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Start Over Author "Khalil, Ali" Publisher elsevier bv
109 results on '"Khalil, Ali"'

6. Comprehensive review of progress made in soil electrokinetic research during 1993–2020, Part II. No.1: materials additives for enhancing the intensification process during 2017–2020

Author

Abou-Shady, Ahmed, primary, Ismail, Sahar, additional, Yossif, Taher M.H., additional, Yassin, Sally A., additional, Ali, Mohamed E.A., additional, Habib, Ashraf AM, additional, Khalil, Ali Kh A, additional, Tag-Elden, Mohamed A., additional, Emam, Tamer M., additional, Mahmoud, Abdelnasser A., additional, Eissa, Doaa, additional, Hegab, Rehab H., additional, Kotp, Yousra H., additional, Osman, Mohamed A., additional, Saudi, Ahmed M., additional, Abdelaziz, Samah M., additional, Yaseen, Rabaa, additional, El-Araby, Heba, additional, Abd-Elmottaleb, Osama, additional, Bahgaat, Asmaa K., additional, and El-Harairy, Ahmed, additional

Published
2023
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16. The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways

Author

Jichao Chen, Farhan Ullah Khan, Hong Ze, Ding Qi-long, Khalil Ali Ahmad, Chen Xuezhuo, and Jinyi Xu

Subjects
0301 basic medicine, Nitric Oxide Synthase Type III, Cell Survival, 030204 cardiovascular system & hematology, Pharmacology, Nitric Oxide, medicine.disease_cause, Antioxidants, Umbilical vein, Glutarates, Superoxide dismutase, Wortmannin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Enos, Malondialdehyde, Human Umbilical Vein Endothelial Cells, medicine, Humans, Phosphorylation, Protein kinase B, Cells, Cultured, chemistry.chemical_classification, Reactive oxygen species, Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, biology, Superoxide Dismutase, Chemistry, Hydrogen Peroxide, General Medicine, biology.organism_classification, humanities, Endothelial stem cell, Oxidative Stress, 030104 developmental biology, Cytoprotection, biology.protein, Phosphatidylinositol 3-Kinase, Reactive Oxygen Species, Proto-Oncogene Proteins c-akt, Oxidative stress, Signal Transduction
Abstract

Antioxidant therapy is considered as promising strategy for treating oxidative stress-induced cardiovascular disease. Bis (β-elemene-13-yl) glutarate (BEG) is a novel β-elemene derivative. Herein, we examined the antioxidant activity of BEG on human umbilical vein endothelial cells (HUVECs) after injury with hydrogen peroxide (H2O2) and investigated the mechanism involved. HUVECs were divided into the following groups: control group (untreated cells); treated groups (cells treated with 0.1, 1, 10 μmol/L of BEG); positive control group (cells treated with 0.1 mM Vitamin E); model group (cells treated with 0.5 mM H2O2 alone). Cells were pre-incubated with or without BEG for 24 h and then incubated for a further 2 h with 0.5 mM H2O2. Our results showed that BEG significantly reduced H2O2 induced loss in endothelial cell viability, reactive oxygen species (ROS) production, reduced lactate dehydrogenase (LDH) release, and malonyldialdehyde (MDA) level in a concentration-dependent manner. Also, BEG increased the cellular the superoxide dismutase (SOD) activity. Moreover, we found that H2O2 decreased Akt and eNOS phosphorylation, which perhaps, indirectly reduced nitric oxide (NO) production. These effects induced by H2O2, however, were reduced by pre-treatment with BEG. BEG effects were inhibited by a PI3K inhibitor (wortmannin) and eNOS inhibitor (L-NAME). In conclusion, the present study demonstrated that BEG has antioxidant activity. Furthermore, BEG reduced H2O2-induced endothelial cells injury by the involvement of antioxidation and PI3K/Akt/eNOS/NO signaling pathways.

Published
2018
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17. Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases

Author

Ding Qi-long, Abdoh Taleb, Nirmala Koju, Awais Ullah Ihsan, Jia Qu, Na Lin, Kamal Hezam, Lei Hui, and Khalil Ali Ahmad

Subjects
0301 basic medicine, Antioxidant, Vascular smooth muscle, medicine.medical_treatment, Cell, Disease, Oxidative phosphorylation, 030204 cardiovascular system & hematology, Pharmacology, Protective Agents, medicine.disease_cause, Antioxidants, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Endothelial dysfunction, business.industry, General Medicine, medicine.disease, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Cardiovascular Diseases, Reactive Oxygen Species, business, Oxidative stress, Silymarin
Abstract

Cardiovascular diseases (CVDs) are considered as the major reason for mortality and morbidity worldwide. Substantial evidence suggests that increased oxidative stress plays a significant role in the pathogenesis of CVDs, including atherosclerosis, hypertension, vascular endothelial dysfunction and ischemic heart disease. Cellular oxidative stress results in the release of toxic free radicals by endothelial cells and vascular smooth muscle cells that interact with cell components such as protein, DNA or lipid resulting in cardiovascular pathology. Silymarin has antioxidant activities against CVDs and offers protection against oxidative stress-induced hypertension, atherosclerosis and cardiac toxicity. We present a comprehensive review regarding the oxidative stress and protective effects of silymarin in CVDs management. We also aim to provide mechanistic insight of the mechanisms of silymarin action in oxidative stress-induced CVDs.

