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160 results on '"Leich, A."'

2. A 3D Bioreactor Model to Study Late Osteocyte Differentiation and Mechanobiology Under Perfusion and Compressive Mechanical Loading

Author

Rindt, Wyonna Darleen, primary, Krug, Melanie, additional, Yamada, Shuntaro, additional, Sennefelder, Franziska, additional, Belz, Louisa, additional, Cheng, Wen-Hui, additional, Azeem, Muhammad, additional, Kuric, Martin, additional, Evers, Marietheres, additional, Leich, Ellen, additional, Hartmann, Tanja Nicole, additional, Pereira, Ana Rita, additional, Hermann, Marietta, additional, Hansmann, Jan, additional, Yassin, Mohammed Ahmed, additional, Mustafa, Kamal, additional, Ebert, Regina, additional, and Jundt, Franziska, additional

Published
2024
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6. P-075: CD200 expression in multiple myeloma is regulated by P53 and exerts its function as immune checkpoint on T cells via DOK2

Author

Shah, Pooja, primary, Stühmer, Thorsten, additional, Haertle, Larissa, additional, Brünnert, Daniela, additional, Munawar, Umair, additional, Leich, Ellen, additional, Solimando, Antonio G., additional, Kraus, Sabrina, additional, Hudecek, Michael, additional, Chatterjee, Manik, additional, Schlosser, Andreas, additional, Kortüm, K. Martin, additional, Rosenwald, Andreas, additional, Bargou, Ralf C., additional, Einsele, Hermann, additional, Berberich-Siebelt, Friederike, additional, and Steinbrunn, Torsten, additional

Published
2022
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8. A novel powder-metallurgical eco-friendly recycling process for tool steel grinding sludge

Author

Felix Großwendt, Vincent Bürk, Bryan Kopanka, Sebastian Jäger, Stefan Pollak, Lennart Leich, Arne Röttger, Marcus Petermann, and Sebastian Weber

Subjects
Renewable Energy, Sustainability and the Environment, Strategy and Management, Building and Construction, Industrial and Manufacturing Engineering, General Environmental Science
Published
2023

9. Open-Source Web-Based Visualizer for Dynamic-Response Shared Taxi Simulations

Author

Charlton, William, Leich, Gregor, and Kaddoura, Ihab

Subjects
0202 electrical engineering, electronic engineering, information engineering, General Earth and Planetary Sciences, 020206 networking & telecommunications, 020201 artificial intelligence & image processing, 02 engineering and technology, ddc:600, General Environmental Science
Abstract

We describe a unique, web-based data visualization portal developed for use by researchers and public transit agencies investigating future shared-taxi fleet scenarios. Augmenting or even replacing fixed-route transit lines with automated, connected, shared taxi fleets may be a desirable alternative in less-densely developed areas. The MATSim agent-based transport microsimulation model is used to study scenarios including the status quo, dynamically-dispatched fleets with drivers, and fully autonomous fleets. This paper focuses on a data visualization portal which includes many interactive views such as agent (taxi) movements color-coded by number of passengers and trip request origins and destinations, changes in roadway and passenger volumes compared to a base case, and more. The agent-based simulation covers a 24 hour simulation period; analysts can hone in on specific times of day to examine, e.g. school pickup/drop-offs or commute trips connecting to rail stations. The tool is in operation for several small cities and rural regions in Germany and was successfully used as an outreach tool in public meetings. In addition, developers of the MATSim DRT extension found the visualizations particularly useful for debugging both the algorithms and the scenario definitions. The code is entirely open source and, while this specific study has a rather esoteric use case, the visualization platform has an extensible design that could be modified for other purposes.

Published
2021

11. Manufacturing of W/steel composites using electro-discharge sintering process

Author

Ganesh, Vishnu, primary, Leich, Lennart, additional, Dorow-Gerspach, Daniel, additional, Heuer, Simon, additional, Coenen, Jan Willem, additional, Wirtz, Marius, additional, Pintsuk, Gerald, additional, Gormann, Friedel, additional, Lied, Philipp, additional, Baumgärtner, Siegfried, additional, Theisen, Werner, additional, and Linsmeier, Christian, additional

Published
2022
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12. Features of Mild-to-Moderate COVID-19 Patients With Dysphonia

Author

Lechien, Jerome R., primary, Chiesa-Estomba, Carlos M., additional, Cabaraux, Pierre, additional, Mat, Quentin, additional, Huet, Kathy, additional, Harmegnies, Bernard, additional, Horoi, Mihaela, additional, Le Bon, Serge Daniel, additional, Rodriguez, Alexandra, additional, Dequanter, Didier, additional, Hans, Stéphane, additional, Crevier-Buchman, Lise, additional, Hochet, Baptiste, additional, Distinguin, Lea, additional, Chekkoury-Idrissi, Younes, additional, Circiu, Marta, additional, El Afia, Fahd, additional, Barillari, Maria Rosaria, additional, Cammaroto, Giovanni, additional, Fakhry, Nicolas, additional, Michel, Justin, additional, Radulesco, Thomas, additional, Martiny, Delphine, additional, Lavigne, Philippe, additional, Jouffe, Lionel, additional, Descamps, Géraldine, additional, Journe, Fabrice, additional, Trecca, Eleonora M.C., additional, Hsieh, Julien, additional, Delgado, Irene Lopez, additional, Calvo-Henriquez, Christian, additional, Vergez, Sebastien, additional, Khalife, Mohamad, additional, Molteni, Gabriele, additional, Mannelli, Giuditta, additional, Cantarella, Giovanna, additional, Tucciarone, Manuel, additional, Souchay, Christel, additional, Leich, Pierre, additional, Ayad, Tareck, additional, and Saussez, Sven, additional

Published
2022
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14. OAB-017: Attenuation of T cell cytotoxicity mediated by CD200 expression on multiple myeloma cells

Author

Shah, Pooja, primary, Stühmer, Thorsten, additional, Brünnert, Daniela, additional, Munawar, Umair, additional, Leich, Ellen, additional, Kraus, Sabrina, additional, Chatterjee, Manik, additional, Schlosser, Andreas, additional, Bargou, Ralf C., additional, Einsele, Hermann, additional, Berberich-Siebelt, Friederike, additional, and Steinbrunn, Torsten, additional

Published
2021
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16. P-075: CD200 expression in multiple myeloma is regulated by P53 and exerts its function as immune checkpoint on T cells via DOK2

Author

Pooja Shah, Thorsten Stühmer, Larissa Haertle, Daniela Brünnert, Umair Munawar, Ellen Leich, Antonio G. Solimando, Sabrina Kraus, Michael Hudecek, Manik Chatterjee, Andreas Schlosser, K. Martin Kortüm, Andreas Rosenwald, Ralf C. Bargou, Hermann Einsele, Friederike Berberich-Siebelt, and Torsten Steinbrunn

Subjects
Cancer Research, Oncology, Hematology
Published
2022

18. Densification of nanocrystalline NdFeB magnets processed by electro-discharge sintering – Microstructure, magnetic, and mechanical properties

Author

Arne Röttger, Martin Krengel, Werner Theisen, and Lennart Leich

Subjects
010302 applied physics, Materials science, Compaction, Sintering, 02 engineering and technology, Coercivity, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Microstructure, 01 natural sciences, Nanocrystalline material, Electronic, Optical and Magnetic Materials, Neodymium magnet, Volume (thermodynamics), Magnet, 0103 physical sciences, Composite material, 0210 nano-technology
Abstract

This work investigates the densification process of nanocrystalline NdFeB powder by electro-discharge sintering (EDS) and the associated magnetic properties. The EDS technique is used as a fast and energy-saving compaction process for metal powders. A large current is discharged from capacitors into a pre-compacted loose powder, thus resulting in complete compaction. In this study, the microstructure, magnetic, and mechanical properties of the compacted, hard magnetic NdFeB specimens were investigated under variation of the energy EEDS and compression load pEDS. For all specimens, the intrinsic coercivity HcJ decreases on increasing the discharge energy. However, the compaction load has apparently no influence on the coercivity HcJ, whereas the residual induction Br decreases only with increasing discharge energy. An increase in the compression load pEDS causes an increase in the specimens’ density and thus promotes residual induction Br. The applied EDS parameters led to the formation of three different microstructures (insufficiently densified zone, fully densified zone, and remelted zone) along the cross-section of the EDS-densified specimens. Volume fractions of the three different microstructures that form during the EDS process determine the resulting mechanical and magnetic properties of the specimens.

Published
2018

19. A NECTAr-based upgrade for the Cherenkov cameras of the H.E.S.S. 12-meter telescopes

Author

Ashton, T., primary, Backes, M., additional, Balzer, A., additional, Berge, D., additional, Bolmont, J., additional, Bonnefoy, S., additional, Brun, F., additional, Chaminade, T., additional, Delagnes, E., additional, Fontaine, G., additional, Füßling, M., additional, Giavitto, G., additional, Giebels, B., additional, Glicenstein, J.-F., additional, Gräber, T., additional, Hinton, J.A., additional, Jahnke, A., additional, Klepser, S., additional, Kossatz, M., additional, Kretzschmann, A., additional, Lefranc, V., additional, Leich, H., additional, Lenain, J.-P., additional, Lüdecke, H., additional, Lypova, I., additional, Manigot, P., additional, Marandon, V., additional, Moulin, E., additional, Murach, T., additional, de Naurois, M., additional, Nayman, P., additional, Ohm, S., additional, Penno, M., additional, Ross, D., additional, Salek, D., additional, Schade, M., additional, Schwab, T., additional, Shiningayamwe, K., additional, Stegmann, C., additional, Steppa, C., additional, Tavernet, J.-P., additional, Thornhill, J., additional, Toussenel, F., additional, and Vincent, P., additional

Published
2020
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22. A NECTAr-based upgrade for the Cherenkov cameras of the H.E.S.S. 12-meter telescopes

Author

H. Leich, Thomas Murach, T. Schwab, Marko Kossatz, P. Nayman, Albert Jahnke, Francois Brun, P. Vincent, J.-P. Lenain, Jim Hinton, Christian Stegmann, A. Balzer, J. Bolmont, J. F. Glicenstein, P. Manigot, M. Füßling, Eric Delagnes, Michael Backes, Gianluca Giavitto, Marek Penno, T. Chaminade, F. Toussenel, Terry Ashton, M. de Naurois, David Salek, E. Moulin, D. Berge, Gerard Fontaine, J.-P. Tavernet, Kleopas Shiningayamwe, S. Ohm, V. Lefranc, A. Kretzschmann, J. Thornhill, H. Lüdecke, V. Marandon, Markus Schade, Stefan Klepser, B. Giebels, Iryna Lypova, D. Ross, Tobias Gräber, S. Bonnefoy, Constantin Steppa, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), 28644743 - Backes, Michael, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Ethernet, data acquisition, atmosphere [Cherenkov counter], computer: communications, High-energy instrumentation upgrade, 01 natural sciences, design [detector], Cherenkov camera, Data acquisition, Software, HESS, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Stereoscopic System, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, FPGA, NECTAr, Physics, Upgrade, H.E.S.S, ddc:540, design [electronics], mechanical engineering, upgrade, Astrophysics - Instrumentation and Methods for Astrophysics, performance, Computer hardware, Photomultiplier, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, FOS: Physical sciences, Cherenkov counter: atmosphere, electrical engineering, programming, 0103 physical sciences, communications [computer], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Electronics, Instrumentation and Methods for Astrophysics (astro-ph.IM), detector: design, Cherenkov radiation, Gamma-ray astronomy, 010308 nuclear & particles physics, business.industry, Astronomy and Astrophysics, PMT Cameras, trigger, electronics: readout, HESS - Abteilung Hinton, photon: detector, readout [electronics], business, detector [photon], electronics: design
Abstract

