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Your search keyword '"Lin, Zhengmei"' showing total 34 results
Start Over Author "Lin, Zhengmei" Publisher elsevier bv
34 results on '"Lin, Zhengmei"'

2. Understanding the multi-functionality and tissue-specificity of decellularized dental pulp matrix hydrogels for endodontic regeneration

Author

Liang, Zelin, primary, Li, Junda, additional, Lin, Hongkun, additional, Zhang, Sien, additional, Liu, Fan, additional, Rao, Zilong, additional, Chen, Jiaxin, additional, Feng, Yuwen, additional, Zhang, Kexin, additional, Quan, Daping, additional, Lin, Zhengmei, additional, Bai, Ying, additional, and Huang, Qiting, additional

Published
2024
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4. Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus

Author

Shen, Zongshan, primary, Kuang, Shuhong, additional, Zhang, Yong, additional, Chen, Jiayao, additional, Wang, Shuting, additional, Xu, Congfei, additional, Huang, Yunjia, additional, Zhang, Min, additional, Huang, Shuheng, additional, Wang, Jun, additional, Zhao, ChuanJiang, additional, Lin, Zhengmei, additional, Shi, Xuetao, additional, and Cheng, Bin, additional

Published
2024
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18. Plasma deposited poly-oxazoline nanotextured surfaces dictate osteoimmunomodulation towards ameliorative osteogenesis

Author

Chen, Zetao, Visalakshan, Rahul, Guo, Jia, Wei, Simon, Zhang, Linjun, Chen, Lingling, Lin, Zhengmei, Vasilev, Krasimir, Xiao, Yin, Chen, Zetao, Visalakshan, Rahul, Guo, Jia, Wei, Simon, Zhang, Linjun, Chen, Lingling, Lin, Zhengmei, Vasilev, Krasimir, and Xiao, Yin

Abstract

Developing “osteoimmune-smart” bone substitute materials have become the forefront of research in bone regeneration. Biocompatible polymer coatings are applied widely to improve the bioactivity of bone substitute materials. In this context, polyoxazolines (Pox) have attracted substantial attention recently due to properties such as biocompatibility, stability, and low biofouling. In view of these useful properties, it is interesting to explore the capacity of Pox as an osteoimmunomodulatory agent to generate a favorable osteoimmune environment for osteogenesis. We applied a technique called plasma polymerization and succeeded in preparing Pox-like coatings (Ppox) and engineered their nanotopography at the nanoscale. We found that Ppox switched macrophages towards M2 extreme, thus inhibiting the release of inflammatory cytokines. The underlying mechanism may be related to the suppression of TLR pathway. The generated osteoimmune environment improved osteogenesis while inhibited osteoclastogenesis. This may be related to the release of osteogenic factors, especially Wnt10b from macrophages. The addition of nanotopography (16 nm, 38 nm, 68 nm) can tune the Ppox-mediated inhibition on inflammation and osteoclastic activities, while no significant effects were observed within the tested nano sizes on the Ppox-mediated osteogenesis. These results collectively suggest that Ppox can be useful as an effective osteoiumunomodulatory agent to endow bone substitute materials with favourable osteoimmunomodulatory property. Statement of Significance: In this study, we succeeded in preparing plasma deposited Pox-like nano-coatings (Ppox) via plasma polymerization and found that Ppox nanotopographies are useful osteoimmunomodulatory tools. Their osteoimmunodolatory effects and underlying mechanisms are unveiled. It is the first investigation into the feasibility of applying poly-oxazoline as an osteoimmunomodulatory agent. This expand the application of poly-oxazoline into the fo

Published
2019

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