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1. Gain monitoring of telescope array photomultiplier cameras for the first 4 years of operation

Author

Y. Uchihori, X. Zhou, B. G. Cheon, Takaaki Ishii, T. Kanbe, Robert M. Anderson, J. Martineau, D. C. Rodriguez, Grigory Rubtsov, Isaac Myers, Y. Kobayashi, A. L. Sampson, S. Kawakami, H. Yoshii, K. Tsutsumi, H. Tokuno, Yuichiro Tameda, John N. Matthews, L. M. Scott, Y. Hayashi, Hiroyuki Sagawa, J. D. Smith, Takayuki Tomida, K. Kitamoto, R. Azuma, T. Matsuura, Mayuko Minamino, K. Honda, Yasunori Kitamura, S. Yoshida, Vladim Kuzmin, R. Zollinger, R. Aida, Masaaki Tanaka, Hideaki Shimodaira, K. Hibino, Yoshiki Tsunesada, K. Yamazaki, Daisuke Ikeda, Fumiya Shibata, Tareq Abu-Zayyad, R. Yamane, R. Ishimori, S. R. Stratton, Ben Stokes, Tiffany Wong, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, T. Fukuda, Takeshi Okuda, Igor Tkachev, Masaki Fukushima, T. Shirahama, S. Y. Roh, Hyun-Il Kim, S. Kitamura, M. Allen, T. Matsuyama, Samuel Blake, E. J. Cho, Y. Kondo, Shoichi Ogio, K. Oki, Michiyuki Chikawa, Inkyu Park, K. Nagasawa, Shingo Kawana, T. Fujii, Eiji Kido, William Hanlon, Sergey Troitsky, S. Machida, R. W. Springer, J. I. Shin, Naoaki Hayashida, Y. Tsuyuguchi, Maxim Pshirkov, Kiyoshi Tanaka, Elliott Barcikowski, Dmitri Ivanov, H. Fujii, K. Hayashi, H. Kawai, K. Kasahara, Fumio Kakimoto, Tomohiro Matsuda, K. Ikuta, Nobuyuki Sakurai, Akitoshi Oshima, K. Kobayashi, Shunsuke Ozawa, John Belz, Y. Murano, Pierre Sokolsky, M. Takeda, Shigehiro Nagataki, K. Kuramoto, Yasuhiro H. Takahashi, Masato Takita, Zach Zundel, O. Kalashev, T. Iguchi, M. Wood, P. Tinyakov, Y. Yamakawa, K. Martens, Hideki Tanaka, Y. J. Kwon, Toshiyuki Nonaka, Hiroshi Yamaoka, Hideyuki Ohoka, J. Yang, H. Ukai, Priti Shah, K. Miyata, Hongsu Kim, Bokkyun Shin, Akimichi Taketa, S. Suzuki, Douglas Bergman, D. Oku, K. Hiyama, Y. Yoneda, N. Inoue, S. I. Lim, M. Ohnishi, S. Udo, C. C. H. Jui, S. B. Thomas, S. W. Nam, W. R. Cho, Toru Nakamura, Kenichi Kadota, Y. Wada, T. J. Sonley, S. Iwamoto, G. Vasiloff, Jyunsei Chiba, Dongsu Ryu, and J. H. Kim

Subjects
Physics, Telescope, Nuclear and High Energy Physics, Photomultiplier, Optics, business.industry, law, Night sky, Optoelectronics, Scintillator, business, Instrumentation, law.invention
Abstract

The stability of the gain of the photomultiplier (PMT) camera for the Fluorescence Detector (FD) of the Telescope Array experiment was monitored using an 241 Am loaded scintillator pulsers (YAP) and a diffused xenon flasher (TXF) for a selected set of 35 PMT-readout channels. From the monitoring of YAP pulses over four years of FD operation, we found slow monotonic drifts of PMT gains at a rate of −1.7~+1.7%/year. An average of the PMT gains over the 35 channels stayed nearly constant with a rate of change measured at −0.01±0.31(stat)±0.21(sys)%/year. No systematic decrease of the PMT gain caused by the night sky background was observed. Monitoring by the TXF also tracked the PMT gain drift of the YAP at 0.88±0.14(stat)%/year.

Published
2014
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2. The energy spectrum of ultra-high-energy cosmic rays measured by the Telescope Array FADC fluorescence detectors in monocular mode

