Search

Your search keyword '"Lin, Can"' showing total 19 results
Start Over Author "Lin, Can" Publisher elsevier bv
19 results on '"Lin, Can"'

8. Targeted Activation of GPER Enhances the Efficacy of Venetoclax by Boosting Leukemic Pyroptosis and Cd8 + T Cell Immune Function in Acute Myeloid Leukemia

Author

Ren, Jun, primary, Tao, Yonghong, additional, Peng, Meixi, additional, Xiao, Qiaoling, additional, Jing, Yipei, additional, Huang, Junpeng, additional, Yang, Jing, additional, Lin, Can, additional, Sun, Minghui, additional, Lei, Li, additional, Yang, Zesong, additional, Yang, Zailin, additional, and Zhang, Ling, additional

Published
2022
Full Text
View/download PDF

13. Prevalence and transmission of antimicrobial-resistant Staphylococci and Enterococci from shared bicycles in Chengdu, China

Author

Gu, Ju, primary, Xie, Xian-Jun, additional, Liu, Jin-Xin, additional, Shui, Jun-Rui, additional, Zhang, Hao-Yu, additional, Feng, Gan-Yu, additional, Liu, Xiao-Yu, additional, Li, Lin-Can, additional, Lan, Qi-Wei, additional, Jin, Qi-Han, additional, Li, Rui, additional, Peng, Li, additional, Lei, Chang-Wei, additional, and Zhang, An-Yun, additional

Published
2020
Full Text
View/download PDF

16. High expression of Notch2 drives tongue squamous cell carcinoma carcinogenesis

Author

Dali Zheng, Dan-ping Zheng, Lin-Can Ding, Yong Zhao, You-Guang Lu, Lisong Lin, and Rui-Huan Gan

Subjects
0301 basic medicine, endocrine system, endocrine system diseases, Carcinogenesis, Mice, Nude, Biology, medicine.disease_cause, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Tongue Carcinoma, medicine, Animals, Humans, Receptor, Notch2, Cells, Cultured, Cell Proliferation, Mice, Inbred BALB C, Oncogene, Cell growth, Cancer, Cell migration, Cell Biology, medicine.disease, Tongue Neoplasms, Up-Regulation, Gene Expression Regulation, Neoplastic, HEK293 Cells, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, Carcinoma, Squamous Cell, Cancer research, Female
Abstract

Tongue squamous cell carcinoma (TSCC) is one of the most common cancers in the oral cavity. Notch signaling is frequently dysregulated in cancer. However, the role of Notch2 in TSCC is not well understood. The aim of this study was to investigate the effect of abnormal expression of Notch2 in TSCC. The expression of Notch2 was tested in 47 pairs of tissues from tongue cancer and normal samples by using immunohistochemical staining. Tongue cancer cells were transfected with siRNA or plasmid. The proliferation of the cells was tested by the CCK8 assay and colony formation assay. Subcutaneous tumor model was established to observe tumor growth. Transwell assay was used to detect the changes of cell migration and invasion ability. A humanized anti-Notch2 antibody was used to TSCC cells. We found that Notch2 was upregulated in tongue carcinoma tissues. Knocking down the expression of Notch2 by siRNA in the TSCC cell lines decreased proliferation ability both in vitro and in vivo. In addition, migration and invasion abilities were inhibited by knockdown of Notch2 in the TSCC cells. However, overexpression of Notch2 increased tongue cancer cell proliferation, invasion and migration. The humanized anti-Notch2 antibody inhibited TSCC cell growth. The results indicated that Notch2 is an oncogene in tongue squamous cell carcinoma and may become the target of a new approach for treating TSCC.

Published
2021

17. Cleaning effects of oxalic acid under ultrasound to the used reverse osmosis membranes with an online cleaning and monitoring system

Author

Lin-Can Shi, Yong-Sheng Li, Xiu-Feng Gao, and Jian-Gang Huang

Subjects
Fouling, Chemistry, Mechanical Engineering, General Chemical Engineering, Inorganic chemistry, Oxalic acid, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Alkali metal, Ammonia, chemistry.chemical_compound, Membrane, 020401 chemical engineering, Chemical engineering, Polyamide, General Materials Science, Ultrasonic sensor, 0204 chemical engineering, 0210 nano-technology, Reverse osmosis, Water Science and Technology
Abstract

A new system was developed for the research on the cleanings of ultrasonic acid and alkali to the used reverse osmosis membrane (UROM). By continuously detecting the absorbance, conductivity and K+/Na+/Cl−/Ca2 + contents in the cleaning solutions with this system, the cleaning information of organic and inorganic fouling on the UROM can be obtained and their cleaning effects can be judged directly. In the research, after comparing the cleaning effects of five kinds of acid solutions to the used polyamide ROMs, it was found that the ultrasonic cleaning effect of oxalic acid is the best. Therefore the concentration and pH of the oxalic acid, the sequence of acid and alkali cleanings were investigated, the results showed that, when the pH of 0.2% oxalic acid was regulated to 2.5 by the ammonia water, the defouling rate of the UROM can be reached 91%, and if employing the acid and alkali solutions to simultaneously clean, the best cleaning effect will be obtained, in which the cleaning order should be the first acid then alkali plus the ultrasound. The results and parameters obtained in this study can be used as a reference basis for designing large-scale chemical and ultrasonic cleaning system of UROM.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results