The High Energy Stereoscopic System (H.E.S.S.) is one of the three arrays of imaging atmospheric Cherenkov telescopes (IACTs) currently in operation. It is composed of four 12-meter telescopes and a 28-meter one, and is sensitive to gamma rays in the energy range ~30 GeV - 100 TeV. The cameras of the 12-m telescopes recently underwent a substantial upgrade, with the goal of improving their performance and robustness. The upgrade involved replacing all camera components except for the photomultiplier tubes (PMTs). This meant developing new hardware for the trigger, readout, power, cooling and mechanical systems, and new software for camera control and data acquisition. Several novel technologies were employed in the cameras: the readout is built around the new NECTAr digitizer chip, developed for the next generation of IACTs; the camera electronics is fully controlled and read out via Ethernet using a combination of FPGA and embedded ARM computers; the software uses modern libraries such as Apache Thrift, ZMQ and Protocol buffers. This work describes in detail the design and the performance of the upgraded cameras., Comment: 35 pages, 14 figures, accepted for publication in "Astroparticle physics"

Published
2020

23. Functional characterization of the RAL-dependent survival pathway in multiple myeloma

Author

K.M. Kortüm, Thorsten Stühmer, Manik Chatterjee, Santiago Barrio, Andreas Schlosser, Anja Mottok, Andreas Rosenwald, Claus Jürgen Scholz, Torsten Steinbrunn, Ellen Leich, Ralf C. Bargou, Hermann Einsele, and Marcel Seibold

Subjects
Cancer Research, Oncology, business.industry, Cancer research, medicine, Hematology, medicine.disease, business, Multiple myeloma
Published
2019

24. Functional characterization of the RAL-dependent survival pathway in multiple myeloma

Author

Seibold, Marcel, primary, Stühmer, Thorsten, additional, Mottok, Anja, additional, Scholz, Claus, additional, Chatterjee, Manik, additional, Leich, Ellen, additional, Barrio, Santiago, additional, Kortüm, K.M., additional, Schlosser, Andreas, additional, Rosenwald, Andreas, additional, Einsele, Hermann, additional, Bargou, Ralf C., additional, and Steinbrunn, Torsten, additional

Published
2019
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28. Application of RNA interference to improve mechanistic understanding of omics responses to a hepatotoxic drug in primary rat hepatocytes

Author

Heidrun Ellinger-Ziegelbauer, Wolfgang Dekant, A. Rosenwald, Melanie Adler, Philip G. Hewitt, E. Leich, and Angela Mally

Subjects
Male, Transcription, Genetic, Cell Survival, Primary Cell Culture, Pharmacology, Biology, Transfection, Toxicology, RNA interference, Gene expression, Receptors, Glucagon, medicine, Animals, Hypoglycemic Agents, Gene silencing, Viability assay, Rats, Wistar, Receptor, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Dose-Response Relationship, Drug, Gene Expression Profiling, Genomics, medicine.anatomical_structure, Gene Expression Regulation, Hepatocyte, Hepatocytes, RNA Interference, Chemical and Drug Induced Liver Injury, Glucagon receptor, Drug metabolism
Abstract

Inhibition of the glucagon receptor (GCGR) has been identified as a potential therapeutic approach for the treatment of type 2 diabetes. However, a small molecule drug candidate antagonizing GCGR (BAY16) failed during preclinical drug development, in part due to drug induced hepatotoxicity in animals. Since there is evidence to suggest that endogenous GCGR signaling might be important for hepatocyte survival, we hypothesized that on-target effects, i.e., modulation of GCGR activity by BAY16, may contribute to BAY16 hepatotoxicity and associated gene expression changes in rats. To understand the role of GCGR inhibition in BAY16 toxicity, we analyzed cell viability and gene expression profiles in non-silenced and GCGR-targeting siRNA transfected primary rat hepatocytes with and without exposure to BAY16 to discriminate between on- and off-target effects of BAY16. siRNA-mediated silencing of the GCGR did not affect cell viability in primary rat hepatocytes, indicating that cytotoxicity of BAY16 occurs independent of its pharmacological effects. In support of this, gene expression analysis of GCGR silenced hepatocytes revealed no transcriptional alterations relevant to toxicity. In contrast, BAY16 caused a concentration-dependent decrease in cell viability, along with changes in the expression of genes associated with altered xenobiotic metabolism, oxidative stress, increased fatty acid synthesis, and alterations in cholesterol and bile acid metabolic processes. Based on gene expression data, it appears that hepatocytes inhibit cholesterol synthesis and increase detoxifying and eliminating processes in order to protect themselves from accumulation of bile acids, cholesterol or drug intermediates. Importantly, comparison of transcriptional changes in the absence and presence of GCGR revealed that the same pathways were affected in both silenced and non-silenced hepatocytes, indicating that BAY16 toxicity occurs independent of the GCGR receptor.

Published
2014

29. FeatureIDE: An extensible framework for feature-oriented software development

Author

Jens Meinicke, Thomas Thüm, Thomas Leich, Gunter Saake, Christian Kästner, and Fabian Benduhn

Subjects
Resource-oriented architecture, Computer science, business.industry, Programming language, Software development, computer.software_genre, Software framework, System programming, Software construction, Component-based software engineering, Software system, business, Software product line, computer, Software
Abstract

FeatureIDE is an open-source framework for feature-oriented software development (FOSD) based on Eclipse. FOSD is a paradigm for the construction, customization, and synthesis of software systems. Code artifacts are mapped to features, and a customized software system can be generated given a selection of features. The set of software systems that can be generated is called a software product line (SPL). FeatureIDE supports several FOSD implementation techniques such as feature-oriented programming, aspect-oriented programming, delta-oriented programming, and preprocessors. All phases of FOSD are supported in FeatureIDE, namely domain analysis, requirements analysis, domain implementation, and software generation.

Published
2014

31. The upgrade of the H.E.S.S. cameras

Author

Giavitto, Gianluca, primary, Ashton, Terry, additional, Balzer, Arnim, additional, Berge, David, additional, Brun, Francois, additional, Chaminade, Thomas, additional, Delagnes, Eric, additional, Fontaine, Gerard, additional, Füßling, Matthias, additional, Giebels, Berrie, additional, Glicenstein, Jean-Francois, additional, Gräber, Tobias, additional, Hinton, Jim, additional, Jahnke, Albert, additional, Klepser, Stefan, additional, Kossatz, Marko, additional, Kretzschmann, Axel, additional, Lefranc, Valentin, additional, Leich, Holger, additional, Lüdecke, Hartmut, additional, Lypova, Iryna, additional, Manigot, Pascal, additional, Marandon, Vincent, additional, Moulin, Emmanuel, additional, Naurois, Mathieu de, additional, Nayman, Patrick, additional, Ohm, Stefan, additional, Penno, Marek, additional, Ross, Duncan, additional, Salek, David, additional, Schade, Markus, additional, Schwab, Thomas, additional, Simoni, Rachel, additional, Stegmann, Christian, additional, Steppa, Constantin, additional, Thornhill, Julian, additional, and Toussnel, Francois, additional

Published
2017
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32. Measurement of the atmospheric muon spectrum from 20 to 3000 GeV