Author

T. Kanbe, Y. Kobayashi, Fumiya Shibata, S. Kitamura, Robert M. Anderson, R. Ishimori, Hidemi Ito, Sergey Troitsky, Grigory Rubtsov, Isaac Myers, T. Matsuyama, Y. Yamakawa, S. Yoshida, H. Ukai, Priti Shah, Yuichiro Tameda, S. Suzuki, Taka Tomida, T. Shirahama, John N. Matthews, Douglas Bergman, Pierre Sokolsky, R. Zollinger, D. Oku, K. Hiyama, Y. J. Kwon, Hiroyuki Sagawa, K. Ikuta, Hideyuki Ohoka, Hideaki Shimodaira, M. Takeda, J. H. Kim, M. Allen, T. J. Sonley, Shigehiro Nagataki, K. Oki, Charlie Jui, J. Ogura, Y. Kondo, Akimichi Taketa, Naoaki Hayashida, Y. Tsuyuguchi, K. Kasahara, K. Kitamoto, J. P. Lundquist, Takaaki Ishii, Toshiyuki Nonaka, Mayuko Minamino, K. Honda, S. Y. Roh, B. G. Cheon, Takeshi Okuda, Igor Tkachev, T. Iguchi, A. L. Sampson, D. C. Rodriguez, S. Iwamoto, John Belz, Inkyu Park, K. Miyata, Masaomi Ono, J. I. Shin, Yasunori Kitamura, K. Yamazaki, Bokkyun Shin, S. Kawakami, Y. Murano, Tareq Abu-Zayyad, Vladim Kuzmin, R. Yamane, T. Fujii, K. Tsutsumi, Hiroshi Yamaoka, R. Aida, Masaaki Tanaka, G. Vasiloff, R. Azuma, T. Matsuura, Elliott Barcikowski, T.-A. Shibata, L. M. Scott, K. Hibino, Jyunsei Chiba, Dongsu Ryu, Gordon Thomson, Tom Stroman, Robert Cady, Y. Hayashi, Hongsu Kim, Dmitri Ivanov, H. Fujii, Y. Uchihori, O. Kalashev, W. R. Cho, H. Kawai, Hyun-Il Kim, Kiyoshi Tanaka, H. Yoshii, Eiji Kido, Yoshiki Tsunesada, K. Kuramoto, Y. Yoneda, N. Inoue, S. I. Lim, Daisuke Ikeda, Toru Nakamura, Kenichi Kadota, S. R. Stratton, M. Ohnishi, S. Machida, S. Udo, J. Yang, Y. Wada, Tiffany Wong, J. Lan, S. B. Thomas, Nobuyuki Sakurai, S. W. Nam, T. Fukuda, Masaki Fukushima, Peter Tinyakov, Samuel Blake, Shoichi Ogio, E. J. Cho, Michiyuki Chikawa, Yasuhiro H. Takahashi, Zach Zundel, Masato Takita, K. Martens, Hideki Tanaka, H. Tokuno, J. D. Smith, R. W. Springer, Tomohiro Matsuda, K. Kobayashi, Shingo Kawana, William Hanlon, Maxim Pshirkov, K. Hayashi, Fumio Kakimoto, Akitoshi Oshima, Shunsuke Ozawa, and Ben Stokes

Subjects
Astroparticle physics, Physics, business.industry, Aperture, Monte Carlo method, Detector, Astronomy and Astrophysics, Cosmic ray, law.invention, Telescope, Optics, law, Ultra-high-energy cosmic ray, business, Event reconstruction
Abstract

We present a measurement of the energy spectrum of ultra-high-energy cosmic rays performed by the Telescope Array experiment using monocular observations from its two new FADC-based fluorescence detectors. After a short description of the experiment, we describe the data analysis and event reconstruction procedures. Since the aperture of the experiment must be calculated by Monte Carlo simulation, we describe this calculation and the comparisons of simulated and real data used to verify the validity of the aperture calculation. Finally, we present the energy spectrum calculated from the merged monocular data sets of the two FADC-based detectors, and also the combination of this merged spectrum with an independent, previously published monocular spectrum measurement performed by Telescope Array’s third fluorescence detector [T. Abu-Zayyad et al., The energy spectrum of Telescope Array’s middle drum detector and the direct comparison to the high resolution fly’s eye experiment, Astroparticle Physics 39 (2012) 109-119, http://dx.doi.org/10.1016/j.astropartphys.2012.05.012 , Available from: ]. This combined spectrum corroborates the recently published Telescope Array surface detector spectrum [T. Abu-Zayyad, et al., The cosmic-ray energy spectrum observed with the surface detector of the Telescope Array experiment, ApJ 768 (2013) L1, http://dx.doi.org/10.1088/2041-8205/768/1/L1 , Available from: ] with independent systematic uncertainties.

Published
2013
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3. Transmission electron microscopy of antiphase boundary-like structure of B19′ martensite in Ti–Ni shape memory alloy

Author

E. Okunishi, K. Kuramoto, Mitsuhiro Matsuda, Minoru Nishida, Sadahiro Tsurekawa, Yasuhiro Morizono, and Toru Hara

Subjects
Materials science, Polymers and Plastics, Condensed matter physics, Plane (geometry), Metals and Alloys, Shape-memory alloy, Crystal structure, Crystallographic defect, Electronic, Optical and Magnetic Materials, Crystallography, Transmission electron microscopy, Diffusionless transformation, Martensite, Ceramics and Composites, Stacking fault
Abstract

An antiphase boundary (APB)-like structure of the B19′ martensite in Ti–Ni alloy was investigated by transmission electron microscopy. The APB-like structure shows atomic shifts on both the (0 1 0)B19′ plane along the c-axis and the (0 0 1)B19′ plane along the b-axis; a kind of ledge-and-step structure on the b–c plane, in addition to a displacement along the a-axis. The displacement vector can be expressed as R = 〈−0.1648 1/2 0.4328〉 in terms of the conventional atomic coordinates of Ti and Ni in the B19′ martensite. The APB-like structure is not inherited from APB in the B2 parent phase. We conclude that the APB-like structure is developed by accidental impingement of differently nucleated martensitic domains during the transformation. This structure is defined as a kind of stacking fault with an APB-like contrast.

