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1. FRI-078-YI Long-term albumin administration in outpatients with decompensated cirrhosis and diabetes mellitus: post-hoc analysis of the ANSWER trial database

Author

Iannone, Giulia, primary, Zaccherini, Giacomo, additional, Pompili, Enrico, additional, Tedesco, Greta, additional, De Venuto, Clara, additional, Baldassarre, Maurizio, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Caraceni, Paolo, additional, and Bernardi, Mauro, additional

Published
2024
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2. Venous thromboembolism in pancreatic neuroendocrine neoplasm: a cohort study

Author

Gervaso, Lorenzo, primary, Laffi, Alice, additional, Gaeta, Aurora, additional, Gandini, Sara, additional, Boldrini, Laura, additional, Meneses-Medina, Monica Isabel, additional, Rubino, Manila, additional, Benini, Lavinia, additional, Borghesani, Michele, additional, Algeri, Laura, additional, Curigliano, Giuseppe, additional, Spada, Francesca, additional, Cella, Chiara Alessandra, additional, and Fazio, Nicola, additional

Published
2024
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3. Complications of left bundle branch area pacing compared with biventricular pacing in candidates for resynchronization therapy: Results of a propensity score-matched analysis from a multicenter registry

Author

Palmisano, Pietro, primary, Dell’Era, Gabriele, additional, Guerra, Federico, additional, Ammendola, Ernesto, additional, Ziacchi, Matteo, additional, Laffi, Mattia, additional, Donateo, Paolo, additional, Guido, Alessandro, additional, Ghiglieno, Chiara, additional, Parlavecchio, Antonio, additional, Russo, Antonio Dello, additional, Nigro, Gerardo, additional, Biffi, Mauro, additional, Gaggioli, Germano, additional, Senes, Jacopo, additional, Patti, Giuseppe, additional, Accogli, Michele, additional, and Coluccia, Giovanni, additional

Published
2024
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4. Prognostic value of mitotic count in leiomyosarcoma: A comprehensive monocentric retrospective study

Author

Grimaudo, Maria Susanna, primary, Renne, Salvatore Lorenzo, additional, Colombo, Piergiuseppe, additional, Giordano, Laura, additional, Gennaro, Nicolò, additional, Laffi, Alice, additional, Cariboni, Umberto, additional, Cananzi, Ferdinando Carlo Maria, additional, Ruspi, Laura, additional, Santoro, Armando, additional, and Bertuzzi, Alexia Francesca, additional

Published
2023
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5. Always look behind the rock: a case of an insulinoma hidden by a pancreatic stone

Author

Andreozzi, Marta, primary, Spadaccini, Marco, additional, Colombo, Matteo, additional, Capretti, Giovanni, additional, Spaggiari, Paola, additional, Di Tommaso, Luca, additional, Laffi, Alice, additional, Lania, Andrea, additional, Lavezzi, Elisabetta, additional, Ferrillo, Giuseppe, additional, Pedicini, Vittorio, additional, Rodari, Marcello, additional, Zerbi, Alessandro, additional, Fugazza, Alessandro, additional, Repici, Alessandro, additional, and Carrara, Silvia, additional

Published
2023
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6. Effectiveness of MicroShunt in Patients with Primary Open-Angle and Pseudoexfoliative Glaucoma

Author

Leon Au, Antonio Maria Fea, E. Martini, Matteo Sacchi, Gian Luca Laffi, Mario A. Economou, and Paolo Caselgrandi

Subjects
Intraocular pressure, medicine.medical_specialty, genetic structures, Minimally invasive glaucoma surgery, Open angle glaucoma, business.industry, medicine.medical_treatment, Glaucoma, Retrospective cohort study, General Medicine, medicine.disease, eye diseases, Ophthalmology, medicine, Glaucoma surgery, Trabeculectomy, sense organs, business, Hyphema
Abstract

PURPOSE To evaluate the effectiveness and safety of the Preserflo MicroShunt implant (Santen) in patients with primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). DESIGN Retrospective, open-label, multicenter study. PARTICIPANTS Patients with insufficiently controlled primary POAG or PXG who underwent a standalone MicroShunt implantation procedure. METHODS Consecutive patients with POAG and PXG who underwent surgery with the ab externo minimally invasive glaucoma surgery device Preserflo MicroShunt with mitomycin C. MAIN OUTCOME MEASURES Primary end points were mean change in intraocular pressure (IOP) and number of hypotensive medications from baseline through month 12. Success was defined as an IOP of 18 mmHg or less and an IOP reduction of 20% or more, with (qualified) or without (complete) any hypotensive medication. RESULTS Among the 130 patients who underwent MicroShunt implantation, 104 fulfilled the inclusion and exclusion criteria and were included in the analysis. Eighty-one eyes (77.9%) were diagnosed with POAG and 23 eyes (22.1%) were diagnosed with PXG. The mean age was 71.4 ± 12.6 years, and 45 patients (43.3%) were women. Mean IOP was lowered significantly from 25.1 ± 6.5 mmHg at baseline to 14.1 ± 3.4 mmHg at month 12 (P < 0.0001). At month 12, 27 eyes (26.0%) were categorized as complete successes and 61 eyes (58.7%) were categorized as qualified successes. The mean number of hypotensive medications was reduced significantly from 3.0 ± 1.0 medications at the preoperative visit to 0.77 ± 0.95 medication at month 12 (P < 0.001). Throughout the study, 19 eyes (18.3%) required needling and 14 eyes (13.5%) underwent surgical revision. Eight eyes (7.7%) showed hyphema and 5 eyes (4.8%) showed choroidal detachment. These were resolved with medical therapy without sequelae. Four patients underwent subsequent surgeries, and 2 patients underwent trabeculectomy (at months 3 and 6): One patient underwent transscleral cyclophotocoagulation at month 3 and 1 patient underwent MicroPulse cyclophotocoagulation at month 4. CONCLUSIONS In this retrospective study, the MicroShunt effectively lowered IOP and the need for IOP-lowering medications.

Published
2022

7. Management of older patients with unexplained, recurrent, traumatic syncope and bifascicular block: Implantable loop recorder versus empiric pacemaker implantation—Results of a propensity-matched analysis

Author

Palmisano, Pietro, primary, Guerra, Federico, additional, Aspromonte, Vittorio, additional, Dell’Era, Gabriele, additional, Pellegrino, Pier Luigi, additional, Laffi, Mattia, additional, Uran, Carlo, additional, De Bonis, Silvana, additional, Accogli, Michele, additional, Dello Russo, Antonio, additional, Patti, Giuseppe, additional, Santoro, Francesco, additional, Torriglia, Antonella, additional, Nigro, Gerardo, additional, Bisignani, Antonio, additional, Coluccia, Giovanni, additional, Stronati, Giulia, additional, Russo, Vincenzo, additional, and Ammendola, Ernesto, additional