Published
2018
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22. Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017

Author

Reiner, Robert C, primary, Wiens, Kirsten E, additional, Deshpande, Aniruddha, additional, Baumann, Mathew M, additional, Lindstedt, Paulina A, additional, Blacker, Brigette F, additional, Troeger, Christopher E, additional, Earl, Lucas, additional, Munro, Sandra B, additional, Abate, Degu, additional, Abbastabar, Hedayat, additional, Abd-Allah, Foad, additional, Abdelalim, Ahmed, additional, Abdollahpour, Ibrahim, additional, Abdulkader, Rizwan Suliankatchi, additional, Abebe, Getaneh, additional, Abegaz, Kedir Hussein, additional, Abreu, Lucas Guimarães, additional, Abrigo, Michael R M, additional, Accrombessi, Manfred Mario Kokou, additional, Acharya, Dilaram, additional, Adabi, Maryam, additional, Adebayo, Oladimeji M, additional, Adedoyin, Rufus Adesoji, additional, Adekanmbi, Victor, additional, Adetokunboh, Olatunji O, additional, Adhena, Beyene Meressa, additional, Afarideh, Mohsen, additional, Ahmadi, Keivan, additional, Ahmadi, Mehdi, additional, Ahmed, Anwar E, additional, Ahmed, Muktar Beshir, additional, Ahmed, Rushdia, additional, Ajumobi, Olufemi, additional, Akal, Chalachew Genet, additional, Akalu, Temesgen Yihunie, additional, Akanda, Ali S, additional, Alamene, Genet Melak, additional, Alanzi, Turki M, additional, Albright, James R, additional, Alcalde Rabanal, Jacqueline Elizabeth, additional, Alemnew, Birhan Tamene, additional, Alemu, Zewdie Aderaw, additional, Ali, Beriwan Abdulqadir, additional, Ali, Muhammad, additional, Alijanzadeh, Mehran, additional, Alipour, Vahid, additional, Aljunid, Syed Mohamed, additional, Almasi, Ali, additional, Almasi-Hashiani, Amir, additional, Al-Mekhlafi, Hesham M, additional, Altirkawi, Khalid, additional, Alvis-Guzman, Nelson, additional, Alvis-Zakzuk, Nelson J, additional, Amare, Azmeraw T, additional, Amini, Saeed, additional, Amit, Arianna Maever Loreche, additional, Andrei, Catalina Liliana, additional, Anegago, Masresha Tessema, additional, Anjomshoa, Mina, additional, Ansari, Fereshteh, additional, Antonio, Carl Abelardo T, additional, Antriyandarti, Ernoiz, additional, Appiah, Seth Christopher Yaw, additional, Arabloo, Jalal, additional, Aremu, Olatunde, additional, Armoon, Bahram, additional, Aryal, Krishna K, additional, Arzani, Afsaneh, additional, Asadi-Lari, Mohsen, additional, Ashagre, Alebachew Fasil, additional, Atalay, Hagos Tasew, additional, Atique, Suleman, additional, Atre, Sachin R, additional, Ausloos, Marcel, additional, Avila-Burgos, Leticia, additional, Awasthi, Ashish, additional, Awoke, Nefsu, additional, Ayala Quintanilla, Beatriz Paulina, additional, Ayano, Getinet, additional, Ayanore, Martin Amogre, additional, Ayele, Asnakew Achaw, additional, Aynalem, Yared A Asmare, additional, Azari, Samad, additional, Babaee, Ebrahim, additional, Badawi, Alaa, additional, Bakkannavar, Shankar M, additional, Balakrishnan, Senthilkumar, additional, Bali, Ayele Geleto, additional, Banach, Maciej, additional, Barac, Aleksandra, additional, Bärnighausen, Till Winfried, additional, Basaleem, Huda, additional, Bassat, Quique, additional, Bayati, Mohsen, additional, Bedi, Neeraj, additional, Behzadifar, Masoud, additional, Behzadifar, Meysam, additional, Bekele, Yibeltal Alemu, additional, Bell, Michelle L, additional, Bennett, Derrick A, additional, Berbada, Dessalegn Ajema, additional, Beyranvand, Tina, additional, Bhat, Anusha Ganapati, additional, Bhattacharyya, Krittika, additional, Bhattarai, Suraj, additional, Bhaumik, Soumyadeep, additional, Bijani, Ali, additional, Bikbov, Boris, additional, Biswas, Raaj Kishore, additional, Bogale, Kassawmar Angaw, additional, Bohlouli, Somayeh, additional, Brady, Oliver J, additional, Bragazzi, Nicola Luigi, additional, Briko, Nikolay Ivanovich, additional, Briko, Andrey Nikolaevich, additional, Burugina Nagaraja, Sharath, additional, Butt, Zahid A, additional, Campos-Nonato, Ismael R, additional, Campuzano Rincon, Julio Cesar, additional, Cárdenas, Rosario, additional, Carvalho, Félix, additional, Castro, Franz, additional, Chansa, Collins, additional, Chatterjee, Pranab, additional, Chattu, Vijay Kumar, additional, Chauhan, Bal Govind, additional, Chin, Ken Lee, additional, Christopher, Devasahayam J, additional, Chu, Dinh-Toi, additional, Claro, Rafael M, additional, Cormier, Natalie M, additional, Costa, Vera M, additional, Damiani, Giovanni, additional, Daoud, Farah, additional, Dandona, Lalit, additional, Dandona, Rakhi, additional, Darwish, Amira Hamed, additional, Daryani, Ahmad, additional, Das, Jai K, additional, Das Gupta, Rajat, additional, Dasa, Tamirat Tesfaye, additional, Davila, Claudio Alberto, additional, Davis Weaver, Nicole, additional, Davitoiu, Dragos Virgil, additional, De Neve, Jan-Walter, additional, Demeke, Feleke Mekonnen, additional, Demis, Asmamaw Bizuneh, additional, Demoz, Gebre Teklemariam, additional, Denova-Gutiérrez, Edgar, additional, Deribe, Kebede, additional, Desalew, Assefa, additional, Dessie, Getenet