Published
2011
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4. Durability test on irradiated rock-like oxide fuels

Author

Toshiyuki Yamashita, K. Kuramoto, and N. Nitani

Subjects
Nuclear and High Energy Physics, Materials science, Metallurgy, Oxide, Pellets, chemistry.chemical_element, Americium, Spent nuclear fuel, chemistry.chemical_compound, Nuclear Energy and Engineering, chemistry, General Materials Science, Cubic zirconia, Nuclide, Leaching (metallurgy), Yttria-stabilized zirconia, Nuclear chemistry
Abstract

For a profitable use of Pu, Japan Atomic Energy Research Institute has been promoting researches for once-through type fuels. The strategy consists of stable rock-like oxide fuel fabrication in conventional fuel facilities followed by almost complete Pu burning in LWR and disposal of chemically stable spent fuel without further processing. Because leach rates of hazardous nuclides, such as TRU and β-emitters, that have long half-lives, are very important for the evaluation of geological safety, leaching tests in deionized water at 363 K were performed with reference to the MCC-1 method. Five irradiated fuel pellets, a single phase fuel of a yttria-stabilized zirconia (YSZ) containing UO2 (U-YSZ), two fuels of U-YSZ particle dispersed in MgAl2O4 (SPI) or Al2O3 (COR) matrix, two homogeneous-blended fuels of U-YSZ and SPI or COR powders, were submitted to the tests. Stainless steel containers with Au coating and ethylene propylene diene monomer were used as leaching vessels and packing, respectively. The evaluated normalized leach rates of Zr, U and Pu were obviously lower than those of the other important elements and nuclides. Americium, Np and especially Y showed unexpectedly high evaluated normalized leach rates. The volatile elements, Cs and I, showed enhanced leaching within particle-dispersed type fuels because of crack formation around the particle.

Published
2003
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5. In-pile irradiation of rock-like oxide fuels

Author

Toshiyuki Yamashita, K. Kuramoto, N. Nitani, Y. Nihei, and Y. Kimura

Subjects
Nuclear and High Energy Physics, Materials science, Spinel, Analytical chemistry, Oxide, Corundum, Electron microprobe, engineering.material, Microstructure, chemistry.chemical_compound, Nuclear Energy and Engineering, chemistry, engineering, General Materials Science, Cubic zirconia, Ceramography, Yttria-stabilized zirconia, Nuclear chemistry
Abstract

Five kinds of rock-like oxide fuels were prepared and irradiated using 20% enriched U instead of Pu. The microstructure analyses for irradiated fuel pellets were carried out by ceramography and electron probe microanalysis (EPMA). For MgAl 2 O 4 (spinel)-based fuel, decomposition of the spinel and vaporization of MgO (magnesia) was observed. For Al 2 O 3 (corundum)-based fuels, significant appearance changes were not observed under the irradiation condition of sufficiently high fuel temperature. Fission product (FP) distributions were also analyzed by EPMA. The distributions of Nd and Ba were similar with those of U and Zr. Mo and Pd were found as fine inclusions in the yttria-stabilized zirconia (YSZ) phase. A part of Cs and Xe migrated to the periphery of YSZ particles and to pores in YSZ. The FP distributions of spinel-based fuel were almost similar to corundum-based fuel.

Published
2003
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6. Corrosion defects of TbFeCo films in magneto-optical disks

Author

M. Tsuchihashi, Hiroshi Kurokawa, Yoshio Fujii, Y. Toide, K. Shindo, Kazuhiko Tsutsumi, H. Sugahara, and K. Kuramoto

Subjects
Fabrication, Materials science, Substrate (electronics), Composite material, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Magneto optical, Corrosion
Abstract

We investigated the corrosion defects of TbFeCo films in magneto-optical disks. There were two types of corrosion defects (A-type and B-type) which arose from the oxides. The A-type defect grew rapidly and became a large corrosion site. The main centre of the A-type defect was a pin-hole with large dust grains in the film. This should be prevented because it seriously degrades media life. The B-type defect was small and it was presumed to break out at the boundary between the substrate and the film. By eliminating the large dust grains, the centres of the A-type growth, we can obtain from the fabrication process highly reliable disks whose median life is estimated to be 336 y.

