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152 results on '"LAN, Yue"'

33. Advances in bioorganic molecules inspired degradation and surface modifications on Mg and its alloys

Author

Lei Cai, Di Mei, Zhao-Qi Zhang, Yuan-ding Huang, Lan-Yue Cui, Shao-Kang Guan, Dong-Chu Chen, M. Bobby Kannan, Yu-feng Zheng, and Rong-Chang Zeng

Subjects
Mechanics of Materials, technology, industry, and agriculture, Metals and Alloys, equipment and supplies
Abstract

Mg alloys possess biodegradability, suitable mechanical properties, and biocompatibility, which make them possible to be used as biodegradable implants. However, the uncontrollable degradation of Mg alloys limits their general applications. In addition to the factors from the metallic materials themselves, like alloy compositions, heat treatment process and microstructure, some external factors, relating to the test/service environment, also affect the degradation rate of Mg alloys, such as inorganic salts, bioorganic small molecules, bioorganic macromolecules. The influence of bioorganic molecules on Mg corrosion and its protection has attracted more and more attentions. In this work, the cutting-edge advances in the influence of bioorganic molecules (i.e., protein, glucose, amino acids, vitamins and polypeptide) and their coupling effect on Mg degradation and the formation of protection coatings were reviewed. The research orientations of biomedical Mg alloys in exploring degradation mechanisms in vitro were proposed, and the impact of bioorganic molecules on the protective approaches were also explored.

Published
2022

41. Dealloying corrosion of anodic and nanometric Mg41Nd5 in solid solution-treated Mg-3Nd-1Li-0.2Zn alloy

Author

Lan-Yue Cui, Rong-Chang Zeng, Mei-Qi Zeng, M. Bobby Kannan, Gui-Jia Gao, Feng-Qin Wang, Daokui Xu, and En-Liang Zhang

Subjects
Kelvin probe force microscope, Materials science, Polymers and Plastics, Scanning electron microscope, Mechanical Engineering, Alloy, Metals and Alloys, 02 engineering and technology, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, 0104 chemical sciences, Corrosion, Chemical engineering, Mechanics of Materials, Materials Chemistry, Ceramics and Composites, engineering, Pitting corrosion, 0210 nano-technology, Polarization (electrochemistry), Solid solution
Abstract

The microstructure and chemical compositions of the solid solution-treated Mg-3Nd-1Li-0.2Zn alloy were characterized using optical microscope, scanning electron microscope (SEM), transmission electron microscope (TEM), electron probe micro-analyzer (EPMA) and X-ray photoelectron spectroscopy (XPS). The corrosion behaviour of the alloy was investigated via electrochemical polarization, electrochemical impedance spectroscopy (EIS), hydrogen evolution test and scanning Kelvin probe (SKP). The results showed that the microstructure of the as-extruded Mg-3Nd-1Li-0.2Zn alloy contained α-Mg matrix and nanometric second phase Mg41Nd5. The grain size of the alloy increased significantly with the increase in the heat-treatment duration, whereas the volume fraction of the second phase decreased after the solid solution treatment. The surface film was composed of oxides (Nd2O3, MgO, Li2O and ZnO) and carbonates (MgCO3 and Li2CO3), in addition to Nd. The as-extruded alloy exhibited the best corrosion resistance after an initial soaking of 10 min, whereas the alloy with 4h-solution-treatment possessed the lowest corrosion rate after a longer immersion (1 h). This can be attributed to the formation of Nd-containing oxide film on the alloys and a dense corrosion product layer. The dealloying corrosion of the second phase was related to the anodic Mg41Nd5 with a more negative Volta potential relative to α-Mg phase. The preferential corrosion of Mg41Nd5 is proven by in-situ observation and SEM. The solid solution treatment of Mg-3Nd-1Li-0.2Zn alloy led to a shift in corrosion type from pitting corrosion to uniform corrosion under long-term exposure.

Published
2021

45. Restoring Color Perception to the Blind

Author

Lan Yue, Mark S. Humayun, Alejandra Calle Gonzalez, Johnny Castillo, and Jay Neitz

Subjects
Brightness, medicine.medical_specialty, Visual perception, genetic structures, business.industry, Color vision, Audiology, Color space, Visual processing, Ophthalmology, Phosphene, Visual prosthesis, Medicine, sense organs, business, Hue
Abstract

Purpose Bioelectronic retinal prostheses that stimulate the remaining inner retinal neurons, bypassing degenerated photoreceptors, have been demonstrated to restore some vision in patients blinded by retinitis pigmentosa (RP). These implants encode luminance of the visual scene into electrical stimulation, however, leaving out chromatic information. Yet color plays an important role in visual processing when it comes to recognizing objects and orienting to the environment, especially at low spatial resolution as generated by current retinal prostheses. In this study, we tested the feasibility of partially restoring color perception in blind RP patients, with the aim to provide chromatic information as an extra visual cue. Design Case series. Participants Seven subjects blinded by advanced RP and monocularly fitted with an epiretinal prosthesis. Methods Frequency-modulated electrical stimulation of retina was tested. Phosphene brightness was controlled by amplitude tuning, and color perception was acquired using the Red, Yellow, Green, and Blue (RYGB) hue and saturation scaling model. Main Outcome Measures Brightness and color of the electrically elicited visual perception reported by the subjects. Results Within the tested parameter space, 5 of 7 subjects perceived chromatic colors along or nearby the blue-yellow axis in color space. Aggregate data obtained from 20 electrodes of the 5 subjects show that an increase of the stimulation frequency from 6 to 120 Hz shifted color perception toward blue/purple despite a significant inter-subject variation in the transition frequency. The correlation between frequency and blue-yellow perception exhibited a good level of consistency over time and spatially matched multi-color perception was possible with simultaneous stimulation of paired electrodes. No obvious correlation was found between blue sensations and array placement or status of visual impairment. Conclusions These findings present a strategy for the generation and control of color perception along the blue-yellow axis in blind patients with RP by electrically stimulating the retina. It could transform the current prosthetic vision landscape by leading in a new direction beyond the efforts to improve the visual acuity. This study also offers new insights into the response of our visual system to electrical stimuli in the photoreceptor-less retina that warrant further mechanistic investigation.

Published
2021

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