Ayalew, additional, Dharmaratne, Samath Dhamminda, additional, Dhillon, Preeti, additional, Dhimal, Meghnath, additional, Dhungana, Govinda Prasad, additional, Diaz, Daniel, additional, Ding, Eric L, additional, Diro, Helen Derara, additional, Djalalinia, Shirin, additional, Do, Huyen Phuc, additional, Doku, David Teye, additional, Dolecek, Christiane, additional, Dubey, Manisha, additional, Dubljanin, Eleonora, additional, Duko Adema, Bereket, additional, Dunachie, Susanna J, additional, Durães, Andre R, additional, Duraisamy, Senbagam, additional, Effiong, Andem, additional, Eftekhari, Aziz, additional, El Sayed, Iman, additional, El Sayed Zaki, Maysaa, additional, El Tantawi, Maha, additional, Elemineh, Demelash Abewa, additional, El-Jaafary, Shaimaa I, additional, Elkout, Hajer, additional, Elsharkawy, Aisha, additional, Enany, Shymaa, additional, Endalamfaw, Aklilu, additional, Endalew, Daniel Adane, additional, Eskandarieh, Sharareh, additional, Esteghamati, Alireza, additional, Etemadi, Arash, additional, Farag, Tamer H, additional, Faraon, Emerito Jose A, additional, Fareed, Mohammad, additional, Faridnia, Roghiyeh, additional, Farioli, Andrea, additional, Faro, Andre, additional, Farzam, Hossein, additional, Fazaeli, Ali Akbar, additional, Fazlzadeh, Mehdi, additional, Fentahun, Netsanet, additional, Fereshtehnejad, Seyed-Mohammad, additional, Fernandes, Eduarda, additional, Filip, Irina, additional, Fischer, Florian, additional, Foroutan, Masoud, additional, Francis, Joel Msafiri, additional, Franklin, Richard Charles, additional, Frostad, Joseph Jon, additional, Fukumoto, Takeshi, additional, Gayesa, Reta Tsegaye, additional, Gebremariam, Kidane Tadesse, additional, Gebremedhin, Ketema Bizuwork Bizuwork, additional, Gebremeskel, Gebreamlak Gebremedhn, additional, Gedefaw, Getnet Azeze, additional, Geramo, Yilma Chisha Dea, additional, Geta, Birhanu, additional, Gezae, Kebede Embaye, additional, Ghashghaee, Ahmad, additional, Ghassemi, Fariba, additional, Gill, Paramjit Singh, additional, Ginawi, Ibrahim Abdelmageed, additional, Goli, Srinivas, additional, Gomes, Nelson G M, additional, Gopalani, Sameer Vali, additional, Goulart, Bárbara Niegia Garcia, additional, Grada, Ayman, additional, Gugnani, Harish Chander, additional, Guido, Davide, additional, Guimares, Rafael Alves, additional, Guo, Yuming, additional, Gupta, Rajeev, additional, Gupta, Rahul, additional, Hafezi-Nejad, Nima, additional, Haile, Michael Tamene, additional, Hailu, Gessessew Bugssa, additional, Haj-Mirzaian, Arvin, additional, Haj-Mirzaian, Arya, additional, Hall, Brian James, additional, Handiso, Demelash Woldeyohannes, additional, Haririan, Hamidreza, additional, Hariyani, Ninuk, additional, Hasaballah, Ahmed I, additional, Hasan, Md. Mehedi, additional, Hasanzadeh, Amir, additional, Hassankhani, Hadi, additional, Hassen, Hamid Yimam, additional, Hayelom, Desta Haftu, additional, Heidari, Behnam, additional, Henry, Nathaniel J, additional, Herteliu, Claudiu, additional, Heydarpour, Fatemeh, additional, Hidru, Hagos D de, additional, Hoang, Chi Linh, additional, Hoogar, Praveen, additional, Hoseini-Ghahfarokhi, Mojtaba, additional, Hossain, Naznin, additional, Hosseini, Mostafa, additional, Hosseinzadeh, Mehdi, additional, Househ, Mowafa, additional, Hu, Guoqing, additional, Humayun, Ayesha, additional, Hussain, Syed Ather, additional, Ibitoye, Segun Emmanuel, additional, Ilesanmi, Olayinka Stephen, additional, Ilic, Milena D, additional, Inbaraj, Leeberk Raja, additional, Irvani, Seyed Sina Naghibi, additional, Islam, Sheikh Mohammed Shariful, additional, Iwu, Chinwe Juliana, additional, Jaca, Anelisa, additional, Jafari Balalami, Nader, additional, Jahanmehr, Nader, additional, Jakovljevic, Mihajlo, additional, Jalali, Amir, additional, Jayatilleke, Achala Upendra, additional, Jenabi, Ensiyeh, additional, Jha, Ravi Prakash, additional, Jha, Vivekanand, additional, Ji, John S, additional, Jia, Peng, additional, Johnson, Kimberly B, additional, Jonas, Jost B, additional, Jozwiak, Jacek Jerzy, additional, Kabir, Ali, additional, Kabir, Zubair, additional, Kahsay, Amaha, additional, Kalani, Hamed, additional, Kanchan, Tanuj, additional, Karami Matin, Behzad, additional, Karch, André, additional, Karki, Surendra, additional, Kasaeian, Amir, additional, Kasahun, Gebremicheal Gebreslassie, additional, Kayode, Gbenga A, additional, Kazemi Karyani, Ali, additional, Keiyoro, Peter Njenga, additional, Ketema, Daniel Bekele, additional, Khader, Yousef Saleh, additional, Khafaie, Morteza Abdullatif, additional, Khalid, Nauman, additional, Khalil, Ali Talha, additional, Khalil, Ibrahim, additional, Khalilov, Rovshan, additional, Khan, Md Nuruzzaman, additional, Khan, Ejaz Ahmad, additional, Khan, Gulfaraz, additional, Khan, Junaid, additional, Khatab, Khaled, additional, Khater, Amir, additional, Khater, Mona M, additional, Khatony, Alireza, additional, Khayamzadeh, Maryam, additional, Khazaei, Mohammad, additional, Khazaei, Salman, additional, Khodamoradi, Ehsan, additional, Khosravi, Mohammad