, Preciado, Priscila, additional, Radhakrishnan, Jai, additional, Rheault, Michelle N, additional, Rote, William E, additional, Tang, Sydney C W, additional, Tesar, Vladimir, additional, Trachtman, Howard, additional, Trimarchi, Hernán, additional, Tumlin, James A, additional, Wong, Muh Geot, additional, Perkovic, Vlado, additional, Abbasciano, Isabella, additional, Abrantes, Catarina, additional, Accarino, Simone, additional, Adler, Sharon, additional, Adoberg, Annika, additional, Afsari, Rouzbeh, additional, Ahmad, Syeda, additional, Ahmed, Jafar, additional, Ahn, Wooin, additional, Ajayi, Bamidele, additional, Aksamit, Dariusz, additional, Al Chalabi, Saif, additional, Alamartine, Eric, additional, Alchi, Bassam, additional, Ali, Mohammad, additional, Aliotta, Roberta, additional, Almaani, Salem, additional, Almeida, Catarina, additional, Almeida, Edgar, additional, Alvarez, Francisco de la Prada, additional, Alves, Patricia, additional, Annese, Francesca, additional, Appel, Gerald, additional, Arduan, Alberto Ortiz, additional, Arena, Maria, additional, Arevalo, Marta Calvo, additional, Arfaania, Dariush, additional, Arias, Carlos, additional, Aristoy, Emma Calatayud, additional, Asakiene, Egle, additional, Ashley, Sarah, additional, Assefi, Ali, additional, Atenza, Alba, additional, Auerbach, Asta, additional, Augustyniak-Bartosik, Hanna, additional, Avella, Monroy, additional, Ayling-Smith, Jonathan, additional, Ayoub, Isabelle, additional, Ayvazyan, Christine, additional, Baccaro, Rocco, additional, Bailey, Asha, additional, Baker, Bruce, additional, Balamuthusamy, Saravanan, additional, Ballarin, Jose, additional, Barata, Rui, additional, Barbic, Jerko, additional, Barisic, Dunja, additional, Barreto, Jose Carlos de Jesus, additional, Barrios, Clara, additional, Belingheri, Mirco, additional, Benesova, Anna, additional, Bernabeu, Ana Avila, additional, Bernhardt, Wanja, additional, Bhadra, Shamik, additional, Biancone, Luigi, additional, Blanchard, Anne, additional, Boaglio, Elena, additional, Bolignano, Davide, additional, Bomback, Andrew, additional, Bonilla, Gustavo Andres Useche, additional, Bordoli, Monica, additional, Bose, Bhadran, additional, Boudville, Neil, additional, Brandon, Donald, additional, Brown, Karen, additional, Broyet, Christian, additional, Bucknall, Thomas, additional, Buffet, Alexandre, additional, Bumblyte', Inga Arune, additional, Burdese, Manuel, additional, Burgos, Natalia Allende, additional, Burguet, Laure, additional, Burtey, Stephane, additional, Busch, Martin, additional, Cakiroglu, Figen, additional, Campbell, Victoria, additional, Canetta, Pietro, additional, Capaccio, Flavia, additional, Carbonell, Juan, additional, Cardoso, Filipa, additional, Carro, Clara Garcia, additional, Carroll, Robert, additional, Carron, Pierre-Louis, additional, Carullo, Nazareno, additional, Cassia, Matthias, additional, Caster, Dawn, additional, Castillo, Belen Vizcaino, additional, Catucci, Davide, additional, Cavalli, Andrea, additional, Chakera, Aron, additional, Chan, Doris, additional, Chan, Gary Chi Wang, additional, Chan, Anthony Ting Pong, additional, Chan, Lai Wan, additional, Chang, Jae Hyun, additional, Chang, Ming-Shan, additional, Chapman, Fiona, additional, Charytan, Chaim, additional, Chaudhry, Asghar, additional, Cheetham, Melissa, additional, Chen, Cheng-Hsu, additional, Chen, Hsin-Yu, additional, Chen, Chien-Liang, additional, Chen, Hung-Yuan, additional, Chen, Hung-Chun, additional, Chenine, Leila, additional, Cheung, Siu Fai, additional, Cheung, Chee Kay, additional, Chiche-Jourde, Noemie, additional, Chiu, Hsien-Fu, additional, Chiu, Yen-Ling, additional, Chiu, Yi-Wen, additional, Chiu, Ian, additional, Choi, Hoon Young, additional, Chou, Kang-Ju, additional, Chowdhury, Paramit, additional, Chowdhury, Pradip, additional, Chrysochou, Constantina, additional, Chukwu, Chukwuma, additional, Chun, Ka Yeong, additional, Chung, Wookyung, additional, Cieniawski, Dominik, additional, Claisse, Guillaume, additional, Clayton, Philip, additional, Cleary, Catalina Martín, additional, Clement, Nisha, additional, Coates, Toby, additional, Cogno, Chiara, additional, Colla, Loredana, additional, Collins, Michael, additional, Colucci, Marco, additional, Combe, Christian, additional, Comi, Nicolino, additional, Comunale, Roderick, additional, Contreras, Gabriel, additional, Cooper, Bruce, additional, Coppock, Gaia, additional, Costa, Ana Cortesão, additional, Costanzi, Stefano, additional, Cozzolino, Mario, additional, Crail, Susan, additional, Cunha, Liliana, additional, Curry, Elizabeth, additional, Dai, Tiane, additional, Daina, Erica, additional, Daneshvari, Sam, additional, Dasgupta, Indranil, additional, DaSilva, Louise, additional, Davidson, Robert, additional, De Bhailis, Aine Maire, additional, de Précigout, Valérie, additional, Decupere, Marc, additional, Delmas, Yahsou, additional, Deodato, Francesca, additional, Dhaun, Neeraj, additional, Dhaygude, Ajay, additional, Dhelaria, Ranjit, additional, Di Maio, Federica, additional, Diezhandino, Maria Angeles