Published
1992
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7. Serous cystadenocarcinoma of the retroperitoneum: CT and sonographic appearance

Author

Y. Kurosaki and K. Kuramoto

Subjects
Retroperitoneal Disease, Pathology, medicine.medical_specialty, business.industry, Serous cystadenocarcinoma, Ovary, General Medicine, medicine.disease, Serous Cystadenoma, Retroperitoneal Neoplasm, Tomography x ray computed, medicine.anatomical_structure, Carcinoma, medicine, Radiology, Nuclear Medicine and imaging, business
Published
1998
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9. SRPX2 is a Novel Chondroitin Sulfate Proteoglycan that is Overexpressed in Gastrointestinal Cancer

Author

T. Hirashima, Y. Omuro, C. Kondo, T. Kanematsu, K. Muraki, Po-Chuan Wang, K. Ishiguro, Young-Ae Park, C.-Y. Lu, C.-C. Liao, H. Tei, H. Takeyama, M. Toishi, A. D. Abdullah, M. Terada, K. Yamamoto, N. Yamamoto, K. Fujii, M. Sugimoto, H. Kakizaki, K. Shinozaki, Y. Okada, Yoko Inaguma, S. Shimizu, Shigeki Ito, H. Y. Lim, N. Nogami, N. Awata, M. Nishioka, H. Ueoka, Tomoya Ishii, Y. Ahn, Kazumichi Kawakubo, Y. Aoyagi, C. Nishijima, R. Kameda, A. Okamoto, Y. Yamashita-Kashima, H. Suzuki, K. Yamao, A. Yonemori, H. Fukuda, H. Katayama, K. Honoki, T. Nomura, Y. Tono, T. Shimoyama, J. Nagano, H. Miyamoto, Y. Takeda, M. Fukutake, N. Katsumata, S. Fujita, K. Fujimoto-Ouchi, D. Tamura, H. Obaishi, S. Mitsunaga, J.-H. Baek, Yuichiro Tada, K. Uno, S. Oura, M. Nakamura, Y. Imanura, Atsushi Kumanogoh, M. Manabe, Kaoru Tanaka, T. Yokota, K. Saito, K. Tamura, Yukihiko Fujii, T. Lim, Toshihiko Tomita, C. Seki, Masafumi Taniwaki, Tomohide Sugiyama, N. Kunami, T. Yoshino, Y. Takeoka, T. Yoshikawa, Won-Suk Lee, M. Hattori, H. Yasui, T. Motoya, T. Nishizaki, N. Kouge, E. Sato, S.H. Park, J.H. Hong, N. Mori, M. Tajika, K. Yasuda, Mika Nakamae, Kazuya Fukuoka, T. Shimomura, A. Suzuki, M. Arima, Hideo Koh, S. Tokunaga, N. Miyamoto, Masao Nakata, T. Ueda, Hideharu Kimura, H. Nakano, Kimikazu Yakushijin, M. Hayashi, K. Ishitani, K. Yoshida, T. Takeuchi, Shohei Yokota, K. Hirano, N. Horikawa, S. Bandoh, G. Naka, Y. Seki, M. A. De Velasco, F. Tanikawa, S. Hirano, S. Ohkawa, S. Kadowaki, M. Sakurai, R. Kaji, J.-I. Lee, K. Kitahara, K. Nihei, T. Sumi, Meiki Fukuda, S. Park, K. Nosaka, T. Maeda, O. Morimura, G. Sano, H.-L. Wu, Haruhiko Hirata, Mizuki Aimoto, Y. Igeta, K. Itoh, Y. Ikari, Kentaro Iwanaga, K. Itatsu, Akira Ueda, C. Oabata, H. Fujiwara, T. W. Kim, K. Misu, H. Mikayama, K. Morise, K. Nagata, M. Sato, Takashi Kijima, Kazuo Kasahara, Takahiro Mori, N. Mizuno, Y. Fujitani, Abdul Aziz Baba, K. Takashima, Kazuhide Higuchi, J.-C. Jo, G. Tamaki, S. Magoshi, R. Watanabe, A. Abe, M. Iino, H. Goto, Junji Tsurutani, Y. Katashiba, K. Kato, K. Hosono, L. Y. Kwan, Y. Okabe, N. Takeuchi, Chih-Hsin Tang, I. Kawase, Takayuki Kii, D. Kishino, K. Matsuura, K. Isobe, K. Monden, H. Udagawa, K. Kim, M. Tada, Kazuyoshi Yanagihara, Cheryn Song, T. Terui, Yasuhito Fujisaka, I. Yamaguchi, Hirokazu Fukui, K. Naito, T. Suzumura, H. A. Jung, N. Ureshino, Wataru Okamoto, H. Miyawaki, N. Nakamura, T. Tsukazaki, K. Furuta, K. Matsuda, S. J. Lee, Y. Ishiura, J.-L. Lee, Y. Kato, Shinichiro Hayashi, Y. Horita, J. H. Kim, Y. Tsutsumi, M. Inaoki, K.