Author

P. Achard, O. Adriani, M. Aguilar-Benitez, M. van den Akker, J. Alcaraz, G. Alemanni, J. Allaby, A. Aloisio, M.G. Alviggi, H. Anderhub, V.P. Andreev, F. Anselmo, A. Arefiev, T. Azemoon, T. Aziz, P. Bagnaia, A. Bajo, G. Baksay, L. Baksay, J. Bähr, S.V. Baldew, S. Banerjee, Sw. Banerjee, A. Barczyk, R. Barillère, P. Bartalini, M. Basile, N. Batalova, R. Battiston, A. Bay, F. Becattini, U. Becker, F. Behner, L. Bellucci, R. Berbeco, J. Berdugo, P. Berges, B. Bertucci, B.L. Betev, M. Biasini, M. Biglietti, A. Biland, J.J. Blaising, S.C. Blyth, G.J. Bobbink, A. Böhm, L. Boldizsar, B. Borgia, S. Bottai, D. Bourilkov, M. Bourquin, S. Braccini, J.G. Branson, F. Brochu, J.D. Burger, W.J. Burger, X.D. Cai, M. Capell, G. Cara Romeo, G. Carlino, A. Cartacci, J. Casaus, F. Cavallari, N. Cavallo, C. Cecchi, M. Cerrada, M. Chamizo, T. Chiarusi, Y.H. Chang, M. Chemarin, A. Chen, G. Chen, G.M. Chen, H.F. Chen, H.S. Chen, G. Chiefari, L. Cifarelli, F. Cindolo, I. Clare, R. Clare, G. Coignet, N. Colino, S. Costantini, B. de la Cruz, S. Cucciarelli, J.A. van Dalen, R. de Asmundis, P. Déglon, J. Debreczeni, A. Degré, K. Dehmelt, K. Deiters, D. della Volpe, E. Delmeire, P. Denes, F. DeNotaristefani, A. De Salvo, M. Diemoz, M. Dierckxsens, L.K. Ding, C. Dionisi, M. Dittmar, A. Doria, M.T. Dova, D. Duchesneau, M. Duda, I. Duran, B. Echenard, A. Eline, A. El Hage, H. El Mamouni, A. Engler, F.J. Eppling, P. Extermann, G. Faber, M.A. Falagan, S. Falciano, A. Favara, J. Fay, O. Fedin, M. Felcini, T. Ferguson, H. Fesefeldt, E. Fiandrini, J.H. Field, F. Filthaut, W. Fisher, I. Fisk, G. Forconi, K. Freudenreich, C. Furetta, Yu. Galaktionov, S.N. Ganguli, P. Garcia-Abia, M. Gataullin, S. Gentile, S. Giagu, Z.F. Gong, H.J. Grabosch, G. Grenier, O. Grimm, H. Groenstege, M.W. Gruenewald, M. Guida, Y.N. Guo, S. Gupta, V.K. Gupta, A. Gurtu, L.J. Gutay, D. Haas, Ch. Haller, D. Hatzifotiadou, Y. Hayashi, Z.X. He, T. Hebbeker, A. Hervé, J. Hirschfelder, H. Hofer, M. Hohlmann, G. Holzner, S.R. Hou, A.X. Huo, Y. Hu, N. Ito, B.N. Jin, C.L. Jing, L.W. Jones, P. de Jong, I. Josa-Mutuberría, V. Kantserov, M. Kaur, S. Kawakami, M.N. Kienzle-Focacci, J.K. Kim, J. Kirkby, W. Kittel, A. Klimentov, A.C. König, E. Kok, A. Korn, M. Kopal, V. Koutsenko, M. Kräber, H.H. Kuang, R.W. Kraemer, A. Krüger, J. Kuijpers, A. Kunin, P. Ladron de Guevara, I. Laktineh, G. Landi, M. Lebeau, A. Lebedev, P. Lebrun, P. Lecomte, P. Lecoq, P. Le Coultre, J.M. Le Goff, Y. Lei, H. Leich, R. Leiste, M. Levtchenko, P. Levtchenko, C. Li, L. Li, Z.C. Li, S. Likhoded, C.H. Lin, W.T. Lin, F.L. Linde, L. Lista, Z.A. Liu, W. Lohmann, E. Longo, Y.S. Lu, C. Luci, L. Luminari, W. Lustermann, W.G. Ma, X.H. Ma, Y.Q. Ma, L. Malgeri, A. Malinin, C. Maña, J. Mans, J.P. Martin, F. Marzano, K. Mazumdar, R.R. McNeil, S. Mele, X.W. Meng, L. Merola, M. Meschini, W.J. Metzger, A. Mihul, A. van Mil, H. Milcent, G. Mirabelli, J. Mnich, G.B. Mohanty, B. Monteleoni, G.S. Muanza, A.J.M. Muijs, B. Musicar, M. Musy, S. Nagy, R. Nahnhauer, V.A. Naumov, S. Natale, M. Napolitano, F. Nessi-Tedaldi, H. Newman, A. Nisati, T. Novak, H. Nowak, R. Ofierzynski, G. Organtini, I. Pal, C. Palomares, P. Paolucci, R. Paramatti, J.-F. Parriaud, G. Passaleva, S. Patricelli, T. Paul, M. Pauluzzi, C. Paus, F. Pauss, M. Pedace, S. Pensotti, D. Perret-Gallix, B. Petersen, D. Piccolo, F. Pierella, M. Pieri, M. Pioppi, P.A. Piroué, E. Pistolesi, V. Plyaskin, M. Pohl, V. Pojidaev, J. Pothier, D. Prokofiev, J. Quartieri, C.R. Qing, G. Rahal-Callot, M.A. Rahaman, P. Raics, N. Raja, R. Ramelli, P.G. Rancoita, R. Ranieri, A. Raspereza, K.C. Ravindran, P. Razis, D. Ren, M. Rescigno, S. Reucroft, P. Rewiersma, S. Riemann, K. Riles, B.P. Roe, A. Rojkov, L. Romero, A. Rosca, C. Rosemann, C. Rosenbleck, S. Rosier-Lees, S. Roth, J.A. Rubio, G. Ruggiero, H. Rykaczewski, R. Saidi, A. Sakharov, S. Saremi, S. Sarkar, J. Salicio, E. Sanchez, C. Schäfer, V. Schegelsky, V. Schmitt, B. Schoeneich, H. Schopper, D.J. Schotanus, C. Sciacca, L. Servoli, C.Q. Shen, S. Shevchenko, N. Shivarov, V. Shoutko, E. Shumilov, A. Shvorob, D. Son, C. Souga, P. Spillantini, M. Steuer, D.P. Stickland, B. Stoyanov, A. Straessner, K. Sudhakar, H. Sulanke, G. Sultanov, L.Z. Sun, S. Sushkov, H. Suter, J.D. Swain, Z. Szillasi, X.W. Tang, P. Tarjan, L. Tauscher, L. Taylor, B. Tellili, D. Teyssier, C. Timmermans, Samuel C.C. Ting, S.M. Ting, S.C. Tonwar, J. Tóth, G. Trowitzsch, C. Tully, K.L. Tung, J. Ulbricht, M. Unger, E. Valente, H. Verkooijen, R.T. van de Walle, R. Vasquez, V. Veszpremi, G. Vesztergombi, I. Vetlitsky, D. Vicinanza, G. Viertel, S. Villa, M. Vivargent, S. Vlachos, I. Vodopianov, H. Vogel, H. Vogt, I. Vorobiev, A.A. Vorobyov, M. Wadhwa, R.G. Wang, Q. Wang, X.L. Wang, X.W. Wang, Z.M. Wang, M. Weber, R. van Wijk, T.A.M. Wijnen, H. Wilkens, S. Wynhoff, L. Xia, Y.P. Xu, J.S. Xu, Z.Z. Xu, J. Yamamoto, B.Z. Yang, C.G. Yang, H.J. Yang, M. Yang, X.F. Yang, Z.G. Yao, S.C. Yeh, Z.Q. Yu, An. Zalite, Yu. Zalite, C. Zhang, F. Zhang, J. Zhang, S. Zhang, Z.P. Zhang, J. Zhao, S.J. Zhou, G.Y. Zhu, R.Y. Zhu, H.L. Zhuang, Q.Q. Zhu, A. Zichichi, B. Zimmermann, M. Zöller, A.N.M. Zwart, L3 (IHEF, IoP, FNWI), P. ACHARD, O. ADRIANI, M. AGUILAR-BENITEZ, J. ALCARAZ, G. ALEMANNI, J. ALLABY, A. ALOISIO, M.G. ALVIGGI, H. ANDERHUB, V.P. ANDREEV, F. ANSELMO, A. AREFIEV, T. AZEMOON, T. AZIZ, P. BAGNAIA, A. BAJO, G. BAKSAY, L. BAKSAY, S.V. BALDEW, S. BANERJEE, SW. BANERJEE, A. BARCZYK, R. BARILLÈRE, P. BARTALINI, M. BASILE, N. BATALOVA, R. BATTISTON, A. BAY, F. BECATTINI, U. BECKER, F. BEHNER, L. BELLUCCI, R. BERBECO, J. BERDUGO, P. BERGES, B. BERTUCCI, B.L. BETEV, M. BIASINI, M. BIGLIETTI, A. BILAND, J.J. BLAISING, S.C. BLYTH, G.J. BOBBINK, A. BÖHM, L. BOLDIZSAR, B. BORGIA, S. BOTTAI, D. BOURILKOV, M. BOURQUIN, S. BRACCINI, J.G. BRANSON, F. BROCHU, J.D. BURGER, W.J. BURGER, X.D. CAI, M. CAPELL, G. CARA ROMEO, G. CARLINO, A. CARTACCI, J. CASAUS, F. CAVALLARI, N. CAVALLO, C. CECCHI, M. CERRADA, M. CHAMIZO, Y.H. CHANG, M. CHEMARIN, A. 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TELLILI, D. TEYSSIER, C. TIMMERMANS, SAMUEL C.C. TING, S.M. TING, S.C. TONWAR, J. TOTH, C. TULLY, K.L. TUNG, J. ULBRICHT, E. VALENTE, R.T. VAN DE WALLE, R. VASQUEZ, V. VESZPREMI, G. VESZTERGOMBI, I. VETLITSKI, D. VICINANZA, G. VIERTEL, S. VILLA, M. VIVARGENT, S. VLACHOS, I. VODOPIANOV, H. VOGEL, H. VOGT, I. VOROBIEV, A.A. VOROBYOV, M. WADHWA, Q. WANG, X.L. WANG, Z.M. WANG, M. WEBER, H. WILKENS, S. WYNHOFF, L. XIA, Z.Z. XU, J. YAMAMOTO, B.Z. YANG, C.G. YANG, H.J. YANG, M. YANG, S.C. YEH, AN. ZALITE, YU. ZALITE, Z.P. ZHANG, J. ZHAO, G.Y. ZHU, R.Y. ZHU, H.L. ZHUANG, A. ZICHICHI, B. ZIMMERMANN, M. ZOELLER, P., Achard, Aloisio, Alberto, Alviggi, Mariagrazia, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Napolitano, Marco, Patricelli, Sergio, C., Sciacca, Lista, Luca, Achard, P, Adriani, O, Aguilar Benitez, M, van den Akker, M, Alcaraz, J, Alemanni, G, Allaby, J, Aloisio, A, Alviggi, M, Anderhub, H, Andreev, V, Anselmo, F, Arefiev, A, Azemoon, T, Aziz, T, Bagnaia, P, Bajo, A, Baksay, G, Baksay, L, Bähr, J, Baldew, S, Banerjee, S, Barczyk, A, Barillère, R, Bartalini, P, Basile, M, Batalova, N, Battiston, R, Bay, A, Becattini, F, Becker, U, Behner, F, Bellucci, L, Berbeco, R, Berdugo, J, Berges, P, Bertucci, B, Betev, B, Biasini, M, Biglietti, M, Biland, A, Blaising, J, Blyth, S, Bobbink, G, Böhm, A, Boldizsar, L, Borgia, B, Bottai, S, Bourilkov, D, Bourquin, M, Braccini, S, Branson, J, Brochu, F, Burger, J, Burger, W, Cai, X, Capell, M, Cara Romeo, G, Carlino, G, Cartacci, A, Casaus, J, Cavallari, F, Cavallo, N, Cecchi, C, Cerrada, M, Chamizo, M, Chiarusi, T, Chang, Y, Chemarin, M, Chen, A, Chen, G, Chen, H, Chiefari, G, Cifarelli, L, Cindolo, F, Clare, I, Clare, R, Coignet, G, Colino, N, Costantini, S, de La Cruz, B, Cucciarelli, S, van Dalen, J, de Asmundis, R, Déglon, P, Debreczeni, J, Degré, A, Dehmelt, K, Deiters, K, della Volpe, D, Delmeire, E, Denes, P, Denotaristefani, F, de Salvo, A, Diemoz, M, Dierckxsens, M, Ding, L, Dionisi, C, Dittmar, M, Doria, A, Dova, M, Duchesneau, D, Duda, M, Duran, I, Echenard, B, Eline, A, El Hage, A, El Mamouni, H, Engler, A, Eppling, F, Extermann, P, Faber, G, Falagan, M, Falciano, S, Favara, A, Fay, J, Fedin, O, Felcini, M, Ferguson, T, Fesefeldt, H, Fiandrini, E, Field, J, Filthaut, F, Fisher, W, Fisk, I, Forconi, G, Freudenreich, K, Furetta, C, Galaktionov, Y, Ganguli, S, Garcia Abia, P, Gataullin, M, Gentile, S, Giagu, S, Gong, Z, Grabosch, H, Grenier, G, Grimm, O, Groenstege, H, Gruenewald, M, Guida, M, Guo, Y, Gupta, S, Gupta, V, Gurtu, A, Gutay, L, Haas, D, Haller, C, Hatzifotiadou, D, Hayashi, Y, He, Z, Hebbeker, T, Hervé, A, Hirschfelder, J, Hofer, H, Hohlmann, M, Holzner, G, Hou, S, Huo, A, Hu, Y, Ito, N, Jin, B, Jing, C, Jones, L, de Jong, P, Josa Mutuberría, I, Kantserov, V, Kaur, M, Kawakami, S, Kienzle Focacci, M, Kim, J, Kirkby, J, Kittel, W, Klimentov, A, König, A, Kok, E, Korn, A, Kopal, M, Koutsenko, V, Kräber, M, Kuang, H, Kraemer, R, Krüger, A, Kuijpers, J, Kunin, A, Ladron de Guevara, P, Laktineh, I, Landi, G, Lebeau, M, Lebedev, A, Lebrun, P, Lecomte, P, Lecoq, P, Le Coultre, P, Le Goff, J, Lei, Y, Leich, H, Leiste, R, Levtchenko, M, Levtchenko, P, Li, C, Li, L, Li, Z, Likhoded, S, Lin, C, Lin, W, Linde, F, Lista, L, Liu, Z, Lohmann, W, Longo, E, Lu, Y, Luci, C, Luminari, L, Lustermann, W, Ma, W, Ma, X, Ma, Y, Malgeri, L, Malinin, A, Maña, C, Mans, J, Martin, J, Marzano, F, Mazumdar, K, Mcneil, R, Mele, S, Meng, X, Merola, L, Meschini, M, Metzger, W, Mihul, A, van Mil, A, Milcent, H, Mirabelli, G, Mnich, J, Mohanty, G, Monteleoni, B, Muanza, G, Muijs, A, Musicar, B, 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Shen, C, Shevchenko, S, Shivarov, N, Shoutko, V, Shumilov, E, Shvorob, A, Son, D, Souga, C, Spillantini, P, Steuer, M, Stickland, D, Stoyanov, B, Straessner, A, Sudhakar, K, Sulanke, H, Sultanov, G, Sun, L, Sushkov, S, Suter, H, Swain, J, Szillasi, Z, Tang, X, Tarjan, P, Tauscher, L, Taylor, L, Tellili, B, Teyssier, D, Timmermans, C, Ting, S, Tonwar, S, Tóth, J, Trowitzsch, G, Tully, C, Tung, K, Ulbricht, J, Unger, M, Valente, E, Verkooijen, H, van de Walle, R, Vasquez, R, Veszpremi, V, Vesztergombi, G, Vetlitsky, I, Vicinanza, D, Viertel, G, Villa, S, Vivargent, M, Vlachos, S, Vodopianov, I, Vogel, H, Vogt, H, Vorobiev, I, Vorobyov, A, Wadhwa, M, Wang, R, Wang, Q, Wang, X, Wang, Z, Weber, M, van Wijk, R, Wijnen, T, Wilkens, H, Wynhoff, S, Xia, L, Xu, Y, Xu, J, Xu, Z, Yamamoto, J, Yang, B, Yang, C, Yang, H, Yang, M, Yang, X, Yao, Z, Yeh, S, Yu, Z, Zalite, A, Zalite, Y, Zhang, C, Zhang, F, Zhang, J, Zhang, S, Zhang, Z, Zhao, J, Zhou, S, Zhu, G, Zhu, R, Zhuang, H, Zhu, Q, Zichichi, A, Zimmermann, B, Zöller, M, Zwart, A, Achard, Pablo, Bourquin, Maurice, Braccini, Saverio, Chamizo Llatas, Maria, Deglon, Patrick, Delmeire, Evelyne, Echenard, Bertrand, Extermann, Pierre, Field, John, Kienzle, Maria-Novella, Natale, Sonia, Pohl, Martin, and Straessner, Arno