Published
2022
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8. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Caraceni, P, Tufoni, M, Zaccherini, G, Riggio, O, Angeli, P, Alessandria, C, Neri, S, Foschi, F, Levantesi, F, Airoldi, A, Simone, L, Svegliati-Baroni, G, Fagiuoli, S, Laffi, G, Cozzolongo, R, Di Marco, V, Sangiovanni, V, Morisco, F, Toniutto, P, Gasbarrini, A, De Marco, R, Piano, S, Nardelli, S, Elia, C, Roncadori, A, Baldassarre, M, Bernardi, M, Domenicali, M, Giannone, F, Antognoli, A, Merli, M, Pasquale, C, Gioia, S, Fasolato, S, Sticca, A, Campion, D, Risso, A, Saracco, G, Prestianni, L, Fidone, F, Maiorca, D, Rizzotto, A, Cappa, F, Lanzi, A, Neri, E, Visani, A, Mastroianni, A, Perricone, G, Alberti, A, Cesarini, L, Mazzarelli, C, Vangeli, M, Vigano, R, Marzioni, M, Capretti, F, Kostandini, A, Magini, G, Colpani, M, Gabbani, T, Marsico, M, Zappimbulso, M, Petruzzi, J, Calvaruso, V, Parrella, G, Caporaso, N, Auriemma, F, Guarino, M, Pugliese, F, Tortora, A, Leo, P, Angelico, M, De Leonardis, F, Pecchioli, A, Rossi, P, Raimondo, G, Cacciola, I, Elia, G, Negri, E, Dallio, M, Loguercio, C, Federico, A, Conte, D, Massironi, S, Natascia Celli, G, Rendina, M, Bringiotti, R, Castellaneta, N, Salerno, F, Boccia, S, Guarisco, R, Galioto, A, Cavallin, M, Andrealli, A, Caraceni P., Tufoni M., Zaccherini G., Riggio O., Angeli P., Alessandria C., Neri S., Foschi F. G., Levantesi F., Airoldi A., Simone L., Svegliati-Baroni G., Fagiuoli S., Laffi G., Cozzolongo R., Di Marco V., Sangiovanni V., Morisco F., Toniutto P., Gasbarrini A., De Marco R., Piano S., Nardelli S., Elia C., Roncadori A., Baldassarre M., Bernardi M., Domenicali M., Giannone F. A., Antognoli A., Merli M., Pasquale C., Gioia S., Fasolato S., Sticca A., Campion D., Risso A., Saracco G. M., Prestianni L., Fidone F., Maiorca D., Rizzotto A., Cappa F. M., Lanzi A., Neri E., Visani A., Mastroianni A., Perricone G., Alberti A. B., Cesarini L., Mazzarelli C., Vangeli M., Vigano R., Marzioni M., Capretti F., Kostandini A., Magini G., Colpani M., Gabbani T., Marsico M., Zappimbulso M., Petruzzi J., Calvaruso V., Parrella G., Caporaso N., Auriemma F., Guarino M., Pugliese F., Tortora A., Leo P., Angelico M., De Leonardis F., Pecchioli A., Rossi P., Raimondo G., Cacciola I., Elia G., Negri E., Dallio M., Loguercio C., Federico A., Conte D., Massironi S., Natascia Celli G. B., Rendina M., Bringiotti R., Castellaneta N. M., Salerno F., Boccia S., Guarisco R., Galioto A., Cavallin M., Andrealli A., Caraceni, P, Tufoni, M, Zaccherini, G, Riggio, O, Angeli, P, Alessandria, C, Neri, S, Foschi, F, Levantesi, F, Airoldi, A, Simone, L, Svegliati-Baroni, G, Fagiuoli, S, Laffi, G, Cozzolongo, R, Di Marco, V, Sangiovanni, V, Morisco, F, Toniutto, P, Gasbarrini, A, De Marco, R, Piano, S, Nardelli, S, Elia, C, Roncadori, A, Baldassarre, M, Bernardi, M, Domenicali, M, Giannone, F, Antognoli, A, Merli, M, Pasquale, C, Gioia, S, Fasolato, S, Sticca, A, Campion, D, Risso, A, Saracco, G, Prestianni, L, Fidone, F, Maiorca, D, Rizzotto, A, Cappa, F, Lanzi, A, Neri, E, Visani, A, Mastroianni, A, Perricone, G, Alberti, A, Cesarini, L, Mazzarelli, C, Vangeli, M, Vigano, R, Marzioni, M, Capretti, F, Kostandini, A, Magini, G, Colpani, M, Gabbani, T, Marsico, M, Zappimbulso, M, Petruzzi, J, Calvaruso, V, Parrella, G, Caporaso, N, Auriemma, F, Guarino, M, Pugliese, F, Tortora, A, Leo, P, Angelico, M, De Leonardis, F, Pecchioli, A, Rossi, P, Raimondo, G, Cacciola, I, Elia, G, Negri, E, Dallio, M, Loguercio, C, Federico, A, Conte, D, Massironi, S, Natascia Celli, G, Rendina, M, Bringiotti, R, Castellaneta, N, Salerno, F, Boccia, S, Guarisco, R, Galioto, A, Cavallin, M, Andrealli, A, Caraceni P., Tufoni M., Zaccherini G., Riggio O., Angeli P., Alessandria C., Neri S., Foschi F. G., Levantesi F., Airoldi A., Simone L., Svegliati-Baroni G., Fagiuoli S., Laffi G., Cozzolongo R., Di Marco V., Sangiovanni V., Morisco F., Toniutto P., Gasbarrini A., De Marco R., Piano S., Nardelli S., Elia C., Roncadori A., Baldassarre M., Bernardi M., Domenicali M., Giannone F. A., Antognoli A., Merli M., Pasquale C., Gioia S., Fasolato S., Sticca A., Campion D., Risso A., Saracco G. M., Prestianni L., Fidone F., Maiorca D., Rizzotto A., Cappa F. M., Lanzi A., Neri E., Visani A., Mastroianni A., Perricone G., Alberti A. B., Cesarini L., Mazzarelli C., Vangeli M., Vigano R., Marzioni M., Capretti F., Kostandini A., Magini G., Colpani M., Gabbani T., Marsico M., Zappimbulso M., Petruzzi J., Calvaruso V., Parrella G., Caporaso N., Auriemma F., Guarino M., Pugliese F., Tortora A., Leo P., Angelico M., De Leonardis F., Pecchioli A., Rossi P., Raimondo G., Cacciola I., Elia G., Negri E., Dallio M., Loguercio C., Federico A., Conte D., Massironi S., Natascia Celli G. B., Rendina M., Bringiotti R., Castellaneta N. M., Salerno F., Boccia S., Guarisco R., Galioto A., Cavallin M., and Andrealli A.

Abstract

Background & Aims: The ANSWER study reported that long-term albumin administration in patients with cirrhosis and uncomplicated ascites improves survival. During treatment, serum albumin increased within a month and remained stable thereafter. In this post hoc analysis, we aimed to determine whether on-treatment serum albumin levels could guide therapy. Methods: Logistic regression was used to assess the association between baseline serum albumin and mortality, as well as to determine on-treatment factors associated with mortality and to predict the achievement of a given on-treatment serum albumin level. Survival was assessed by Kaplan-Meier estimates and second-order polynomial regression. Patients whose on-treatment serum albumin remained below normal were compared with a subset of patients from the control arm matched by principal score. Results: Baseline serum albumin was closely associated with 18-month mortality in untreated patients; albumin treatment almost effaced this relationship. On-treatment serum albumin and MELD-Na at month 1 were the sole independent variables associated with mortality. Second-order polynomial regression revealed that survival improved in parallel with increased 1-month on-treatment serum albumin. Kaplan-Meier estimations showed that any value of 1-month on-treatment serum albumin (0.1 g/dl intervals) in the range 2.5–4.5 g/dl discriminated patient survival. In the normal range of serum albumin, the best discriminant value was 4.0 g/dl. Compared to untreated patients, survival even improved in patients whose on-treatment serum albumin remained below normal. Conclusion: Baseline serum albumin per se should not guide the decision to start albumin therapy. Conversely, 1-month on-treatment serum albumin levels are strongly associated with outcomes and could guide the use of albumin – 4.0 g/dl being the target threshold. However, even patients whose serum albumin remains below normal benefit from long-term albumin administration. Lay

Published
2021

9. Causes of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: Findings from the SYNCOPACED registry

Author

Gabriele Dell'Era, Natale Daniele Brunetti, Enrico Boggio, Pier Luigi Pellegrino, Antonio Dello Russo, Germano Gaggioli, Alessandro Guido, Mauro Biffi, Gerardo Nigro, Ernesto Ammendola, Giuseppe Patti, Mattia Laffi, Matteo Ziacchi, Federico Guerra, Pietro Palmisano, Vittorio Aspromonte, Lorenzo Pimpini, Cardiac Pacing, Michele Accogli, and Francesco Santoro

Subjects
Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, Syncope, Bifascicular block, 03 medical and health sciences, Orthostatic vital signs, 0302 clinical medicine, Heart Rate, Recurrence, Physiology (medical), Internal medicine, medicine, Humans, In patient, Prospective Studies, Registries, 030212 general & internal medicine, Vasovagal syncope, Collapse (medical), Aged, biology, business.industry, Incidence, Cardiac Pacing, Artificial, Syncope (genus), Atrial fibrillation, medicine.disease, biology.organism_classification, Italy, Chronic Disease, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Atrioventricular block, Follow-Up Studies
Abstract

Background Few studies have examined the causes of syncope/collapse recurrences in patients with a previously implanted pacemaker for bradyarrhythmic syncope. Objective The purpose of this study was to assess the causes of syncope/collapse recurrences after pacemaker implantation for bradyarrhythmic syncope in a large patient population. Methods The SYNCOpal recurrences in patients treated with permanent PACing for bradyarrhythmic syncope (SYNCOPACED) registry was a prospective multicenter observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation for bradyarrhythmic syncope. During follow-up, the time to the first syncope/collapse recurrence was recorded. Patients with syncope/collapse recurrences underwent a predefined diagnostic workup aimed at establishing the mechanism of syncope/collapse. Results During a median follow-up of 50 months, 213 patients (15.6%) reported at least 1 syncope/collapse recurrence. The risk of syncope/collapse recurrence was highest in patients who underwent implantation for cardioinhibitory vasovagal syncope (26.4%), followed by unexplained syncope and chronic bifascicular block (21.5%), cardioinhibitory carotid sinus syndrome (17.2%), atrial fibrillation needing pacing (15.5%), atrioventricular block (13.6%), and sinus node disease (12.5%) (P = .017). The most frequent cause of syncope/collapse recurrence was reflex syncope (27.7%), followed by orthostatic hypotension (26.3%), pacemaker or lead malfunction (5.6%), structural cardiac disease (5.2%), and atrial and ventricular tachyarrhythmias (4.7% and 3.8%, respectively). In 26.8% of cases, the mechanism of syncope/collapse remained unexplained. Conclusion In patients receiving a pacemaker for bradyarrhythmic syncope, reflex syncope and orthostatic hypotension are the most frequent mechanisms of syncope/collapse recurrence after implantation. Pacing system malfunction, structural cardiac diseases, and tachyarrhythmias are rare mechanisms. The mechanism remains unexplained in >25% of patients.