-P. Kim, Y. Ishigatsubo, T. Mikawa, M. Yamane, A. Husin, Yasufumi Takeshita, S. Kobayashi, N. Kubo, N. Hosono, Yeong-Shiau Pu, M. Ando, Keita Kudo, Hitoshi Nishitani, M. Mori, H. Daga, T. Fukuda, A. Nakaya, N. Fuse, I. Miki, W. Yamamoto, M. Fukushima, T. Ikezoe, H. Ueno, J.-H. Ahn, T. Matsumoto, A. Kuwahara, T. Ogura, N. Hirai, S. Mizuta, A. Ochiai, N. Masumori, S. Kim, Y. Ohki, Yoshinori Imamura, T. Tamaki, K. Nishino, Y. Aoyama, T. Ogawa, T. Koyama, M. Morise, K. Kawada, T. Masaki, Keishi Yamashita, S. Yamamoto, K. Tanimoto, M. Hori, Atsuo Okamura, Masataka Ikeda, K. Oishi, H. Hashimoto, Y. Ohe, M. Yasui, Y. Akatsuka, F. Imamura, Y. Hirayama, Ho Young Kim, S. Kishi, M. Jung, Y. Inukai, K. Miwa, S.-H. Nam, T. Hishima, T. Okusaka, Y. Horiuchi, A. Ioka, W. Fukushima, M. Yamauchi, N. Hokamura, K. Hirata, Y. Katou, K. Tada, K. Suzuki, K. Teramoto, Syusai Yamada, M. Iikura, Takeo Shimasaki, Y. Inoue, K. Kawahara, T. Kitani, H. Sawai, T. Terashima, K. Honda, Hitomi Umeguchi, Masataka Okamoto, M. Kita, Y. Yatabe, Y.-M. Cho, Sojiro Kusumoto, K. Hokkoku, Takaaki Sasaki, Masayuki Hino, M. Omi, H. Tanaka, S. Kawazoe, M. Sakai, H. Tsuchihashi, Kazushi Endo, R. Mauchi, K. Ohashi, H. Takasaki, N. Naganobu, K. Aoe, S.Y. Oh, C. Honma, Takahiro Miyamoto, K. Yamazaki, M. Fujii, T. Fujisawa, S. Morikawa, T. Yamauchi, Masayoshi Kobune, K. Kuwano, T. Onikubo, M. Kuyama, M. Asayama, T. Kozuki, M. Kanie, Masahiko Shibuya, Y. Yamamoto, N. Morishita, Y. Yoshii, Toru Mukohara, K. Izumi, Y.S. Park, N.-R. Lee, Y. Horio, K. Nakamura, M. Matsuda, K. Sugino, S.H. Lee, S. Ueno, Tsutomu Sato, Y. Hasumi, H. Yamamoto, T. Karasuno, Yong Chan Ahn, M. Kitamura, Y. Namba, K. Karasawa, S. Hayasi, K. Hashimoto, Y. Ozaki, Takayuki Takahama, A. Todaka, M. Inoue, S. Boku, A. Ohtsu, Tadashi Matsunaga, K. Togitani, H.-H. Wu, Hirofumi Kogure, H. Kitamura, T. Matsuzaki, M. Gouchi, Hyun-Jin Kim, T. Shiroyama, K. Okada, Y. Terasaki, K. Park, H. Katou, N. Kobayashi, D. Mohri, Y. Hasegawa, T. Yoshimasu, Masahiro Tabata, S. Hijioka, Y.-Y. Chen, Shinji Nakao, M. Kodaira, Akihiko Gemma, T. Yoshida, Hiroya Takiuchi, Masaki Fujimura, A. Shimoda, Hiroyuki Isayama, K. Ohta, T.-L. Chen, T. Maruyama, K. Maruyama, K.-W. Lee, Takashi Hirose, Y. Fujita, H. Kato, Maya Watanabe, S. Iwasa, H. Okuyama, Cherry Wu, A. Hata, K. Myo, M. Takase, Y. Urasaki, K. Shingu, Shingo Nishikawa, M. Tsuzuki, I. Hoshi, T. Maruo, Hiroki Yoshita, Hirohisa Nakamae, Shigeru Hatabe, Hideko Ikeda, Hayato Koba, Y. Hata, S. Matsushima, M. Yunokawa, S. Tamaru, J. S. Ahn, T. Funakoshi, S.-J. Jang, S. Kageyama, K. Nakagawa, H. Nishimori, Eizaburo Sueoka, K. Hashidume, S. H. Hong, Atsushi Kawaguchi, Tomomi Nakamura, H. Kaneko, A. Seki, K.-L. Tan, T. Ichimura, Y. Matsuda, M. Nezu, M. Kudo, H. Fujii, K. Shibata, S. J. Sym, K. Takeuchi, Chiharu Tabata, M. Takeshita, Y. Ueda, A. Nakayama, N. Nishiyama, Sang We Kim, Y. S. Kim, H. Suzushima, S. Soma, K. Miura, H. Gonda, D. Gomi, A. Mogi, K. Ishizuka, T. Mizutani, Y. Yamada, A. Sato, G. Kaneko, T. Samejima, R. Shimabukuro, Masahide Fujita, K. Horie, R. Ohhashi, T. Wakasa, H. Nomura, K. Sato, T. Hamaguchi, S. Horiguchi, M. Ootsuka, S. Kawabata, Y. Okamoto, A. Yoshida, H. Takeda, M. Sugiyama, Y. S. Hong, Y. Yanagita, Yasushi Ichikawa, K. Tomii, T. Enokida, Tzyh-Chyuan