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The paper examines the theoretical merit of “semantic molecules” in Natural Semantic Metalanguage (NSM). Although semantic molecules are said to trace semantic dependence and necessity, compress complexity, and to account for what I call its productivity, that doesn't appear to be the case. This can be illustrated on the basis of a comparison of two explications for the same complex meaning—one containing a molecule and the other its decomposed elements. Counterfactual considerations suggest that the latter is not semantically dependent on the lexicalized molecule and that it is, in turn, not necessary. The other side of the comparison cements the point. This leaves the issue of compression, complexity, and productivity—none of which are helped by semantic molecules, as they appear to do little more than conceal complexity. Meanwhile, they are not required to account for productivity. It seems that molecules may need to be rethought.