Hossein, additional, Khubchandani, Jagdish, additional, Kiadaliri, Aliasghar A, additional, Kim, Yun Jin, additional, Kimokoti, Ruth W, additional, Kisa, Sezer, additional, Kisa, Adnan, additional, Kissoon, Niranjan, additional, Kondlahalli, Shivakumar KM KM M, additional, Kosek, Margaret N, additional, Koyanagi, Ai, additional, Kraemer, Moritz U G, additional, Krishan, Kewal, additional, Kugbey, Nuworza, additional, Kumar, G Anil, additional, Kumar, Manasi, additional, Kumar, Pushpendra, additional, Kusuma, Dian, additional, La Vecchia, Carlo, additional, Lacey, Ben, additional, Lal, Aparna, additional, Lal, Dharmesh Kumar, additional, Lami, Faris Hasan, additional, Lansingh, Van C, additional, Lasrado, Savita, additional, Lee, Paul H, additional, Leili, Mostafa, additional, Lenjebo, Tsegaye Tsegaye Lolaso Lolaso, additional, Levine, Aubrey J, additional, Lewycka, Sonia, additional, Li, Shanshan, additional, Linn, Shai, additional, Lodha, Rakesh, additional, Longbottom, Joshua, additional, Lopukhov, Platon D, additional, Magdeldin, Sameh, additional, Mahasha, Phetole Walter, additional, Mahotra, Narayan Bahadur, additional, Malta, Deborah Carvalho, additional, Mamun, Abdullah A, additional, Manafi, Navid, additional, Manafi, Farzad, additional, Manda, Ana-Laura, additional, Mansournia, Mohammad Ali, additional, Mapoma, Chabila Christopher, additional, Marami, Dadi, additional, Marczak, Laurie B, additional, Martins-Melo, Francisco Rogerlândio, additional, März, Winfried, additional, Masaka, Anthony, additional, Mathur, Manu Raj, additional, Maulik, Pallab K, additional, Mayala, Benjamin K, additional, McAlinden, Colm, additional, Mehndiratta, Man Mohan, additional, Mehrotra, Ravi, additional, Mehta, Kala M, additional, Meles, Gebrekiros Gebremichael, additional, Melese, Addisu, additional, Memish, Ziad A, additional, Mena, Alemayehu Toma, additional, Menezes, Ritesh G, additional, Mengesha, Melkamu Merid, additional, Mengistu, Desalegn Tadese, additional, Mengistu, Getnet, additional, Meretoja, Tuomo J, additional, Miazgowski, Bartosz, additional, Mihretie, Kebadnew Mulatu M, additional, Miller-Petrie, Molly K, additional, Mills, Edward J, additional, Mir, Seyed Mostafa, additional, Mirabi, Parvaneh, additional, Mirrakhimov, Erkin M, additional, Mohamadi-Bolbanabad, Amjad, additional, Mohammad, Karzan Abdulmuhsin, additional, Mohammad, Yousef, additional, Mohammad, Dara K, additional, Mohammad Darwesh, Aso, additional, Mohammad Gholi Mezerji, Naser, additional, Mohammadifard, Noushin, additional, Mohammed, Ammas Siraj, additional, Mohammed, Shafiu, additional, Mohammed, Jemal Abdu, additional, Mohebi, Farnam, additional, Mokdad, Ali H, additional, Monasta, Lorenzo, additional, Moodley, Yoshan, additional, Moradi, Masoud, additional, Moradi, Ghobad, additional, Moradi-Joo, Mohammad, additional, Moradi-Lakeh, Maziar, additional, Moraga, Paula, additional, Mosapour, Abbas, additional, Mouodi, Simin, additional, Mousavi, Seyyed Meysam, additional, Mozaffor, Miliva Mozaffor Mozaffor, additional, Muluneh, Atalay Goshu, additional, Muriithi, Moses K, additional, Murray, Christopher J L, additional, Murthy, GVS, additional, Musa, Kamarul Imran, additional, Mustafa, Ghulam, additional, Muthupandian, Saravanan, additional, Naderi, Mehdi, additional, Nagarajan, Ahamarshan Jayaraman, additional, Naghavi, Mohsen, additional, Najafi, Farid, additional, Nangia, Vinay, additional, Nazari, Javad, additional, Ndwandwe, Duduzile Edith, additional, Negoi, Ionut, additional, Ngunjiri, Josephine W, additional, Nguyen, QuynhAnh P, additional, Nguyen, Trang Huyen, additional, Nguyen, Cuong Tat, additional, Nigatu, Dabere, additional, Ningrum, Dina Nur Anggraini, additional, Nnaji, Chukwudi A, additional, Nojomi, Marzieh, additional, Noubiap, Jean Jacques, additional, Oh, In-Hwan, additional, Okpala, Oluchi, additional, Olagunju, Andrew T, additional, Omar Bali, Ahmed, additional, Onwujekwe, Obinna E, additional, Ortega-Altamirano, Doris D V, additional, Osarenotor, Osayomwanbo, additional, Osei, Frank B, additional, Owolabi, Mayowa Ojo, additional, P A, Mahesh, additional, Padubidri, Jagadish Rao, additional, Pana, Adrian, additional, Pashaei, Tahereh, additional, Pati, Sanghamitra, additional, Patle, Ajay, additional, Patton, George C, additional, Paulos, Kebreab, additional, Pepito, Veincent Christian Filipino, additional, Pereira, Alexandre, additional, Perico, Norberto, additional, Pesudovs, Konrad, additional, Pigott, David M, additional, Piroozi, Bakhtiar, additional, Platts-Mills, James A, additional, Poljak, Mario, additional, Postma, Maarten J, additional, Pourjafar, Hadi, additional, Pourmalek, Farshad, additional, Pourshams, Akram, additional, Poustchi, Hossein, additional, Prada, Sergio I, additional, Preotescu, Liliana, additional, Quintana, Hedley, additional, Rabiee, Navid, additional, Rabiee, Mohammad, additional, Radfar, Amir, additional, Rafiei, Alireza, additional, Rahim, Fakher, additional, Rahimi-Movaghar, Vafa, additional, Rahman, Muhammad Aziz, additional, Rajati, Fatemeh, additional, Ramezanzadeh, Kiana, additional, Rana, Saleem