Hour, Y. Takeyama, Y. Matsuura, Y. Kakehi, S. Kanazawa, S. Kimura, T. Yamada-Murano, D. Abe, Nagio Takigawa, T. Yana, A. Ogino, R. Sakai, S. Watanabe, K. A. Kwon, Y. Nakai, O. Watanabe, Naokatsu Nakada, Masanori Toyoda, H. Inomata, R. Sekine, J. S. Lee, T. Shukuya, O. Ishiko, Y. Ikeda, K. Nakase, S. Kuzu, H. Mukai, K. Ozaki, R. Koyama, Takashi Nakano, K. Hashizume, E. Noguchi, N. Hida, Y. Takamatsu, Tomoko Yamagishi, H. Agatsuma, S. Miyamoto, D.H. Lee, H. Kunimoto, H. Ogino, T. Miya, Naoki Sasahira, A. Yamane, T. Takami, N. Imai, Y. Fukui, Tae Min Kim, T. Kita, Jiro Watari, H. Kawabata, N. Motohashi, K. Aomatsu, T. Obayashi, H. Hayashi, S.-H. Li, S. Sakata, H. Okada, K. Masa, T. Iwata, H. Yoshida, Tokuzo Arao, R. Hassan, H. Imaoka, M. Kobayashi, H. Iwasaki, K. Nomura, H. Harada, T. Watanabe, K. Kaneko, H. Nakagawa, K. Sakamoto, A. Hiasa, Katsuyuki Hotta, Nobuhiko Emi, S. Maruyama, M. Yonemura, H. Tsurumi, Takuhiro Yamaguchi, M. Nagata, T. Nakai, Motoki Yoshida, S. Motomura, A. Sakai, H. Inoue, Toshimitsu Yamaoka, T. Morikita, S. Hirokawa, Hideaki Ijichi, Namiki Masayuki, Meiko Nishimura, Y. Ishii, A. Shimatani, Jong-Hyeok Kim, M. Ujihara, Yuko Kanbayashi, Y. Nakashima, T. Hosoda, K. Sanada, S. Kondo, Y. Honma, S. Sakamoto, H. Kubo, M. Kondo, F. Nomura, M. Hashizume, T. Shiraishi, B.-S. Kim, T. Kouno, T. Maki, H. Akaike, Z. Saito, Junya Fukuoka, T. Ohnishi, C. H. Maeng, M. Wada, Jong-Mu Sun, C. Morizane, Y. Matsumoto, K. Migita, Y. Okamura, Sun Young Rha, Hiroyoshi Ichihara, J. Kato, N. Yoshimura, W.-J. Wu, N. Wada, M. Yoshihara, K. Hamai, Kazuhiko Koike, Woo Kyun Bae, Y. Maeda, S. Mimura, Y. Sakai, H. Wakasugi, H. Nishimoto, M. Nagano, K. Taira, I. Park, T. Inokuma, Katsuhiko Shimizu, Y. Nakahara, S. Okamura, K. Ogawa, F. Saito, Y. Miura, Hyo Jin Lee, K. Fujita, K. Takagi, T. Shiina, Charny Park, Shin Kuwakado, N. Moto, Y.-C. Chiu, S. Saji, T. Araya, J. Takeshita, H. Iwase, Naoe Goto, H. Murakami, T. Hayashi, K. Otsuka, Rishu Takimoto, H. Nakahama, C.-C. Shih, Naoko Aragane, S. Hamauchi, H. K. Ahn, N. Tomita, N. Chyayahara, T. Hida, K. Watanabe, Y. Kokubo, N. Katusmata, L. K. Chi, M. Okumura, T. Kusakabe, S. Homma, H. Nakagomi, Hiroo Katsuya, D. B. Shin, Naoko Chayahara, F. Fukuta, Kazutoshi Shibuya, Ayumu Hosokawa, F. Ota, R. Yoshino, M. Goto, Y. Shibata, J. E. Kim, H. Watanabe, K. Mandai, T. Shimamura, S. Inoue, M. Fujimoto, S. Mitsuoka, Kunio Okamoto, M.-J. Kim, E. Chung, H. Moriwaki, Y. Misumi, S. Ogawa, K. C. Lee, J.-O. Lee, H. Hirosawa, Yoshiki Terada, A. Kinoshita, J. Hong, Y. J. Kim, A. Kido, M. Kijima, Y. Shiota, H. Hayase, A. Sekikawa, M. Ahn, K. Komuta, M. Sasaki, T. Murakami, M. Okuda, N. Matsubara, R. Saitou, R. Nakamura, K. Masuo, Kazuko Matsumoto, K. Mouri, Y. Ookuma, Kazutoshi Komiya, K. Sakai, N. Yogo, Takahiko Nakane, M. Mukai, Isao Tachibana, Shiro Kimbara, Kentaro Okuda, T. Fujisaki, S.-J. Chuang, Y. Niwa, H. Oda, Y. Nishida, T. Ando, Yuichi Ando, J. Tong, C. Shimizu, J. Choi, Satoshi Iyama, H. Imai, K. H. Park, T. Misao, Yohei Funakoshi, Chang-Sik Yu, Tadashi Kimura, J. Hori, M. Itoh, S. Ebihara, S.-H. Gan, T. Yano, H. Okamoto, E. Fukutani, U. Tateishi, T. Ishihara, Takuro Yoshimura, T. Shinkai, A. Yokoyama, T. Kikuchi, Y. Yamashita, K. Hagiwara, Y. Noda, Y. Oyama, K. Okuno, Naomi Kiyota, K. Yonemori, K. Kuramoto, T. Shimoi, H. Hong, Ryuya Yamanaka, E. Matsuki, O. Kondo, H. Gondou, Yusuke Nakamura, M.