Goicoechea, additional, Dika, Zivka, additional, Dinic, Miriana, additional, Dittmer, Ian, additional, Dobre, Mirela, additional, Doctor, Gabriel, additional, Donati, Gabriele, additional, Doubel, Peter, additional, Douthit, Nicole, additional, Draganova, Diliana, additional, Drexler, Yelena, additional, Drinkovic, Martin, additional, Drinovska, Klara, additional, Dudreuilh, Caroline, additional, Dumond, Clement, additional, Durlen, Ivan, additional, Dussol, Bertrand, additional, Encarnacion, Montserrat Diaz, additional, Endre, Zoltan, additional, Enrique, Jorge, additional, Eqbal, Yusuf, additional, Erlich, Jonathan, additional, Esposito, Vittoria, additional, Esposito, Ciro, additional, Fakih, Faisal, additional, Fang, Hua-Chang, additional, Farinha, Ana, additional, Fearday, Aaron, additional, Felgueiras, Joana de Sousa Soares, additional, Felicjanczuk, Elzbieta, additional, Fernandes, João Carlos, additional, Fernandes, Sara, additional, Fernandes, Adriana, additional, Fernandez, Jose Luño, additional, Fernandez, Victor, additional, Fernando, Mangalee, additional, Figueiredo, Ana Carolina, additional, Firre, Eric, additional, Flossmann, Oliver, additional, Floyd, Lauren, additional, Fonseca, Nuno, additional, Fonseca, Jose Nuno de Almeida Agapito, additional, Foote, Celine, additional, Forbes, Suzanne, additional, Forcen, Angel, additional, Fornoni, Alessia, additional, Fouassier, David, additional, Fraser, Ian, additional, Fung, Ka Shun Samuel, additional, Furlano, Monica, additional, Furtado, Teresa, additional, Gadh, Rajdeep, additional, Gaisset, Roxane, additional, Gallagher, Martin, additional, Gameiro, Joana, additional, Gangadharan, Muralikrishna, additional, Garcia, Fabiola Alonso, additional, Garcia, Olga Gracia, additional, Garg, Gunjan, additional, Garrouste, Cyril, additional, Gautam, Archana, additional, Geara, Abdallah, additional, Geddes, Colin, additional, Gellineo, Lana, additional, Germain, Michael, additional, Ghalli, Farid, additional, Giaroni, Francesco, additional, Giles, Harold, additional, Gillies, Alastair, additional, Gimeno, Ana Vilar, additional, Girardet, Annette, additional, Glaze, Jeffrey, additional, Goh, Tze, additional, Gois, Mario, additional, Goldsmith, Christopher, additional, Goma, Elena, additional, Gomes, Ana Marta, additional, Goncalves, Luis Pedro Falcao, additional, Goncalves, Sara, additional, Gontarek-Kacprzak, Julita, additional, Gonzalez, Carlos, additional, Gopu, Arun, additional, Gowda, Nayan, additional, Gray, Nicholas, additional, Greco, Barbara, additional, Green, Heather, additional, Greze, Clarisse, additional, Griffin, Sian, additional, Guldris, Secundino Cigarran, additional, Guzman, Ursula Verdalles, additional, Ha, Jeffrey Tsun Kit, additional, Hall, Amanda, additional, Hamilton, Patrick, additional, Han, Seung Hyeok, additional, Haws, Robert, additional, Hayat, Ashik, additional, Heath, Lauren, additional, Heinrichs, Sven, additional, Henderson, Andrew, additional, Henderson, Amy, additional, Hendren, Elizabeth, additional, Heng, Anne-Elisabeth, additional, Heres, Salia Virxinia Pol, additional, Herfurth, Johann Konstantin, additional, Herrero, Evangelina Merida, additional, Ho, Tzung-Yo, additional, Hogan, Jonathan, additional, Hohenstein, Bernd, additional, Hollett, Peter, additional, Horvatic, Ivica, additional, Hsu, Bang-Gee, additional, Hsu, Chia-Tien, additional, Hsu, Chih-Yang, additional, Hsu, Shih-Ping, additional, Huang, Chien-Wei, additional, Hudson, Amy, additional, Hung, Chi-Chih, additional, Hwang, Shang-Jyh, additional, Hwang, Daw-Yang, additional, Hyun, Young Youl, additional, Ilmoja, Madis, additional, Irish, Georgina, additional, Jacob, Radu, additional, Jahan, Sadia, additional, Jain, Arunima, additional, Jamar, Sofie, additional, Jander, Anna, additional, Jang, Hye Ryoun, additional, Janko, Catherine, additional, Jardine, Meg, additional, Jaskowski, Piotr, additional, Jeantet, Guillaume, additional, Jelakovic, Bojan, additional, Jeon, Junseok, additional, Jeong, Jong Cheol, additional, Jesudason, Shilpanjali, additional, Jittirat, Arksarapuk, additional, Jo, Sang-Kyung, additional, Jones, Rachel, additional, Joo, Narae, additional, Jorge, Sofia, additional, Julian, Bruce, additional, Jung, JiYong, additional, Jyothinagaram, Praveena, additional, Kadakia, Jigar, additional, Kamal, Fahameedah, additional, Kanigicherla, Durga, additional, Karanovic, Sandra, additional, Karras, Alexandre, additional, Kasimatis, Theodoros, additional, Kassem, Mohamad, additional, Kattamanchi, Siddhartha, additional, Keller, Christopher, additional, Kentric, Dubravka Trajbar, additional, Kettner, Christiane, additional, Khalil, Kassem, additional, Kim, Dana, additional, Kim, Se Joong, additional, Kim, Yeong Hoon, additional, Kim, Yunmi, additional, Kim, Hyung Wook, additional, Kim, Sunggyun, additional, Kim, Jwa-Kyung, additional, Kim, Aejin, additional, Kim, Myung-Gyu, additional, Kimber, Cassandra, additional, Klamm, Kathryn, additional, Koch, Annegret, additional, Koester, Eric, additional, Kolvald, Kulli, additional, Kon, Sui, additional, Kotwal, Sradha, additional, Krajewska, Magdalena, additional, Kratka, Karolina, additional, Krishnan, Anoushka, additional, Krishnasamy, Rathika, additional, Krueger, Thilo, additional, Kruljac, Ivan, additional, Kulka, Simone, additional, Kunzendorf, Ulrich, additional, Kuo, Mei-Chuan, additional, Kuo, Hung-Tien, additional, Kuo, Sheng, additional, Kwan, Lorraine