Subjects
Nuclear and High Energy Physics, Particle physics, L3,CERN-LEP-L3, Physics::Instrumentation and Detectors, Ciencias Físicas, Astrophysics::High Energy Astrophysical Phenomena, momentum spectrum, FOS: Physical sciences, Cosmic ray, ddc:500.2, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, purl.org/becyt/ford/1 [https], Momentum, Nuclear physics, Atmospheric muon spectrum, High Energy Physics - Experiment (hep-ex), Muon spectrometer, muon, l3, cern lab, cosmic radiation, angular dependence, magnetic detector, 0103 physical sciences, Vertical direction, Nuclear Experiment, 010306 general physics, Cosmic rays, High-energy hadronic interactions, Zenith, Physics, Muon, 010308 nuclear & particles physics, Física, purl.org/becyt/ford/1.3 [https], Astronomía, Pair production, Muon flux, Physics::Accelerator Physics, High Energy Physics::Experiment, CIENCIAS NATURALES Y EXACTAS, Particle Physics - Experiment, FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
Abstract

The absolute muon flux between 20 and 3000 GeV is measured with the L3 magnetic muon spectrometer for zenith angles ranging from 0°to 58°. Due to the large exposure of about 150 m2sr d, and the excellent momentum resolution of the L3 muon chambers, a precision of 2.3% at 150 GeV in the vertical direction is achieved.The ratio of positive to negative muons is studied between 20 and 500 GeV, and the average vertical muon charge ratio is found to be 1.285±0.003(stat.)±0.019(syst.)., Physics Letters B, 598 (1-2), ISSN:0370-2693, ISSN:0031-9163, ISSN:1873-2445

Published
2004

33. Femtosecond pulse-induced fiber Bragg gratings for in-core temperature measurement in optically pumped Yb-doped silica fibers

Author

Julia Fiebrandt, Martin Leich, Sylvia Jetschke, Anka Schwuchow, Sonja Unger, and Hartmut Bartelt

Subjects
All-silica fiber, PHOSFOS, Materials science, business.industry, Plastic-clad silica fiber, Physics::Optics, Long-period fiber grating, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Optics, Fiber Bragg grating, Fiber laser, Optoelectronics, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, business, Hard-clad silica optical fiber, Photonic-crystal fiber
Abstract

We report on the in-core fiber temperature measurements in Yb 2 O 3 -doped aluminum silicate fibers during optical pumping using UV femtosecond-induced fiber Bragg gratings (FBGs). The FBG containing fiber samples show a different temperature behavior during pumping before and after thermal annealing, caused by absorption centers generated during grating inscription. These absorption centers can be removed completely by thermal annealing. In this way, remaining temperature rise during pumping due to the quantum defect of the Yb 3+ ions is determined depending on the Yb concentration in the range 0.14–0.46 mol% and the pump wavelength.

Published
2012

34. Access control in feature-oriented programming

Author

Christian Kästner, Thomas Leich, Sven Apel, Sergiy S. Kolesnikov, Martin Kuhlemann, and Jörg Liebig

Subjects
Fuji, Computer science, Programming language, business.industry, Access control, Access modifier model, computer.software_genre, Modularity, Encapsulation (networking), Feature-oriented programming, Feature modularity, Compiler, Isolation (database systems), Access modifiers, Programmer, business, computer, Software
Abstract

In feature-oriented programming (FOP) a programmer decomposes a program in terms of features. Ideally, features are implemented modularly so that they can be developed in isolation. Access control mechanisms in the form of access or visibility modifiers are an important ingredient to attain feature modularity as they allow programmers to hide and expose internal details of a module’s implementation. But developers of contemporary feature-oriented languages have not considered access control mechanisms so far. The absence of a well-defined access control model for FOP breaks encapsulation of feature code and leads to unexpected program behaviors and inadvertent type errors. We raise awareness of this problem, propose three feature-oriented access modifiers, and present a corresponding access modifier model. We offer an implementation of the model on the basis of a fully-fledged feature-oriented compiler. Finally, by analyzing ten feature-oriented programs, we explore the potential of feature-oriented modifiers in FOP.

Published
2012

35. Towards a monolithic fiber laser with deep UV femtosecond-induced fiber Bragg gratings

Author

Martin Leich, Eric Lindner, Martin Becker, Sonja Unger, Sylvia Jetschke, Hartmut Bartelt, Sven Brückner, and Manfred Rothhardt

Subjects
PHOSFOS, Distributed feedback laser, Materials science, business.industry, Physics::Optics, Polarization-maintaining optical fiber, Long-period fiber grating, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Optics, Fiber Bragg grating, Fiber laser, Optoelectronics, Dispersion-shifted fiber, Physics::Atomic Physics, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, business, Photonic-crystal fiber
Abstract

Fiber Bragg grating inscription with a deep ultraviolet (DUV) femtosecond laser and two-beam interferometry allows grating inscription in germanium-free fibers without classical UV photosensitivity. Therefore such a writing technology is a promising solution for the fabrication of fiber Bragg gratings in the active fiber material to realize a fully integrated all-fiber solution. In this paper we report on the use of the DUV femtosecond laser fiber Bragg grating technology to build a grating-stabilized fiber laser with high spectral purity. Output powers up to 158 W at 1083 nm and a slope efficiency of 76% have been demonstrated.

Published
2011

36. Pathology, pathogenesis and molecular genetics of follicular NHL

Author

Andreas Rosenwald, Ellen Leich, and German Ott

Subjects
medicine.medical_specialty, Pathology, Lymphoma, B-Cell, Clinical Biochemistry, Follicular lymphoma, Antineoplastic Agents, Biology, Translocation, Genetic, Pathogenesis, Molecular genetics, microRNA, Biomarkers, Tumor, Tumor Microenvironment, medicine, Humans, Neoplasm, Lymphoma, Follicular, Chromosomes, Human, Pair 14, B-Lymphocytes, Tumor microenvironment, Gene Expression Profiling, DNA Methylation, Germinal Center, medicine.disease, Lymphoma, MicroRNAs, Proto-Oncogene Proteins c-bcl-2, Oncology, DNA methylation, Immunology, Chromosomes, Human, Pair 18
Abstract

Follicular lymphoma (FL) is a germinal centre-derived indolent B-cell lymphoma representing the second most common Non Hodgkin lymphoma in the Western world. This chapter focuses on the pathology of FL and summarizes the current knowledge about genetic and molecular features that are relevant for the pathogenesis of this neoplasm. The translocation t(14;18) is present in approximately 90% of FL leading to the upregulation of the anti-apoptotic protein BCL2, that may constitute a promising molecular target for therapeutic approaches. FL lacking the t(14;18) also exist, and B-cells carrying the t(14;18) can be detected in a subset of healthy individuals. In addition to the t(14;18), secondary genetic alterations are present in most FL and, more recently, deeper insights into the methylation and microRNA expression patterns in the tumour cells have been gained. The tumour microenvironment appears to be particularly important for the biology and the clinical course of FL.

Published
2011

37. DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

Author

Marie K. Zeitlinger, Markus Sauer, Thorsten Stiewe, Rasa Beinoraviciute-Kellner, Joël P. Charles, Birgit Samans, Ellen Leich, Andreas Rosenwald, Katharina Schlereth, Anne Catherine Bretz, Caroline Kisker, Fotini Vogiatzi, and Martin Eilers

Subjects
Mutation, Programmed cell death, genetic structures, HMG-box, DNA damage, Cooperativity, Cell Biology, Biology, medicine.disease_cause, Molecular biology, Cell biology, chemistry.chemical_compound, chemistry, medicine, Binding site, Molecular Biology, DNA, P53 binding
Abstract

p53 limits the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. How the decision between survival and death is made at the level of p53 binding to target promoters remains unclear. Using cancer cell lines, we show that the cooperative nature of DNA binding extends the binding spectrum of p53 to degenerate response elements in proapoptotic genes. Mutational inactivation of cooperativity therefore does not compromise the cell-cycle arrest response but strongly reduces binding of p53 to multiple proapoptotic gene promoters (BAX, PUMA, NOXA, CASP1). Vice versa, engineered mutants with increased cooperativity show enhanced binding to proapoptotic genes, which shifts the cellular response to cell death. Furthermore, the cooperativity of DNA binding determines the extent of apoptosis in response to DNA damage. Because mutations, which impair cooperativity, are genetically linked to cancer susceptibility in patients, DNA binding cooperativity contributes to p53's tumor suppressor activity.

Published
2010
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38. Specific Detection of CD56 (NCAM) Isoforms for the Identification of Aggressive Malignant Neoplasms with Progressive Development

Author

Edgar Serfling, Ralf C. Bargou, Hans Konrad Müller-Hermelink, Hermann Einsele, Hans-Ulrich Völker, Stefan Gattenlöhner, Thorsten Stühmer, Ellen Leich, Benjamin Etschmann, Matthias Reinhard, Andreas Rosenwald, and Georg Ertl

Subjects
Gene isoform, Blotting, Western, Apoptosis, chemical and pharmacologic phenomena, Biology, Transfection, medicine.disease_cause, Antibodies, Pathology and Forensic Medicine, Natural killer cell, Antibody Specificity, Cell Line, Tumor, Neoplasms, Biomarkers, Tumor, medicine, Humans, Protein Isoforms, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Kinase, Gene Expression Profiling, Alternative splicing, hemic and immune systems, Flow Cytometry, Immunohistochemistry, CD56 Antigen, Gene expression profiling, stomatognathic diseases, medicine.anatomical_structure, Tumor progression, Immunology, Disease Progression, Cancer research, Neural cell adhesion molecule, Carcinogenesis, Regular Articles
Abstract

Alternative splicing of transcripts from many cancer-associated genes is believed to play a major role in carcinogenesis as well as in tumor progression. Alternative splicing of one such gene, the neural cell adhesion molecule CD56 (NCAM), impacts the progression, inadequate therapeutic response, and reduced total survival of patients who suffer from numerous malignant neoplasms. Although previous investigations have determined that CD56 exists in three major isoforms (CD56(120kD), CD56(140kD), and CD56(180kD)) with individual structural and functional properties, neither the expression profiles nor the functional relevance of these isoforms in malignant tumors have been consistently investigated. Using new quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) strategies and novel CD56 isoform-specific antibodies, CD56(140kD) was shown to be exclusively expressed in a number of highly malignant CD56(+) neoplasms and was associated with the progression of CD56(+) precursor lesions of unclear malignant potential. Moreover, only CD56(140kD) induced antiapoptotic/proliferative pathways and specifically phosphorylated calcium-dependent kinases that are relevant for tumorigenesis. We conclude, therefore, that the specific detection of CD56 isoforms will help to elucidate their individual functions in the pathogenesis and progression of malignant neoplasms and may have a positive impact on the development of CD56-based immunotherapeutic strategies.

