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concentration during NAC, while no trend was observed in oxyhemoglobin, deoxyhemoglobin, and bulk lipid. The percent change in water after two to three months of chemotherapy correlates strongly with age (r=0.752, p = 0.0019). Conclusion: Water concentration correlated with the MRI fibroglandular density. Ovarian suppression induced by NAC may be responsible for the reduced breast density, explaining the significant water concentration reduction in premenopausal subjects. No significant changes were noted in bulk lipid in any subject. This suggests that relatively fast changes in breast density induced by NAC occur due to the reduction of fibroglandular tissue rather than by increases or replacement by bulk lipid. These results suggest that DOSI is a low-cost, bed-side imaging modality capable of monitoring breast density as a prognostic marker.