Pui Yuen, additional, Kwella, Norbert, additional, Kwella, Bogna, additional, Kyaw, Kay, additional, Labat, Aurore, additional, Lagatta, Mark, additional, Lam, Chi Kwan Darwin, additional, Lambie, Mark, additional, Lanaret, Camille, additional, Latif, Farah, additional, Laute, Margo, additional, Law, Wai Ping, additional, Lawman, Sarah, additional, Lazo, Mercedes Salgueira, additional, Lee, Hajeong, additional, Lee, Moon Hyoung, additional, Lee, Kyu-Beck, additional, Lee, Hyung-seok, additional, Lee, JungEun, additional, Lee, Hyun Hee, additional, Lee, Po-Tsang, additional, Leis, Liisi, additional, Lemahieu, Wim, additional, Leung, Janson, additional, Li, Yan, additional, Lie, Davina Ngoi Wah, additional, Lifland, Howard, additional, Lilienthal, Kadri, additional, Lim, Wai, additional, Limardo, Monica, additional, Livrozet, Marine, additional, Longhi, Selena, additional, Lopes, Daniela, additional, Lopes, Jose Antonio, additional, Lorde, Nathan, additional, Luxton, Grant, additional, Ma, Mingyao, additional, Madhrira, Machaiah, additional, Madonia, Phillip, additional, Mahadevan, Kumaradevan, additional, Mahdi, Amar, additional, Mahdi, Eamon, additional, Maillard, Nicolas, additional, Maixnerova, Dita, additional, Majstorovic Barac, Karolina, additional, Malecki, Robert, additional, Malfait, Thomas, additional, Malvica, Silvia, additional, Mandayam, Sreedhar, additional, Manley, Paul, additional, Mansfield, Nick, additional, Marcantoni, Carmelita, additional, Mariat, Christophe, additional, Marin, Tamara Malek, additional, Marin, Lida Maria Rodas, additional, Mark, Patrick, additional, Marques, Joana, additional, Martinez, Eduardo Gutierrez, additional, Martinez, Stacy, additional, Masset, Catherine, additional, Masson, Ingrid, additional, Mather, Amanda, additional, Maung Myint, Thida Maung, additional, Mayet, Valentin, additional, McCafferty, Kieran, additional, McCarthy, Ellen, additional, McDonald, Stephen, additional, McGreal, Kerri, additional, McMahon, Kellyn, additional, McNally, Andrew, additional, McQuarrie, Emily, additional, Medina, Allyson, additional, Meeus, Gert, additional, Mehta, Kshama, additional, Mendoza, Elder, additional, Menezes, Maria, additional, Meng, Jerry, additional, Messa, Piergiorgio, additional, Messias, Ana, additional, Miarka, Przemyslaw, additional, Miglinas, Marius, additional, Mikacic, Ivana, additional, Mikhail, Ashraf, additional, Milicevic, Martina, additional, Minasian, Raffi, additional, Moeller, Marcus, additional, Mohey, Hesham, additional, Mojarrab, Javad, additional, Mok, Maggie Ming Yee, additional, Moncasi, Eduardo Parra, additional, Moonen, Martial, additional, Morales, Wenceslao Adrian Aguilera, additional, Moreno, Eduardo Verde, additional, Moreno, Antolina, additional, Morris, Adam, additional, Moutzouris, Dimitrios, additional, Moya, Mercedes Gonzalez, additional, Mucha, Simon, additional, Musolino, Michela, additional, Napodano, Pietro, additional, Natario, Ana, additional, Negrea, Lavinia, additional, Nelson, Bradley, additional, Neuen, Brendon, additional, Newsome, Britt, additional, Ng, Kit Chung Jack, additional, Nguyen, Thu, additional, Nguyen, Viet, additional, Nicolo, Clementine, additional, Nitschke, Martin, additional, Noble, Euan, additional, Nolasco, Fernando, additional, O'Lone, Emma, additional, Ochoa, Adriana Sierra, additional, Oh, Kook-Hwan, additional, Oh, SeWon, additional, Okoh, Pedro, additional, Ombelet, Sara, additional, O'Shaughnessy, Michelle, additional, Ou, Shih-Hsiang, additional, Packham, David, additional, Padiyar, Aparna, additional, Pai, Mei-Fen, additional, Pamplona, Irene Agraz, additional, Pan, Szu-Yu, additional, Pandya, Bhavna, additional, Papadia, Federica, additional, Pardinhas, Clara, additional, Parikh, Nishita, additional, Parikh, Samir, additional, Park, Hyeong Cheon, additional, Park, Jung Tak, additional, Parreira, Lucia, additional, Passerini, Patrizia, additional, Patak, Ramachandra, additional, Patecki, Margret, additional, Patel, Rajan, additional, Patel, Jusmin, additional, Patel Suthar, Meera, additional, Patella, Gemma, additional, Patrikyan, Artashes, additional, Pavlovic, Drasko, additional, Paxton, William, additional, Peh, Chen, additional, Peleg, Yonatan, additional, Pelicano, Josep Miquel Blasco, additional, Peng, Yu-Sen, additional, Pereira de Vicente, Manuel, additional, Perez, Jonay Pantoja, additional, Perez, Erika, additional, Perez de Jose, Ana, additional, Pérez Gómez, María Vanessa, additional, Perez Lluna, Leticia, additional, Peri, Usha, additional, Perico, Norberto, additional, Philipponnet, Carole, additional, Phua, Elaine, additional, Piel, Julia, additional, Pillai, Unnikrishnan, additional, Pilmore, Helen, additional, Plavljanic, Djuro, additional, Plaza, Mercedes Velo, additional, Pollock, Carol, additional, Ponnusamy, Arvind, additional, Ponti, Serena, additional, Powell, Thomas, additional, Pradhan, Nishigandha, additional, Prado, Raul Fernandez, additional, Prkacin, Ingrid, additional, Pruthi, Rishi, additional, Pugh, Dan, additional, Quinn, Sarah, additional, Quintana, Luis