Published
2009

40. RalA and RalB are Potential Therapeutic Targets in Multiple Myeloma Which Mediate Cell Survival Independently of Oncogenic RAS

Author

Steinbrunn, Torsten, primary, Seibold, Marcel, additional, Stühmer, Thorsten, additional, Schmiedl, Nadine, additional, Mottok, Anja, additional, Leich, Ellen, additional, Scholz, Claus, additional, Chatterjee, Manik, additional, Rosenwald, Andreas, additional, Einsele, Hermann, additional, and Bargou, Ralf C., additional

Published
2017
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41. Tandemization Endows Bovine Pancreatic Ribonuclease with Cytotoxic Activity

Author

Ulrich Arnold, Jens Köditz, Renate Ulbrich-Hofman, and Franziska Leich

Subjects
Models, Molecular, Protein Conformation, RNase P, In Vitro Techniques, Protein Engineering, Bovine pancreatic ribonuclease, RNase PH, Structural Biology, Enzyme Stability, Animals, Humans, Ribonuclease III, Enzyme Inhibitors, RNase H, Molecular Biology, Cell Death, biology, Cytotoxins, Circular Dichroism, RNA, Ribonuclease, Pancreatic, Molecular biology, Recombinant Proteins, Kinetics, RNase MRP, S-tag, Biochemistry, biology.protein, Thermodynamics, Cattle, K562 Cells, Dimerization
Abstract

Due to their ability to degrade RNA, selected members of the bovine pancreatic ribonuclease A (RNase A) superfamily are potent cytotoxins. These cytotoxic ribonucleases enter the cytosol of target cells, where they degrade cellular RNA and cause cell death. The cytotoxic activity of most RNases, however, is abolished by the cytosolic ribonuclease inhibitor (RI). Consequently, the development of RNase derivatives with the ability to evade RI binding is a desirable goal. In this study, tandem enzymes consisting of two RNase A units that are bound covalently via a peptide linker were generated by gene duplication. As deduced from the crystal structure of the RNase A.RI complex, one RNase A unit of the tandem enzyme can still be bound by RI. The other unit, however, should remain unbound because of steric hindrance. This free RNase A unit is expected to maintain its activity and to act as a cytotoxic agent. The study of the influence of the linker sequence on the conformation and stability of these constructs revealed that tandemization has only minor effects on the activity and stability of the constructs in comparison to monomeric RNase A. Relative activity was decreased by 10-50% and the melting temperature was decreased by less than 2.5 K. Furthermore, the cytotoxic potency of the RNase A tandem enzymes was investigated. Despite an in vitro inhibition by RI, tandemization was found to endow RNase A with remarkable cytotoxic activity. While monomeric RNase A is not cytotoxic, IC(50) values of the RNase A tandem variants decreased to 70.3-12.9 microM. These findings might establish the development of a new class of chemotherapeutic agents based on pancreatic ribonucleases.