-J. Ahn, Yoshiki Hayashi, Shiro Koh, S. Kosaka, Masahiro Gotoh, S. Mizuno, H. Nakamura, S. Okazaki, E. Ichiki, M. Ishizu, K. Ishikawa, Hiroyasu Kaneda, R. Yamamura, Tomonobu Koizumi, R. Ankathil, T. Takahashi, S. Nakatsuka, A. Kamuro, M. Ueno, T. Eguchi, S. Hirai, G. Saito, S. Kudoh, Masanao Nakashima, N. Okamoto, K. Akiyoshi, Hironobu Minami, K. Kubota, K. Okafuji, M. Aoe, T. Ito, K. Nishimura, S. Ota, C. Wong, A. Ooki, Takao Shirai, Wen-Yi Chou, M. Tamiya, H. Tabuse, Y. Kaneko, Y. Shimizu, Y. Murata, A. Okada, S. Sasada, Y. Takagi, A. Naitou, N. Katayama, Kaori Ito, T. Araki, Y. Fujiwara, H. Yokota, Shinya Kajiura, M. Imano, T. Iwai, T. Kobayashi, T. Kubota, N. Kanaji, M. Ohdate, T. Tsukamoto, S. Zenda, A. Fukutomi, T. Kumura, R. Ogawa, K. Shintaku, Kazuto Nishio, T. Morimoto, W. Shioyama, E. K. Cho, H.-I. Lu, Y. Suginoshita, K. Yamaguchi, Y. Shindo, N. Hirokami, J. Shimizu, Chihiro Makimura, K. Araki, T. Taniyama, T. Tanaka, Y. Tanbo, Hiroto Miwa, Y. Hirai, J. Park, Asao Hirose, M. Doi, A. Goto, S. Nomura, S. Ikegaya, A. Yoshii, M. Akahane, T. Kakuma, K. Miyabayashi, S. Y. Kim, H. Kitade, B. Han, K. Yamada, Tadayuki Oshima, J. Ishizawa, M. Miyata, E. Sasak, R. Aibara, N. Takahara, S. Kanno, T. Kojima, I. Ohno, E. Sasaki, E. Tone, A. Morita, R. Suzuki, Yukio Hosomi, Hiroo Ishida, T. Akimoto, N. Hashimoto, T. Takakuwa, K. Umekawa, A. Toyoshima, K. Hara, J. Kitagawa, H. Taniguchi, T. Kamiya, M. Takai, Y. Watanabe, Yasuhito Tanaka, A. Sawada, T. Yasui, Y. Onozawa, Akihiro Hirakawa, S. Okamoto, K. K. Kim, Y.-M. Wang, Y. Takai, T. Tsumura, H. Hirama, Shigeo Horiike, K. Kawasumi, N. Shimeno, Junya Kuroda, C.-Y. Huang, Y.-H. Chen, H. Ogata, S. Matsumoto, I. Takahashi, Hideo Tomioka, I. Okamoto, Itaru Endo, T. M. S. Kam, K. Sekihara, C.-T. Liu, K. Chikamori, N. Hirota, K. Hiramatsu, D. Hamaguchi, T. Nishii, N. Ohmiya, T. Shimizu, T. Sakaizawa, Hiromichi Matsuoka, K. Kawa, J. H. Ji, S. Izumi, T. Hara, Y. Tsuyumu, T. Oguri, T. Akiyama, Y. Ichida, A. Simoyama, T. Hirakata, Y. Yoshimitsu, Y. Sasaki, T. Yamazaki, T. Tsushima, R. Okamoto, Y. Tsukioka, Nobuhiko Seki, S.-M. Bang, Y. Kubota, N. Harada, C.-H. Huang, J. Y. Hong, T. Andou, T. Shimada, T. Doi, Yoshihiro Ono, S. Nanjo, H. Hara, Y. Kikukawa, M. K. Choi, K.-M. Rau, Y. Tomizawa, O. Maeda, K. Ishida, Y. Naito, N. Machida, T. Otsuka, T. Hase, H. Morishita, K. Fukuhara, M. Yoshino, M. Takahashi, H. Takahashi, Heui June Ahn, M. Nisimoto, Y. Sunakawa, Y. Miyakawa, Choung Soo Kim, S.-W. Wang, Takashi Sone, M. Iguchi, T. Shimokawa, Tomoyuki Nagai, K. Morioka, A. Numata, R. Toyozawa, R. Miyahara, Y. M. Ahn, Hyo Song Kim, D. W. Hwang, H. Takamori, Shin-Hee Lee, Narikazu Boku, T. Mizuno, N. Katakami, J. H. Lee, Y. Okuma, Koji Kurokawa, K. Takeda, N. Sakiyama, R. Tachikawa, Satoshi Morita, T. K. Fai, K. H. Seong, K. Yorozu, T. Okamura, Ryo Takahashi, T. Kotake, Y. Arai, T. Kawamura, K. Yakushijinn, Y. Shimada, H. Sugiyama, S. Kamachi, A. Mugitani, T. Yasue, Y. Sugihara, S. Shu, Y. Osaki, Kazuhisa Takahashi, Y. Hashiguchi, K. Funasaka, Y. S. Koo, Tohru Ohmori, S. J. Koh, N. Kanemura, H. Kotani, M. Hsin, T. Kagoo, and A. Inoue