Published
2021

10. Correction and prevention of hyponatremia in patients with cirrhosis and ascites-post hoc analysis of the ANSWER study database

Author

Zaccherini, Giacomo, primary, Baldassarre, Maurizio, additional, Tufoni, Manuel, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco Giuseppe, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Bernardi, Mauro, additional, and Caraceni, Paolo, additional

Published
2022
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13. Transjugular Intrahepatic Portosystemic Shunt does not affect the efficacy and safety of direct-acting antivirals in patients with advanced cirrhosis: A real-life, case-control study

Author

Pietro Andreone, Silvia Aspite, Claudia Campani, Francesco Vizzutti, Fabio Marra, Pasquale Apolito, Sinan Sadalla, Filippo Schepis, A. Scuteri, Laura Turco, Stefano Gitto, Fabio Conti, Giacomo Laffi, Federica Lombardo, Umberto Arena, Giovanni Vitale, Erica Villa, Fabrizio Fanelli, W. Debernardi-Venon, Gitto S., Vizzutti F., Schepis F., Turco L., Aspite S., Vitale G., Arena U., Villa E., Laffi G., Debernardi-Venon W., Fanelli F., Andreone P., Marra F., Apolito P., Campani C., Sadalla S., Lombardo F., Conti F., and Scuteri A.

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis complication, medicine.medical_treatment, Kaplan-Meier Estimate, Antiviral therapy, Advanced liver disease, Cirrhosis complications, Portal hypertension, Hepatology, Gastroenterology, Logistic regression, Antiviral Agents, Severity of Illness Index, End Stage Liver Disease, 03 medical and health sciences, Liver disease, Postoperative Complications, 0302 clinical medicine, Internal medicine, Hypertension, Portal, medicine, Humans, Adverse effect, Aged, Univariate analysis, business.industry, Case-control study, Middle Aged, medicine.disease, Hepatitis C, Logistic Models, Treatment Outcome, Italy, Case-Control Studies, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Portasystemic Shunt, Transjugular Intrahepatic, business, Transjugular intrahepatic portosystemic shunt
Abstract

Background Transjugular Intrahepatic Portosystemic Shunt (TIPS) is a well-established treatment for complications of portal hypertension. Aims To analyze the impact of TIPS on virologic response and safety profile in patients treated with direct-acting antivirals (DAAs). Methods We analyzed data from HCV-positive cirrhotic patients treated with DAAs. Twenty-one patients with previous TIPS placement were compared with 42 matched subjects without TIPS. Logistic regression was used to identify predictors of hepatic function worsening and adverse events. Results No differences were found between the two groups in particular regarding sustained virologic response (92.5 and 97.6% in TIPS vs no-TIPS, p = 0.559). Model for End-stage Liver Disease (MELD) of both TIPS and no-TIPS groups declined from baseline to week 24 of follow-up (from 12.5 ± 3.5 to 10.8 ± 3.4 and from 11.1 ± 3.5 to 10.3 ± 3.4, p = 0.044 and 0.025). There were no differences in adverse event rates. At univariate analysis, age was associated with MELD increase from baseline to week 24 (OR 1.111, 95% CI 1.019-1.211, p = 0.017), and patients with higher baseline MELD developed serious adverse events more frequently (OR 0.815, 95% CI 0.658–1.010, p = 0.062). Patients with or without TIPS did not show differences in transplant-free survival. Conclusion TIPS placement does not affect virologic response and clinical outcome of patients receiving DAAs.

Published
2019

14. A calibration methodology for light sources aimed at using immersive virtual reality game engine as a tool for lighting design in buildings

Author

Michelangelo Scorpio, Roberta Laffi, Ainoor Teimoorzadeh, Giovanni Ciampi, Massimiliano Masullo, Sergio Sibilio, Scorpio, M., Laffi, R., Teimoorzadeh, A., Ciampi, G., Masullo, M., and Sibilio, S.

Subjects
DIALux evo, Immersive virtual reality, Unreal game engine, Mechanics of Materials, Building performance, Innovative lighting design, Architecture, Building and Construction, Safety, Risk, Reliability and Quality, Civil and Structural Engineering
Abstract

Immersive virtual reality represents one of the most promising technologic aids in the development of a functional lighting design, especially when considering different points of view as users’ satisfaction. This paper presents a new methodology to use Unreal Engine 4.22 as a tool for lighting applications, allowing correct reproduction of artificial light distribution in the game engine by identifying and properly setting a restricted set of parameters. A real office was carefully reproduced, in both the Unreal Engine and DIALux evo software, as comparative case study. Then, the luminance distribution is calculated with both programs on the same surfaces in the virtual environment and compared with the real one. The results suggest a good reliability of the Unreal Engine in reproducing the light distribution, underlining slight differences under certain conditions. In light of these findings, the proposed method seems to validate the use of Unreal Engine as a light design tool.

Published
2022

15. Long-term albumin administration eases the management of hyponatremia in outpatients with decompensated cirrhosis: data from the ANSWER Trial

Author

Zaccherini, G., primary, Baldassarre, M., additional, Tufoni, M., additional, Riggio, O., additional, Angeli, P., additional, Alessandria, C., additional, Neri, S., additional, Foschi, F.G., additional, Levantesi, F., additional, Airoldi, A., additional, Simone, L., additional, Svegliati-Baroni, G., additional, Fagiuoli, S., additional, Laffi, G., additional, Cozzolongo, R., additional, Di Marco, V., additional, Sangiovanni, V., additional, Morisco, F., additional, Toniutto, P., additional, Tortora, A., additional, De Marco, R., additional, Nardelli, S., additional, Piano, S., additional, Elia, C., additional, Bernardi, M., additional, and Caraceni, P., additional

Published
2022
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17. Correction and prevention of hyponatremia in patients with cirrhosis and ascites-post hoc analysis of the ANSWER study database

Author

Giacomo Zaccherini, Baldassarre, Maurizio, Tufoni, Manuel, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco Giuseppe, Levantesi, Fabio, Airoldi, Aldo, Simone, Loredana, Svegiati-Baroni, Gianluca, Fagiuoli, Stefano, Laffi, Giacomo, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, Marco, Rosanna, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Bernardi, Mauro, and Caraceni, Paolo

Subjects
Hepatology
Published
2022

19. Material deprivation affects the management and clinical outcome of hepatocellular carcinoma in a high-resource environment

Author

Cucchetti, Alessandro, primary, Gramenzi, Annagiulia, additional, Johnson, Philip, additional, Giannini, Edoardo G., additional, Tovoli, Francesco, additional, Rapaccini, Gian Ludovico, additional, Marra, Fabio, additional, Cabibbo, Giuseppe, additional, Caturelli, Eugenio, additional, Gasbarrini, Antonio, additional, Svegliati-Baroni, Gianluca, additional, Sacco, Rodolfo, additional, Zoli, Marco, additional, Morisco, Filomena, additional, Di Marco, Maria, additional, Mega, Andrea, additional, Foschi, Francesco G., additional, Biasini, Elisabetta, additional, Masotto, Alberto, additional, Nardone, Gerardo, additional, Raimondo, Giovanni, additional, Azzaroli, Francesco, additional, Vidili, Gianpaolo, additional, Brunetto, Maurizia R., additional, Farinati, Fabio, additional, Trevisani, Franco, additional, Avanzato, Francesca, additional, Biselli, Maurizio, additional, Caraceni, Paolo, additional, Garuti, Francesca, additional, Neri, Andrea, additional, Santi, Valentina, additional, Pellizzaro, Filippo, additional, Imondi, Angela, additional, Sartori, Anna, additional, Penzo, Barbara, additional, Sanmarco, Ambra, additional, Granito, Alessandro, additional, Muratori, Luca, additional, Piscaglia, Fabio, additional, Sansone, Vito, additional, Forgione, Antonella, additional, Dajti, Elton, additional, Marasco, Giovanni, additional, Ravaioli, Federico, additional, Cappelli, Alberta, additional, Golfieri, Rita, additional, Mosconi, Cristina, additional, Renzulli, Matteo, additional, Cela, Ester Marina, additional, Facciorusso, Antonio, additional, Cacciato, Valentina, additional, Casagrande, Edoardo, additional, Moscatelli, Alessandro, additional, Pellegatta, Gaia, additional, de Matthaeis, Nicoletta, additional, Allegrini, Gloria, additional, Lauria, Valentina, additional, Ghittoni, Giorgia, additional, Pelecca, Giorgio, additional, Chegai, Fabrizio, additional, Coratella, Fabio, additional, Ortenzi, Mariano, additional, Missale, Gabriele, additional, Olivani, Andrea, additional, Inno, Alessandro, additional, Marchetti, Fabiana, additional, Busacca, Anita, additional, Cammà, Calogero, additional, Di Martino, Vincenzo, additional, Maria Rizzo, Giacomo Emanuele, additional, Franzè, Maria Stella, additional, Saitta, Carlo, additional, Sauchella, Assunta, additional, Berardinelli, Dante, additional, Bevilacqua, Vittoria, additional, Borghi, Alberto, additional, Gardini, Andrea Casadei, additional, Conti, Fabio, additional, Dall'Aglio, Anna Chiara, additional, Ercolani, Giorgio, additional, Adotti, Valentina, additional, Arena, Umberto, additional, Di Bonaventura, Chiara, additional, Campani, Claudia, additional, Dragoni, Gabriele, additional, Gitto, Stefano, additional, Laffi, Giacomo, additional, Coccoli, Pietro, additional, Malerba, Antonio, additional, Guarino, Maria, additional, Capasso, Maria, additional, Oliveri, Filippo, additional, and Romagnoli, Veronica, additional