Published
2006

42. Observation of jet production in deep inelastic scattering with a large rapidity gap at HERA

Author

David Bailey, Derrick, M., Krakauer, D., Magill, S., Musgrave, B., Repond, J., Schlereth, J., Stanek, R., Talaga, R. L., Thron, J., Arzarello, F., Ayad, R., Bari, G., Basile, M., Bellagamba, L., Boscherini, D., Bruni, A., Bruni, G., Bruni, P., Cara Romeo, G., Castellini, G., Chiarini, M., Cifarelli, L., Cindolo, F., Ciralli, F., Contin, A., Auria, S. D., Del Papa, C., Frasconi, F., Giusti, P., Iacobucci, G., Laurenti, G., Levi, G., Maccarrone, G., Margotti, A., Massam, T., Nania, R., Nemoz, C., Palmonari, F., Sartorelli, G., Timellini, R., Zamora Garcia, Y., Zichichi, A., Bargende, A., Crittenden, J., Desch, K., Diekmann, B., Doeker, T., Feld, L., Frey, A., Geerts, M., Geitz, G., Hartmann, H., Haun, D., Heinloth, K., Hilger, E., Jakob, H. P., Katz, U. F., Kramarczyk, S., Mass, A., Mengel, S., Mollen, J., Paul, E., Ch Rembser, Schattevoy, R., Schneider, J. L., Schramm, D., Stamm, J., Wedemeyer, R., Campbell-Robson, S., Cassidy, A., Dyce, N., Foster, B., George, S., Gilmore, R., Heath, G. P., Heath, H. F., Llewellyn, T. J., Morgado, C. J. S., Norman, D. J. P., Mara, J. A. O., Tapper, R. J., Wilson, S. S., Yoshida, R., Rau, R. R., Arneodo, M., Schioppa, M., Susinno, G., Bernstein, A., Caldwell, A., Gialas, I., Parsons, J. A., Ritz, S., Sciulli, F., Straub, P. B., Wai, L., Yang, S., Borzemski, P., Chwastowski, J., Eskreys, A., Piotrzkowski, K., Zachara, M., Zawiejski, L., Adamczyk, L., Bednarek, B., Eskreys, K., Jeleń, K., Kisielewska, D., Kowalski, T., Rulikowska-Zarȩbska, E., Suszycki, L., Zaja̧c, J., Kȩdzierski, T., Kotański, A., Przybycień, M., Bauerdick, L. A. T., Behrens, U., Bienlein, J. K., Böttcher, S., Coldewey, C., Drews, G., Flasiński, M., Fleck, I., Gilkinson, D. J., Göttlicher, P., Gutjahr, B., Haas, T., Hagge, L., Hain, W., Hasell, D., Heßling, H., Hultschig, H., Joos, P., Kasemann, M., Klanner, R., Koch, W., Köpke, L., Kötz, U., Kowalski, H., Kröger, W., Krüger, J., Labs, J., Ladage, A., Löhr, B., Löwe, M., Lüke, D., Mainusch, J., Mańczak, O., Ng, J. S. T., Nickel, S., Notz, D., Ohrenberg, K., Rohde, M., Roldán, J., Schneekloth, U., Schroeder, J., Schulz, W., Selonke, F., Stiliaris, E., Tsurugai, T., Vogel, W., Westphal, D., Wolf, G., Youngman, C., Grabosch, H. J., Leich, A., Meyer, A., Rethfeldt, C., Schlenstedt, S., Barbagli, G., Nuti, M., Pelfer, P., Anzivino, G., Pasquale, S., Qian, S., Votano, L., Bamberger, A., Freidhof, A., Poser, T., Stefan Soldner-Rembold, Theisen, G., Trefzger, T., Brook, N. H., Bussey, P. J., Doyle, A. T., Forbes, J. R., Jamieson, V. A., Raine, C., Saxon, D. H., Stavrianakou, M., Wilson, A. S., Dannemann, A., Holm, U., Horstmann, D., Kammerlocher, H., Krebs, B., Neumann, T., Sinkus, R., Wick, K., Badura, E., Burow, B. D., Fürtjes, A., Lohrmann, E., Milewski, J., Nakahata, M., Pavel, N., Poelz, G., Schott, W., Terron, J., Zetsche, F., Bacon, T. C., Beuselinck, R., Butterworth, I., Gallo, E., Harris, V. L., Long, K. R., Miller, D. B., Morawitz, P., Prinias, A., Sedgbeer, J. K., Vorvolakos, A., Whitfield, A., Bienz, T., Kreutzmann, H., Mallik, U., Mccliment, E., Roco, M., Wang, M. Z., Cloth, P., Filges, D., An, S. H., Hong, S. M., Kim, C. O., Kim, T. Y., Nam, S. W., Park, S. K., Suh, M. H., Yon, S. H., Imlay, R., Kartik, S., Kim, H. J., Mcneil, R. R., Metcalf, W., Nadendla, V. K., Barreiro, F., Cases, G., Graciani, R., Hernández, J. M., Hervás, L., Labarga, L., Del Peso, J., Puga, J., Trocóniz, J. F., Ikraiam, F., Mayer, J. K., Smith, G. R., Corriveau, F., Hanna, D. S., Hartmann, J., Hung, L. W., Lim, J. N., Matthews, C. G., Mitchell, J. W., Patel, P. M., Sinclair, L. E., Stairs, D. G., St Laurent, M., Ullmann, R., Bashkirov, V., Dolgoshein, B. A., Stifutkin, A., Bashindzhagyan, G. L., Ermolov, P. F., Gladilin, L. K., Golubkov, Y. A., Kobrin, V. D., Kuzmin, V. A., Kuznetsov, E. N., Savin, A. A., Solomin, A. N., Voronin, A. G., Zotov, N. P., Bentvelsen, S., Botje, M., Chlebana, F., Dake, A., Engelen, J., Jong, P., Kamps, M., Kooijman, P., Kruse, A., V. O'Dell, Tenner, A., Tiecke, H., Verkerke, W., Vreeswijk, M., Wiggers, L., Wolf, E., Woudenberg, R., Acosta, D., Bylsma, B., Durkin, L. S., Honscheid, K., Li, C., Ling, T. Y., Mclean, K. W., Murray, W. N., Park, I. H., Romanowski, T. A., Seidlein, R., Bailey, D. S., Blair, G. A., Byrne, A., Cashmore, R. J., Cooper-Sarkar, A. M., Daniels, D., Devenish, R. C. E., Harnew, N., Lancaster, M., Luffman, P. E., Mcfall, J., Nath, C., Quadt, A., Uijterwaal, H., Walczak, R., Wilson, F. F., Yip, T., Abbiendi, G., Bertolin, A., Brugnera, R., Carlin, R., Dal Corso, F., Giorgi, M., Dosselli, U., Gasparini, F., Limentani, S., Morandin, M., Posocco, M., Stanco, L., Stroili, R., Voci, C., Bulmahn, J., Butterworth, J. M., Feild, R. G., Oh, B. Y., Whitmore, J. J., Agostini, G. D., Guida, M., Iori, M., Mari, S. M., Marini, G., Mattioli, M., Nigro, A., Hart, J. C., Mccubbin, N. A., Prytz, K., Shah, T. P., Short, T. L., Barberis, E., Cartiglia, N., Heusch, C., Hook, M., Hubbard, B., Lockman, W., Sadrozinski, H. F. W., Seiden, A., Zer-Zion, D., Biltzinger, J., Seifert, R. J., Walenta, A. H., Zech, G., Abramowicz, H., Dagan, S., Levy, A., Hasegawa, T., Hazumi, M., Ishii, T., Kuze, M., Mine, S., Nagasawa, Y., Nagira, T., Nakao, M., Suzuki, I., Tokushuku, K., Yamada, S., Yamazaki, Y., Chiba, M., Hamatsu, R., Hirose, T., Homma, K., Kitamura, S., Nagayama, S., Nakamitsu, Y., Cirio, R., Costa, M., Ferrero, M. I., Lamberti, L., Maselli, S., Peroni, C., Sacchi, R., Solano, A., Staiano, A., Dardo, M., Bailey, D. C., Bandyopadhyay, D., Benard, F., Bhadra, S., Brkic, M., Crombie, M. B., Gingrich, D. M., Hartner, G. F., Levman, G. M., Martin, J. F., Orr, R. S., Sampson, C. R., Teuscher, R. J., Bullock, F. W., Catterall, C. D., Giddings, J. C., Jones, T. W., Khan, A. M., Lane, J. B., Makkar, P. L., Shaw, D., Shulman, J., Blankenship, K., Kochocki, J., Lu, B., Mo, L. W., Bogusz, W., Charchuła, K., Ciborowski, J., Gajewski, J., Grzelak, G., Kasprzak, M., Krzyzanowski, M., Muchorowski, K., Nowak, R. J., Pawlak, J. M., Tymieniecka, T., Wróblewski, A. K., Zakrzewski, J. A., Zarnecki, A. F., Adamus, M., Eisenberg, Y., Glasman, C., Karshon, U., Revel, D., Shapira, A., Ali, I., Behrens, B., Dasu, S., Fordham, C., Foudas, C., Goussiou, A., Loveless, R. J., Reeder, D. D., Silverstein, S., Smith, W. H., Frisken, W. R., Furutani, K. M., Iga, Y., Derrick, M, Krakauer, D, Magill, S, Musgrave, B, Repond, J, Schlereth, J, Stanek, R, Talaga, Rl, Thron, J, Arzarello, F, Ayad, R, Bari, G, Basile, M, Bellagamba, L, Boscherini, D, Bruni, A, Bruni, G, Bruni, P, Romeo, Gc, Castellini, G, Chiarini, M, Cifarelli, L, Cindolo, F, Ciralli, F, Contin, A, Dauria, S, Delpapa, C, Frasconi, F, Giusti, P, Iacobucci, G, Laurenti, G, Levi, G, Maccarrone, G, Margotti, A, Massam, T, Nania, R, Nemoz, C, Palmonari, F, Sartorelli, G, Timellini, R, Garcia, Yz, Zichichi, A, Bargende, A, Crittenden, J, Desch, K, Diekmann, B, Doeker, T, Feld, L, Frey, A, Geerts, M, Geitz, G, Hartmann, H, Haun, D, Heinloth, K, Hilger, E, Jakob, Hp, Katz, Uf, Kramarczyk, S, Mass, A, Mengel, S, Mollen, J, Paul, E, Rembser, C, Schattevoy, R, Schneider, Jl, Schramm, D, Stamm, J, Wedemeyer, R, Campbellrobson, S, Cassidy, A, Dyce, N, Foster, B, George, S, Gilmore, R, Heath, Gp, Heath, Hf, Llewellyn, Tj, Morgado, Cj, Norman, Djp, Omara, Ja, Tapper, Rj, Wilson, S, Yoshida, R, Rau, Rr, Arneodo, M, Schioppa, M, Susinno, G, Bernstein, A, Caldwell, A, Gialas, I, Parsons, Ja, Ritz, S, Sciulli, F, Straub, Pb, Wai, L, Yang, S, Borzemski, P, Chwastowski, J, Eskreys, A, Piotrzkowski, K, Zachara, M, Zawiejski, L, Adamczyk, L, Bednarek, B, Eskreys, K, Jelen, K, Kisielewska, D, Kowalski, T, Rulikowskazarebska, E, Suszycki, L, Zajac, J, Kedzierski, T, Kotanski, A, Przybycien, M, Bauerdick, Lat, Behrens, U, Bienlein, Jk, Bottcher, S, Coldewey, C, Drews, G, Flasinski, M, Fleck, I, Gilkinson, Dj, Gottlicher, P, Gutjahr, B, Haas, T, Hagge, L, Hain, W, Hasell, D, Hessling, H, Hultschig, H, Joos, P, Kasemann, M, Klanner, R, Koch, W, Kopke, L, Kotz, U, Kowalski, H, Kroger, W, Kruger, J, Labs, J, Ladage, A, Lohr, B, Lowe, M, Luke, D, Mainusch, J, Manczak, O, Ng, Jst, Nickel, S, Notz, D, Ohrenberg, K, Rohde, M, Roldan, J, Schneekloth, U, Schroeder, J, Schulz, W, Selonke, F, Stiliaris, E, Tsurugai, T, Vogel, W, Westphal, D, Wolf, G, Youngman, C, Grabosch, Hj, Leich, A, Meyer, A, Rethfeldt, C, Schlenstedt, S, Barbagli, G, Nuti, M, Pelfer, P, Anzivino, G, Depasquale, S, Qian, S, Votano, L, Bamberger, A, Freidhof, A, Poser, T, Soldnerrembold, S, Theisen, G, Trefzger, T, Brook, Nh, Bussey, Pj, Doyle, At, Forbes, Jr, Jamieson, Va, Raine, C, Saxon, Dh, Stavrianakou, M, Wilson, A, Dannemann, A, Holm, U, Horstmann, D, Kammerlocher, H, Krebs, B, Neumann, T, Sinkus, R, Wick, K, Badura, E, Burow, Bd, Furtjes, A, Lohrmann, E, Milewski, J, Nakahata, M, Pavel, N, Poelz, G, Schott, W, Terron, J, Zetsche, F, Bacon, Tc, Beuselinck, R, Butterworth, I, Gallo, E, Harris, Vl, Long, Kr, Miller, Db, Morawitz, P, Prinias, A, Sedgbeer, Jk, Vorvolakos, A, Whitfield, A, Bienz, T, Kreutzmann, H, Mallik, U, Mccliment, E, Roco, M, Wang, Mz, Cloth, P, Filges, D, An, Sh, Hong, S, Kim, Co, Kim, Ty, Nam, Sw, Park, Sk, Suh, Mh, Yon, Sh, Imlay, R, Kartik, S, Kim, Hj, Mcneil, Rr, Metcalf, W, Nadendla, Vk, Barreiro, F, Cases, G, Graciani, R, Hernandez, Jm, Hervas, L, Labarga, L, Delpeso, J, Puga, J, Detroconiz, Jf, Ikraiam, F, Mayer, Jk, Smith, Gr, Corriveau, F, Hanna, D, Hartmann, J, Hung, Lw, Lim, Jn, Matthews, Cg, Mitchell, Jw, Patel, Pm, Sinclair, Le, Stairs, Dg, Stlaurent, M, Ullmann, R, Bashkirov, V, Dolgoshein, Ba, Stifutkin, A, Bashindzhagyan, Gl, Ermolov, Pf, Gladilin, Lk, Golubkov, Ya, Kobrin, Vd, Kuzmin, Va, Kuznetsov, En, Savin, Aa, Solomin, An, Voronin, Ag, Zotov, Np, Bentvelsen, S, Botje, M, Chlebana, F, Dake, A, Engelen, J, Dejong, P, Dekamps, M, Kooijman, P, Kruse, A, Odell, V, Tenner, A, Tiecke, H, Verkerke, W, Vreeswijk, M, Wiggers, L, Dewolf, E, Vanwoudenberg, R, Acosta, D, Bylsma, B, Durkin, L, Honscheid, K, Li, C, Ling, Ty, Mclean, Kw, Murray, Wn, Park, Ih, Romanowski, Ta, Seidlein, R, Bailey, D, Blair, Ga, Byrne, A, Cashmore, Rj, Coopersarkar, Am, Daniels, D, Devenish, Rce, Harnew, N, Lancaster, M, Luffman, Pe, Mcfall, J, Nath, C, Quadt, A, Uijterwaal, H, Walczak, R, Wilson, Ff, Yip, T, Abbiendi, G, Bertolin, A, Brugnera, R, Carlin, R, Dalcorso, F, Degiorgi, M, Dosselli, U, Gasparini, F, Limentani, S, Morandin, M, Posocco, M, Stanco, L, Stroili, R, Voci, C, Bulmahn, J, Butterworth, Jm, Field, Rg, Oh, By, Whitmore, Jj, Dagostini, G, Guida, M, Iori, M, Mari, Stefano Maria, Marini, G, Mattioli, M, Nigro, A, Hart, Jc, Mccubbin, Na, Prytz, K, Shah, Tp, Short, Tl, Barberis, E, Cartiglia, N, Heusch, C, Vanhook, M, Hubbard, B, Lockman, W, Sadrozinski, Hfw, Seiden, A, Zerzion, D, Biltzinger, J, Seifert, Rj, Walenta, Ah, Zech, G, Abramowicz, H, Dagan, S, Levy, A, Hasegawa, T, Hazumi, M, Ishii, T, Kuze, M, Mine, S, Nagasawa, Y, Nagira, T, Nakao, M, Suzuki, I, Tokushuku, K, Yamada, S, Yamazaki, Y, Chiba, M, Hamatsu, R, Hirose, T, Homma, K, Kitamura, S, Nagayama, S, Nakamitsu, Y, Cirio, R, Costa, M, Ferrero, Mi, Lamberti, L, Maselli, S, Peroni, C, Sacchi, R, Solano, A, Staiano, A, Dardo, M, Bailey, Dc, Bandyopadhyay, D, Benard, F, Bhadra, S, Brkic, M, Crombie, Mb, Gingrich, Dm, Hartner, Gf, Levman, Gm, Martin, Jf, Orr, R, Sampson, Cr, Teuscher, Rj, Bullock, Fw, Catterall, Cd, Giddings, Jc, Jones, Tw, Khan, Am, Lane, Jb, Makkar, Pl, Shaw, D, Shulman, J, Blankenship, K, Kochocki, J, Lu, B, Mo, Lw, Bogusz, W, Charchula, K, Ciborowski, J, Gajewski, J, Grzelak, G, Kasprzak, M, Krzyzanowski, M, Muchorowski, K, Nowak, Rj, Pawlak, Jm, Tymieniecka, T, Wroblewski, Ak, Zakrzewski, Ja, Zarnecki, Af, Adamus, M, Eisenberg, Y, Glasman, C, Karshon, U, Revel, D, Shapira, A, Ali, I, Behrens, B, Dasu, S, Fordham, C, Foudas, C, Goussiou, A, Loveless, Rj, Reeder, Dd, Silverstein, S, Smith, Wh, Frisken, Wr, Furutani, Km, and Iga, Y.

Subjects
LUND MONTE-CARLO, DIFFRACTION DISSOCIATION, POMERON STRUCTURE, E+E-PHYSICS, ZEUS, VERSION, FRAGMENTATION, CALORIMETER, DETECTOR, EVENTS, Nuclear and High Energy Physics, Particle physics, jet production, Astrophysics::High Energy Astrophysical Phenomena, deep inelastic scattering, large rapidity gap, Virtual particle, Electron, Nuclear physics, Energy flow, Rapidity, Nuclear Experiment, Physics, Scattering, HERA, Deep inelastic scattering, Transverse plane, High Energy Physics::Experiment
Abstract

Events with a large rapidity gap in deep inelastic scattering with Q2 greater-than-or-equal-to 10 GeV2 have been studied in the ZEUS detector. The properties of these events with W > 140 GeV are consistent with a leading twist diffractive production mechanism. In the laboratory frame, with E(T)jet greater-than-or-equal-to 4 GeV, 15% of the events are of the 1-jet type with negligible 2-jet production. The single jet is back-to-back in azimuth with the scattered electron. No energy flow is observed between the jet and the proton direction. With a lower jet transverse energy cut 2-jet production is observed both in the laboratory and the gamma*p centre-of-mass systems, demonstrating the presence of hard scattering in the virtual photon proton interactions that give rise to large rapidity gap events.