Subjects
biology, Molecular mass, business.industry, Angiogenesis, Hematology, Cell biology, chemistry.chemical_compound, Oncology, chemistry, Proteoglycan, Chondroitin sulfate proteoglycan, Cancer cell, medicine, biology.protein, Hepatocyte growth factor, Antibody, Cell adhesion, business, medicine.drug
Abstract

SRPX2 (Sushi repeat-containing protein, X-linked 2) has recently emerged as a multifunctional protein that is involved in seizure disorders, angiogenesis and cellular adhesion. Here, we analyzed this protein biochemically. SRPX2 protein was secreted with a highly post-translational modification. Chondroitinase ABC treatment completely decreased the molecular mass of purified SRPX2 protein to its predicted size, whereas heparitinase, keratanase and hyaluroinidase did not. Secreted SRPX2 protein was also detected using an anti-chondroitin sulfate antibody. These results indicate that SRPX2 is a novel chondroitin sulfate proteoglycan (CSPG). Furthermore, a binding assay revealed that hepatocyte growth factor dose-dependently binds to SRPX2 protein, and a ligand–glycosaminoglycans interaction was speculated to be likely in proteoglycans. Regarding its molecular architecture, SRPX2 has sushi repeat modules similar to four other CSPGs/lecticans; however, the molecular architecture of SRPX2 seems to be quite different from that of the lecticans. Taken together, we found that SRPX2 is a novel CSPG that is overexpressed in gastrointestinal cancer cells. Our findings provide key glycobiological insight into SRPX2 in cancer cells and demonstrate that SRPX2 is a new member of the cancer-related proteoglycan family.

Published
2012
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10. Palliative Care for Bone and Soft Tissue Sarcoma Patients

Author

E. Ichiki, D. Hamaguchi, R. Sekine, and K. Kuramoto

Subjects
Leiomyosarcoma, medicine.medical_specialty, Palliative care, business.industry, Soft tissue sarcoma, Hematology, medicine.disease, Synovial sarcoma, Surgery, Oncology, Medicine, Intractable pain, Angiosarcoma, Sarcoma, Chondrosarcoma, business
Abstract

Background There have been few studies on palliative care for patients with bone and soft tissue sarcoma due to its low prevalence. We report 19 cases of patients with bone and soft tissue sarcoma who were consulted to the palliative care team. Method We retrospectively reviewed all medical records of patients with bone and sot tissue sarcoma who were hospitalized for chemotherapy and consulted to the palliative care team from January 2010 to 15 October 2011. Results Nineteen patients (6 males and 13 females) were reviewed in this study. The median age was 50 years (23–87). The histological subtypes included leiomyosarcoma (n = 8), gastrointestinal stromal tumor (n = 3), Ewing sarcoma (n = 2), angiosarcoma (n = 2), osteosarcoma (n = 1), chondrosarcoma (n = 1), synovial sarcoma (n = 1), and malignant fibrous sarcoma (n = 1). The sites of metastases were lung (n = 11), pelvic viscera (n = 8), liver (n = 7), and bone (n = 7). The median number of chemotherapy regimens was 2 (0–5). The most common life-threatening complication was respiratory failure (n = 6), followed by bleeding of the tumor (n = 3), pulmonary embolism (n = 2), and bowel perforation (n = 1). Reasons of consultation were psychological support (n = 7), intractable pain (n = 6), and lymphedema (n = 6). Fifteen patients (79%) used opioids, including fentanyl patch 33%, fentanyl continuous infusion 20%, oral oxycodone 20%, oral morphine 13%, and morphine continuous infusion 13%. One patient used an antidepressant drug. Conclusions The patients with bone and soft tissue sarcoma tended to be highly distressed by the absence of enough information about their disease and standard chemotherapy in the early stage of therapy, therefore they needed psychological support. In the middle and the late stage of disease, they tended to have life-threatening complications that worsen the prognosis.

Published
2012
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