F, additional, Raakesh, Lathika, additional, Rabindranath, Kannaiyan, additional, Radermacher, Luc, additional, Ragy, Omar Sherin Ibrahim, additional, Raichoudhury, Ritesh, additional, Raimundo, Mario, additional, Randone, Paolo, additional, Razavian, Mona, additional, Reichel, Helmut, additional, Reis, Marina, additional, Remuzzi, Giuseppe, additional, Reynolds, Annie, additional, Ricchiuto, Anna, additional, Rico, Ivon Maritza Bobadilla, additional, Rigothier, Claire, additional, Ritchie, Angus, additional, Rivero, Maria Antonieta Azancot, additional, Rizk, Dana, additional, Ro, Han, additional, Rodriguez, Alfred, additional, Rodriguez Garcia, Eva, additional, Roger, Simon, additional, Rony, Mohammad, additional, Rosenberg, Mai, additional, Roueff, Stephane, additional, Rovin, Brad, additional, Roxburgh, Sarah, additional, Ruiz, Mario, additional, Rusinol, Helena Marco, additional, Rychlik, Ivan, additional, Sá, Helena, additional, Salehi, Tania, additional, Sánchez de la Nieta, Maria Dolores, additional, Sanden, Silja, additional, Santockiene, Lina, additional, Santos, Patricia Valerio, additional, Santos, Iara Da Silva, additional, Sargsyan, Mari, additional, Sarnow, Franziska, additional, Sat, Sebahat, additional, Satora, Ewa, additional, Savuk, Ana, additional, Sayer, Matthew, additional, Schlieper, Georg, additional, Schlosser, Mandy, additional, Schmidt-Guertler, Hans, additional, Schockaert, Olivier, additional, Schulte, Kevin, additional, Schulz, Lisa, additional, Selvaskandan, Haresh, additional, Semple, David, additional, Sen, Shaundeep, additional, Seppet, Elviira, additional, Serrano, Antonio Galan, additional, Serre, Jean-Emmanuel, additional, Sevillano, Angel, additional, Shah, Sapna, additional, Shen, Yvonne, additional, Sheridan, Brittany, additional, Shu, Kai-Hsiang, additional, Sightler, Ford, additional, Silva, Sónia, additional, Silva, Arnold, additional, Sinha, Smeeta, additional, Siriwardana, Amanda, additional, Sitas, Zvonimir, additional, Sivo, Carmen, additional, Sizeland, Peter, additional, Sly, Cathylee, additional, Smith, Priscilla, additional, Snow, Brian, additional, Soares, Elsa Sofia Quadrado, additional, Solazzo, Andrea, additional, Solis, Elena Gutierrez, additional, Solomon, Laurence, additional, Song, Young Rim, additional, Sousa, Helena, additional, Spinowitz, Bruce, additional, Stallworthy, Elizabeth, additional, Stamellou, Eleni, additional, Stanczyk, Malgorzata, additional, Stangenberg, Stefanie, additional, Stankovic, Marija, additional, Stankuviene, Asta, additional, Stea, Emma Diletta, additional, Stompor, Tomasz, additional, Storrar, Joshua, additional, Sullivan, James, additional, Sulowicz, Wladyslaw, additional, Suyumova, Irina, additional, Szeto, Cheuk Chun, additional, Tamarit, Esther, additional, Tan, Eddie, additional, Tan, May, additional, Tang, Sydney Chi Wai, additional, Tang, Hon, additional, Teixeira, Catarina, additional, Telling, Kadri, additional, Terrades, Natalia Ramos, additional, Tez, Didem, additional, Thervet, Eric, additional, Thibaudin, Damien, additional, Thomas, Mark, additional, Thyagarajan, Nikhil, additional, Tkaczyk, Marcin, additional, Torreggiani, Massimo, additional, Trillini, Matias, additional, Tsai, Shang-Feng, additional, Tsai, Wan-Chuan, additional, Tsai, Jer-Chia, additional, Tseng, Po-Yu, additional, Tumlin, James, additional, Tung, Kuei-Ting, additional, Turnbull, Angus, additional, Udani, Suneel, additional, Uhlinova, Jana, additional, Unt, Kristin, additional, Urciuolo, Federica, additional, Vanacker, An, additional, Vandewiele, Bert, additional, Vaz, Alvaro, additional, Veermae, Kristi, additional, Viaene, Liesbeth, additional, Vickiene, Alvita, additional, Vigano, Sara, additional, Vila, Maria Antonia Munar, additional, Vilayur, Eswari, additional, Villanueva, Caridad Martinez, additional, Villarroya, Cristina Medrano, additional, Villen, Alejandro Soria, additional, Viramontes, Veronica, additional, Vita, Caterina, additional, Vujcic, Dunja, additional, Wahba, Mona, additional, Wan, Susan, additional, Wang, Chih-Hsien, additional, Warling, Xavier, additional, Waters, Gerald, additional, Waugh, Jane, additional, Weiland, Lea, additional, Weiner, Stefan, additional, Weinreich, Thomas, additional, Werth, Stephan Christian, additional, Wickens, Olivia, additional, Wijeratne, Vidu, additional, Wilder, Karen, additional, Willcocks, Lisa, additional, Williams, Allister, additional, Winiarska, Agata, additional, Wirtz, Nikolaus, additional, Wolf, Lothar, additional, Wolf, Gunter, additional, Wong, Yick Hei, additional, Wong, Sze Ho Sunny, additional, Workeneh, Biruh, additional, Wu, Ming-Ju, additional, Wu, Hon-Yen, additional, Wyndham, Roger, additional, Yang, Jihyun, additional, Yang, Ju-Yeh, additional, Yeap, Chii, additional, Yim, Ka Fai, additional, Yong, Kenneth, additional, Yoo, Tae-Hyun, additional, Yoon, Songuk, additional, Yu, Tung-Min, additional, Yue, Tak Tai Andrew, additional, Zakari, Michel, additional, Zakauskiene, Urte, additional, Zaoui, Philippe, additional, Zbrzezniak, Justyna, additional, Zielinska, Dorota, additional, and Zizzi, Carlotta Federica, additional