Published
2021
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20. Long-term albumin administration eases the management of hyponatremia in outpatients with decompensated cirrhosis: data from the ANSWER Trial

Author

G. Zaccherini, M. Baldassarre, M. Tufoni, O. Riggio, P. Angeli, C. Alessandria, S. Neri, F.G. Foschi, F. Levantesi, A. Airoldi, L. Simone, G. Svegliati-Baroni, S. Fagiuoli, G. Laffi, R. Cozzolongo, V. Di Marco, V. Sangiovanni, F. Morisco, P. Toniutto, A. Tortora, R. De Marco, S. Nardelli, S. Piano, C. Elia, M. Bernardi, and P. Caraceni

Subjects
Hepatology, Gastroenterology
Published
2022

21. Corrigendum to ‘Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study’ [European Journal of Cancer 154 (2021) 246-252]

Author

Fazio, Nicola, primary, Gervaso, Lorenzo, additional, Halfdanarson, Thorvardur R., additional, La Salvia, Anna, additional, Hofland, Johannes, additional, Hernando, Jorge, additional, Sonbol, Mohamad B., additional, Garcia-Carbonero, Rocio, additional, Capdevila, Jaume, additional, de Herder, Wouter W., additional, Koumarianou, Anna, additional, Kaltsas, Gregory, additional, Rossi, Maura, additional, Grozinsky-Glasberg, Simona, additional, Oleinikov, Kira, additional, Boselli, Sabrina, additional, Tamayo, Darina, additional, Bagnardi, Vincenzo, additional, Laffi, Alice, additional, Rubino, Manila, additional, and Spada, Francesca, additional

Published
2021
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23. Should temozolomide be used on the basis of O6-methylguanine DNA methyltransferase status in patients with advanced neuroendocrine tumors? A systematic review and meta-analysis

Author

Trillo Aliaga, P., primary, Spada, F., additional, Peveri, G., additional, Bagnardi, V., additional, Fumagalli, C., additional, Laffi, A., additional, Rubino, M., additional, Gervaso, L., additional, Guerini Rocco, E., additional, Pisa, E., additional, Curigliano, G., additional, and Fazio, N., additional

Published
2021
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24. Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study

Author

Fazio, Nicola, primary, Gervaso, Lorenzo, additional, Halfdanarson, Thorvardur R., additional, La Salvia, Anna, additional, Hofland, Johannes, additional, Hernando, Jorge, additional, Sonbol, Mohamad B., additional, Garcia-Carbonero, Rocio, additional, Capdevila, Jaume, additional, de Herder, Wouter W., additional, Koumarianou, Anna, additional, Kaltsas, Gregory, additional, Rossi, Maura, additional, Grozinsky-Glasberg, Simona, additional, Oleinikov, Kira, additional, Boselli, Sabrina, additional, Tamayo, Darina, additional, Bagnardi, Vincenzo, additional, Laffi, Alice, additional, Rubino, Manila, additional, and Spada, Francesca, additional

Published
2021
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25. Corrigendum to ‘Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study’ [European Journal of Cancer 154 (2021) 246-252]

Author

Rocio Garcia-Carbonero, Alice Laffi, Wouter W. de Herder, Manila Rubino, Gregory Kaltsas, Thorvardur R. Halfdanarson, Simona Grozinsky-Glasberg, Johannes Hofland, Kira Oleinikov, Jaume Capdevila, J. Hernando, S. Boselli, D. Tamayo, Lorenzo Gervaso, Mohamad Bassam Sonbol, Francesca Spada, Vincenzo Bagnardi, Anna La Salvia, Anna Koumarianou, Nicola Fazio, and Maura Rossi

Subjects
Cancer Research, 2019-20 coronavirus outbreak, Oncology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medicine, Cancer, In patient, business, medicine.disease, Virology
Published
2022

26. Should temozolomide be used on the basis of O6-methylguanine DNA methyltransferase status in patients with advanced neuroendocrine tumors? A systematic review and meta-analysis

Author

Vincenzo Bagnardi, E. Guerini Rocco, Nicola Fazio, Giulia Peveri, Lorenzo Gervaso, Caterina Fumagalli, Alice Laffi, Francesca Spada, Giuseppe Curigliano, P. Trillo Aliaga, Eleonora Pisa, Manila Rubino, Trillo Aliaga, P, Spada, F, Peveri, G, Bagnardi, V, Fumagalli, C, Laffi, A, Rubino, M, Gervaso, L, Guerini Rocco, E, Pisa, E, Curigliano, G, and Fazio, N

Subjects
Oncology, medicine.medical_specialty, Cochrane Library, Neuroendocrine tumors, Neuroendocrine tumor, Internal medicine, Temozolomide, medicine, Radiology, Nuclear Medicine and imaging, Prospective cohort study, neoplasms, business.industry, Absolute risk reduction, O-6-methylguanine-DNA methyltransferase, General Medicine, medicine.disease, Confidence interval, NET, methylguanine DNA methyltransferase, Meta-analysis, TEM, MGMT, TMZ, business, medicine.drug
Abstract

Background: Temozolomide (TEM) is an active treatment in metastatic neuroendocrine tumors (NETs). Patients affected by glioblastoma multiforme or advanced melanoma treated with TEM who have deficiency of O6-methylguanine DNA methyltransferase (MGMT) have a better responses and survival. However, the predictive role of MGMT in patients with NETs treated with TEM is still debated. Methods: We conducted a systematic review of the literature and meta-analysis, based on PRISMA methodology, searching in the main databases (PubMed, Embase, Scopus, Web of Science, Cochrane Library and clinical trial.gov) and the proceedings of the main international congresses, until April 26, 2021. Results: Twelve out of 616 articles were selected for our analysis, regarding a total of 858 NET patients treated with TEM-based chemotherapy. The status of MGMT had been tested in 513 (60%) patients, using various methods. The pooled overall response rate (ORR) was higher in MGMT-deficient compared with MGMT-proficient NETs, with a risk difference of 0.31 (95% confidence interval, CI: 0.13–0.50; p < 0.001; I2: 73%) and risk ratio of 2.29 (95% CI: 1.34–3.91; p < 0.001; I2: 55%). The pooled progression free survival (PFS) (hazard ratio, HR = 0.56; 95% CI: 0.43–0.74; p < 0.001) and overall survival (OS) (HR = 0.41; 95% CI: 0.20–0.62; p = 0.011) were longer in MGMT-deficient versus MGMT-proficient NETs. Conclusions: Our meta-analysis suggested that MGMT status may be predictive of TEM efficacy. However, due to the high heterogeneity of the evaluated studies the risk of biases should be considered. On this hypothesis future homogeneous prospective studies are warranted.

Published
2021

27. Causes of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: Findings from the SYNCOPACED registry

Author

Palmisano, Pietro, primary, Dell’Era, Gabriele, additional, Pellegrino, Pier Luigi, additional, Ammendola, Ernesto, additional, Ziacchi, Matteo, additional, Guerra, Federico, additional, Aspromonte, Vittorio, additional, Laffi, Mattia, additional, Pimpini, Lorenzo, additional, Santoro, Francesco, additional, Boggio, Enrico, additional, Guido, Alessandro, additional, Patti, Giuseppe, additional, Brunetti, Natale Daniele, additional, Nigro, Gerardo, additional, Biffi, Mauro, additional, Russo, Antonio Dello, additional, Gaggioli, Germano, additional, and Accogli, Michele, additional