Published
1994

43. Results from the AMANDA neutrino telescope

Author

P. Niessen, I. Taboada, Y. Minaeva, C.P. Burgess, D. Bertrand, P. Ekström, K. Rawlins, T. Becka, James Madsen, M. Kestel, J. L. Kelley, C. P. McParland, T. DeYoung, P. B. Price, T. Burgess, T. Neunhöffer, M. Ribordy, A. Karle, A. Goldschmidt, S. Böser, Elisa Resconi, Gerald Przybylski, R. Porrata, Kurt Woschnagg, A. Silvestri, D. Steele, Glenn Spiczak, D. F. Cowen, A. Gross, L. Gerhardt, Dmitry Chirkin, T. Messarius, D. J. Boersma, Torsten Harenberg, Othmane Bouhali, Ph. Olbrecht, Hakki Ögelman, B. Hughey, J. W. Nam, Matthias Leuthold, D. R. Nygren, M. Solarz, K. Helbing, Kyle T. Mandli, P. Steffen, J. Rodríguez Martino, R. C. Bay, Jan Conrad, T. Feser, S. Tilav, R. Nahnhauer, J. Ahrens, C. H. Wiebusch, R. Ganugapati, C. Walck, R. Hardtke, J. K. Becker, Olga Botner, L. Thollander, T. Hauschildt, David A. Schneider, C. Spiering, Thomas K. Gaisser, G. B. Yodh, M. Bartelt, P. Miocinovic, Adam Bouchta, C.P. de los Heros, Allan Hallgren, G. C. Hill, K. Münich, Heiko Geenen, Xinhua Bai, K.-H. Becker, T. Castermans, K. Hultqvist, H. Albrecht, C. De Clercq, Karl-Heinz Sulanke, Markus Ackermann, S. W. Barwick, S. Hundertmark, James E. Braun, M. Walter, Ph. Herquet, Kael Hanson, Yi Wang, Paolo Desiati, M. Krasberg, H. Leich, S. Schlenstedt, Joseph T. Hodges, H. S. Matis, Francis Halzen, K. Kuehn, K. Schinarakis, Jodi Cooley, S. Richter, M. Hellwig, H. G. Sander, B. Collin, D. Hubert, I. Liubarsky, L. Köpke, R. Morse, K. H. Kampert, R. Schwarz, Wolfgang Rhode, M. Kowalski, Elisa Bernardini, R. G. Stokstad, R. Wischnewski, Michael Stamatikos, P. O. Hulth, H. Wissing, Wolfgang Wagner, A. C. Pohl, Pawel Marciniewski, Anna Davour, and Janet Jacobsen

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Solar neutrino, High Energy Physics::Phenomenology, Dark matter, Astronomy, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Solar neutrino problem, Atomic and Molecular Physics, and Optics, law.invention, Telescope, Neutrino detector, law, Measurements of neutrino speed, High Energy Physics::Experiment, Neutrino astronomy, Neutrino
Abstract

The Amanda neutrino telescope at the South Pole has been taking data since 1996. Stepwise upgraded, it reached its final stage in January 2000. We present results from the search for extraterrestrial neutrinos, neutrinos from dark matter annihilation and magnetic monopoles.

Published
2004

44. Measurement of the cosmic ray composition at the knee with the SPASE-2/AMANDA-B10 detectors

Author

T. Messarius, M. Solarz, A. Silvestri, Freddy Binon, T. Burgess, S. Böser, J. P Dewulf, P. B. Price, A. C. Pohl, Y. Minaeva, R. Schwarz, Hakki Ögelman, J. Rodríguez Martino, Kyle T. Mandli, I. Taboada, D. Bertrand, T. O. B. Schmidt, J. Ahrens, K. Rawlins, D. J. Boersma, A. Biron, Kurt Woschnagg, P. Ekström, R. Nahnhauer, M. Hellwig, Matthias Leuthold, Paul Evenson, D. R. Nygren, E. Andres, H. G. Sander, P. Steffen, C. P. McParland, Dmitry Chirkin, Michael Stamatikos, James Madsen, Jan Conrad, T. Feser, R. Porrata, T. DeYoung, Staffan Carius, I. Liubarsky, M. Ribordy, Xinhua Bai, L. Gerhardt, A. Goldschmidt, Gerald Przybylski, Glenn Spiczak, D. Ross, R. Engel, K.-H. Becker, K. H. Sulanke, B. Hughey, T. Neunhöffer, R. Hardtke, T. Becka, M. Gaug, James Kim, Albrecht Karle, R. Morse, R. C. Bay, P. Niessen, Todor Stanev, Yajun Wang, S. Schlenstedt, R. Ganugapati, D. Hubert, C. Wiedemann, Olga Botner, D. Steele, C. Walck, Ph. Herquet, S. Tilav, P. C. Mock, D. F. Cowen, Marek Kowalski, P. Miocinovic, Kael Hanson, Thomas K. Gaisser, G. B. Yodh, L. Köpke, Paolo Desiati, Ph. Olbrechts, H. Leich, C. Pérez de los Heros, T. Castermans, Wolfgang Rhode, C. De Clercq, Christopher Wiebusch, Markus Ackermann, S. W. Barwick, Othmane Bouhali, W. Wu, David A. Schneider, G. C. Hill, Heiko Geenen, Pawel Marciniewski, Anna Davour, Janet Jacobsen, Wolfgang Wagner, P. O. Hulth, H. Wissing, Elisa Bernardini, Jim Hinton, R. G. Stokstad, R. Wischnewski, P. Lindahl, Christian Spiering, S. Hundertmark, K. Rochester, K. Kuehn, Alan Watson, J. I. Lamoureux, K. Schinarakis, Jodi Cooley, T. Hauschildt, K. Hultqvist, S. Young, T. Miller, J. Lloyd-Evans, Adam Bouchta, S. Richter, H. S. Matis, Allan Hallgren, Francis Halzen, E. Dickinson, and Elisa Resconi

Subjects
Astroparticle physics, Physics, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Cosmic Rays, Mass composition, Neutrino astronomy, Atomic mass, Air shower, Ultra-high-energy cosmic ray, Neutrino, Cherenkov radiation
Abstract

The mass composition of high-energy cosmic rays at energies above 1015 eV can provide crucial information for the understanding of their origin. Air showers were measured simultaneously with the SPASE-2 air shower array and the AMANDA-B10 Cherenkov telescope at the South Pole. This combination has the advantage to sample almost all high-energy shower muons and is thus a new approach to the determination of the cosmic ray composition. The change in the cosmic ray mass composition was measured versus existing data from direct measurements at low energies. Our data show an increase of the mean log atomic mass 〈lnA〉 by about 0.8 between 500 TeV and 5 PeV. This trend of an increasing mass through the "knee" region is robust against a variety of systematic effects. © 2004 Elsevier B.V. All rights reserved.

Published
2004

45. Muon track reconstruction and data selection techniques in AMANDA

Author

P. B. Price, T. O. B. Schmidt, C. Pérez de los Heros, T. Becka, M. Kestel, Kurt Woschnagg, T. DeYoung, Dmitry Chirkin, Staffan Carius, D. Steele, S. Böser, Jodi Cooley, Matthias Leuthold, Elisa Bernardini, D. R. Nygren, R. Ganugapati, P. Herquet, D. F. Cowen, Marek Kowalski, P. Steffen, M. Solarz, Jan Conrad, T. Feser, S. Richter, I. Taboada, T. Castermans, H. S. Matis, K. Rawlins, M. Hellwig, P. Miocinovic, Yajun Wang, H. G. Sander, Francis Halzen, Michael Stamatikos, S. Schlenstedt, C. P. McParland, R. Hardtke, Markus Gaug, B. Collin, D. J. Boersma, James Madsen, C. Wiedemann, A. Goldschmidt, I. Liubarsky, David A. Schneider, A. Silvestri, J. P Dewulf, G. C. Hill, R. G. Stokstad, C. H. Wiebusch, Hakki Ögelman, R. Wischnewski, P. Lindahl, Christian Spiering, Y. Minaeva, R. C. Bay, K.-H. Becker, M. Ribordy, K. Helbing, Heiko Geenen, R. Nahnhauer, J. Rodríguez Martino, K. Kuehn, K. Schinarakis, T. Burgess, Othmane Bouhali, T. Messarius, R. Morse, L. Gerhardt, J. Ahrens, Ph. Olbrechts, K. Münich, K. Hultqvist, T. Neunhöffer, Albrecht Karle, A. Biron, Glenn Spiczak, Xinhua Bai, J. W. Nam, L. Thollander, B. Hughey, H. Leich, S. Tilav, P. C. Mock, R. Schwarz, Kael Hanson, Paolo Desiati, R. Porrata, A. C. Pohl, Gerald Przybylski, K. H. Sulanke, Olga Botner, D. Bertrand, C. De Clercq, S. W. Barwick, C. Walck, Thomas K. Gaisser, G. B. Yodh, Torsten Harenberg, Elisa Resconi, J. K. Becker, T. Hauschildt, Adam Bouchta, Allan Hallgren, Ole Streicher, S. Hundertmark, J. I. Lamoureux, P. Niessen, D. Hubert, Axel Groß, L. Köpke, D. Ross, Pawel Marciniewski, Anna Davour, Janet Jacobsen, Wolfgang Wagner, P. O. Hulth, H. Wissing, Wolfgang Rhode, and P. Ekström

Subjects
Antarctic Muon And Neutrino Detector Array, Physics, AMANDA, Nuclear and High Energy Physics, Particle physics, Neutrino astrophysics, Neutrino telescope, Track reconstruction, Muon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics (astro-ph), Detector, FOS: Physical sciences, Astrophysics, IceCube Neutrino Observatory, Neutrino detector, High Energy Physics::Experiment, Muon neutrino, Neutrino, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, Lepton
Abstract

The Antarctic Muon And Neutrino Detector Array (AMANDA) is a high-energy neutrino telescope operating at the geographic South Pole. It is a lattice of photo-multiplier tubes buried deep in the polar ice between 1500m and 2000m. The primary goal of this detector is to discover astrophysical sources of high energy neutrinos. A high-energy muon neutrino coming through the earth from the Northern Hemisphere can be identified by the secondary muon moving upward through the detector. The muon tracks are reconstructed with a maximum likelihood method. It models the arrival times and amplitudes of Cherenkov photons registered by the photo-multipliers. This paper describes the different methods of reconstruction, which have been successfully implemented within AMANDA. Strategies for optimizing the reconstruction performance and rejecting background are presented. For a typical analysis procedure the direction of tracks are reconstructed with about 2 degree accuracy., 40 pages, 16 Postscript figures, uses elsart.sty

Published
2004

46. Calibration and survey of AMANDA with the SPASE detectors

Author

G. M. Splczak, Yajun Wang, S. Schlenstedt, P. Niessen, D. Bertrand, C. Wiedemann, I. Taboada, R. C. Bay, L. Gerhardt, P. Ekström, David A. Schneider, Ph. Herquet, T. Becka, C. Pérez de los Heros, Xinhua Bai, T. Messarius, G. C. Hill, Kael Hanson, C. Wiebusch, S. Böser, Todor Stanev, Staffan Carius, K. Rawlins, R. Schwarz, Ph. Olbrechts, Heiko Geenen, Matthias Leuthold, D. R. Nygren, M. Gaug, James Madsen, Paolo Desiati, K. H. Sulanke, D. Steele, P. Steffen, Jodi Cooley, R. Porrata, R. Ganugapati, C. P. McParland, R. Engel, A. Biron, Elisa Bernardini, Hakki Ögelman, Jan Conrad, T. Feser, Kyle T. Mandli, D. F. Cowen, S. Young, Marek Kowalski, P. B. Price, Jim Hinton, A. Goldschmidt, Gerald Przybylski, A. Silvestri, T. O. B. Schmidt, M. Ribordy, M. Hellwig, H. G. Sander, Kurt Woschnagg, L. Köpke, Paul Evenson, B. Hughey, T. Neunhöffer, James Kim, Albrecht Karle, Y. Minaeva, R. Hardtke, Dmitry Chirkin, R. G. Stokstad, K.-H. Becker, R. Wischnewski, S. Richter, I. Liubarsky, J. Rodríguez Martino, Ch. Weinheimer, H. Leich, T. DeYoung, Othmane Bouhali, P. Miocinovic, Wolfgang Rhode, J. Ahrens, A. C. Pohl, Michael Stamatikos, W. Wu, R. Morse, D. Ross, S. Tilav, P. C. Mock, K. Kuehn, K. Schinarakis, H. S. Matis, Freddy Binon, T. Burgess, Francis Halzen, Olga Botner, P. Lindahl, Christian Spiering, K. Rochester, Alan Watson, P. O. Hulth, H. Wissing, Wolfgang Wagner, M. Solarz, Pawel Marciniewski, T. Hauschildt, Anna Davour, J. Lloyd-Evans, Janet Jacobsen, K. Hultqvist, Adam Bouchta, Allan Hallgren, P. Romenesko, Elisa Resconi, D. Martello, T. Castermans, C. De Clercq, S. W. Barwick, C. Walck, Thomas K. Gaisser, G. B. Yodh, S. Hundertmark, J. I. Lamoureux, T. C. Miller, and P. Doksus