Published
2023
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19. Imaging presentation of extraskeletal osteosarcomas on CT and MRI and correlation with patients outcome: A two-center retrospective study of 54 patients

Author

Amandine Crombé, Paolo Spinnato, Alberto Righi, Martina Piccinni Leopardi, Maria Carpenzano, Federica Izzo, Anna Parmeggiani, Pierre-Antoine Linck, Raul Perret, Marilena Cesari, Alessandra Longhi, Marco Miceli, Michèle Kind, and Giuseppe Bianchi

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, General Medicine
Published
2023
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27. SARS-COV-2 specific t-cells in patients with thyroid disorders related to COVID-19 are enriched in the thyroid and acquire a tissue-resident memory phenotype

Author

Silvestri, Ylenia, primary, Clemente, Francesca, additional, Moschetti, Giorgia, additional, Maioli, Sara, additional, Carelli, Elena, additional, Espadas de Arias, Alejandro, additional, Torelli, Rosanna, additional, Longhi, Elena, additional, De Feo, Tullia, additional, Crosti, MariaCristina, additional, Sarnicola, Maria Lucia, additional, Salvi, Mario, additional, Mantovani, Giovanna, additional, Arosio, Maura, additional, Bombaci, Mauro, additional, Pesce, Elisa, additional, Grifantini, Renata, additional, Abrignani, Sergio, additional, Geginat, Jens, additional, and Muller, Ilaria, additional

Published
2023
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28. Myoepithelial carcinoma of soft tissues and bone

Author

Aiba, Hisaki, primary, Errani, Costantino, additional, Ciani, Giovanni, additional, Gambarotti, Marco, additional, Righi, Alberto, additional, Maioli, Margherita, additional, Spinnato, Paolo, additional, Frega, Giorgio, additional, Ibrahim, Toni, additional, and Longhi, Alessandra, additional

Published
2023
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30. Transforming National League for Nursing Advancing Care Excellence for Seniors Unfolding Cases into Virtual Simulations: An Innovative Approach for Interactive Learning

Author

Julie A. Longhi and Abbey M. Holthaus

Subjects
Nursing (miscellaneous), Coronavirus disease 2019 (COVID-19), Process (engineering), Best practice, media_common.quotation_subject, League, Education, Interactive Learning, Nursing, Excellence, Modeling and Simulation, Principles of learning, Student learning, Psychology, media_common
Abstract

Background Two National League for Nursing (NLN) Advancing Care Excellence for Seniors (ACE.S) cases were transformed into engaging and interactive virtual simulation learning experiences due to the COVID-19 pandemic. Methods The purpose of this article is to describe the process of designing and implementing this novel approach to virtual simulation. Results Faculty aligned each virtual simulation with existing course outcomes, student learning outcomes, concept-based learning principles, and best practices of The International Nursing Association for Clinical Simulation and Learning (INACSL) standards. Conclusions Practical strategies used to convert these unfolding case studies into virtual simulations for a small private Christian university of undergraduate junior level accelerated nursing students will be revealed.

Published
2022
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31. Prognosis of Transthyretin Cardiac Amyloidosis Without Heart Failure Symptoms

Author

Esther Gonzalez-Lopez, Luis Escobar-Lopez, Laura Obici, Giulia Saturi, Mélanie Bezard, Sunil E. Saith, Omar F. AbouEzzeddine, Roberta Mussinelli, Christian Gagliardi, Mounira Kharoubi, Jan M. Griffin, Angela Dispenzieri, Silvia Vilches, Stefano Perlini, Simone Longhi, Silvia Oghina, Adrian Rivas, Martha Grogan, Mathew S. Maurer, Thibaud Damy, Giovanni Palladini, Claudio Rapezzi, and Pablo Garcia-Pavia

Subjects
Oncology, Cardiology and Cardiovascular Medicine
Abstract

Transthyretin amyloid cardiomyopathy (ATTR-CM) is increasingly recognized as a treatable cause of heart failure (HF). Advances in diagnosis and therapy have increased the number of patients diagnosed at early stages, but prognostic data on patients without HF symptoms are lacking. Moreover, it is unknown whether asymptomatic patients benefit from early initiation of transthyretin (TTR) stabilizers.The aim of this study was to describe the natural history and prognosis of ATTR-CM in patients without HF symptoms.Clinical characteristics and outcomes of patients with ATTR-CM without HF symptoms were retrospectively collected at 6 international amyloidosis centers.A total of 118 patients (78.8% men, median age 66 years [IQR: 53.8-75 years], 68 [57.6%] with variant transthyretin amyloidosis, mean left ventricular ejection fraction 60.5% ± 9.9%, mean left ventricular wall thickness 15.4 ± 3.1 mm, and 53 [45%] treated with TTR stabilizers at baseline or during follow-up) were included. During a median follow-up period of 3.7 years (IQR: 1-6 years), 38 patients developed HF symptoms (23 New York Heart Association functional class II and 14 functional class III or IV), 32 died, and 2 required cardiac transplantation. Additionally, 20 patients received pacemakers, 13 developed AF, and 1 had a stroke. Overall survival was 96.5% (95% CI: 91%-99%), 90.4% (95% CI: 82%-95%), and 82% (95% CI: 71%-89%) at 1, 3, and 5 years, respectively. Treatment with TTR stabilizers was associated with improved survival (HR: 0.31; 95% CI: 0.12-0.82;After a median follow-up period of 3.7 years, 1 in 3 patients with asymptomatic ATTR-CM developed HF symptoms, and nearly as many died or required cardiac transplantation. Treatment with TTR stabilizers was associated with improved prognosis.

Published
2022
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34. Nutritional intake in high-performance para athletes.