M, additional, Ranabhat, Chhabi Lal, additional, Rasella, Davide, additional, Rawaf, Salman, additional, Rawaf, David Laith, additional, Rawal, Lal, additional, Remuzzi, Giuseppe, additional, Renjith, Vishnu, additional, Renzaho, Andre M N, additional, Reta, Melese Abate, additional, Rezaei, Satar, additional, Ribeiro, Ana Isabel, additional, Rickard, Jennifer, additional, Rios González, Carlos Miguel, additional, Rios-Blancas, Maria Jesus, additional, Roever, Leonardo, additional, Ronfani, Luca, additional, Roro, Elias Merdassa, additional, Rostami, Ali, additional, Rothenbacher, Dietrich, additional, Rubagotti, Enrico, additional, Rubino, Salvatore, additional, Saad, Anas M, additional, Sabour, Siamak, additional, Sadeghi, Ehsan, additional, Safari, Saeed, additional, Safdarian, Mahdi, additional, Sagar, Rajesh, additional, Sahraian, Mohammad Ali, additional, Sajadi, S. Mohammad, additional, Salahshoor, Mohammad Reza, additional, Salam, Nasir, additional, Salehi, Farkhonde, additional, Salehi Zahabi, Saleh, additional, Salem, Marwa R Rashad, additional, Salem, Hosni, additional, Salimi, Yahya, additional, Salimzadeh, Hamideh, additional, Sambala, Evanson Zondani, additional, Samy, Abdallah M, additional, Sanabria, Juan, additional, Santos, Itamar S, additional, Saraswathy, Sivan Yegnanarayana Iyer, additional, Sarker, Abdur Razzaque, additional, Sartorius, Benn, additional, Sathian, Brijesh, additional, Satpathy, Maheswar, additional, Sbarra, Alyssa N, additional, Schaeffer, Lauren E, additional, Schwebel, David C, additional, Senbeta, Anbissa Muleta, additional, Senthilkumaran, Subramanian, additional, Shabaninejad, Hosein, additional, Shaheen, Amira A, additional, Shaikh, Masood Ali, additional, Shalash, Ali S, additional, Shallo, Seifadin Ahmed, additional, Shams-Beyranvand, Mehran, additional, Shamsi, MohammadBagher, additional, Shamsizadeh, Morteza, additional, Sharif, Mehdi, additional, Shey, Muki Shehu, additional, Shibuya, Kenji, additional, Shiferaw, Wondimeneh Shibabaw Shibabaw, additional, Shigematsu, Mika, additional, Shil, Apurba, additional, Shin, Jae Il, additional, Shiri, Rahman, additional, Shirkoohi, Reza, additional, Si, Si, additional, Siabani, Soraya, additional, Singh, Jasvinder A, additional, Singh, Narinder Pal, additional, Sinha, Dhirendra Narain, additional, Sisay, Malede Mequanent, additional, Skiadaresi, Eirini, additional, Smith, David L, additional, Sobhiyeh, Mohammad Reza, additional, Sokhan, Anton, additional, Soofi, Moslem, additional, Soriano, Joan B, additional, Sorrie, Muluken Bekele, additional, Soyiri, Ireneous N, additional, Sreeramareddy, Chandrashekhar T, additional, Sudaryanto, Agus, additional, Sufiyan, Mu'awiyyah Babale, additional, Suleria, Hafiz Ansar Rasul, additional, Sykes, Bryan L, additional, Tamirat, Koku Sisay, additional, Tassew, Aberash Abay, additional, Taveira, Nuno, additional, Taye, Bineyam, additional, Tehrani-Banihashemi, Arash, additional, Temsah, Mohamad-Hani, additional, Tesfay, Berhe etsay, additional, Tesfay, Fisaha Haile, additional, Tessema, Zemenu Tadesse, additional, Thankappan, Kavumpurathu Raman, additional, Thirunavukkarasu, Sathish, additional, Thomas, Nihal, additional, Tlaye, Kenean Getaneh, additional, Tlou, Boikhutso, additional, Tovani-Palone, Marcos Roberto, additional, Traini, Eugenio, additional, Tran, Khanh Bao, additional, Trihandini, Indang, additional, Ullah, Irfan, additional, Unnikrishnan, Bhaskaran, additional, Valadan Tahbaz, Sahel, additional, Valdez, Pascual R, additional, Varughese, Santosh, additional, Veisani, Yousef, additional, Violante, Francesco S, additional, Vollmer, Sebastian, additional, Vos, Theo, additional, Wada, Fiseha Wadilo, additional, Waheed, Yasir, additional, Wang, Yafeng, additional, Wang, Yuan-Pang, additional, Weldesamuel, Girmay Teklay, additional, Welgan, Catherine A, additional, Westerman, Ronny, additional, Wiangkham, Taweewat, additional, Wijeratne, Tissa, additional, Wiysonge, Charles Shey Shey, additional, Wolde, Haileab Fekadu, additional, Wondafrash, Dawit Zewdu, additional, Wonde, Tewodros Eshete, additional, Wu, Ai-Min, additional, Xu, Gelin, additional, Yadollahpour, Ali, additional, Yahyazadeh Jabbari, Seyed Hossein, additional, Yamada, Tomohide, additional, Yaseri, Mehdi, additional, Yenesew, Muluken Azage, additional, Yeshaneh, Alex, additional, Yilma, Mekdes Tigistu, additional, Yimer, Ebrahim M, additional, Yip, Paul, additional, Yirsaw, Biruck Desalegn, additional, Yisma, Engida, additional, Yonemoto, Naohiro, additional, Younis, Mustafa Z, additional, Yousof, Hebat-Allah Salah A, additional, Yu, Chuanhua, additional, Yusefzadeh, Hasan, additional, Zamani, Mohammad, additional, Zambrana-Torrelio, Carlos, additional, Zandian, Hamed, additional, Zeleke, Ayalew Jejaw, additional, Zepro, Nejimu Biza, additional, Zewale, Taye Abuhay, additional, Zhang, Dongyu, additional, Zhang, Yunquan, additional, Zhao, Xiu-Ju, additional, Ziapour, Arash, additional, Zodpey, Sanjay, additional, and Hay, Simon I, additional