Subjects
Antarctic Muon And Neutrino Detector Array, Physics, Nuclear and High Energy Physics, Muon, Detector, Astronomy, Cosmic ray, Particle detector, Air shower, Neutrino detector, Cosmic rays, Neutrino telescopes, Coincident, Instrumentation
Abstract

We report on the analysis of air showers observed in coincidence by the Antarctic Muon and Neutrino detector array (AMANDA-B10) and the South Pole Air Shower Experiment (SPASE-1 and SPASE-2). We discuss the use of coincident events for calibration and survey of the deep AMANDA detector as well as the response of AMANDA to muon bundles. This analysis uses data taken during 1997 when both SPASE-1 and SPASE-2 were in operation to provide a stereo view of AMANDA. © 2003 Elsevier B.V. All rights reserved.

Published
2004

47. Status of the IceCube Neutrino Observatory

Author

Olga Botner, C. Pérez de los Heros, John N. Bahcall, T. Becka, Othmane Bouhali, K. Hultqvist, R. C. Bay, K. Rawlins, S. Yoshida, M. Ribordy, N. van Eijndhoven, Gerald Przybylski, W Carithers, A. C. Pohl, S. Hundertmark, J. Cavin, A. W. Jones, James Madsen, D. Steele, H. Kawai, C. P. McParland, H. S. Matis, Ph. Herquet, J. I. Lamoureux, G. W. Sullivan, Soebur Razzaque, R. Paulos, R. G. Stokstad, Anna Davour, A. Goldschmidt, R. Wischnewski, J. Pretz, Ph. Olbrechts, Francis Halzen, R. H. Minor, Kael Hanson, R. Ganugapati, T. Hauschildt, Janet Jacobsen, D. F. Cowen, M. Solarz, Marek Kowalski, K.-H. Becker, Adam Bouchta, R. Schwarz, R. M. Gunasingha, Y. Minaeva, S. Patton, P. B. Price, Paolo Desiati, Allan Hallgren, R.-R Wang, Christian Bohm, Michael Stamatikos, R. Hardtke, George Japaridze, David A. Schneider, J. A. Goodman, Kurt Woschnagg, Hakki Ögelman, P. Niessen, D. Hubert, Wolfgang Wagner, K. Helbing, D. Berley, G. C. Hill, Paul Evenson, Todor Stanev, I. Taboada, S. Schlenstedt, C. Wiedemann, Christian Spiering, P. O. Hulth, H. Miyamoto, Dmitry Chirkin, Elisa Resconi, D. Seckel, Jean Gallagher, L. Köpke, Heiko Geenen, A. R. Fazely, H. Leich, H. Wissing, S. Tilav, N. Kitamura, R. Nahnhauer, Elisa Bernardini, J. Ahrens, D. R. Nygren, T. Neunhöffer, C. Walck, T. Messarius, K. Schinarakis, P. Steffen, Albrecht Karle, Thomas K. Gaisser, Jodi Cooley, Xinhua Bai, Jan Conrad, T. Feser, Wolfgang Rhode, T. J. Sumner, T. Castermans, Peter Mészáros, C. De Clercq, W. Chinowsky, D. Bertrand, S. Richter, M. Hellwig, R. W. Ellsworth, H. G. Sander, B. Collin, I. Liubarsky, C. H. Wiebusch, R. Morse, T. Stezelberger, D. Hays, R. Ehrlich, S. Böser, A. J. Smith, K. H. Sulanke, T. Burgess, M. Kestel, T. DeYoung, E. Blaufuss, D. Z. Besson, D. J. Boersma, Glenn Spiczak, B. Hughey, R. Koch, and P. Miocinovic

Subjects
Physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Solar neutrino, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Astrophysics, Solar neutrino problem, IceCube Neutrino Observatory, law.invention, Telescope, Neutrino detector, Space and Planetary Science, law, Measurements of neutrino speed, High Energy Physics::Experiment, Neutrino, Neutrino astronomy
Abstract

The IceCube neutrino telescope, to be constructed near the Antarctic South Pole, represents the next generation of neutrino telescope. Its large 1 km3 size will make it uniquely sensitive to the detection of neutrinos from astrophysical sources. The current design of the detector is presented. The basic performance of the detector and its ability to search for neutrinos from various astrophysical sources has been studied using detailed simulations and is discussed.

Published
2004

48. Results from the AMANDA telescope

Author

J. Ahrens, X. Bai, S.W. Barwick, T. Becka, K.-H. Becker, E. Bernardini, D. Bertrand, F. Binon, A. Biron, S. Böser, O. Botner, O. Bouhali, T. Burgess, S. Carius, T. Castermans, D. Chirkin, J. Conrad, J. Cooley, D.F. Cowen, A. Davour, C. De Clercq, T. DeYoung, P. Desiati, J.-P. Dewulf, P. Ekström, T. Feser, T.K. Gaisser, R. Ganupati, M. Gaug, H. Geenen, L. Gerhardt, A. Goldschmidt, A. Hallgren, F. Halzen, K. Hanson, R. Hardtke, T. Hauschildt, M. Hellwig, Ph. Herquet, G.C. Hill, P.O. Hulth, K. Hultqvist, S. Hundertmark, J. Jacobsen, A. Karle, L. Köpke, K. Kuehn, M. Kowalski, J.I. Lamoureux, H. Leich, M. Leuthold, P. Lindahl, I. Liubarsky, J. Madsen, K. Mandli, P. Marciniewski, H.S. Matis, C.P. McParland, T. Messarius, Y. Minaeva, P. Miočinović, R. Morse, R. Nahnhauer, T. Neunhöffer, P. Niessen, D.R. Nygren, H. Ogelman, Ph. Olbrechts, C. Pérez de los Heros, A.C. Pohl, P.B. Price, G.T. Przybylski, K. Rawlins, E. Resconi, W. Rhode, M. Ribordy, S. Richter, J. Rodríguez Martino, H.-G. Sander, T. Schmidt, D. Schneider, K. Schinarakis, R. Schwarz, A. Silvestri, M. Solarz, G.M. Spiczak, C. Spiering, D. Steele, P. Steffen, R.G. Stokstad, P. Sudoff, K.-H. Sudoff, K.-H. Sulanke, I. Taboada, L. Thollander, S. Tilav, W. Wagner, C. Walck, C. Weinheimer, C.H. Wiebusch, C. Wiedemann, R. Wischnewski, H. Wissing, K. Woschnagg, G. Yodh, and S. Young

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Flux, Cosmic ray, Astrophysics, Particle detector, law.invention, Massless particle, Telescope, Neutrino detector, law, High Energy Physics::Experiment, Neutrino, Lepton
Abstract

We present results from the AMANDA high energy neutrino telescope located at the South Pole. They include measurements of the atmospheric neutrino flux, search for UHE point sources, and diffuse sources producing electromagnetic/hadronic showers at the detector or close to it.

Published
2003

49. Results from the Antarctic Muon and Neutrino Detector Array

Author

J. Ahrens, X. Bai, S.W. Barwick, T. Becka, K.-H. Becker, E. Bernaxdini, D. Bertrand, F. Binon, A. Birone, S. Böser, O. Botnerg, O. Bouhali, T. Burgess, S. Carius, T. Castermans, A. Chen, D. Chirkin, J. Conrad, J. Cooley, D.F. Cowen, A. Davour, C. De Clercq, T. DeYoung, P. Desiati, J.-P. Dewulf, P. Doksus, P. Ekström, T. Feser, T.K. Gaisser, M. Gaug, L. Gerhardt, A. Goldschmidt, A. Hallgren, F. Halzen, K. Hanson, R. Hardtke, T. Hauschildt, M. Hellwig, P. Herquet, G.C. Hill, P.O. Hulth, S. Hundertmark, J. Jacobsen, A. Karle, B. Koci, L. Köpke, K. Kuehn, M. Kowalski, J.I. Lamoureux, H. Leich, M. Leuthold, P. Lindahl, I. Liubarsky, J. Madsen, P. Marciniewski, H.S. Matis, C.P. McParland, Y. Minaeva, P. Miočinović, R. Morse, R. Nahnhauer, T. Neunhöffer, P. Niessen, D.R. Nygren, H. Ogelman, Ph. Olbrechts, C. Pérez de los Heros, A.C. Pohl, P.B. Price, G.T. Przybylski, K. Rawlins, E. Resconi, W. Rhode, M. Ribordy, S. Richter, J. Rodríguez Martino, D. Ross, H.-G. Sander, T. Schmidt, D. Schneider, R. Schwarz, A. Silvestri, M. Solarz, G.M. Spiczak, C. Spiering, D. Steele, P. Steffen, R.G. Stokstad, P. Sudhoff, K.-H. Sulanke, I. Taboada, L. Thollander, S. Tilav, C. Walck, C. Weinheimer, C.H. Wiebusch, C. Wiedemann, R. Wischnewski, H. Wissing, K. Woschnagg, G. Yodh, and S. Young

Subjects
Antarctic Muon And Neutrino Detector Array, Physics, Nuclear and High Energy Physics, Muon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Hadron, Detector, Flux, Astrophysics, Atomic and Molecular Physics, and Optics, Nuclear physics, High Energy Physics::Experiment, Muon neutrino, Ultrahigh energy, Neutrino
Abstract

We show new results from both the older and newer incarnations of AMANDA (AMANDA-B10 and AMANDA-II, respectively). These results demonstrate that AMANDA is a functioning, multipurpose detector with significant physics and astrophysics reach. They include a new higher-statistics measurement of the atmospheric muon neutrino flux and preliminary results from searches for a variety of sources of ultrahigh energy neutrinos: generic point sources, gamma-ray bursters and diffuse sources producing muons in the detector, and diffuse sources producing electromagnetic or hadronic showers in or near the detector.

Published
2003

50. RalA and RalB are Potential Therapeutic Targets in Multiple Myeloma Which Mediate Cell Survival Independently of Oncogenic RAS

Author

Torsten Steinbrunn, Manik Chatterjee, Andreas Rosenwald, Marcel Seibold, Hermann Einsele, Thorsten Stühmer, Nadine Schmiedl, Anja Mottok, Ellen Leich, Claus J. Scholz, and Ralf C. Bargou

Subjects
Cancer Research, RALB, Oncology, business.industry, Cancer research, Medicine, Hematology, business, medicine.disease, RALA, Cell survival, Multiple myeloma
Published
2017

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