Author

Duarte, Miguel Angelo, primary, Enriquez-Martinez, Oscar Geovanny, additional, Brisola, Kênia Mara, additional, Oliveira, Jessé, additional, Molina, Maria del Carmen Bisi, additional, Trakman, Gina Louise, additional, de Mello, Marco Tulio, additional, and Longhi, Rafael, additional

Published
2023
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35. Imaging presentation of extraskeletal osteosarcomas on CT and MRI and correlation with patients outcome: A two-center retrospective study of 54 patients

Author

Crombé, Amandine, primary, Spinnato, Paolo, additional, Righi, Alberto, additional, Leopardi, Martina Piccinni, additional, Carpenzano, Maria, additional, Izzo, Federica, additional, Parmeggiani, Anna, additional, Linck, Pierre-Antoine, additional, Perret, Raul, additional, Cesari, Marilena, additional, Longhi, Alessandra, additional, Miceli, Marco, additional, Kind, Michèle, additional, and Bianchi, Giuseppe, additional

Published
2023
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37. Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Author

Heerspink, Hiddo J L, primary, Radhakrishnan, Jai, additional, Alpers, Charles E, additional, Barratt, Jonathan, additional, Bieler, Stewart, additional, Diva, Ulysses, additional, Inrig, Jula, additional, Komers, Radko, additional, Mercer, Alex, additional, Noronha, Irene L, additional, Rheault, Michelle N, additional, Rote, William, additional, Rovin, Brad, additional, Trachtman, Howard, additional, Trimarchi, Hernán, additional, Wong, Muh Geot, additional, Perkovic, Vlado, additional, Alarmartine, Eric, additional, Chae, Dong Wan, additional, Del Vecchio, Lucia, additional, Floege, Jurgen, additional, Hwang, Shang-Jyh, additional, Jelakovic, Bojan, additional, Maes, Bart, additional, Malecki, Robert, additional, Miglinas, Marius, additional, Nolasco, Fernando Eduardo Barbosa, additional, Praga, Manual, additional, Rabindranath, Kannaiyan, additional, Rosenberg, Mai, additional, Tang, Sydney Chi Wai, additional, Tesar, Vladmir, additional, Bose, Bhadran, additional, Gangadharan, Muralikrishna, additional, McDonald, Stephen, additional, Peh, Chen, additional, Jahan, Sadia, additional, Yeap, Chii, additional, Clayton, Philip, additional, Irish, Georgina, additional, Thyagarajan, Nikhil, additional, Hollett, Peter, additional, Krishnasamy, Rathika, additional, Carroll, Robert, additional, Jesudason, Shilpanjali, additional, Crail, Susan, additional, Coates, Toby, additional, Waugh, Jane, additional, Noble, Euan, additional, Mahadevan, Kumaradevan, additional, Campbell, Victoria, additional, Salehi, Tania, additional, Lim, Wai, additional, Boudville, Neil, additional, Chakera, Aron, additional, Chan, Doris, additional, Krishnan, Anoushka, additional, Eqbal, Yusuf, additional, Gillies, Alastair, additional, Vilayur, Eswari, additional, Maung Myint, Thida Maung, additional, Gray, Nicholas, additional, Cheetham, Melissa, additional, Pollock, Carol, additional, Cooper, Bruce, additional, Mather, Amanda, additional, Roxburgh, Sarah, additional, Shen, Yvonne, additional, Stangenberg, Stefanie, additional, Siriwardana, Amanda, additional, O'Lone, Emma, additional, Wan, Susan, additional, Neuen, Brendon, additional, Tsun Kit Ha, Jeffrey, additional, Kim, Dana, additional, Heath, Lauren, additional, Jain, Arunima, additional, Phua, Elaine, additional, Li, Yan, additional, Gallagher, Martin, additional, Jardine, Meg, additional, Ritchie, Angus, additional, Razavian, Mona, additional, Foote, Celine, additional, Wyndham, Roger, additional, Sen, Shaundeep, additional, Endre, Zoltan, additional, Erlich, Jonathan, additional, Fernando, Mangalee, additional, Yong, Kenneth, additional, Luxton, Grant, additional, Kotwal, Sradha, additional, Roger, Simon, additional, Wijeratne, Vidu, additional, Packham, David, additional, Fraser, Ian, additional, Vandewiele, Bert, additional, Laute, Margo, additional, Lemahieu, Wim, additional, Jamar, Sofie, additional, Ombelet, Sara, additional, Meeus, Gert, additional, Decupere, Marc, additional, Schockaert, Olivier, additional, Doubel, Peter, additional, Viaene, Liesbeth, additional, Radermacher, Luc, additional, Masset, Catherine, additional, Moonen, Martial, additional, Firre, Eric, additional, Milicevic, Martina, additional, Warling, Xavier, additional, Vanacker, An, additional, Malfait, Thomas, additional, Durlen, Ivan, additional, Horvatic, Ivica, additional, Savuk, Ana, additional, Gellineo, Lana, additional, Karanovic, Sandra, additional, Dika, Zivka, additional, Plavljanic, Djuro, additional, Mikacic, Ivana, additional, Trajbar Kentric, Dubravka, additional, Barisic, Dunja, additional, Stankovic, Marija, additional, Majstorovic Barac, Karolina, additional, Kruljac, Ivan, additional, Pavlovic, Drasko, additional, Drinkovic, Martin, additional, Prkacin, Ingrid, additional, Barbic, Jerko, additional, Sitas, Zvonimir, additional, Vujcic, Dunja, additional, Rychlik, Ivan, additional, Benesova, Anna, additional, Drinovska, Klara, additional, Kratka, Karolina, additional, Maixnerova, Dita, additional, Ilmoja, Madis, additional, Unt, Kristin, additional, Lilienthal, Kadri, additional, Auerbach, Asta, additional, Leis, Liisi, additional, Piel, Julia, additional, Adoberg, Annika, additional, Kolvald, Kulli, additional, Veermae, Kristi, additional, Telling, Kadri, additional, Seppet, Elviira, additional, Uhlinova, Jana, additional, Zaoui, Philippe, additional, Carron, Pierre-Louis, additional, Masson, Ingrid, additional, Dinic, Miriana, additional, Thibaudin, Damien, additional, Broyet, Christian, additional, Maillard, Nicolas, additional, Mohey, Hesham, additional, Mariat, Christophe, additional, Claisse, Guillaume, additional, Alamartine, Eric, additional, Dussol, Bertrand, additional, Burtey, Stephane, additional, Chiche-Jourde, Noemie, additional, Serre, Jean-Emmanuel, additional, Jeantet, Guillaume, additional, Chenine, Leila, additional, Blanchard, Anne, additional, Roueff, Stephane, additional, Thervet, Eric, additional, Fouassier, David, additional, Buffet, Alexandre, additional, Livrozet, Marine, additional, Gaisset, Roxane, additional, Karras, Alexandre, additional, Heng, Anne-Elisabeth, additional, Garrouste, Cyril, additional, Philipponnet, Carole, additional, Nicolo, Clementine, additional, Atenza, Alba, additional, Lanaret, Camille, additional, Greze, Clarisse, additional, Mayet, Valentin, additional, Dumond, Clement, additional, Delmas, Yahsou, additional, Combe, Christian, additional, Rigothier, Claire, additional, Burguet, Laure, additional, Labat, Aurore, additional, Mucha, Simon, additional, de Précigout, Valérie, additional, Weinreich, Thomas, additional, Reichel, Helmut, additional, Draganova, Diliana, additional, Wolf, Lothar, additional, Hohenstein, Bernd, additional, Heinrichs, Sven, additional, Kulka, Simone, additional, Sat, Sebahat, additional, Weiland, Lea, additional, Krueger, Thilo, additional, Wolf, Gunter, additional, Kettner, Christiane, additional, Schlosser, Mandy, additional, Herfurth, Johann Konstantin, additional, Koch, Annegret, additional, Busch, Martin, additional, Werth, Stephan Christian, additional, Nitschke, Martin, additional, Cakiroglu, Figen, additional, Sarnow, Franziska, additional, Schulz, Lisa, additional, Weiner, Stefan, additional, Wirtz, Nikolaus, additional, Koester, Eric, additional, Moeller, Marcus, additional, Stamellou, Eleni, additional, Sanden, Silja, additional, Schmidt-Guertler, Hans, additional, Bernhardt, Wanja, additional, Patecki, Margret, additional, Schlieper, Georg, additional, Schulte, Kevin, additional, Girardet, Annette, additional, Kunzendorf, Ulrich, additional, Kwan, Lorraine