Published
2021
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28. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Caraceni, Paolo, primary, Tufoni, Manuel, additional, Zaccherini, Giacomo, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco G., additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegliati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Gasbarrini, Antonio, additional, De Marco, Rosanna, additional, Piano, Salvatore, additional, Nardelli, Silvia, additional, Elia, Chiara, additional, Roncadori, Andrea, additional, Baldassarre, Maurizio, additional, Bernardi, Mauro, additional, Domenicali, Marco, additional, Giannone, Ferdinando A., additional, Antognoli, Agnese, additional, Merli, Manuela, additional, Pasquale, Chiara, additional, Gioia, Stefania, additional, Fasolato, Silvano, additional, Sticca, Antonietta, additional, Campion, Daniela, additional, Risso, Alessandro, additional, Saracco, Giorgio M., additional, Prestianni, Loredana, additional, Fidone, Federica, additional, Maiorca, Daniela, additional, Rizzotto, Agostino, additional, Cappa, Federica Mirici, additional, Lanzi, Arianna, additional, Neri, Elga, additional, Visani, Anna, additional, Mastroianni, Antonio, additional, Perricone, Giovanni, additional, Alberti, Alberto B., additional, Cesarini, Lucia, additional, Mazzarelli, Chiara, additional, Vangeli, Marcello, additional, Viganò, Raffaella, additional, Marzioni, Marco, additional, Capretti, Francesca, additional, Kostandini, Alba, additional, Magini, Giulia, additional, Colpani, Maria, additional, Gabbani, Tommaso, additional, Marsico, Maria, additional, Zappimbulso, Marianna, additional, Petruzzi, Josè, additional, Calvaruso, Vincenza, additional, Parrella, Giovanni, additional, Caporaso, Nicola, additional, Auriemma, Francesco, additional, Guarino, Maria, additional, Pugliese, Fabio, additional, Tortora, Annalisa, additional, Leo, Pietro, additional, Angelico, Mario, additional, De Leonardis, Francesco, additional, Pecchioli, Alessandra, additional, Rossi, Piera, additional, Raimondo, Giovanni, additional, Cacciola, Irene, additional, Elia, Gianfranco, additional, Negri, Elisa, additional, Dallio, Marcello, additional, Loguercio, Carmelina, additional, Federico, Alessandro, additional, Conte, Dario, additional, Massironi, Sara, additional, Natascia Celli, Giorgio Ballardini, additional, Rendina, Maria, additional, Bringiotti, Roberto, additional, Castellaneta, Nicola Maurizio, additional, Salerno, Francesco, additional, Boccia, Sergio, additional, Guarisco, Riccardo, additional, Galioto, Alessandra, additional, Cavallin, Marta, additional, and Andrealli, Alida, additional

Published
2021
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29. 1104P Functional imaging and clinical outcomes in grade 3 neuroendocrine tumors (NETs G3): A single-center retrospective analysis

Author

Massimo Barberis, Eleonora Pisa, Vincenzo Bagnardi, G. Buonsanti, Manila Rubino, Francesca Spada, M.C. Grana, Marzia Colandrea, Samuele Frassoni, Alice Laffi, and Nicola Fazio

Subjects
Functional imaging, medicine.medical_specialty, Oncology, business.industry, medicine, Retrospective analysis, Hematology, Radiology, Neuroendocrine tumors, Single Center, medicine.disease, business
Published
2021

32. Pre-transplant diabetes predicts atherosclerotic vascular events and cardiovascular mortality in liver transplant recipients: a long-term follow-up study

Author

Gitto, Stefano, primary, De Maria, Nicola, additional, Marzi, Luca, additional, Magistri, Paolo, additional, Falcini, Margherita, additional, Vitale, Giovanni, additional, Olivieri, Tiziana, additional, Guerrini, Gian Piero, additional, Serra, Valentina, additional, Forte, Paolo, additional, Carrai, Paola, additional, De Simone, Paolo, additional, Mega, Andrea, additional, Zoller, Heinz, additional, Piai, Guido, additional, Schepis, Filippo, additional, Marocchi, Margherita, additional, Villa, Erica, additional, Marra, Fabio, additional, Andreone, Pietro, additional, Di Benedetto, Fabrizio, additional, Vizzutti, Francesco, additional, Laffi, Giacomo, additional, Borelli, Edoardo, additional, Ballarin, Roberto, additional, Tarantino, Giuseppe, additional, Di Sandro, Stefano, additional, Puntili, Rachele, additional, Petruccelli, Stefania, additional, Valente, Giovanna, additional, and Turco, Laura, additional

Published
2020
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33. Long-term albumin administration is not futile in patients with cirrhosis and uncomplicated ascites not normalizing serum albumin concentration with treatment

Author

Tufoni, Manuel, primary, Caraceni, Paolo, additional, Zaccherini, Giacomo, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco Giuseppe, additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegiati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Tortora, Annalisa, additional, De Marco, Rosanna, additional, Nardelli, Silvia, additional, Piano, Salvatore, additional, Elia, Chiara, additional, Roncadori, Andrea, additional, Baldassarre, Maurizio, additional, and Bernardi, Mauro, additional

Published
2020
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34. Pre-transplant diabetes independently predicts atherosclerotic vascular event and death due to cardiovascular disease in liver transplant recipients: a long term multicenter observational study

Author

Gitto, Stefano, primary, De Maria, Nicola, additional, Marzi, Luca, additional, Magistri, Paolo, additional, Falcini, Margherita, additional, Vitale, Giovanni, additional, Olivieri, Tiziana, additional, Tarantino, Giuseppe, additional, Serra, Valentina, additional, Forte, Paolo, additional, Campani, Claudia, additional, Puntili, Rachele, additional, Carrai, Paola, additional, Petruccelli, Stefania, additional, De Simone, Paolo, additional, Mega, Andrea, additional, Zoller, Heinz, additional, Piai, Guido, additional, Valente, Giovanna, additional, Schepis, Filippo, additional, Vizzutti, Francesco, additional, Aspite, Silvia, additional, Di Bonaventura, Chiara, additional, Laffi, Giacomo, additional, Villa, Erica, additional, Marra, Fabio, additional, Andreone, Pietro, additional, and Di Benedetto, Fabrizio, additional

Published
2020
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35. Impact on All-Cause and Cardiovascular Mortality of Cardiac Implantable Electronic Device Complications

Author

Palmisano, Pietro, primary, Guerra, Federico, additional, Dell’Era, Gabriele, additional, Ammendola, Ernesto, additional, Ziacchi, Matteo, additional, Laffi, Mattia, additional, Troiano, Francesca, additional, Prenna, Eleonora, additional, Russo, Vincenzo, additional, Angeletti, Andrea, additional, Guido, Alessandro, additional, Occhetta, Eraldo, additional, Nigro, Gerardo, additional, Biffi, Mauro, additional, Gaggioli, Germano, additional, Capucci, Alessandro, additional, and Accogli, Michele, additional

Published
2020
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36. Long-term albumin therapy is not futile in patients with cirrhosis and uncomplicated ascites not normalizing on-treatment serum albumin concentration

Author

Tufoni, M., primary, Caraceni, P., additional, Zaccherini, G., additional, Riggio, O., additional, Angeli, P., additional, Alessandria, C., additional, Neri, S., additional, Foschi, F.G., additional, Levantesi, F., additional, Airoldi, A., additional, Simone, L., additional, Svegliati-Baroni, G., additional, Fagiuoli, S., additional, Laffi, G., additional, Cozzolongo, R., additional, Di Marco, V., additional, Sangiovanni, V., additional, Morisco, F., additional, Toniutto, P., additional, Tortora, A., additional, De Marco, R., additional, Nardelli, S., additional, Piano, S., additional, Elia, C., additional, Roncadori, A., additional, Baldassarre, M., additional, and Bernardi, M., additional

Published
2020
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38. Investigation on efficiency of gas liquid contactor used as tritium extraction unit for HCLL-TBM Pb-16Li loop

Author

A. Aiello, Italo Ricapito, Marco Utili, A. Malavasi, and L. Laffi

Subjects
Packed bed, Liquid metal, Materials science, Mechanical Engineering, Nuclear engineering, Blanket, 01 natural sciences, 010305 fluids & plasmas, Coolant, Nuclear Energy and Engineering, 0103 physical sciences, Mass flow rate, Nuclear fusion, General Materials Science, Tritium, 010306 general physics, Gas–liquid contactor, Civil and Structural Engineering
Abstract

One of the main open issues in the design of the HCLL Test Blanket System for nuclear fusion energy applications is the design and testing of the Tritium Extraction Unit (TEU). The lead-lithium alloy which, in the HCLL blanket project, is used both as tritium breeder and neutron multiplier, will generate tritium that must be extracted with an efficiency as high as possible in order to keep low the tritium concentration in the liquid metal, then minimizing tritium permeation into the main coolant, the consequent CPS load and, last but not least, tritium permeation into the Port Cell through the PbLi loop pipes. Gas-liquid contactors (GLC) and, more in detail, packed columns are the reference technology for TEU of European ITER HCLL-TBS. An experimental campaign on a GCL packed column was performed in TRIEX (TRItium Extraction) facility in ENEA Brasimone Research Centre. Starting from the experimental results a parametric analysis was performed in order determine the basic parameters of the gas extraction process and consequently the efficiency of this technology in different operative conditions. Experiments were conducted at a constant temperature of 450 °C varying the mass flow rate in the range 0,1–0,35 kg/s for lead lithium and 5–150 Nl/h for Ar stripping gas. The hydrogen partial pressure in lead lithium at extractor inlet was investigated in the range between 8.000–14.300 Pa. The experimental results have shown a tritium extraction efficiency in the range between 10 and 30% in good agreement with past experimental results obtained in MELODIE loop in CEA using similar packing material.

