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40 results on '"Lambrichts, Ivo"'

4. Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis

Author

Schepers, Melissa, primary, Paes, Dean, additional, Tiane, Assia, additional, Rombaut, Ben, additional, Piccart, Elisabeth, additional, van Veggel, Lieve, additional, Gervois, Pascal, additional, Wolfs, Esther, additional, Lambrichts, Ivo, additional, Brullo, Chiara, additional, Bruno, Olga, additional, Fedele, Ernesto, additional, Ricciarelli, Roberta, additional, ffrench-Constant, Charles, additional, Bechler, Marie E., additional, van Schaik, Pauline, additional, Baron, Wia, additional, Lefevere, Evy, additional, Wasner, Kobi, additional, Grünewald, Anne, additional, Verfaillie, Catherine, additional, Baeten, Paulien, additional, Broux, Bieke, additional, Wieringa, Paul, additional, Hellings, Niels, additional, Prickaerts, Jos, additional, and Vanmierlo, Tim, additional

Published
2023
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5. The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

Author

Vanherle, Sam, primary, Jorissen, Winde, additional, Dierckx, Tess, additional, Loix, Melanie, additional, Grajchen, Elien, additional, Mingneau, Fleur, additional, Guns, Jeroen, additional, Gervois, Pascal, additional, Lambrichts, Ivo, additional, Dehairs, Jonas, additional, Swinnen, Johannes V., additional, Mulder, Monique T., additional, Remaley, Alan T., additional, Haidar, Mansour, additional, Hendriks, Jerome J.A., additional, and Bogie, Jeroen J.F., additional

Published
2022
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11. Zoledronic Acid Induces Site-Specific Structural Changes and Decreases Vascular Area in the Alveolar Bone

Author

Soares, Mariana Quirino Silveira, primary, Van Dessel, Jeroen, additional, Jacobs, Reinhilde, additional, da Silva Santos, Paulo Sérgio, additional, Cestari, Tania Mary, additional, Garlet, Gustavo Pompermaier, additional, Duarte, Marco Antonio Hungaro, additional, Imada, Thaís Sumie Nozu, additional, Lambrichts, Ivo, additional, and Rubira-Bullen, Izabel Regina Fischer, additional

Published
2018
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13. SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

Author

García-León, Juan Antonio, primary, Kumar, Manoj, additional, Boon, Ruben, additional, Chau, David, additional, One, Jennifer, additional, Wolfs, Esther, additional, Eggermont, Kristel, additional, Berckmans, Pieter, additional, Gunhanlar, Nilhan, additional, de Vrij, Femke, additional, Lendemeijer, Bas, additional, Pavie, Benjamin, additional, Corthout, Nikky, additional, Kushner, Steven A., additional, Dávila, José Carlos, additional, Lambrichts, Ivo, additional, Hu, Wei-Shou, additional, and Verfaillie, Catherine M., additional

Published
2018
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15. Direct detection of nano-scale extracellular vesicles derived from inflammation-triggered endothelial cells using surface plasmon resonance

Author

Hosseinkhani, Baharak, primary, van den Akker, Nynke, additional, D'Haen, Jan, additional, Gagliardi, Mick, additional, Struys, Tom, additional, Lambrichts, Ivo, additional, Waltenberger, Johannes, additional, Nelissen, Inge, additional, Hooyberghs, Jef, additional, Molin, Daniel G.M., additional, and Michiels, Luc, additional

Published
2017
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17. Cardiac atrial appendage stem cells promote angiogenesis in vitro and in vivo

Author

Fanton, Yanick, primary, Houbrechts, Cynthia, additional, Willems, Leen, additional, Daniëls, Annick, additional, Linsen, Loes, additional, Ratajczak, Jessica, additional, Bronckaers, Annelies, additional, Lambrichts, Ivo, additional, Declercq, Jeroen, additional, Rummens, Jean-Luc, additional, Hendrikx, Marc, additional, and Hensen, Karen, additional

Published
2016
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38. The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