Published
2020
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24. Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway

Author

Meng-Yan Deng, Qiao-Qiao Han, Rana Muhammad Shoaib, Xin-Yan Li, Khalil Ali Ahmad, Yong-Xiang Wang, and Zi-Ying Wang

Subjects
Male, (+)-Naloxone, Pharmacology, Biochemistry, Proinflammatory cytokine, medicine, Animals, Rats, Wistar, Cells, Cultured, Multiple myeloma, Lenalidomide, Dose-Response Relationship, Drug, Microglia, business.industry, beta-Endorphin, medicine.disease, Pomalidomide, Interleukin-10, Rats, Thalidomide, medicine.anatomical_structure, Neuropathic pain, Neuralgia, business, Immunosuppressive Agents, Signal Transduction, medicine.drug
Abstract

Thalidomide is an antiinflammatory, antiangiogenic and immunomodulatory agent which has been used for the treatment of erythema nodosum leprosum and multiple myeloma. It has also been employed in treating complex regional pain syndromes. The current study aimed to reveal the molecular mechanisms underlying thalidomide-induced pain antihypersensitive effects in neuropathic pain. Thalidomide gavage, but not its more potent analogs lenalidomide and pomalidomide, inhibited mechanical allodynia and thermal hyperalgesia in neuropathic pain rats induced by tight ligation of spinal nerves, with ED50 values of 44.9 and 23.5 mg/kg, and Emax values of 74% and 84% MPE respectively. Intrathecal injection of thalidomide also inhibited mechanical allodynia and thermal hyperalgesia in neuropathic pain. Treatment with thalidomide, lenalidomide and pomalidomide reduced peripheral nerve injury-induced proinflammatory cytokines (TNFα, IL-1β and IL-6) in the ipsilateral spinal cords of neuropathic rats and LPS-treated primary microglial cells. In contrast, treatment with thalidomide, but not lenalidomide or pomalidomide, stimulated spinal expressions of IL-10 and β-endorphin in neuropathic rats. Particularly, thalidomide specifically stimulated IL-10 and β-endorphin expressions in microglia but not astrocytes or neurons. Furthermore, pretreatment with the IL-10 antibody blocked upregulation of β-endorphin in neuropathic rats and cultured microglial cells, whereas it did not restore thalidomide-induced downregulation of proinflammatory cytokine expression. Importantly, pretreatment with intrathecal injection of the microglial metabolic inhibitor minocycline, IL-10 antibody, β-endorphin antiserum, and preferred or selective μ-opioid receptor antagonist naloxone or CTAP entirely blocked thalidomide gavage-induced mechanical antiallodynia. Our results demonstrate that thalidomide, but not lenalidomide or pomalidomide, alleviates neuropathic pain, which is mediated by upregulation of spinal microglial IL-10/β-endorphin expression, rather than downregulation of TNFα expression.

Published
2021
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25. مدى جاهزية الجامعات الفلسطينية الخاصة نحو التحول الرقمي (The Readiness Of Private Palestinian Universities Towards The Digital Transformation)

Author

Tareq AbuHjayyer and Khalil Ali Madi

Subjects
Important research, Arabic, Approval rate, Statistics, language, Educational qualification, language.human_language, Mathematics
Abstract