Published
2016

39. Under-dilated TIPS Associate With Efficacy and Reduced Encephalopathy in a Prospective, Non-randomized Study of Patients With Cirrhosis

Author

Tommaso Di Maira, Stefano Fagiuoli, Rita Golfieri, Umberto Arena, Fabio Marra, Stefano Gitto, Stefano Colopi, Alessandro Cannavale, Filippo Schepis, Pietro Torricelli, Luca S. Belli, Pietro Quaretti, Giacomo Laffi, Angelo Luca, Cristian Caporali, Roberto Agazzi, Roberto Miraglia, Federico Banchelli, Nicola De Maria, Guido Marzocchi, Ilaria Fiorina, Roberto Nani, Antonio Rampoldi, Erica Villa, Mario De Santis, Raffaele Bruno, Lorenzo Paolo Moramarco, Guadalupe Garcia-Tsao, Aldo Airoldi, Francesco Vizzutti, Fabrizio Fanelli, L. Rega, Matteo Renzulli, Cristina Mosconi, Fabrizio Di Benedetto, Schepis, F, Vizzutti, F, Garcia-Tsao, G, Marzocchi, G, Rega, L, De Maria, N, Di Maira, T, Gitto, S, Caporali, C, Colopi, S, De Santis, M, Arena, U, Rampoldi, A, Airoldi, A, Cannavale, A, Fanelli, F, Mosconi, C, Renzulli, M, Agazzi, R, Nani, R, Quaretti, P, Fiorina, I, Moramarco, L, Miraglia, R, Luca, A, Bruno, R, Fagiuoli, S, Golfieri, R, Torricelli, P, Di Benedetto, F, Belli, L, Banchelli, F, Laffi, G, Marra, F, Villa, E, Schepis, Filippo, Vizzutti, Francesco, Garcia-Tsao, Guadalupe, Marzocchi, Guido, Rega, Luigi, De Maria, Nicola, Di Maira, Tommaso, Gitto, Stefano, Caporali, Cristian, Colopi, Stefano, De Santis, Mario, Arena, Umberto, Rampoldi, Antonio, Airoldi, Aldo, Cannavale, Alessandro, Fanelli, Fabrizio, Mosconi, Cristina, Renzulli, Matteo, Agazzi, Roberto, Nani, Roberto, Quaretti, Pietro, Fiorina, Ilaria, Moramarco, Lorenzo, Miraglia, Roberto, Luca, Angelo, Bruno, Raffaele, Fagiuoli, Stefano, Golfieri, Rita, Torricelli, Pietro, Di Benedetto, Fabrizio, Belli, Luca Saverio, Banchelli, Federico, Laffi, Giacomo, Marra, Fabio, and Villa, Erica

Subjects
Male, medicine.medical_specialty, Cirrhosis, medicine.medical_treatment, Liver, liver, portal hypertensive bleeding, portal hypertensive complications, treatment, vascular disease, Hemodynamics, Inferior vena cava, 03 medical and health sciences, 0302 clinical medicine, Model for End-Stage Liver Disease, Vascular Disease, Ascites, medicine, Humans, Prospective Studies, Aged, Hepatology, Vascular disease, business.industry, Incidence, Gastroenterology, Stent, Middle Aged, medicine.disease, Fibrosis, Surgery, Treatment, Treatment Outcome, Italy, Portal Hypertensive Bleeding, medicine.vein, Hepatic Encephalopathy, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Portasystemic Shunt, Transjugular Intrahepatic, medicine.symptom, business, Transjugular intrahepatic portosystemic shunt
Abstract

Background & Aims: Portosystemic encephalopathy (PSE) is a major complication of trans-jugular intrahepatic porto-systemic shunt (TIPS) placement. Most devices are self-expandable polytetrafluoroethylene-covered stent grafts (PTFE-SGs) that are dilated to their nominal diameter (8 or 10 mm). We investigated whether PTFE-SGs dilated to a smaller caliber (under-dilated TIPS) reduce PSE yet maintain clinical and hemodynamic efficacy. We also studied whether under-dilated TIPS self-expand to nominal diameter over time. Methods: We performed a prospective, non-randomized study of 42 unselected patients with cirrhosis who received under-dilated TIPS (7 and 6 mm) and 53 patients who received PTFE-SGs of 8 mm or more (controls) at referral centers in Italy. After completion of this study, dilation to 6 mm became the standard and 47 patients were included in a validation study. All patients were followed for 6 months; Doppler ultrasonography was performed 2 weeks and 3 months after TIPS placement and every 6 months thereafter. Stability of PTFE-SG diameter was evaluated by computed tomography analysis of 226 patients with cirrhosis whose stent grafts increased to 6, 7, 8, 9, or 10 mm. The primary outcomes were incidence of at least 1 episode of PSE grade 2 or higher during follow up, incidence of recurrent variceal hemorrhage or ascites, incidence of shunt dysfunction requiring TIPS recanalization, and reduction in porto-caval pressure gradient. Results: PSE developed in a significantly lower proportion of patients with under-dilated TIPS (27%) than controls (54%) during the first year after the procedure (P =.015), but the proportions of patients with recurrent variceal hemorrhage or ascites did not differ significantly between groups. No TIPS occlusions were observed. These results were confirmed in the validation cohort. In an analysis of self-expansion of stent grafts, during a mean follow-up period of 252 days after placement, none of the PTFE-SGs self-expanded to the nominal diameter in hemodynamically relevant sites (such as portal and hepatic vein vascular walls). Conclusions: In prospective, non-randomized study of patients with cirrhosis, we found under-dilation of PTFE-SGs during TIPS placement to be feasible, associated with lower rates of PSE, and effective.

Published
2018

40. Assessment of liver fibrosis in primary biliary cholangitis: Comparison between indirect serum markers and fibrosis morphometry

Author

Luisa Leoncini, Maria Rosa Biagini, Umberto Arena, Cristina Stasi, Stefano Milani, Giacomo Laffi, Fabio Marra, and S. Madiai

Subjects
Male, medicine.medical_specialty, Pathology, Biopsy, Gastroenterology, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Primary biliary cirrhosis, Fibrosis, Internal medicine, Image Processing, Computer-Assisted, medicine, Humans, Aspartate Aminotransferases, Stage (cooking), Sirius Red, Aged, Retrospective Studies, Hepatology, medicine.diagnostic_test, biology, Liver Cirrhosis, Biliary, business.industry, Biopsy, Needle, Alanine Transaminase, Retrospective cohort study, gamma-Glutamyltransferase, Middle Aged, Alkaline Phosphatase, medicine.disease, Liver, chemistry, Alanine transaminase, 030220 oncology & carcinogenesis, Disease Progression, biology.protein, Female, 030211 gastroenterology & hepatology, business, Biomarkers
Abstract

The accuracy of non-invasive methods for the quantification of liver fibrosis in primary biliary cholangitis (PBC) is still debated.To determine the histo-morphometric measurement of fibrotic tissue and to explore the possible association between indirect markers (APRI, FORNS, FIB-4, and Lok) and morphometry.Retrospective analysis of medical data from patients with PBC, on whom needle liver biopsy was performed as part of the diagnostic assessment. One section of each biopsy stained with Sirius red was used for calculating the percentage of collagen. Quantitative measure of fibrotic tissue (fibrosis morphometry) was calculated as a percentage of collagen content by digital image analysis. Morphometry results were divided into four groups reflecting Ludwig's staging and compared with values for indirect serum markers.50 PBC patients were enrolled (86% females, mean age 57 ± 12.30 years), 19 were Ludwig's stage I (38%), 14 stage II (28%), 12 stage III (24%), and five stage IV (10%). Morphometry results were significantly different among Ludwig stages (p0.05). No significant differences were found for indirect serum markers. A significant correlation was found between morphometry results and indirect serum markers tested (p0.05).In our cohort, the histo-morphometric values of fibrotic tissue increased progressively with Ludwig's stages of PBC, while non-invasive markers did not.