Author

Sam Vanherle, Winde Jorissen, Tess Dierckx, Melanie Loix, Elien Grajchen, Fleur Mingneau, Jeroen Guns, Pascal Gervois, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Monique T. Mulder, Alan T. Remaley, Mansour Haidar, Jerome J.A. Hendriks, Jeroen J.F. Bogie, Guns, Jeroen/0000-0003-0464-2601, VANHERLE, Sam, JORISSEN, Winde, DIERCKX, Tess, LOIX, Melanie, GRAJCHEN, Elien, MINGNEAU, Fleur, GUNS, Jeroen, GERVOIS, Pascal, LAMBRICHTS, Ivo, Dehairs, Jonas, Swinnen, Johannes, V, Mulder, Monique T., Remaley, Alan T., HAIDAR, Mansour, HENDRIKS, Jerome, BOGIE, Jeroen, and Internal Medicine

Subjects
Apolipoprotein A-I, Neuroscience [CP], phagocyte, lipid droplet degradation, myelin debris clearance, General Biochemistry, Genetics and Molecular Biology, remyelination, Remyelination, ApoA-I mimetic peptide 5A, Humans, Peptides, Myelin Sheath, Demyelinating Diseases
Abstract

The progressive nature of demyelinating diseases lies in the inability of the central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure of CNS remyelination. Extensive accumulation of myelin-derived lipids and an inability to process these lipids was found to induce a disease-promoting phagocyte phenotype. Hence, restoring the ability of these phagocytes to metabolize and efflux myelin-derived lipids represents a promising strategy to promote remyelination. Here, we show that ApoA-I mimetic peptide 5A, a molecule well known to promote activity of the lipid efflux transporter ABCA1, markedly enhances remyelination. Mechanistically, we find that the repair-inducing properties of 5A are attributable to increased clearance and metabolism of remyelination-inhibiting myelin debris via the fatty acid translocase protein CD36, which is transcriptionally controlled by the ABCA1-JAK2-STAT3 signaling pathway. Altogether, our findings indi-cate that 5A promotes remyelination by stimulating clearance and degradation of myelin debris. We thank M.P. Tulleners for excellent technical assistance. The work was financially supported by the Research Foundation of Flanders (FWO Vlaanderen; 1S15519N, G099618FWO, and 12J9119N) and the Interreg V-A EMR program (EURLIPIDS, EMR23). The funding agencies had no role in the design, analysis, or writing of the article.

Published
2022

39. Cardiac atrial appendage stem cells promote angiogenesis in vitro and in vivo

Author

Jean-Luc Rummens, Yanick Fanton, Marc Hendrikx, Ivo Lambrichts, Karen Hensen, Cynthia Houbrechts, Jessica Ratajczak, Annelies Bronckaers, Annick Daniëls, Loes Linsen, Leen Willems, Jeroen Declercq, FANTON, Yanick, Houbrechts, Cynthia, WILLEMS, Leen, Daniëls, Annick, LINSEN, Loes, RATAJCZAK, Jessica, BRONCKAERS, Annelies, LAMBRICHTS, Ivo, DECLERCQ, Jeroen, RUMMENS, Jean-Luc, HENDRIKX, Marc, and HENSEN, Karen

Subjects
Proteomics, Vascular Endothelial Growth Factor A, 0301 basic medicine, medicine.medical_specialty, Angiogenesis, medicine.medical_treatment, Neovascularization, Physiologic, Chick Embryo, 030204 cardiovascular system & hematology, Biology, Endothelial progenitor cell, Neovascularization, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, Atrial Appendage, Molecular Biology, Cells, Cultured, Tube formation, Endothelin-1, Stem Cells, Growth factor, angiogenesis, growth factors and cytokines, stem cell, cardiac progenitor cells, endothelial cell, Endothelial Cells, Vascular endothelial growth factor, Endothelial stem cell, Insulin-Like Growth Factor Binding Protein 3, 030104 developmental biology, Endocrinology, chemistry, Tissue Array Analysis, Culture Media, Conditioned, Cancer research, Angiogenesis Inducing Agents, Stem cell, medicine.symptom, Cardiology and Cardiovascular Medicine, Biomarkers
Abstract