Pui Yuen, additional, Mok, Maggie Ming Yee, additional, Chan, Gary Chi Wang, additional, Ma, Mingyao, additional, Lie, Davina Ngoi Wah, additional, Chan, Anthony Ting Pong, additional, Szeto, Cheuk Chun, additional, Ng, Kit Chung Jack, additional, Cheung, Siu Fai, additional, Yue, Tak Tai Andrew, additional, Fung, Ka Shun Samuel, additional, Tang, Hon, additional, Yim, Ka Fai, additional, Law, Wai Ping, additional, Wong, Yick Hei, additional, Lam, Chi Kwan Darwin, additional, Wong, Sze Ho Sunny, additional, Marcantoni, Carmelita, additional, Aliotta, Roberta, additional, Deodato, Francesca, additional, Patella, Gemma, additional, Comi, Nicolino, additional, Vita, Caterina, additional, Carullo, Nazareno, additional, Bolignano, Davide, additional, Musolino, Michela, additional, Trillini, Matias, additional, Perico, Norberto, additional, Remuzzi, Giuseppe, additional, Daina, Erica, additional, Biancone, Luigi, additional, Colla, Loredana, additional, Burdese, Manuel, additional, Cogno, Chiara, additional, Boaglio, Elena, additional, Abbasciano, Isabella, additional, Zizzi, Carlotta Federica, additional, Randone, Paolo, additional, Napodano, Pietro, additional, Ricchiuto, Anna, additional, Cassia, Matthias, additional, Accarino, Simone, additional, Cozzolino, Mario, additional, Baccaro, Rocco, additional, Costanzi, Stefano, additional, Di Maio, Federica, additional, Arena, Maria, additional, Urciuolo, Federica, additional, Vigano, Sara, additional, Cavalli, Andrea, additional, Limardo, Monica, additional, Bordoli, Monica, additional, Ponti, Serena, additional, Longhi, Selena, additional, Solazzo, Andrea, additional, Giaroni, Francesco, additional, Donati, Gabriele, additional, Torreggiani, Massimo, additional, Catucci, Davide, additional, Colucci, Marco, additional, Esposito, Vittoria, additional, Esposito, Ciro, additional, Gesualdo, Loreto, additional, Capaccio, Flavia, additional, Diletta Stea, Emma, additional, Sivo, Carmen, additional, Annese, Francesca, additional, Papadia, Federica, additional, Messa, Piergiorgio, additional, Belingheri, Mirco, additional, Passerini, Patrizia, additional, Malvica, Silvia, additional, Vickiene, Alvita, additional, Zakauskiene, Urte, additional, Asakiene, Egle, additional, Bumblyte', Inga Arune, additional, Stankuviene, Asta, additional, Santockiene, Lina, additional, Hayat, Ashik, additional, Williams, Allister, additional, Sizeland, Peter, additional, Tan, Eddie, additional, Waters, Gerald, additional, Chan, Lai Wan, additional, Henderson, Andrew, additional, Turnbull, Angus, additional, McNally, Andrew, additional, Reynolds, Annie, additional, Pilmore, Helen, additional, Dittmer, Ian, additional, Manley, Paul, additional, Stallworthy, Elizabeth, additional, Goh, Tze, additional, Semple, David, additional, Collins, Michael, additional, Curry, Elizabeth, additional, Ahmed, Jafar, additional, Nguyen, Thu, additional, Winiarska, Agata, additional, Zbrzezniak, Justyna, additional, Stompor, Tomasz, additional, Krajewska, Magdalena, additional, Augustyniak-Bartosik, Hanna, additional, Zielinska, Dorota, additional, Jander, Anna, additional, Stanczyk, Malgorzata, additional, Tkaczyk, Marcin, additional, Miarka, Przemyslaw, additional, Aksamit, Dariusz, additional, Jaskowski, Piotr, additional, Sulowicz, Wladyslaw, additional, Cieniawski, Dominik, additional, Gontarek-Kacprzak, Julita, additional, Felicjanczuk, Elzbieta, additional, Kwella, Norbert, additional, Kwella, Bogna, additional, Satora, Ewa, additional, Fernandes, João Carlos, additional, Gomes, Ana Marta, additional, Reis, Marina, additional, Lopes, Daniela, additional, Almeida, Catarina, additional, Sá, Helena, additional, Figueiredo, Ana Carolina, additional, Pardinhas, Clara, additional, Almeida, Edgar, additional, Raimundo, Mario, additional, Cortesão Costa, Ana, additional, Falcao Goncalves, Luis Pedro, additional, Fernandes, Sara, additional, Silva, Sónia, additional, Teixeira, Catarina, additional, Fernandes, Adriana, additional, Nolasco, Fernando, additional, Alves, Patricia, additional, Gois, Mario, additional, Fonseca, Nuno, additional, Messias, Ana, additional, Menezes, Maria, additional, Cardoso, Filipa, additional, Sousa, Helena, additional, Marques, Joana, additional, Barata, Rui, additional, Lopes, Jose Antonio, additional, Jorge, Sofia, additional, Gameiro, Joana, additional, de Almeida Agapito Fonseca, Jose Nuno, additional, Goncalves, Sara, additional, Farinha, Ana, additional, Valerio Santos, Patricia, additional, Natario, Ana, additional, de Jesus Barreto, Jose Carlos, additional, Abrantes, Catarina, additional, Quadrado Soares, Elsa Sofia, additional, Soares Felgueiras, Joana de Sousa, additional, Cunha, Liliana, additional, Parreira, Lucia, additional, Furtado, Teresa, additional, Vaz, Alvaro, additional, Oh, Kook-Hwan, additional, Lee, Hajeong, additional, Joong Kim, Se, additional, Jeong, Jong Cheol, additional, Hoon Kim, Yeong, additional, Kim, Yunmi, additional, Park, Hyeong Cheon, additional, Choi, Hoon Young, additional, Wook Kim, Hyung, additional, Lee, Moon Hyoung, additional, Yoon, Songuk, additional, Lee, Kyu-Beck, additional, Hyun, YoungYoul, additional, Yoo, Tae-Hyun, additional, Han, Seung Hyeok, additional, Park, Jung Tak, additional, Kim, Sunggyun, additional, Song, Young Rim, additional, Kim, Jwa-Kyung, additional, Lee, Hyung-seok, additional, Joo, Narae, additional, Lee, JungEun, additional, Ryoun Jang, Hye, additional, Jeon, Junseok, additional, Chung, Wookyung, additional, Lee, HyunHee, additional, Chang, Jae Hyun, additional, Chun, Ka Yeong, additional, Jung, Ji Yong, additional, Ro, Han, additional, Kim, Aejin, additional, Jo, Sang-Kyung, additional, Yang, Jihyun, additional, Kim, Myung-Gyu, additional, Oh, SeWon, additional, Martinez Villanueva, Caridad, additional, Gimeno, Ana Vilar, additional, Andres Useche Bonilla, Gustavo, additional, Tamarit, Esther, additional, Galan Serrano, Antonio, additional, Verde Moreno, Eduardo, additional, Fernandez, Jose Luño, additional, Goicoechea Diezhandino, Maria Angeles, additional, Verdalles Guzman, Ursula, additional, de Jose, Ana Perez, additional, Ortiz Arduan, Alberto, additional, Pérez Gómez, María Vanessa, additional, Martín Cleary, Catalina, additional, Prado, Raul Fernandez, additional, Goma, Elena, additional, Ballarin, Jose, additional, Encarnacion, Montserrat Diaz, additional, Da Silva Santos, Iara, additional, Marco Rusinol, Helena, additional, Furlano, Monica, additional, Arias, Carlos, additional, Barrios, Clara, additional, Garcia, Eva Rodriguez, additional, Sierra Ochoa, Adriana, additional, Vizcaino Castillo, Belen, additional, Pantoja Perez, Jonay, additional, Gonzalez Moya, Mercedes, additional, Sargsyan, Mari, additional, Calatayud Aristoy, Emma, additional, Bernabeu, Ana Avila, additional, Perez Lluna, Leticia, additional, Malek Marin, Tamara, additional, Antonia Munar Vila, Maria, additional, Bobadilla Rico, Ivon Maritza, additional, Allende Burgos, Natalia, additional, Gutierrez Martinez, Eduardo, additional, Gutierrez Solis, Elena, additional, Sevillano, Angel, additional, Merida Herrero, Evangelina, additional, Miquel Blasco Pelicano, Josep, additional, Rodas Marin, Lida Maria, additional, Quintana, Luis F, additional, Antonieta Azancot Rivero, Maria, additional, Ramos Terrades, Natalia, additional, Garcia Carro, 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Published
2023
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42. Metakaolin-based geopolymers: Efflorescence and its effect on microstructure and mechanical properties