Published
2016

43. Transjugular Intrahepatic Portosystemic Shunt does not affect the efficacy and safety of direct-acting antivirals in patients with advanced cirrhosis: A real-life, case-control study

Author

Gitto, Stefano, primary, Vizzutti, Francesco, additional, Schepis, Filippo, additional, Turco, Laura, additional, Aspite, Silvia, additional, Vitale, Giovanni, additional, Arena, Umberto, additional, Villa, Erica, additional, Laffi, Giacomo, additional, Debernardi-Venon, Wilma, additional, Fanelli, Fabrizio, additional, Andreone, Pietro, additional, Marra, Fabio, additional, Apolito, Pasquale, additional, Campani, Claudia, additional, Sadalla, Sinan, additional, Lombardo, Federica, additional, Conti, Fabio, additional, and Scuteri, Alessandra, additional

Published
2019
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46. Systemic therapies in patients with advanced well-differentiated pancreatic neuroendocrine tumors (PanNETs): When cytoreduction is the aim. A critical review with meta-analysis

Author

Pozzari, Marta, primary, Maisonneuve, Patrick, additional, Spada, Francesca, additional, Berruti, Alfredo, additional, Amoroso, Vito, additional, Cella, Chiara Alessandra, additional, Laffi, Alice, additional, Pellicori, Stefania, additional, Bertani, Emilio, additional, and Fazio, Nicola, additional

Published
2018
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47. Dysregulated Intrahepatic CD4+ T-Cell Activation Drives Liver Inflammation in Ileitis-Prone SAMP1/YitFc Mice

Author

Theresa T. Pizarro, Alex Yee-Chen Huang, Saada Eid, Wendy A. Goodman, Sara Omenetti, Marco Brogi, Fabio Cominelli, Colleen M. Croniger, Massimo Pinzani, Giacomo Laffi, and Tania Roskams

Subjects
Severe combined immunodeficiency, Hepatology, Regulatory T cell, Gastroenterology, FOXP3, Dendritic cell, Autoimmune hepatitis, Biology, medicine.disease, Regulatory T Cells, 3. Good health, IBD-Associated Liver Inflammation, Liver disease, medicine.anatomical_structure, Immunology, medicine, lcsh:Diseases of the digestive system. Gastroenterology, Liver Sinusoidal Endothelial Cells, Ileitis, lcsh:RC799-869, SAMP1/YitFc Mice, Antigen-presenting cell, Hepatic CD4+ T Cells
Abstract

Background & Aims: Liver inflammation is a common extraintestinal manifestation of inflammatory bowel disease (IBD), but whether liver involvement is a consequence of a primary intestinal defect or results from alternative pathogenic processes remains unclear. Therefore, we sought to determine the potential pathogenic mechanism(s) of concomitant liver inflammation in an established murine model of IBD. Methods: Liver inflammation and immune cell subsets were characterized in ileitis-prone SAMP1/YitFc (SAMP) and AKR/J (AKR) control mice, lymphocyte-depleted SAMP (SAMPxRag-1â/â), and immunodeficient SCID recipient mice receiving SAMP or AKR donor CD4+ T cells. Proliferation and suppressive capacity of CD4+ T-effector (Teff) and T-regulatory (Treg) cells from gut-associated lymphoid tissue (GALT) and livers of SAMP and AKR mice were measured. Results: Surprisingly, prominent inflammation was detected in 4-week-old SAMP livers before histologic evidence of ileitis, whereas both disease phenotypes were absent in age-matched AKR mice. SAMP liver disease was characterized by abundant infiltration of lymphocytes, required for hepatic inflammation to occur, a TH1-skewed environment, and phenotypically activated CD4+ T cells. SAMP intrahepatic CD4+ T cells also had the ability to induce liver and ileal inflammation when adoptively transferred into SCID recipients, whereas GALT-derived CD4+ T cells produced milder ileitis but not liver inflammation. Interestingly, SAMP intrahepatic CD4+ Teff cells showed increased proliferation compared with both SAMP GALT- and AKR liver-derived CD4+ Teff cells, and SAMP intrahepatic Tregs were decreased among CD4+ T cells and impaired in in vitro suppressive function compared with AKR. Conclusions: Activated intrahepatic CD4+ T cells induce liver inflammation and contribute to experimental ileitis via locally impaired hepatic immunosuppressive function. Keywords: Hepatic CD4+ T Cells, IBD-Associated Liver Inflammation, Liver Sinusoidal Endothelial Cells, Regulatory T Cells, SAMP1/YitFc Mice

Published
2015
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48. Portal Vein Thrombosis Relevance on Liver Cirrhosis: Italian Venous Thrombotic Events Registry

Author

Violi F., Corazza R. G., Caldwell S. H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., Palasciano G., D'Alitto F., Palmieri V. O., Santovito D., Di Michele D., Croce G., Sacerdoti D., Brocco S., Fasolato S., Cecchetto L., Bombonato G., Bertoni M., Restuccia R., Andreozzi P., Liguori L. M., Caroleo B., Perticone M., Staltari O., Manfredini R., De Giorgi A., Averna M., Giammanco A., Granito A., Pettinari I., Marinelli S., Bolondi L., Falsetti L., Salvi A., Durante-Mangoni E., Cesaro F., Farinaro V., Ragone E., Morana I., Andriulli A., Ippolito A., Iacobellis A., Niro G., Merla A., Raimondo G., Maimone S., Cacciola I., Varvara D., Drenaggi D., Staffolani S., Picardi A., Vespasiani-Gentilucci U., Galati G., Gallo P., Davi G., Schiavone C., Santilli F., Tana C., Licata A., Soresi M., Bianchi B. G., Carderi I., Pinto A., Tuttolomondo A., Ferrari G., Gresele P., Fierro T., Morelli O., Laffi G., Romanelli R. G., Arena U., Cristina S., Gasbarrini A., Gargovich M., Zocco Z. M., Riccardi L., Ainora M. E., Capeci W., Martino M. G., Lorenzo N., Cavallo M., Frugiuele P., Greco A., Pietrangelo A., Ventura P., Cuoghi C., Marcacci M., Serviddio G., Vendemiale G., Villani R., Gargano R., Vidili G., Di Cesare V., Masala M., Delitala G., Invernizzi P., Di Minno G., Tufano A., Purrello F., Privitera G., Forgione A., Curigliano V., Senzolo M., Rodriguez-Castro K. -I., Giannelli G., Serra C., Neri S., Pignataro P., Rizzetto M., Debernardi V. W., Svegliati B. G., Bergamaschi G., Costanzo F., Angelico F., Del Ben M., Polimeni L., Talerico G., Proietti M., Romiti G. F., Ruscio E., Toriello F., Violi, F., Corazza, R. G., Caldwell, S. H., Perticone, F., Gatta, A., Angelico, M., Farcomeni, A., Masotti, M., Napoleone, L., Vestri, A., Raparelli, V., Basili, S., Palasciano, G., D'Alitto, F., Palmieri, V. O., Santovito, D., Croce, G., Sacerdoti, D., Brocco, S., Fasolato, S., Cecchetto, L., Bombonato, G., Restuccia, R., Andreozzi, P., Liguori, L. M., Perticone, M., Staltari, O., Manfredini, R., De Giorgi, A., Averna, M., Giammanco, A., Granito, A., Marinelli, S., Bolondi, L., Falsetti, L., Salvi, A., Durante-Mangoni, E., Cesaro, F., Farinaro, V., Ragone, E., Morana, I., Andriulli, A., Ippolito, A., Iacobellis, A., Niro, G., Merla, A., Raimondo, G., Maimone, S., Cacciola, I., Varvara, D., Drenaggi, D., Staffolani, S., Picardi, A., Vespasiani-Gentilucci, U., Galati, G., Gallo, P., Davi, G., Schiavone, C., Santilli, F., Tana, C., Licata, A., Soresi, M., Bianchi, B. G., Carderi, I., Pinto, A., Tuttolomondo, A., Ferrari, G., Gresele, P., Fierro, T., Morelli, O., Laffi, G., Romanelli, R. G., Arena, U., Cristina, S., Gasbarrini, A., Gargovich, M., Zocco, Z. M., Riccardi, L., Ainora, M. E., Capeci, W., Martino, M. G., Lorenzo, N., Cavallo, M., Frugiuele, P., Greco, A., Pietrangelo, A., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Di Cesare, V., Masala, M., Delitala, G., Invernizzi, P., Di Minno, G., Tufano, A., Purrello, F., Privitera, G., Forgione, A., Curigliano, V., Senzolo, M., Rodriguez-Castro, K. -I., Giannelli, G., Serra, C., Neri, S., Pignataro, P., Rizzetto, M., Debernardi, V. W., Svegliati, B. G., Bergamaschi, G., Costanzo, F., Angelico, F., Del Ben, M., Polimeni, L., Talerico, G., Proietti, M., Romiti, G. F., Ruscio, E., Toriello, F., Violi, F, Corazza, R, Caldwell, S, Perticone, F, Gatta, A, Angelico, M, Farcomeni, A, Masotti, M, Napoleone, L, Vestri, A, Raparelli, V, Basili, S, Palasciano, G, D'Alitto, F, Palmieri, V, Santovito, D, Di Michele, D, Croce, G, Sacerdoti, D, Brocco, S, Fasolato, S, Cecchetto, L, Bombonato, G, Bertoni, M, Restuccia, R, Andreozzi, P, Liguori, L, Caroleo, B, Perticone, M, Staltari, O, Manfredini, R, De Giorgi, A, Averna, M, Giammanco, A, Granito, A, Pettinari, I, Marinelli, S, Bolondi, L, Falsetti, L, Salvi, A, Durante-Mangoni, E, Cesaro, F, Farinaro, V, Ragone, E, Morana, I, Andriulli, A, Ippolito, A, Iacobellis, A, Niro, G, Merla, A, Raimondo, G, Maimone, S, Cacciola, I, Varvara, D, Drenaggi, D, Staffolani, S, Picardi, A, Vespasiani-Gentilucci, U, Galati, G, Gallo, P, Davi, G, Schiavone, C, Santilli, F, Tana, C, Licata, A, Soresi, M, Bianchi, B, Carderi, I, Pinto, A, Tuttolomondo, A, Ferrari, G, Gresele, P, Fierro, T, Morelli, O, Laffi, G, Romanelli, R, Arena, U, Cristina, S, Gasbarrini, A, Gargovich, M, Zocco, Z, Riccardi, L, Ainora, M, Capeci, W, Martino, M, Lorenzo, N, Cavallo, M, Frugiuele, P, Greco, A, Pietrangelo, A, Ventura, P, Cuoghi, C, Marcacci, M, Serviddio, G, Vendemiale, G, Villani, R, Gargano, R, Vidili, G, Di Cesare, V, Masala, M, Delitala, G, Invernizzi, P, Di Minno, G, Tufano, A, Purrello, F, Privitera, G, Forgione, A, Curigliano, V, Senzolo, M, Rodriguez-Castro, K, Giannelli, G, Serra, C, Neri, S, Pignataro, P, Rizzetto, M, Debernardi, V, Svegliati, B, Bergamaschi, G, Costanzo, F, Angelico, F, Del Ben, M, Polimeni, L, Talerico, G, Proietti, M, Romiti, G, Ruscio, E, Toriello, F, Violi F., Corazza R.G., Caldwell S.H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., Palasciano G., D'Alitto F., Palmieri V.O., Santovito D., Di Michele D., Croce G., Sacerdoti D., Brocco S., Fasolato S., Cecchetto L., Bombonato G., Bertoni M., Restuccia R., Andreozzi P., Liguori L.M., Caroleo B., Perticone M., Staltari O., Manfredini R., De Giorgi A., Averna M., Giammanco A., Granito A., Pettinari I., Marinelli S., Bolondi L., Falsetti L., Salvi A., Durante-Mangoni E., Cesaro F., Farinaro V., Ragone E., Morana I., Andriulli A., Ippolito A., Iacobellis A., Niro G., Merla A., Raimondo G., Maimone S., Cacciola I., Varvara D., Drenaggi D., Staffolani S., Picardi A., Vespasiani-Gentilucci U., Galati G., Gallo P., Davi G., Schiavone C., Santilli F., Tana C., Licata A., Soresi M., Bianchi B.G., Carderi I., Pinto A., Tuttolomondo A., Ferrari G., Gresele P., Fierro T., Morelli O., Laffi G., Romanelli R.G., Arena U., Cristina S., Gasbarrini A., Gargovich M., Zocco Z.M., Riccardi L., Ainora M.E., Capeci W., Martino M.G., Lorenzo N., Cavallo M., Frugiuele P., Greco A., Pietrangelo A., Ventura P., Cuoghi C., Marcacci M., Serviddio G., Vendemiale G., Villani R., Gargano R., Vidili G., Di Cesare V., Masala M., Delitala G., Invernizzi P., Di Minno G., Tufano A., Purrello F., Privitera G., Forgione A., Curigliano V., Senzolo M., Rodriguez-Castro K.-I., Giannelli G., Serra C., Neri S., Pignataro P., Rizzetto M., Debernardi V.W., Svegliati B.G., Bergamaschi G., Costanzo F., Angelico F., Del Ben M., Polimeni L., Talerico G., Proietti M., Romiti G.F., Ruscio E., and Toriello F.