Cardiac atrial appendage stem cells (CASCs) show extraordinary myocardial differentiation properties, making them ideal candidates for myocardial regeneration. However, since the myocardium is a highly vascularized tissue, revascularization of the ischemic infarct area is essential for functional repair. Therefore, this study assessed if CASCs contribute to cardiac angiogenesis via paracrine mechanisms. First, it was demonstrated that CASCs produce and secrete high levels of numerous angiogenic growth factors, including vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and insulin-like growth factor binding protein 3 (IGFBP-3). Functional in vitro assays with a human microvascular endothelial cell line (HMEC-1) and CASC CM showed that CASCs promote endothelial cell proliferation, migration and tube formation, the most important steps of the angiogenesis process. Addition of inhibitory antibodies against identified growth factors could significantly reduce these effects, indicating their importance in CASC-induced neovascularization. The angiogenic potential of CASCs and CASC CM was also confirmed in a chorioallantoic membrane assay, demonstrating that CASCs promote blood vessel formation in vivo. In conclusion, this study shows that CASCs not only induce myocardial repair by cardiomyogenic differentiation, but also stimulate blood vessel formation by paracrine mechanisms. The angiogenic properties of CASCs further strengthen their therapeutic potential and make them an optimal stem cell source for the treatment of ischemic heart disease. This work was supported by the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa (SALK 2014N002124); the foundation Limburg Sterk Merle (LSM-124); Hasselt University; Ziekenhuis Oost-Limburg and Jessa Hospital. In addition, support has been provided via a postdoctoral grant of the FWO (Research Foundation - Flanders) to Annelies Bronckaers, a DOC-PhD grant of Hasselt University for Yanick Fanton and a Ph.D. grant of the Agency for Innovation by Science and Technology in Flanders (IWT) for Leen Willems.

Published
2016

40. Photobiomodulation for the prevention of radiodermatitis: Preliminary results of a randomized controlled clinical trial in breast cancer patients

Author

Ivo Lambrichts, Paul Bulens, Lore Bussé, An Timmermans, Jolien Robijns, Niels Hellings, Stefan Claes, Veerle Somers, Jeroen Mebis, Sandrine Censabella, Annelies Maes, ROBIJNS, Jolien, Censabella, Sandrine, Claes, Stefan, Bussé, Lore, HELLINGS, Niels, LAMBRICHTS, Ivo, Timmermans, An, MAES, Annelies, BULENS, Paul, SOMERS, Veerle, and MEBIS, Jeroen

Subjects
medicine.medical_specialty, business.industry, Alternative medicine, Hematology, medicine.disease, Radiation dermatitis, laser therapy, photobiomodulation therapy, breast cancer, radiotherapy, language.human_language, Clinical trial, Flemish, Breast cancer, Oncology, Internal medicine, Physical therapy, language, Medicine, Radiodermatitis, business
Abstract

Background: The aim of our study was to investigate the efficacy of photobiomodulation therapy (PBMT) for the prevention of radiodermatitis (RD) in breast cancer patients. Methods: This is a randomized controlled, patient-blinded study with breast cancer patients that underwent an identical radiotherapy (RT) regime post-lumpectomy. A total of 57 patients were enrolled and randomly assigned to the intervention group to receive laser therapy (LT, n = 30) or the control group to receive a sham treatment (n = 27). LT or sham was applied two days a week, immediately after the RT session, starting at the first day of RT. LT was delivered using a class IV MLS® laser that combines two synchronized laser diodes in the infrared range (808-905 nm) with a fixed energy density (4 J/cm2). There were no significant differences between the two groups with respect to patient- and treatment-related characteristics. The skin reactions were evaluated by trained, blinded nurses at fraction 20 and at the end of RT (fraction 33) according to the criteria of the Radiation Therapy Oncology Group (RTOG). Results: At fraction 20 of RT the distribution of the RTOG grades was comparable between both groups ( p= .238), with most of the patients presenting RTOG grade 1. At the end of RT, the severity of RD significantly differed between the two groups ( p= .035), with a greater proportion of patients experiencing RD grade 2 or higher in the control group (30% vs. 7%, for the control and LT group, resp.). The skin reactions of the patients in the control group aggravated ( p= .006), while they remained stable in the LT group ( p= .205).Conclusions: In the control group the skin reactions developed into more severe forms (e.g. moist desquamation) towards the end of RT, whereas in the LT group the skin reactions remained stable. Results of this study show that PBMT is able to prevent aggravation of acute skin reactions of breast cancer patients undergoing RT. Hasselt University, Limburg Sterk Merk, Province of Limburg, Jessa Hospital, Flemish Government, Limburgs Kankerfonds, ASA srl

Published
2016

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