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52 results on '"Li, Zhinian"'

27. Surface coupling of methyl radicals for efficient low-temperature oxidative coupling of methane

Author

Zou, Shihui, primary, Li, Zhinian, additional, Zhou, Qiuyue, additional, Pan, Yang, additional, Yuan, Wentao, additional, He, Lei, additional, Wang, Shenliang, additional, Wen, Wu, additional, Liu, Juanjuan, additional, Wang, Yong, additional, Du, Yonghua, additional, Yang, Jiuzhong, additional, Xiao, Liping, additional, Kobayashi, Hisayoshi, additional, and Fan, Jie, additional

Published
2021
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30. Design, synthesis and structure–activity relationship of novel diphenylamine derivatives

Author

Yong Xie, Huichao Li, Aiying Guan, Li Zhinian, Jie Lan, Chang-Ling Liu, and Guang Huang

Subjects
Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, 010402 general chemistry, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Structure–activity relationship, Bioassay, Organic chemistry, Derivatization, Molecular Biology, Plant Diseases, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Diphenylamine, Fungi, Oryza, Fungicides, Industrial, 0104 chemical sciences, Fungicide, chemistry, Drug Design, Proton NMR, Molecular Medicine, Downy mildew, Cucumis sativus, Lead compound
Abstract

Diphenylamine derivatives have been reported with good fungicidal, insecticidal, acaricidal, rodenticidal and/or herbicidal activities. To find new lead compound of this kind, a series of novel diphenylamine derivatives were designed and synthesized by the approach of Intermediate Derivatization Methods. All compounds were identified by (1)H NMR and elemental analysis. Bioassays demonstrated that some compounds substituted at 2,4,6-positions or 2,4,5-positions of phenyl ring B exhibited excellent fungicidal activities. The optimal compounds P30 and P33 showed 80% and 85% control respectively against cucumber downy mildew at 12.5mgL(-1), both 100% control against rice blast at 0.3mgL(-1) and both 100% control against cucumber gray mold at 0.9mgL(-1). The relationship between structure and fungicidal activities was discussed as well.

Published
2016

33. Synthesis and fungicidal activity of fluorine-containing chlorothalonil derivatives

Author

Chang-Ling Liu, Hui-Chao Li, Li Zhinian, Ying Xu, Hao Shulin, Guang Huang, Aiying Guan, and Yong Xie

Subjects
Trifluoromethyl, Chlorothalonil, Organic Chemistry, Fluorine-19 NMR, Carbon-13 NMR, Biochemistry, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Proton NMR, Environmental Chemistry, Organic chemistry, Physical and Theoretical Chemistry, Derivatization, Benzene, Fluazinam
Abstract

Fourteen new fluorine-containing chlorothalonil derivatives were synthesized by using intermediate derivatization method (IDM) in order to discover novel antifungal compounds for controlling corn rust. The structures of synthesized compounds were confirmed by 1H NMR, 13C NMR, 19F NMR, elemental analysis, HRMS and X-ray. The bioassay results indicated that compound 2,4,5-trichloro-6-(2,6-dichloro-4-[trifluoromethyl]phenylamino)isophthalonitrile (3j, Rn is 2,6-Cl2-4-CF3) had the optimal structure with best fungicidal activity against corn rust (98%, 70% controls) at 25 and 6.25 mg/L concentration, respectively, much better than chlorothalonil and fluazinam, highlighting the importance of trifluoromethyl group on 4-position of benzene ring. The structure–activity relationship of the synthesized compounds was discussed as well.

Published
2014

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