Subjects
Registrie, Liver Cirrhosis, Male, Cirrhosis, Hepatocellular carcinoma, 030204 cardiovascular system & hematology, Gastroenterology, 0302 clinical medicine, Esophageal varices, Prevalence, Medicine, Prospective Studies, Registries, Prospective cohort study, Multivariate Analysi, Venous Thrombosis, Portal Vein, Anticoagulants, Liver failure, Splanchnic venous thrombosis, Emergency Medicine, Internal Medicine, Middle Aged, Portal vein thrombosis, Venous thrombosis, Splanchnic venous thrombosis , Anticoagulants , Liver failure , Hepatocellular carcinoma , Esophageal varices, Italy, Liver, Female, 030211 gastroenterology & hepatology, medicine.symptom, Settore SECS-S/01 - Statistica, Human, medicine.medical_specialty, Liver Cirrhosi, Socio-culturale, Asymptomatic, 03 medical and health sciences, Anticoagulants, Esophageal varices, Hepatocellular carcinoma, Liver failure, Splanchnic venous thrombosis, Internal medicine, Humans, Aged, Hepatology, Esophageal varice, business.industry, Anticoagulant, Splanchnic venous thrombosi, medicine.disease, Surgery, Prospective Studie, Splanchnic venous thrombosis, Anticoagulants, Liver failure, Hepatocellular carcinoma, Esophageal varices, Multivariate Analysis, Upper gastrointestinal bleeding, Complication, business
Abstract

Portal vein thrombosis may occur in cirrhosis; nevertheless, its prevalence, and predictors are still elusive. To investigate this issue, the Italian Society of Internal Medicine undertook the “Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry” (PRO-LIVER). This prospective multicenter study includes consecutive cirrhotic patients undergoing Doppler ultrasound examination of the portal area to evaluate the prevalence and incidence of portal vein thrombosis over a 2-year scheduled follow-up. Seven hundred and fifty-three (68% men; 64±12years) patients were included in the present analysis. Fifty percent of the cases were cirrhotic outpatients. Viral (44%) etiology was predominant. Around half of the patients had a mild-severity disease according to the Child–Pugh score; hepatocellular carcinoma was present in 20%. The prevalence of ultrasound-detected portal vein thrombosis was 17% (n=126); it was asymptomatic in 43% of the cases. Notably, more than half of the portal vein thrombosis patients (n=81) were not treated with anticoagulant therapy. Logistic step-forward multivariate analysis demonstrated that previous portal vein thrombosis (p&nbsp

Published
2016

49. Reconstruction and Rehabilitation of Severe Mandibular Atrophy Using Distraction Osteogenesis Technique: A Case Report

Author

Alberto Merlini, Matteo Simonetti, Nicola Laffi, Joseph Garibaldi, Albino Triaca, and Paolo Balbi

Subjects
Mandibular symphysis, medicine.medical_treatment, education, Osteogenesis, Distraction, Dentistry, Bone grafting, behavioral disciplines and activities, Atrophy, Distraction, Radiography, Panoramic, medicine, Humans, Mandibular Diseases, Rehabilitation, business.industry, Middle Aged, medicine.disease, humanities, Implant placement, medicine.anatomical_structure, Otorhinolaryngology, Removable prosthesis, Distraction osteogenesis, Female, Surgery, Oral Surgery, business, psychological phenomena and processes
Abstract

Purpose The purpose of this article is to describe a rehabilitation technique for patients with severe anterior atrophy using a combination of distraction osteogenesis and implants to support fixed or removable prostheses. Materials and Methods The surgical technique involves the use of an extraosseous distraction device followed by more than 14 mm of distraction of the mandibular symphysis. Results The patient was successfully treated by the application of 4 implants in the region of the mandibular symphysis, stabilized by an Ackerman bar, and a removable prosthesis. Conclusion Osseous distraction techniques, when possible, are preferable to block bone grafting techniques because they present considerable advantages for patients and surgeons. The combination of distraction and implant placement can rehabilitate patients with severe defects.

Published
2014

50. Hydraulic characterization of the full scale divertor cassette prototype

Author

P.A. Di Maio, L. Laffi, Giuseppe Vella, B. Riccardi, A. Tincani, M.G. D’Angelo, Gioacchino Miccichè, D. Paradiso, S Nucci, L. Rapezzi, Tincani, A, D’Angelo, M, Di Maio, P, Laffi, L, Miccichè, G, Nucci, S, Paradiso, D, Rapezzi, L, Riccardi, B, and Vella, G

Subjects
System code, Nuclear Energy and Engineering, ITER, Divertor, Draining and drying, Mechanical Engineering, Nuclear engineering, Divertor, Full scale, Environmental science, General Materials Science, Transient (oscillation), Settore ING-IND/19 - Impianti Nucleari, Civil and Structural Engineering
Abstract

In the frame of the activities related to ITER divertor R&D, ENEA C.R. Brasimone was in charge by Fusion For Energy (F4E) to perform the assembly, the hydraulic tests and the theoretical simulation of the hydraulic behavior of the full scale divertor cassette prototype. The objective of these activities was aimed at the investigation of the thermal-hydraulic behavior of the full-scale divertor cassette both under steady state condition and during draining and drying operational transient. In particular, the steady state tests were focused on finally check whether the hydraulic design of the divertor components is able to ensure a uniform and proper cooling for the plasma facing components, with an acceptable pressure drop; whilst the transient ones were aimed at defining proper procedures for draining and drying the divertor cassette as well as for refilling it with water. This paper presents the results of the steady state and transient hydraulic experimental test campaigns performed at ENEAC.R. Brasimone as well as the relevant numerical analysis performed at the Department of Nuclear Engineering of the University of Palermo adopting the RELAP5 Mod3.3 thermal-hydraulic system code.

Published
2011

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