Author

Ana Paula Kirchheim, Erich D. Rodríguez, John L. Provis, Diego Eckhard, Márlon A. Longhi, Brant Walkley, and Zuhua Zhang

Subjects
Materials science, Process Chemistry and Technology, Microstructure, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, law.invention, Geopolymer, Efflorescence, Portland cement, Flexural strength, law, Ultimate tensile strength, Materials Chemistry, Ceramics and Composites, Crystallization, Composite material, Metakaolin
Abstract

Efflorescence in geopolymers results from mobility of excess alkali and consequent crystallization of alkali carbonates. Efflorescence potential of various geopolymers has been reported previously but the knowledge regarding the effect of efflorescence on the microstructure and mechanical properties of geopolymers remains limited. In this work, metakaolin-based geopolymers were exposed to air, partially immersed in water, and fully immersed, to simulate different processes involved in efflorescence formation. The mechanical properties were assessed by compressive, splitting tensile and flexural strengths, and linear deformation. The microstructural features were investigated by SEM, synchrotron XRD, multinuclear MAS NMR, MIP and synchrotron X-ray microtomography. Extensive efflorescence resulted in a reduction of mechanical strength and changes in the nanostructure and microstructure, which is different from observations for Portland cement-based materials, where efflorescence is usually regarded as a surface or aesthetic problem. The understanding of the relationship between efflorescence formation, the synthesis and exposure conditions provides important insight into the manufacturing and application conditions of geopolymer related materials.

Published
2022
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