Arabic Abstract: هدف البحث إلى معرفة مدى جاهزية الجامعات الفلسطينية الخاصة نحو التحول الرقمي، وقد استخدم الباحثان المنهج الوصفي التحليلي، وتم استخدام الاستبانة كأداة لجمع المعلومات، وتمثل مجتمع الدراسة في الموظفين العاملين في الجامعات الفلسطينية الخاصة في المحافظات الجنوبية (جامعة فلسطين، جامعة غزة، جامعة الإسراء) وقد تم استخدام طريقة العينة العشوائية الطبقية حسب الجامعة، حيث تم توزيع (170) استبانة على مجتمع الدراسة وتم الحصول على (110) استبانة صالحة للتحليل بنسبة استرداد 65% تقريبا، وقد توصل البحث إلى عدة نتائج من أهمها: أن هناك موافقة كبيرة بنسبة 81.52% لدعم الإدارة العليا للتحول الرقمي، وبنسبة أقل لمجال التوجهات الاستراتيجية الملائمة للتحول الرقمي بنسبة 78.82% بينما مجال توفر البنية التحتية الفنية اللازمة للتحول الرقمي جاء بنسبة 77.88%، ومجال البيئة الإدارية والمالية المناسبة للتحول الرقمي بنسبة 76.20% وفي المرتبة الأخيرة مجال الموارد البشرية والتنظيمية اللازمة للتحول الرقمي بنسبة 74.97%، كما تبين أنه توجد فروق ذات دلالة إحصائية بين متوسطات درجات تقدير أفراد عينة الدراسة تعزى الى (العمر، الوظيفة)، بينما لا توجد فروق ذات دلالة إحصائية بين متوسطات درجات تقدير أفراد عينة الدراسة تعزى الى (الجنس، المؤهل العلمي، الخبرة، الجامعة)، وبناء على نتائج البحث، كان من أهم توصياته: العمل على توفير كافة العوامل الداعمة لجهوزية الجامعات الفلسطينية نحو التحول الرقمي مع التركيز على توفير البيئة الإدارية والمالية إضافة إلى تأهيل الموارد البشرية والتنظيمية اللازمة لنجاح عملية التحول التي ثبت أن لها العديد من المزايا في العملية التعليمية. English Abstract: The research targeted the readiness of local private Palestinian Universities towards the digital transformation. The researchers used the descriptive analytical approach, and the questionnaire was adopted as a tool to collect information. A stratified random sample method was used with accordance to the targeted University, where (170) questionnaires were distributed, and (110) questionnaires valid for analysis were obtained at a rate of recovery of approximately 65%. The research demonstrated several results, the most important of which are: There is a significant approval rate of 81.52% to support senior management of digital transformation, and with a lower percentage for the field of strategic directions appropriate for digital transformation by 78.82% while the field of technical infrastructure availability for digital transformation came with a rate of 77.88%, The field of administrative environment And the appropriate financing for digital transformation by 76.20%, The human and organizational resources needed for digital transformation by 74.97%, as it was found that there are statistically significant differences between the mean scores for the individuals of the study sample attributed to (age, job), while there are no significant differences A statistic between the mean scores for the estimate of the individuals of the study sample attributed to (gender, educational qualification, experience, university). One of the most important research outcomes recommendations was: Working to provide all the factors that support the readiness of Palestinian universities towards digital transformation, with a focus on providing the administrative and financial environment in addition to qualifying the human and organizational resources necessary for the success of the transformation process.

Published
2020
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33. Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis

Author

Aida A. Mahmoud and Abdellah Hamed Khalil Ali

Subjects
medicine.medical_specialty, Tuberculosis, Population, Calcitriol receptor, vitamin D deficiency, Internal medicine, Genotype, medicine, Vitamin D and neurology, Vitamin D, education, Gene, lcsh:RC705-779, education.field_of_study, biology, business.industry, lcsh:Diseases of the respiratory system, medicine.disease, FokI, Endocrinology, Vitamin D receptor, FokI genotypes, Immunology, biology.protein, business
Abstract

Background: Vitamin D is a potent immunomodulator of innate immune responses, and its deficiency was implicated in the activation of tuberculosis (TB). The effects of vitamin D are exerted by the interaction with the vitamin D receptor (VDR) and may be influenced by polymorphisms in the VDR gene. Methods: We conducted a case–control study to identify 25(OH) D levels and FOK1 polymorphism of the VDR gene in a group of newly diagnosed pulmonary TB patients and compared to the findings in a group of healthy controls. Results: Obtained results revealed that 25(OH) D levels were significantly lower in the patients than in the controls (P 0.05). Also, no association between VDR genotype and 25(OH) D levels was found. Conclusion: FokI polymorphisms in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in the Egyptian population. However, vitamin D deficiency may be a cause of the susceptibility to tuberculosis.

Published
2014
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35. Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives

Author

Iqbal, Javed, primary, Abbasi, Banzeer Ahsan, additional, Ahmad, Riaz, additional, Batool, Riffat, additional, Mahmood, Tariq, additional, Ali, Barkat, additional, Khalil, Ali Talha, additional, Kanwal, Sobia, additional, Afzal Shah, Sayed, additional, Alam, Muhammad Maqsood, additional, Bashir, Sheeza, additional, Badshah, Hussain, additional, and Munir, Akhtar, additional

Published
2019
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38. Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress

Author

Ihsan, Awais Ullah, primary, Khan, Farhan Ullah, additional, Khongorzul, Puregmaa, additional, Ahmad, Khalil Ali, additional, Naveed, Muhammad, additional, Yasmeen, Sufia, additional, Cao, Yanfang, additional, Taleb, Abdoh, additional, Maiti, Richinandan, additional, Akhter, Fahad, additional, Liao, Xiaoqian, additional, Li, Xue, additional, Cheng, Yijie, additional, Khan, Hidayat Ullah, additional, Alam, Khurshid, additional, and Zhou, Xiaohui, additional

Published
2018
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42. Computed tomography lymphography by transbronchial injection of iopamidol to identify sentinel nodes in preoperative patients with non–small cell lung cancer: A pilot study

Author

Koichiro Kajiura, Shoji Sakiyama, Kazuya Kondo, Akira Tangoku, Abdellah Hamed Khalil Ali, Hiromitsu Takizawa, and Hiroaki Toba

