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Your search keyword '"Kakehasi, Adriana Maria"' showing total 13 results
Start Over Author "Kakehasi, Adriana Maria" Publisher elsevier bv
13 results on '"Kakehasi, Adriana Maria"'

2. Sarcopenia is associated with type 2 diabetes and sedentary lifestyle in patients with chronic hepatitis B

Author

de Lima Santos, Cecy Maria, primary, Pires, Aline Marcos, additional, Viana, Nataly Lopes, additional, Sigales, Emile Amador, additional, Kakehasi, Adriana Maria, additional, Malheiro, Olivio Brito, additional, Sarquis Soares, Maria Marta, additional, Teixeira, Rosangela, additional, Rocha, Gifone Aguiar, additional, Bering, Tatiana Bering, additional, and Silva, Luciana Diniz, additional

Published
2020
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3. Increased resting metabolism in neurofibromatosis type 1

Author

Souza, Marcio Leandro Ribeiro de, primary, Jansen, Ann Kristine, additional, Rodrigues, Luiz Oswaldo Carneiro, additional, Vilela, Darlene Larissa de Souza, additional, Kakehasi, Adriana Maria, additional, Martins, Aline Stangherlin, additional, Souza, Juliana Ferreira de, additional, and Rezende, Nilton Alves de, additional

Published
2019
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4. Infliximabe, metotrexato e sua combinação no tratamento da artrite reumatoide: revisão sistemática e metanálise

Author

Costa, Juliana de Oliveira, Lemos, Lívia Lovato Pires de, Machado, Marina Amaral de Ávila, Almeida, Alessandra Maciel, Kakehasi, Adriana Maria, Araújo, Vânia de Eloísa, Cherchiglia, Mariângela Leal, Andrade, Eli Iola Gurgel, and Acurcio, Francisco de Assis

Subjects
musculoskeletal diseases, Efficacy, Artrite reumatoide, Infliximab, Arthritis, Rheumatoid, Infliximabe, Metanálise, Meta-analysis, Methotrexate, immune system diseases, Revisão sistemática, Antirheumatic Agents, Systematic review, Humans, General Earth and Planetary Sciences, Drug Therapy, Combination, Eficácia, Rheumatoid arthritis, skin and connective tissue diseases, General Environmental Science
Abstract

Foi feita uma revisão sistemática para avaliar a eficácia e a segurança do esquema infliximabe + metotrexato (IFX + MTX) versus MTX isoladamente ou em combinação com outros medicamentos modificadores do curso da doença (MMCD). Pesquisou‐se nas principais bases de dados eletrônicas e na literatura cinzenta e fez‐se uma busca manual. Dois revisores independentes fizeram a seleção, extração de dados e análise da qualidade dos estudos. A metanálise foi feita com o software Review Manager® 5.1. Incluíram‐se nove estudos. O escore médio na escala de Jadad modificada foi de 4,4, mas somente um estudo mostrou baixo risco de viés. O esquema IFX + MTX apresentou melhores respostas nos desfechos clínicos de ACR e do DAS28 por até 54 semanas e na progressão radiográfica por até 104 semanas. As perdas de seguimento decorrentes da falta de eficácia foram menores no grupo IFX + MTX. Não foi observada diferença estatisticamente significante nos eventos adversos. A combinação IFX + MTX é mais eficaz do que o tratamento com MTX isolado ou em combinação com MMCD. Esse esquema apresentou boa tolerabilidade em pacientes previamente tratados com MMCD, não tratados com MTX ou com respostas insuficientes ao MTX. A eficácia do regime IFX + MTX é observada principalmente durante os períodos iniciais do tratamento. Altas doses de IFX foram tão eficazes quanto a dose padrão, mas com a possibilidade maior risco de infecções graves. Recomenda‐se, portanto, que os médicos utilizem a dose padrão de IFX de 3 mg/kg a cada oito semanas. We performed a systematic review to evaluate the efficacy and safety of infliximab + methotrexate (IFX + MTX) regimens versus MTX alone or in combination with other disease-modifying anti-rheumatic drugs (DMARDs). We searched through major databases, the grey literature and did a manual search. Two independent reviewers conducted the selection, data extraction and analysis of the quality of the studies. Meta-analysis was conducted using Review Manager® 5.1 software. Nine trials were included. The mean modified Jadad score was 4.4, but only one study showed low risk of bias. IFX + MTX regimen presented better responses in clinical outcomes of ACR and DAS28 by up to 54 weeks, and of radiographic progression by up to 104 weeks. Withdrawals due to lack of efficacy was lower in the IFX + MTX group. No significant difference in adverse events was observed. The IFX + MTX combination is more effective than treatment with MTX alone or DMARDs combination. This regimen presented good tolerability in patients previously treated with DMARDs, not treated with MTX or with insufficient responses to MTX. The efficacy of IFX + MTX is noted primarily during initial periods of treatment. High doses of IFX were as effective as the standard dose, but with possible higher risk of serious infections. Therefore, we advise clinicians to use the standard dose of IFX 3 mg/kg every 8 weeks.

Published
2015

10. Infliximab, methotrexate and their combination for the treatment of rheumatoid arthritis: a systematic review and meta-analysis

Author

Costa, Juliana de Oliveira, primary, Lemos, Lívia Lovato Pires de, additional, Machado, Marina Amaral de Ávila, additional, Almeida, Alessandra Maciel, additional, Kakehasi, Adriana Maria, additional, Araújo, Vânia de Eloísa, additional, Cherchiglia, Mariângela Leal, additional, Andrade, Eli Iola Gurgel, additional, and Acurcio, Francisco de Assis, additional

Published
2015
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11. Rituximab for rheumatoid arthrits treatment: a systematic review

Author

Lemos, Lívia Lovato Pires de, primary, Costa, Juliana de Oliveira, additional, Machado, Marina Amaral de Ávila, additional, Almeida, Alessandra Maciel, additional, Barbosa, Mariana Michel, additional, Kakehasi, Adriana Maria, additional, Araújo, Vânia Eloísa de, additional, Júnior, Augusto Afonso Guerra, additional, and Acurcio, Francisco de Assis, additional

Published
2014
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12. Erratum of “Adalimumab in rheumatoid arthritis treatments: a systematic review and meta-analysis of randomized clinical trials”

Author

Machado, Marina Amaral de Ávila, primary, Maciel, Alessandra Almeida, additional, Lemos, Lívia Lovato Pires de, additional, Costa, Juliana Oliveira, additional, Kakehasi, Adriana Maria, additional, Andrade, Eli Iola Gurgel, additional, Cherchiglia, Mariangela Leal, additional, and Acurcio, Francisco de Assis, additional

Published
2014
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