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Contrast Media, Pilot Projects, Iopamidol, Injections, Pneumonectomy, Carcinoma, Non-Small-Cell Lung, Hounsfield scale, medicine, Humans, Lung cancer, Lymph node, Aged, Neoplasm Staging, Sentinel Lymph Node Biopsy, Thoracic Surgery, Video-Assisted, business.industry, Lymphography, Middle Aged, Sentinel node, medicine.disease, Dissection, medicine.anatomical_structure, Female, Surgery, Radiology, Tomography, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Objective The objective of the present study was to assess the safety and feasibility of computed tomography lymphography by transbronchial injection of a water-soluble extracellular computed tomography contrast agent. Methods From April 2010 to May 2011, patients with clinical stage I non–small cell lung cancer who were candidates for lobectomy were enrolled in the present study. An ultrathin bronchoscope was inserted to the target bronchus under the guidance of virtual bronchoscopic navigation images. Computed tomography images of the chest were obtained 0.5 and 5 minutes after 2 or 3 mL of iopamidol was injected through a microcatheter. Sentinel nodes were identified when the maximum computed tomography attenuation value of the lymph nodes on the postcontrast computed tomography images increased by 30 Hounsfield units or more compared with the precontrast images. Patients underwent lobectomy with standard lymph node dissection. Results The ultrathin bronchoscope could access the targeted bronchus, and iopamidol was delivered into the peritumoral area in all 13 patients without any complications. Sentinel nodes were identified in 12 (92.3%) of the 13 patients. The average number of sentinel nodes was 1.5 (range, 1–2). Pathologic examination revealed metastatic lymph nodes in 2 patients. Metastatic nodes were included with the sentinel nodes. Conclusions Computed tomography lymphography by transbronchial injection of iopamidol was a safe and feasible method to identify the sentinel nodes in patients with clinical stage I non–small cell lung cancer.

Published
2012
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43. 5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor

Author

Hisashi Matsuoka, Kazuya Kondo, Hiroaki Toba, Koichiro Kenzaki, Yasushi Nakagawa, Hiromitsu Takizawa, Shoji Sakiyama, Abdellah Hamed Khalil Ali, Soji Kakiuchi, Akira Tangoku, Yoshitaka Sekido, and Saburo Sone

Subjects
Mesothelioma, Pulmonary and Respiratory Medicine, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Carcinosis, Pleural Neoplasms, Protoporphyrins, Mice, SCID, Sensitivity and Specificity, Fluorescence, Mice, Pleural disease, chemistry.chemical_compound, In vivo, Cell Line, Tumor, medicine, Fluorescence microscope, Animals, Humans, Photosensitizer, Neoplasm Metastasis, Lung cancer, Photosensitizing Agents, Protoporphyrin IX, business.industry, Carcinoma, Cancer, Aminolevulinic Acid, Neoplasms, Experimental, medicine.disease, Tumor Burden, Microscopy, Fluorescence, Oncology, chemistry, business
Abstract

Background It is known that endogenously synthesized protoporphyrin IX (PpIX) following the administration of 5-aminolevulinic acid (5-ALA) is an effective photosensitizer for photodynamic diagnosis (PDD). We tested in vivo and in vitro susceptibility of human lung cancer and mesothelioma cells to photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) as a photosensitizer. Methods Human lung cancer cell lines A549, Ma44-3, FT821 and human mesothelioma cell lines MSTO-211H, NCI-H290, Y-MESO-14 were incubated with 0.03% 5-ALA for 4 h. After incubation, protoporphyrin IX (PpIX) fluorescence was detected using a fluorescence microscope. Pleural carcinosis was induced in severe combined immunodeficiency disease mice using the previous cell lines to test the efficacy of PDD in vivo. The mice were sacrificed 4 h after oral administration of 400 mg/kg of 5-ALA. We counted the visible tumors under white light then fluorescence light. Results In vitro, clear red fluorescence was observed in all cell lines. The mean fluorescence intensity was stronger in A549 and FT821 cells than Ma44-3 cells (165.59 ± 26.49, 157.62 ± 18.93 vs. 104.01 ± 17.58). Also, MSTO-211H and NCI-H290 cells had stronger fluorescence intensity than Y-MESO-14 cells (142.51 ± 26.85, 165.16 ± 12.91 vs. 92.31 ± 8.69). In vivo, the tumor detection rate of fluorescence diagnosis was 1.1–4.5 times higher than that of white light. The mean number of metastases detected by the PDD was significantly higher than that of white light for FT821 (p = 0.004), Ma44-3 (p = 0.006) and Y-MESO-14 cell lines (p = 0.005), but not for A549, NCI-H290 and MSTO-211H cell lines. Small lesions were detected by fluorescence diagnosis even though the lesions were invisible macroscopically under white light. Conclusion Our results suggest the possibility of clinical application of fluorescence diagnosis with intrapleural malignant tumors.

Published
2011
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47. An increase of intelligence in Saudi Arabia, 1977–2010

Author

Richard Lynn, Adel A. Batterjee, Khalil Ali, and Omar Khaleefa

Subjects
Raven's Progressive Matrices, Arts and Humanities (miscellaneous), Intelligence quotient, Flynn effect, Developmental and Educational Psychology, Mathematics education, Normative, Experimental and Cognitive Psychology, Sample (statistics), Psychology, Demography
Abstract

Normative data for 8–15 year olds for the Standard Progressive Matrices in Saudi Arabia were obtained in 1977 and 2010. The 2010 sample obtained higher average scores than the 1977 sample by .78d, equivalent to 11.7 IQ points. This represents a gain of 3.55 IQ points a decade over the 33 year period.

Published
2013
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50. Differential Diagnostic Efficiency of T Cells Subsets Versus Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Adenosine Deaminase in Distinguishing Tuberculous From Malignant Pleural Effusions

Author

Tamer Mohmoud and Abdellah Hamed Khalil Ali

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Tuberculosis, biology, Interferon type II, business.industry, Alpha (ethology), T lymphocyte, Critical Care and Intensive Care Medicine, Interferon gamma/tumor necrosis factor, medicine.disease, Adenosine deaminase, biology.protein, Medicine, Tumor necrosis factor alpha, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
2015
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